Prof Christopher Yeo

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Name: Christopher Yeo Email: c.yeo@ucl.ac.uk
Title: Prof Tel: 020 7679 7377
Department: Neuroscience, Physiology & Pharmacology Fax: 020 7679 7377
Position: Professor of Behavioural Neuroscience Address: Dept. Anatomy & Developmental Biology, University College, London, WC1E 6BT
Research Domain: Basic Life Sciences, Biomedical Imaging (Frontier Disciplines), Experimental Medicine, Neuroscience, Personalised Medicine Web Page: Personal Web Page

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Research Description

In analysing how the brain controls behaviour, an ideal approach is to characterise the activity of a real network of neurons with an essential role in the control of an identified behaviour. In selecting such a network for investigation, the cerebellum stands out. Its influence upon behaviour is ubiquitous. Long seen as an important regulator of reflex and voluntary movements, it is now recognized that the cerebellum is critically important in many aspects of sensorimotor control and learning. Recent evidence that cerebellar damage may be associated with dyslexia, autism and disturbances of time estimation have led to suggestions that the cerebellum is also important for cognitive function.
Three special properties recommend the cerebellar neural network for investigation:
First, the cerebellum has prodigious computational power â?" it contains more than half of all the neurons in the brain.
Second, because of its special architecture, the size of this neuronal population does not deter analysis. Cerebellar neurons are arranged in a regularly repeating, geometrical array to form a large set of regularly repeating microcircuits.
The anatomical and physiological similarity of these microcircuits suggests a consistent type of information processing - the cerebellar algorithm.
Third, the microcircuits are mapped in an orderly fashion within the cerebellum. Each receives an appropriate set of sensory inputs but applies the computational result solely to a specific output region. For many cerebellar microcircuits this output is, ultimately, to a small set of motoneurons that control an individual muscle or group of synergist muscles.
These unique features of the cerebellar architecture enable a very special approach to the analysis of behavioural control. A specific target movement can be selected and the properties of the cerebellar neurons contained only in those microcircuits that directly control that movement can be analysed. Since the cerebellum is specifically implicated in learning, a target movement that can be shown to undergo modification through learning can be analysed. This strategy enables us to investigate how, with specified inputs and outputs, local synaptic change in an identified set of cerebellar microcircuits can generate a globally intelligent behaviour.
A leading candidate behaviour for investigation is classical conditioning of the rabbit eyeblink/nictitating membrane response (NMR). Lesion and reversible inactivation studies have revealed its dependence upon the cerebellum but have not revealed how the essential neural plasticity is distributed across and within the cerebellar cortical and nuclear circuitry. Our work in defining how the cerebellum generates this behaviour is at several levels of analysis. We are working to:
1. Describe how plasticity essential for eyeblink/NMR conditioning is partitioned between cortical and nuclear levels.
2. Define whether learning-related cerebellar plasticity has properties similar to previously identified in vitro forms.
3. Analyse how the relevant cerebellar Purkinje cells and nuclear neurons behave during reflex and learned eyeblinks and describe how their activities are related.
4. Determine how Purkinje cell simple and complex spikes change their behaviour as learning proceeds.
5. Use information from the empirical work to make descriptive, and then computational, models of cerebellar action that will explain how local synaptic learning rules result in overall intelligent behaviour.

Research Activities

Learning and memory in cerebellum.

Education Description

UCL Collaborators

External Collaborators

Publications

    2012

    • Hoffland BS, Bologna M, Kassavetis P, Teo JT, Rothwell JC, Yeo CH, van de Warrenburg BP, Edwards MJ (2012). Cerebellar theta burst stimulation impairs eyeblink classical conditioning.. J Physiol, 590(Pt 4), 887 - 897. doi:10.1113/jphysiol.2011.218537

