Prof Steve Moss


Personal Profile

Name: Steve Moss Email:
Title: Prof Tel: 020 7679 7908
Department: Neuro, Physiology & Pharmacology Fax: 020 7679 7805
Position: Professor of Molecular Pharmacology and Cell Biology Address: , , ,
Research Domain: Neuroscience Web Page: Personal Web Page


Research Description

Research Activities

Assembly, membrane trafficking and regulation of GABA receptors

Education Description

UCL Collaborators

External Collaborators



    • Arancibia-Carcamo IL, Yuen EY, Muir J, Lumb MJ, Michels G, Saliba RS, Smart TG, Yan Z, Kittler JT, Moss SJ (2009). Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. Proceedings of the National Academy of Sciences of the United States of America, 106(41), 17552 - 17557. doi:10.1073/pnas.0905502106


    • Terenuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ (2008). Deficits in phosphorylation of GABAA receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. Journal of Neuroscience, 28, 376 - 384. doi:10.1523/JNEUROSCI.4346-07.2008
    • Kittler JT, Chen G, Kukhtina V, Vahedi-Faridi A, Gu Z, Tretter V, Smith KR, McAinsh K, Arancibia-Carcamo IL, Saenger W, Haucke V, Yan Z, Moss SJ (2008). Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.. Proceedings of the National Academy of Sciences of the United States of America, 105, 3616 - 3621.
    • Smith KR, McAinsh K, Chen G, Arancibia-Carcamo IL, Haucke V, Yan Z, Moss SJ, Kittler JT (2008). Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABAA receptor β and γ- subunits with the clathrin AP2 adaptor. Neuropharmacology, 55, 844 - 850. doi:10.1016/j.neuropharm.2008.06.072


    • Houston CM, Lee HH, Hosie AM, Moss SJ, Smart TG (2007). Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors.. Journal of Biological Chemistry, 282(24), 17855 - 17865.
    • Kanematsu T, Fujii M, Mizokami A, Kittler JT, Nabekura J, Moss SJ, Hirata M (2007). Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex. Journal of Neurochemistry, 101, 898 - 905. doi:10.1111/j.1471-4159.2006.04399.x
    • Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, Cooper E, Smart TG, Pangalos MN, Moss SJ (2007). Phospho-Dependent Functional Modulation of GABA(B) Receptors by the Metabolic Sensor AMP-Dependent Protein Kinase.. Neuron, 53(2), 233 - 247.


    • Bogdanov Y, Michels G, Armstrong-Gold C, Haydon PG, Lindstrom J, Pangalos M, Moss SJ (2006). Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts.. The EMBO Journal, 25(18), 4381 - 4389.
    • Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler JT, Jovanovic JN, Takenaka K, Nakayama KI, Fukami K, Takenawa T, Moss SJ, Nabekura J, Hirata M (2006). Modulation of GABAA Receptor Phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying BDNF-dependent regulation of GABAergic inhibition.. Journal of Biological Chemistry, 281(31), 221080 - 221089. doi:10.1074/jbc.M603118200
    • Arancibia-Carcamo IL, Moss SJ (2006). Molecular organization and assembly of the central inhibitory postsynapse.. Results and Problems in Cell Differentiation, 43, 25 - 47.
    • Arancibia-Carcamo L, Fairfax BP, Moss SJ, Kittler JT (2006). Studying the subcellular localisation, surface stability and endocytosis of ionotropic receptors by antibody labelling and biotinylation approaches. In Kittler JT, Moss SJ (Ed.), The dynamic synapse : molecular methods in ionotropic receptor biology (pp. 91 - 118). : CRC/Taylor & Francis, 2006..
    • Chen G, Kittler JTJ, Moss SJ, Yan Z (2006). Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. Journal of Neuroscience, 26(9), 2513 - 2521. doi:10.1523/JNEUROSCI.4712-05.2006


