Dr Martin Stocker

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Name: Martin Stocker Email: m.stocker@ucl.ac.uk
Title: Dr Tel: 020 7679 7244
Department: Neuro, Physiology & Pharmacology Fax: 020 7679 7245
Position: Reader in Molecular and Cellular Neuroscience Address: LMP, MRC Laboratory of Molecular & Cellular Biology, Gower Street, London, WC1E 6BT
Research Domain: Basic Life Sciences, Neuroscience Web Page: Personal Web Page

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Research Description

The laboratory studies several aspects of potassium channel molecular physiology, combining molecular biology with electrophysiology, histochemistry and biochemistry. In particular, we investigate the mechanisms responsible for targeting, clustering and regulation of calcium-activated potassium channels to understand how these channels influence the signal processing of neurons in the central nervous system. A second line of research concerns the structural and functional properties of the modulatory potassium channel subunits, which comprise one-fourth of all voltage-gated K+ channels. The aim is to understand the physiological relevance of these ion channels in particular in the central nervous system. Finally, we are screening and characterizing novel drugs and toxins acting as highly selective blockers or openers of potassium channels. These molecules are invaluable tools to define the function of different potassium channels.

Research Activities

Potassium channels as multiprotein complexes: targeting, localisation and functional correlation

Regulation of G Protein-Coupled Receptor Function by the G Protein-Coupled Receptor Kinase Family

Regulation of signal processing in neurons

Visual function and disease

Education Description

UCL Collaborators

Prof Paola Pedarzani; Prof Daniel Cutler; Prof David Hunt; Prof Chris Richards; Dr Julie Pitcher; Prof Tom Salt; Prof Glen Jeffery; Prof Andrew Webster; Prof Jim Bowmaker

External Collaborators

Publications

    2013

    • Tonini R, Ferraro T, Sampedro-Castañeda M, Cavaccini A, Stocker M, Richards CD, Pedarzani P (2013). Small-conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons.. J Neurophysiol, 109(6), 1514 - 1524. doi:10.1152/jn.00346.2012
    • Gymnopoulos M, Cingolani LA, Pedarzani P, Stocker M (2013). Developmental mapping of small conductance calcium-activated potassium channel expression in the rat nervous system.. J Comp Neurol, , - . doi:10.1002/cne.23466
    • Taylor RD, Madsen MG, Krause M, Sampedro-Castañeda M, Stocker M, Pedarzani P (2013). Pituitary adenylate cyclase-activating polypeptide (PACAP) inhibits the slow afterhyperpolarizing current sIAHP in CA1 pyramidal neurons by activating multiple signaling pathways.. Hippocampus, , - . doi:10.1002/hipo.22201

    2012

    • Smith KE, Wilkie SE, Tebbs-Warner JT, Jarvis BJ, Gallasch L, Stocker M, Hunt DM (2012). Functional analysis of missense mutations in Kv8.2 causing cone dystrophy with supernormal rod electroretinogram.. J Biol Chem, 287(52), 43972 - 43983. doi:10.1074/jbc.M112.388033

    2008

    • Pedarzani P, Stocker M (2008). Molecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.. Cell Mol Life Sci, 65(20), 3196 - 3217. doi:10.1007/s00018-008-8216-x

    2007

    • Nolting A, Ferraro T, D'hoedt D, Stocker M (2007). An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels.. J Biol Chem, 282(6), 3478 - 3486. doi:10.1074/jbc.M607213200

    2005

    • Pedarzani P, McCutcheon JE, Rogge G, Jensen BS, Christophersen P, Hougaard C, Strøbaek D, Stocker M (2005). Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.. J Biol Chem, 280(50), 41404 - 41411. doi:10.1074/jbc.M509610200
    • Kerschensteiner D, Soto F, Stocker M (2005). Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits.. Proc Natl Acad Sci U S A, 102(17), 6160 - 6165. doi:10.1073/pnas.0500468102

    2004

    • Stocker M (2004). Ca(2+)-activated K+ channels: molecular determinants and function of the SK family.. Nat Rev Neurosci, 5(10), 758 - 770. doi:10.1038/nrn1516
    • Stocker M, Hirzel K, D'hoedt D, Pedarzani P (2004). Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations.. Toxicon, 43(8), 933 - 949. doi:10.1016/j.toxicon.2003.12.009
    • D'hoedt D, Hirzel K, Pedarzani P, Stocker M (2004). Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity.. Journal of Biological Chemistry, 279(13), 12088 - 12092.
    • Scuvee-Moreau J, Boland A, Graulich A, Van Overmeire L, D'hoedt D, Graulich-Lorge F, Thomas E, Abras A, Stocker M, Liegeois JF, Seutin V (2004). Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices. British Journal of Pharmacology, 143(6), 753 - 764.
    • Ferber M, Al-Sabi A, Stocker M, Olivera BM, Terlau H (2004). Identification of a mammalian target of kappaM-conotoxin RIIIK. Toxicon, 43(8), 915 - 921.