    2010

    • Mostofi A, Holtzman T, Grout AS, Yeo CH, Edgley SA (2010). Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.. J Neurosci, 30(26), 8920 - 8934. doi:10.1523/JNEUROSCI.6117-09.2010
    • Lepora NF, Porrill J, Yeo CH, Dean P (2010). Sensory prediction or motor control? Application of Marr-Albus type models of cerebellar function to classical conditioning. FRONT COMPUT NEUROSC, 4, - . doi:10.3389/fncom.2010.00140
    • Kellett DO, Fukunaga I, Chen-Kubota E, Dean P, Yeo CH (2010). Memory consolidation in the cerebellar cortex.. PLoS One, 5(7), e11737 - . doi:10.1371/journal.pone.0011737

    2009

    • Lepora NF, Porrill J, Yeo CH, Evinger C, Dean P (2009). Recruitment in Retractor Bulbi Muscle During Eyeblink Conditioning: EMG Analysis and Common-Drive Model. J NEUROPHYSIOL, 102(4), 2498 - 2513. doi:10.1152/jn.00204.2009
    • Naidich TP, Duvernoy HM, Delman BN, Sorensen AG, Kollias SS, Haacke EM, Contributing author Yeo CH (2009). Duvernoy's Atlas of the Human Brain Stem and Cerebellum.

    2007

    • Lepora NF, Mavritsaki E, Porrill J, Yeo CH, Evinger C, Dean P (2007). Evidence from retractor bulbi EMG for linearized motor control of conditioned nictitating membrane responses. Journal of Neurophysiology, 98(4), 2074 - 2088. doi:10.1152/jn.00210.2007
    • Mavritsaki E, Lepora N, Porrill J, Yeo CH, Dean P (2007). Response linearity determined by recruitment strategy in detailed model of nictitating membrane control. Biological Cybernetics, 96(1), 39 - 57. doi:10.1007/s00422-006-0105-5
    • Fukunaga I, Yeo CH, Batchelor AM (2007). The mGlu1 antagonist CPCCOEt enhances the climbing fibre response in Purkinje neurones independently of glutamate receptors. Neuropharmacology, 52(2), 450 - 458. doi:10.1016/j.neuropharm.2006.08.014
    • Fukunaga I, Yeo CH, Batchelor AM (2007). Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. British Journal of Pharmacology, 151(6), 870 - 876. doi:10.1038/sj.bjp.0707286

    2005

    • De Zeeuw CI, Yeo CH (2005). Time and tide in cerebellar memory formation. Current Opinion in Neurobiology, 15, 667 - 674.

    2004

    • Cooke S, Attwell PJE, Yeo CH (2004). Temporal properties of cerebellar-dependent memory consolidation. Journal of Neuroscience, 24, 2934 - 2941. doi:10.1523/JNEUROSCI.5505-03.2004
    • Yeo CH (2004). Memory and the cerebellum. Current Neurology and Neuroscience Reports, 4, 87 - 89.

    2003

    • Rogelj B, Hartmann CEA, Yeo CH, Hunt SP, Giese KP (2003). Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus. European Journal of Neuroscience, 18(11), 3089 - 3096.

    2002

    • Hesslow G, Yeo CH (2002). The functional anatomy of skeletal conditioning. In Moore JW (Ed.), A Neuroscientists Guide to Classical Conditioning (pp. 86 - 146). : Springer.
    • Attwell PJE, Cooke S, Yeo CH (2002). Cerebellar function in consolidation of a motor memory. Neuron, 34, 1011 - 1020. doi:10.1016/S0896-6273(02)00719-5
    • Sanchez M, Sillitoe RV, Attwell PJE, Ivarsson M, Rahman S, Yeo CH, Hawkes R (2002). Compartmentation of the rabbit cerebellar cortex. The Journal of Comparative Neurology, 444, 159 - 173. doi:10.1002/cne.10144
    • Attwell PJE, Ivarsson M, Millar L, Yeo CH (2002). Cerebellar mechanisms in eyeblink conditioning. Annals of the New York Academy of Sciences, 978, 79 - 92.
    • Ivarsson M, Millar L, Yeo CH (2002). Electrophysiological mapping of eyeblink microzones in rabbit.