    • Pascual O, Casper KB, Kubera C, Zhang J, Revilla-Sanchez R, Sul JY, Takano H, Moss SJ, McCarthy K, Haydon PG (2005). Astrocytic purinergic signaling coordinates synaptic networks.. Science, 310(5745), 113 - 116.
    • Jacob TC, Bogdanov YD, Magnus C, Saliba RS, Kittler JT, Haydon PG, Moss SJ (2005). Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors. Journal of Neuroscience, 25(45), 10469 - 10478.
    • Goto H, Terunuma M, Kanematsu T, Misumi Y, Moss SJ, Hirata M (2005). Direct interaction of N-ethylmaleimide-sensitive factor with GABA(A) receptor beta subunits.. Molecular and Cellular Neuroscience, 30(2), 197 - 206.
    • Kittler JT, Chen GC, Honing S, Bogdanov Y, McAinsh K, Arancibia-Carcamo L, Jovanovic JN, Pangalos MN, Haucke V, Yan Z, Moss SJ (2005). Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proceedings of the National Academy of Sciences, 102(41), 14871 - 14876. doi:10.1073/pnas.0506653102
    • Restituito S, Couve A, Bawagan H, Jourdain S, Pangalos MN, Calver AR, Freeman KB, Moss SJ (2005). Multiple motifs regulate the trafficking of GABA(B) receptors at distinct checkpoints within the secretory pathway.. Molecular and Cellular Neuroscience, 28(4), 747 - 756.


    • Kittler JT, Thomas P, Tretter V, Bogdanov YD, Haucke V, Smart TG, Moss SJ (2004). Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proceedings of the National Academy of Sciences of the United States of America, 101(34), 12736 - 12741. doi:10.1073/pnas.0401860101
    • Kittler JT, Arancibia-Carcamo IL, Moss SJ (2004). Association of GRIP1 with a GABA(A) receptor associated protein suggests a role for GRIP1 at inhibitory synapses.. Biochemical Pharmacology, 68, 1649 - 1654.
    • Rathenberg J, Kittler JT, Moss SJ (2004). Palmitoylation regulates the clustering and cell surface stability of GABAA receptors.. Molecular and Cellular Neuroscience, 26(2), 251 - 257.
    • Thuault SJ, Brown JT, Sheardown SA, Jourdain S, Fairfax B, Spencer JP, Restituito S, Nation JH, Topps S, Medhurst AD, Randall AD, Couve A, Moss SJ, Collingridge GL, Pangalos MN, Davies CH, Calver AR (2004). The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors.. Biochemical Pharmacology, 68(8), 1655 - 1666.
    • Fairfax BP, Pitcher JA, Scott MG, Calver AR, Pangalos MN, Moss SJ, Couve A (2004). Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability.. Journal of Biological Chemistry, 279(13), 12565 - 12573. doi:10.1074/jbc.M311389200
    • Couve A, Calver AR, Fairfax B, Moss SJ, Pangalos MN (2004). Unravelling the unusual signalling properties of the GABA(B) receptor.. Biochemical Pharmacology, 68(8), 1527 - 1536.
    • Couve A, Restituito S, Brandon JM, Charles KJ, Bawagan H, Freeman KB, Pangalos MN, Calver AR, Moss SJ (2004). Marlin-1, a novel RNA-binding protein associates with GABA receptors.. Journal of Biological Chemistry, 279(14), 13934 - 13943.
    • Jovanovic JN, Thomas P, Kittler JT, Smart TG, Moss SJ (2004). BDNF modulates fast synaptic inhibition by regulating GABAA receptor phosphorylation, activity and cell surface stability.. Journal of Neuroscience, 24(2), 522 - 530. doi:10.1523/JNEUROSCI.3606-03.2004


    • Kittler JT, Moss SJ (2003). Modulation of GABAA receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition. Current Opinion in Neurobiology, 13, 341 - 347. doi:10.1016/S0959-4388(03)00064-3
    • Preece P, Virley DJ, Costandi M, Coombes R, Moss SJ, Mudge AW, Jazin E, Cairns NJ (2003). Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease.. Molecular Brain Research, 116(1), 155 - 158.
    • Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (2003). A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor ? subunits. Molecular and Cellular Neuroscience, 22(1), 87 - 97. doi:10.1016/S1044-7431(02)00017-9
    • Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM (2003). The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. Journal of Biological Chemistry, 278, 1220 - 1228.