    2003

    • Winklhofer M, Matthias K, Seifert G, Stocker M, Sewing S, Herget T, Steinhauser C, Saaler-Reinhardt S (2003). Analysis of phosphorylation-dependent modulation of Kv1.1 potassium channels. Neuropharmacology, 44(6), 829 - 842.
    • Kerschensteiner D, Monje F, Stocker M (2003). Structural determinants of the regulation of the voltage-gated potassium channel Kv2.1 by the modulatory alpha-subunit Kv9.3. Journal of Biological Chemistry, 278(20), 18154 - 18161. doi:10.1074/jbc.M213117200

    2002

    • Krause M, Offermanns S, Stocker M, Pedarzani P (2002). Functional specificity of G alpha q and G alpha11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons. Journal of Neuroscience, 22(3), 666 - 673.
    • Hentrich K, Gymnopoulos M, Ruppelt A, Stocker M (2002). BKAP, a novel protein interacting with mammalian large-conductance calcium-activated (BK) potassium channels.
    • Cingolani LA, Gymnopoulos M, Boccaccio A, Stocker M, Pedarzani P (2002). Developmental regulation of small-conductance Ca2+-activated K+ channel expression and function in rat Purkinje neurons.. J Neurosci, 22(11), 4456 - 4467.
    • Pedarzani P, D'hoedt D, Doorty KB, Wadsworth JDF, Joseph JS, Jeyaseelan K, Kini RM, Gadre SV, Sapatnekar SM, Stocker M, Strong PN (2002). Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. Journal of Biological Chemistry, 277(48), 46101 - 46109.
    • Kerschensteiner D, Monje F, Stocker M (2002). Structural determinants of modulation of Kv2.1 inactivation by Kv9.3.

    2001

    • Pedarzani P, Mosbacher J, Rivard A, Cingolani LA, Oliver D, Stocker M, Adelman JP, Fakler B (2001). Control of electrical activity in central neurons by modulating the gating of small conductance Ca2+-activated K+ channels. Journal of Biological Chemistry, 276(13), 9762 - 9769. doi:10.1074/jbc.M010001200

    2000

    • Stocker M, Pedarzani P (2000). Differential distribution of three Ca(2+)-activated K(+) channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system.. Mol Cell Neurosci, 15(5), 476 - 493. doi:10.1006/mcne.2000.0842
    • Kerschensteiner D, Stocker M (2000). Kv9.3, a modulatory alpha subunit changing the state dependence of inactivation.
    • Pedarzani P, Kulik A, Muller M, Ballanyi K, Stocker M (2000). Molecular determinants of Ca2+-dependent K+ channel function in rat dorsal vagal neurones.. J Physiol, 527 Pt 2, 283 - 290.
    • Jacobsen RB, Koch ED, Lange-Malecki B, Stocker M, Verhey J, Van Wagoner RM, Vyazovkina A, Olivera BM, Terlau H (2000). Single amino acid substitutions in kappa-conotoxin PVIIA disrupt interaction with the Shaker K+ channel. Journal of Biological Chemistry, 276(32), 24639 - 24644.

    1999

    • Stocker M, Krause M, Pedarzani P (1999). An apamin-sensitive Ca2+-activated K+ current in hippocampal pyramidal neurons.. Proc Natl Acad Sci U S A, 96(8), 4662 - 4667.
    • Kerschensteiner D, Stocker M (1999). Heteromeric assembly of Kv2.1 with Kv9.3: effect on the state dependence of inactivation.. Biophysical Journal, 77(1), 248 - 257.
    • Stocker M, Hellwig M, Kerschensteiner D (1999). Subunit assembly and domain analysis of electrically silent K+ channel ?-subunits of the rat Kv9 subfamily.. Journal of Neurochemistry, 72(4), 1725 - 1734. doi:10.1046/j.1471-4159.1999.721725.x

    1998

    • Shon KJ, Stocker M, Terlau H, Stühmer W, Jacobsen R, Walker C, Grilley M, Watkins M, Hillyard DR, Gray WR, Olivera BM (1998). ?-Conotoxin PVIIA is a peptide inhibiting the Shaker K channel.. Journal of Biological Chemistry, 273(11), 33 - 38.
    • Stocker M, Kerschensteiner D (1998). Cloning and tissue distribution of two new potassium channel ?-subunits from rat brain.. Biochemical and Biophysical Research Communications, 248(3), 927 - 934. doi:10.1006/bbrc.1998.9072
    • Shon KJ, Stocker M, Terlau H, Stuhmer W, Jacobsen R, Walker C, Grilley M, Watkins M, Hillyard DR, Gray WR, Olivera BM (1998). kappa-conotoxin PVIIA is a peptide inhibiting the Shaker K+ channel. J BIOL CHEM, 273(1), 33 - 38.

    1997

    • Terlau H, Jacobson R, Shon KJ, Stocker M, Stuhmer W, Olivera BM (1997). K-conotoxin PVIIa, a Conus peptide targeted to potassium channels H..