    2001

    • Attwell PJ, Rahman S, Yeo CH (2001). Acquisition of eyeblink conditioning is critically dependent on normal function in cerebellar cortical lobule HVI.. J Neurosci, 21(15), 5715 - 5722.
    • Yeo CH (2001). Habituation. In Blakemore C, Jenner S (Ed.), The Oxford Companion to the Body (pp. - ). : Oxford University Press.

    2000

    • Ivarsson M, Rahman S, Yeo CH (2000). Conditioning eyelid and nictitating membrane responses - Both are controlled by cerebellar cortical lobule HV1. EUR J NEUROSCI, 12, 138 - 138.
    • Cooke SF, Attwell PJE, Yeo CH (2000). Consolidation of motor learning: Functions of the cerebellar cortex and nuclei dissociated.. EUR J NEUROSCI, 12, 84 - 84.
    • Rahman S, Yeo CH (2000). Reversible inactivation of the cerebellar cortex prevents extinction of conditioned nictitating membrane responses in rabbits. EUR J NEUROSCI, 12, 438 - 438.

    1999

    • Attwell PJE, Rahman S, Ivarsson M, Yeo CH (1999). Cerebellar cortical AMPA/kainate receptor blockade prevents performance of classically conditioned nictitating membrane responses. Journal of Neuroscience, 19, - .

    1998

    • Yeo CH, Hesslow G (1998). Cerebellum and conditioned reflexes. Trends in Cognitive Sciences, 2, 322 - 337.
    • Hesslow G, Yeo CH (1998). Cerebellum and learning - a complex problem. Science, 280, 1817 - 1818.

    1997

    • Yeo CH, Lobo DJ, Baum A (1997). Acquisition of a new-latency conditioned nictitating membrane response - major, but not complete, dependence upon ispilateral cerebellum. Learning and Memory, 3, 557 - 577.

    1996

    • van Ham JJ, Yeo CH (1996). Trigeminal inputs to eyeblink motoneurons in the rabbit.. Exp Neurol, 142(2), 244 - 257. doi:10.1006/exnr.1996.0195
    • van Ham JJ, Yeo CH (1996). The central distribution of primary afferents from the external eyelids, conjunctiva, and cornea in the rabbit, studied using WGA-HRP and B-HRP as transganglionic tracers.. Exp Neurol, 142(2), 217 - 225. doi:10.1006/exnr.1996.0193
    • Hardiman MJ, Ramnani N, Yeo CH (1996). Reversible inactivations of the cerebellum with muscimol prevent the acquisition and extinction of conditioned nictitating membrane responses in the rabbit.. Exp Brain Res, 110(2), 235 - 247.
    • Ramnani N, Yeo CH (1996). Reversible inactivations of the cerebellum prevent the extinction of conditioned nictitating membrane responses in rabbits.. J Physiol, 495 ( Pt 1), 159 - 168.

    1995

    • Gruart A, Yeo CH (1995). Cerebellar cortex and eyeblink conditioning: bilateral regulation of conditioned responses.. Exp Brain Res, 104(3), 431 - 448.

    1993

    • HARVEY JA, WELSH JP, YEO CH, ROMANO AG (1993). RECOVERABLE AND NONRECOVERABLE DEFICITS IN CONDITIONED-RESPONSES AFTER CEREBELLAR CORTICAL-LESIONS. J NEUROSCI, 13(4), 1624 - 1635.