    • Knight D, Harris R, McAlister MS, Phelan JP, Geddes S, Moss SJ, Driscoll PC, Keep NH (2002). The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein.. Journal of Biological Chemistry, 277(7), 5556 - 5561. doi:10.1074/jbc.M109753200
    • Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (2002). Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.. Journal of Neurochemistry, 80(5), 815 - 823.
    • Dunne EL, Hosie AM, Wooltorton JRA, Duguid IC, Harvey K, Moss SJ, Harvey RJ, Smart TG (2002). N-terminal histidine regulates zinc inhibition on the murine GABA-A receptor beta3 subunit. British Journal of Pharmacology, 137, 29 - 38. doi:10.1038/sj.bjp.0704835
    • Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (2002). The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Molecular and Cellular Neuroscience, 19(2), 152 - 164.
    • Kittler JT, McAinsh K, Moss SJ (2002). Mechanisms of GABAA receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission. Molecular Neurobiology, 26, 251 - 268. doi:10.1385/MN:26:2-3:251
    • Couve A, Thomas P, Calver AR, Hirst WD, Pangalos MN, Walsh FS, Smart TG, Moss SJ (2002). Cyclic AMP-dependent protein kinase phosphorylation facilitates GABAB receptor-effector coupling. Nature Neuroscience, 5(5), 415 - 424.
    • Moss FJ, Viard P, Davies A, Bertaso F, Page KM, Graham A, Canti C, Plumpton M, Plumpton C, Clare JJ, Dolphin AC (2002). The novel product of a five-exon stargazin-related gene abolishes Cav2.2 calcium channel expression. The EMBO Journal, 21(7), 1514 - 1523. doi:10.1093/emboj/21.7.1514
    • Brandon NJ, Jovanovic JN, Smart TG, Moss SJ (2002). Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors.. Journal of Neuroscience, 22(15), 6353 - 6361.


    • Moss SJ, Smart TG (2001). Constructing inhibitory synapses. Nature Reviews Neuroscience, 2, 240 - 250.
    • Bedford FK, Kittler JT, Muller E, Thomas P, Uren JM, Merlo D, Wisden W, Triller A, Smart TG, Moss SJ (2001). GABAA receptor cell surface number and subunit stability are regulated by the ubiquitin like protein Plic-1. Nature Neuroscience, 4, 917 - 926. doi:10.1038/nn0901-908
    • Calver AR, Robbins MJ, Cosio C, Rice SQ, Babbs AJ, Hirst WD, Boyfield I, Wood MD, Russell RB, Price GW, Couve A, Moss SJ, Pangalos M (2001). The C-terminal domains of the GABAB receptor subunits mediate intracellular trafficking but are not required for receptor signalling. Journal of Neuroscience, 21, 1203 - 1210.
    • Couve A, Kittler JT, Uren JM, Calver AR, Pangalos M, Walsh FS, Moss SJ (2001). Association of GABAB receptors and members of the 14-3-3 family of signalling proteins. Molecular and Cellular Neuroscience, 17(2), 317 - 328.
    • Kittler JT, Moss SJ (2001). Neurotransmitter receptor trafficking and the regulation of synaptic strength. Traffic, 2, 437 - 448. doi:10.1034/j.1600-0854.2001.20702.x
    • Robbins MJ, Calver AR, Filippov AK, Hirst W, Russell RB, Wood M, Nasir S, Couve A, Brown DA, Moss SJ, Pangalos M (2001). GABAB2 is essential for G-protein coupling of the GABAB receptor heterodimer. Journal of Neuroscience, 21, 8043 - 8052.
    • Kittler JT, Rostaing P, Schiavo G, Fritschy JM, Olsen R, Triller A, Moss SJ (2001). The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABAA receptors. Molecular and Cellular Neuroscience, 18, 13 - 25. doi:10.1006/mcne.2001.1005
    • Brandon J, Delmas P, Hill J, Smart TG, Moss SJ (2001). Constitutive tyrosine phosphorylation of the GABAA receptor GABA2 subunit in rat brain. Neuropharmacology, 41, 745 - 752.
    • Harris R, McAlister MSB, Sankar A, Phelan JP, Moss SJ, Keep NH, Driscoll PC (2001). Backbone 1H, 13C and 15N resonance assignments for a 14kD protein, GABAA receptor associated protein (GABARAP). Journal of Biomolecular NMR, 21, 185 - 186.