    1996

    • Terlau H, Stocker M, Shon KJ, McIntosh JM, Olivera BM (1996). MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I.. J Neurophysiol, 76(3), 1423 - 1429.
    • Terlau H, Shon KJ, Grilley M, Stocker M, Stuhmer W, Olivera BM (1996). Strategy for rapid immobilization of prey by a fish-hunting marine snail. NATURE, 381(6578), 148 - 151.
    • Strong PN, Stocker M, Jenkinson DH (1996). Apamin binding proteins and oligosaccharyltransferases. TOXICON, 34(5), 507 - 509.

    1994

    • Stocker M, Miller C (1994). Electrostatic distance geometry in a K+ channel vestibule.. Proc Natl Acad Sci U S A, 91(20), 9509 - 9513.
    • MILLER C, STOCKER M, GOLDSTEIN SAN (1994). CHARYBDOTOXIN AS A STRUCTURAL PROBE OF SHAKER - COMPLEMENTARY MUTAGENESIS AND ELECTROSTATIC DISTANCE GEOMETRY.

    1992

    • Rettig J, Wunder F, Stocker M, Lichtinghagen R, Mastiaux F, Beckh S, Kues W, Pedarzani P, Schröter KH, Ruppersberg JP (1992). Characterization of a Shaw-related potassium channel family in rat brain.. EMBO J, 11(7), 2473 - 2486.
    • PONGS O, WUNDER F, RETTIG J, STOCKER M, HEINEMANN SH, STUHMER W (1992). VOLTAGE-GATED K-CHANNELS EXPRESSED IN HEART-TISSUE.

    1991

    • RUPPERSBERG JP, FRANK R, PONGS O, STOCKER M (1991). CLONED NEURONAL IK(A) CHANNELS REOPEN DURING RECOVERY FROM INACTIVATION. NATURE, 353(6345), 657 - 660.
    • RUPPERSBERG JP, STOCKER M, PONGS O, HEINEMANN SH, FRANK R, KOENEN M (1991). REGULATION OF FAST INACTIVATION OF CLONED MAMMALIAN IK(A) CHANNELS BY CYSTEINE OXIDATION. NATURE, 352(6337), 711 - 714.
    • Stocker M, Pongs O, Hoth M, Heinemann SH, Stühmer W, Schröter KH, Ruppersberg JP (1991). Swapping of functional domains in voltage-gated K+ channels.. Proc Biol Sci, 245(1313), 101 - 107. doi:10.1098/rspb.1991.0094
    • Wittka R, Stocker M, Boheim G, Pongs O (1991). Molecular basis for different rates of recovery from inactivation in the Shaker potassium channel family.. FEBS Lett, 286(1-2), 193 - 200.
    • STUHMER W, CONTI F, STOCKER M, PONGS O, HEINEMANN SH (1991). GATING CURRENTS OF INACTIVATING AND NONINACTIVATING POTASSIUM CHANNELS EXPRESSED IN XENOPUS OOCYTES. PFLUG ARCH EUR J PHY, 418(4), 423 - 429.
    • SCHROTER KH, RUPPERSBERG JP, WUNDER F, RETTIG J, STOCKER M, PONGS O (1991). CLONING AND FUNCTIONAL EXPRESSION OF A TEA-SENSITIVE A-TYPE POTASSIUM CHANNEL FROM RAT-BRAIN. FEBS LETT, 278(2), 211 - 216.

    1990

    • Grupe A, Schröter KH, Ruppersberg JP, Stocker M, Drewes T, Beckh S, Pongs O (1990). Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.. EMBO J, 9(6), 1749 - 1756.
    • RUPPERSBERG JP, SCHROTER KH, SAKMANN B, STOCKER M, SEWING S, PONGS O (1990). HETEROMULTIMERIC CHANNELS FORMED BY RAT-BRAIN POTASSIUM-CHANNEL PROTEINS. NATURE, 345(6275), 535 - 537.
    • Lichtinghagen R, Stocker M, Wittka R, Boheim G, Stühmer W, Ferrus A, Pongs O (1990). Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster.. EMBO J, 9(13), 4399 - 4407.
    • Stocker M, Stühmer W, Wittka R, Wang X, Müller R, Ferrus A, Pongs O (1990). Alternative Shaker transcripts express either rapidly inactivating or noninactivating K+ channels.. Proc Natl Acad Sci U S A, 87(22), 8903 - 8907.

    1989

    • STUHMER W, RUPPERSBERG JP, SCHROTER KH, SAKMANN B, STOCKER M, GIESE KP, PERSCHKE A, BAUMANN A, PONGS O (1989). MOLECULAR-BASIS OF FUNCTIONAL DIVERSITY OF VOLTAGE-GATED POTASSIUM CHANNELS IN MAMMALIAN BRAIN. EMBO J, 8(11), 3235 - 3244.

    1988

    • STUHMER W, STOCKER M, SAKMANN B, SEEBURG P, BAUMANN A, GRUPE A, PONGS O (1988). POTASSIUM CHANNELS EXPRESSED FROM RAT-BRAIN CDNA HAVE DELAYED RECTIFIER PROPERTIES. FEBS LETT, 242(1), 199 - 206.