    1992

    • GILBERT P, YEO C (1992). CEREBELLAR FUNCTION - ONLINE CONTROL AND LEARNING. BEHAVIORAL AND BRAIN SCIENCES, 15(4), 743 - 744.
    • Yeo CH, Hardiman MJ (1992). Cerebellar cortex and eyeblink conditioning: a reexamination.. Exp Brain Res, 88(3), 623 - 638.
    • Van Ham JJ, Yeo CH (1992). Somatosensory Trigeminal Projections to the Inferior Olive, Cerebellum and other Precerebellar Nuclei in Rabbits.. Eur J Neurosci, 4(4), 302 - 317.
    • Hardiman MJ, Yeo CH (1992). The Effect of Kainic Acid Lesions of the Cerebellar Cortex on the Conditioned Nictitating Membrane Response in the Rabbit.. Eur J Neurosci, 4(10), 966 - 980.

    1991

    • YEO C (1991). CEREBELLUM AND CLASSICAL-CONDITIONING OF MOTOR-RESPONSES. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 627, 292 - 304. doi:10.1111/j.1749-6632.1991.tb25933.x
    • Yeo CH (1991). Cerebellum and classical conditioning of motor responses.. Ann N Y Acad Sci, 627, 292 - 304.

    1989

    • Wells GR, Hardiman MJ, Yeo CH (1989). Visual projections to the pontine nuclei in the rabbit: orthograde and retrograde tracing studies with WGA-HRP.. J Comp Neurol, 279(4), 629 - 652. doi:10.1002/cne.902790410

    1987

    • JAMES GO, HARDIMAN MJ, YEO CH (1987). HIPPOCAMPAL-LESIONS AND TRACE CONDITIONING IN THE RABBIT. BEHAV BRAIN RES, 23(2), 109 - 116.

    1986

    • YEO CH, HARDIMAN MJ, GLICKSTEIN M (1986). CLASSICAL-CONDITIONING OF THE NICTITATING-MEMBRANE RESPONSE OF THE RABBIT .4. LESIONS OF THE INFERIOR OLIVE. EXP BRAIN RES, 63(1), 81 - 92.

    1985

    • YEO CH, HARDIMAN MJ, GLICKSTEIN M (1985). CLASSICAL-CONDITIONING OF THE NICTITATING-MEMBRANE RESPONSE OF THE RABBIT .1. LESIONS OF THE CEREBELLAR NUCLEI. EXP BRAIN RES, 60(1), 87 - 98.
    • YEO CH, HARDIMAN MJ, GLICKSTEIN M (1985). CLASSICAL-CONDITIONING OF THE NICTITATING-MEMBRANE RESPONSE OF THE RABBIT .2. LESIONS OF THE CEREBELLAR CORTEX. EXP BRAIN RES, 60(1), 99 - 113.
    • YEO CH, HARDIMAN MJ, GLICKSTEIN M (1985). CLASSICAL-CONDITIONING OF THE NICTITATING-MEMBRANE RESPONSE OF THE RABBIT .3. CONNECTIONS OF CEREBELLAR LOBULE HVI. EXP BRAIN RES, 60(1), 114 - 126.
    • YEO CH, HARDIMAN MJ (1985). THE ROLE OF THE CEREBELLAR CORTEX AND INFERIOR OLIVE IN A SIMPLE FORM OF MOTOR LEARNING. BEHAV BRAIN RES, 16(2-3), 236 - 236.

    1984

    • YEO CH, HARDIMAN MJ, GLICKSTEIN M (1984). DISCRETE LESIONS OF THE CEREBELLAR CORTEX ABOLISH THE CLASSICALLY-CONDITIONED NICTITATING-MEMBRANE RESPONSE OF THE RABBIT. BEHAV BRAIN RES, 13(3), 261 - 266.
    • YEO CH, HARDIMAN MJ, MOORE JW, RUSSELL IS (1984). TRACE CONDITIONING OF THE NICTITATING-MEMBRANE RESPONSE IN DECORTICATE RABBITS. BEHAV BRAIN RES, 11(1), 85 - 88.
    • HARDIMAN MJ, YEO CH (1984). THE EFFECTS OF CEREBELLAR NUCLEI LESIONS ON THE CONDITIONED NICTITATING-MEMBRANE RESPONSE OF THE RABBIT. BEHAV BRAIN RES, 12(2), 197 - 198.
    • GLICKSTEIN M, HARDIMAN MJ, YEO CH (1984). LESIONS OF CEREBELLAR LOBULUS SIMPLEX ABOLISH THE CLASSICALLY-CONDITIONED NICTITATING-MEMBRANE RESPONSE OF THE RABBIT. J PHYSIOL-LONDON, 350(MAY), P31 - P31.
    • YEO CH, HARDIMAN MJ (1984). LESIONS OF CEREBELLAR CORTEX ABOLISH CONDITIONING OF THE RABBITS NICTITATING-MEMBRANE RESPONSE. BEHAV BRAIN RES, 12(2), 251 - 252.