    • Brandon N, Delmas P, Kittler JT, McDonald BJ, Sieghart W, Brown DA, Smart TG, Moss SJ (2000). GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway. Journal of Biological Chemistry, 275, 38856 - 38862.
    • Kittler JT, Wang J, Connolly CN, Vicini S, Smart TG, Moss SJ (2000). Analysis of GABAA receptor assembly in mammalian cell lines and hippocampal neurons using 2 subunit green fluorescent protein chimeras. Molecular and Cellular Neuroscience, 16, 440 - 452.
    • Kittler JT, Delmas P, Jovanovic JN, Brown DA, Smart TG, Moss SJ (2000). Constitutive endocytosis of GABA(A) receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. Journal of Neuroscience, 20(21), 7972 - 7977.
    • Calver AR, Medhurst AD, Robbins MJ, Charles KJ, Evans ML, Harrison DC, Stammers M, Hughes A, Hervieu G, Couve A, Moss SJ, Middlemiss DN, Pangalos MN (2000). mRNA and protein distribution of GABAB receptor splice variants in human and rodent central nervous system and peripheral tissues. Neuroscience, 100, 165 - 170.
    • Hanley JG, Jones EMC, Moss SJ (2000). GABA receptor p1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. Journal of Biological Chemistry, 275, 840 - 846.
    • Flores-Hernandez J, Hernandez S, Snyder G, Yan Z, Fienberg AA, Moss SJ, Greengard P, Surmeier DJ (2000). D1 dopamine receptor activation reduces GABAA receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade. Journal of Neurophysiology, 83, 2996 - 3004.
    • Filippov AK, Couve A, Pangalos MN, Walsh FS, Brown DA, Moss SJ (2000). Heteromeric assembly of GABABR1 and GABABR2 receptor subunits inhibits Ca2+ current in sympathetic neurons. Journal of Neuroscience, 20, 2867 - 2874.
    • Couve A, Moss SJ, Pangalos MN (2000). GABAB receptors: A new paradigm in G protein signaling. Molecular and Cellular Neuroscience, 16, 296 - 312.
    • Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). GABAc receptor sensitivity is modulated by interaction with MAP1B . Journal of Neuroscience, 20(23), 8643 - 8650.
    • Brandon NJ, Moss SJ (2000). Receptor cross talk: ligand-gated ion channels start to communicate.. Signal Transduction Knowledge Environment, 2000(55), PE1 - .
    • Brandon N, Smart TG, Moss SJ (2000). Regulation of GABAA receptors by protein phosphorylation. In Olsen R (Ed.), GABA in the Nervous System (pp. 191 - 206). : Lippincott, Williams and Wilkins.
    • Taylor PM, Connolly CN, Kittler JT, Gorrie GH, Hosie A, Smart TG, Moss SJ (2000). Identification of residues within GABAA receptor ? subunits that mediate specific assembly with receptor subunits. Journal of Neuroscience, 20, 1297 - 1306.


    • Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (1999). GABAA -receptor-associated protein links GABAA receptors and the cytoskeleton. Nature, 397, 69 - 72.
    • Connolly CN, Uren JM, Thomas P, Gorrie GH, Gibson A, Smart TG, Moss SJ (1999). Subcellular localization and endocytosis of homomeric gg2 subunit splice variants of gg-aminobutyric acid type A receptors. Molecular and Cellular Neuroscience, 113, 259 - 271.
    • Connolly CN, Kittler JT, Thomas P, Uren JM, Brandon NJ, Smart TG, Moss SJ (1999). Cell surface stability of gg-aminobutyric acid type A receptors. Journal of Biological Chemistry, 274(51), 36565 - 36572.
    • Marie H, Bedford F, Moss S, Attwell D (1999). Looking for protein interactions with glutamate transporters. 1.Use of the yeast two-hybrid system to identify proteins that interact with the rat glutamate transporter GLT-1.
    • Forbes LV, Moss SJ, Segal AW (1999). Phosphorylation of p67phox in the neutrophil occurs in the cytosol and is independent of p47phox. Federation of European Biochemical Societies Letters, 449, 225 - 229.
    • Forbes LV, Truong O, Wientjes FB, Moss SJ, Segal AW (1999). The major phosphorylation site of the NADPH oxidase component p67phox is Thr233. Biochemical Journal, 338, 99 - 105.
    • Hanley JG, Koulen P, Bedford F, Gordon-Weeks PR, Moss SJ (1999). The protein MAP-1B links GABAc receptors to the cytoskeleton at retinal synapses. Nature, 397, 66 - 69.
    • Brandon NJ, Bedford FK, Connolly CN, Couve A, Kittler JT, Hanley JG, Jovanovic JN, Uren J, Taylor PW, Thomas P, Smart TG, Moss SJ (1999). Synaptic targeting and regulation of GABA(A) receptors. Biochemical Society Transactions, 27(4), 527 - 530. doi:10.1042/bst0270527
    • Patel R, Holt M, Philipova R, Moss S, Schulman H, Hidaka H, Whitaker M (1999). Calcium /calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells. Journal of Biological Chemistry, 274(12), 7958 - 7968.
    • Fitzgerald E, Okuse K, Dolphin A, Wood JN, Moss S (1999). Cyclic AMP-dependent phosphorylation of the Tetrodotoxin-resistant voltage-dependent sodium channel, SNS. The Journal of Physiology, 516, 433 - 446.
    • Brandon NJ, Uren JM, Kittler JT, Wang H, Olsen R, Parker PJ, Moss SJ (1999). Subunit-specific association of protein kinase C and the receptor for activated C kinase with GABA type A receptors. Journal of Neuroscience, 19(21), 9228 - 9234.
    • Taylor PM, Thomas P, Gorrie GH, Connolly CN, Smart TG, Moss SJ (1999). Identification of amino acid residues within GABAA receptor á subunits that mediate both homomeric and heteromeric receptor expression. Journal of Neuroscience, 19(15), 6360 - 6371.
    • Fitzgerald EM, Okuse K, Wood JN, Dolphin AC, Moss SJ (1999). cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS. The Journal of Physiology, 516(2), 433 - 446.


    • Couve A, McDonald RJ, Filippov AK, Moss SJ (1998). Intracellular retention of recombinant GABAB receptors.
    • Couve A, Filippov AK, Bettler B, Brown DA, Moss SJ (1998). Intracellular retention of recombinant GABAB receptors. Journal of Biological Chemistry, 273, 26361 - 26367.
    • Krishek BJ, Moss SJ, Smart TG (1998). Interaction of H+ and Zn2+ on recombinant and native rat neuronal GABAA receptors. The Journal of Physiology, 507, 639 - 652.
    • McDonald BJ, Amato A, Connolly CN, Benke D, Moss SJ, Smart TG (1998). Distinct regulation of GABAA receptors by cAMP-dependent protein kinase is mediated by differential phosphorylation of receptor á subunits. Nature Neuroscience, 1, 23 - 27.
    • Chen AC, McDonald B, Moss SJ, Gurling HM (1998). Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long-term treatment with cis-and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment. Brain Res Mol Brain Res, 54, 92 - 100.


    • Sivilotti L, Okuse K, Akopian AN, Moss S, Wood JN (1997). A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channnel SNS. Federation of European Biochemical Societies Letters, 409(1), 49 - 52.


    • Millar NS, Moss SJ, Green WN (1995). Assembly, post-translational processing, and subcellular localization of ion channels. In Ashley RH (Ed.), Ion Channels A Practical Approach (pp. 191 - 217). : IRL Press.