    1983

    • YEO CH, HARDIMAN MJ, MOORE JW, RUSSELL IS (1983). RETENTION OF CONDITIONED INHIBITION OF THE NICTITATING-MEMBRANE RESPONSE IN DECORTICATE RABBITS. BEHAV BRAIN RES, 10(2-3), 383 - 392.
    • GLICKSTEIN M, HARDIMAN MJ, YEO CH (1983). THE EFFECTS OF CEREBELLAR LESIONS ON THE CONDITIONED NICTITATING-MEMBRANE RESPONSE OF THE RABBIT. J PHYSIOL-LONDON, 341(AUG), P30 - P31.

    1982

    • YEO CH, HARDIMAN MJ (1982). CEREBRAL-CORTEX AND CONDITIONED INHIBITION. BEHAV BRAIN RES, 5(1), 127 - 128.

    1981

    • CROWNE DP, YEO CH, RUSSELL IS (1981). THE EFFECTS OF UNILATERAL FRONTAL EYE FIELD LESIONS IN THE MONKEY - VISUAL-MOTOR GUIDANCE AND AVOIDANCE-BEHAVIOR. BEHAV BRAIN RES, 2(2), 165 - 187.

    1980

    • MOORE JW, YEO CH, OAKLEY DA, RUSSELL IS (1980). CONDITIONED INHIBITION OF THE NICTITATING-MEMBRANE RESPONSE IN DECORTICATE RABBITS. BEHAV BRAIN RES, 1(5), 397 - 409.
    • ALLAN AM, DESMOND JE, STOCKMAN ER, ROMANO AG, MOORE JW, YEO CH, STEELERUSSELL I (1980). EFFICIENT CONDITIONED INHIBITION OF THE RABBITS NICTITATING-MEMBRANE RESPONSE WITH MASSED TRAINING. B PSYCHONOMIC SOC, 16(5), 321 - 324.

    1979

    • YEO CH, MOORE JW (1979). CEREBRAL-CORTEX AND INHIBITORY LEARNING. EXP BRAIN RES, 36(3), R25 - R25.

    1978

    • CROWNE DP, YEO CH, RUSSELL IS (1978). IMPAIRED VISUAL-MOTOR GUIDANCE AND SENSORY INATTENTION FOLLOWING UNILATERAL FRONTAL EYE FIELD LESIONS IN MONKEY. EXP BRAIN RES, 32(3), R9 - R10.

    1976

    • YEO C, SAVAGE G (1976). MESENCEPHALIC AND DIENCEPHALIC COMMISSURES AND INTEROCULAR TRANSFER IN GOLDFISH. EXPERIMENTAL NEUROLOGY, 53(1), 51 - 63. doi:10.1016/0014-4886(76)90280-6

    1975

    • YEO C (1975). PATHWAYS OF INTEROCULAR TRANSFER IN GOLDFISH. EXPERIMENTAL BRAIN RESEARCH, 23, 223 - 223.
    • YEO C, SAVAGE G (1975). TECTAL COMMISSURE AND INTEROCULAR TRANSFER OF A SHAPE DISCRIMINATION IN GOLDFISH. EXPERIMENTAL NEUROLOGY, 49(1), 291 - 298. doi:10.1016/0014-4886(75)90212-5