Prof Troy Margrie

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Personal Profile

Name: Troy Margrie Email: t.margrie@ucl.ac.uk
Title: Prof Tel: 2076790979
Department: Neuroscience, Physiology & Pharmacology Fax:
Position: Professor of Neuroscience Address: 21 University Street, , London, WC1E 6JJ
Research Domain: Neuroscience Web Page: Personal Web Page

Profile

Research Description

Information about the world around us is gathered by our sensory organs and relayed to the brain, where it is processed and integrated by neuronal circuits. Such stimulus-related network activity is thought to represent an organism's external world and underlie cognitive processing and the generation of motor output. Our major aim is to determine the ways in which synaptic potentials, oscillatory rhythms and plasticity within neural circuits contribute to the representation and processing of the necessary information. We combine genetics, physiology, behavior and theory to examine the integrative elements that are involved in processing at various levels of sensory pathway. More specifically we use behavioral techniques in mice to determine the temporal constraints of olfactory processing. Subtle genetic manipulations of the olfactory circuit allows us to monitor in vivo the contribution of specific assemblies of cells to odor discrimination. Secondly we use in vivo recordings from individual and multiple cells in the cortex to investigate how information arriving from different sensory modalities influence the representation of a given sensory stimulus.

Research Activities

determining how individual neurons and small neuronal circuits contribute to the processes underlying sensation

Education Description

UCL Collaborators

External Collaborators

Publications

    2013

    • Bracey EF, Pichler B, Schaefer AT, Wallace DJ, Margrie TW (2013). Perceptual judgements and chronic imaging of altered odour maps indicate comprehensive stimulus template matching in olfaction.. Nat Commun, 4, 2100 - . doi:10.1038/ncomms3100

    2012

    • Angelo K, Rancz, EA , Pimentel D, Hundahl C, Hannibal J, Fleischmann A, Pichler B, Margrie TW (2012). A biophysical signature of network affiliation and sensory processing in mitral cells.. Nature, 488, 375 - 378.

    2011

    • Rancz EA, Franks K, Schwarz M, Pichler B, Schaefer AT, Margrie TW (2011). Transfection via whole-cell recordings in vivo: Bridging single-cell physiology, genetics and connectomics. Nature Neuroscience, 14, 527 - 532.

    2008

    • Pimentel D, Margrie TW (2008). Glutamatergic transmission and plasticity between olfactory bulb mitral cells. The Journal of Physiology, 586(8), 2107 - 2119. doi:10.1113/jphysiol.2007.149575
    • Arenz A, Silver AR, Schaefer AT, Margrie TW (2008). The contribution of single synapses to sensory representation in vivo. Science, 321(5891), 977 - 980. doi:10.1126/science.1158391

    2007

    • Schaefer AT, Margrie TW (2007). Spatiotemporal representations in the olfactory system.. Trends in Neuroscience, 30(3), 92 - 100.

    2006

    • Komai S, Denk W, Osten P, Brecht MM, T W (2006). Two photon targeted patching (TPTP) in vivo. Nature Protocols, 1(2), 647 - 652. doi:10.1038/nprot.2006.100
    • Graham BA, Schofield PR, Walker S, Sah P, Margrie TW, and Callister RJ (2006). Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants, spastic, spasmodic and oscillator. Journal of Neuroscience, 26(18), 4880 - 4890. doi:10.1523/JNEUROSCI.3991-05.2006
    • Brecht M, Grinevich V, Jin TE, Margrie T, Osten P (2006). Cellular mechanisms of motor control in the vibrissal system. Pflugers Archiv-European Journal of Physiology, 453(3), 269 - 281. doi:10.1007/s00424-006-0101-6
    • Schaefer AT, Angelo K, Spors H, Margrie TW (2006). Neuronal oscillations optimize stimulus discrimination by ensuring action potential precision. PLoS Biology, 4(6), 163 - 178. doi:10.1371/journal.pbio.0040163

    2004

    • Brecht M, Krauss A, Muhammad S, Sinai-Esfahani L, Bellanca S, Margrie TW (2004). Organization of rat vibrissa motor cortex and adjacent areas according to cytoarchitectonics, microstimulation, and intracellular stimulation of identified cells.. The Journal of Comparative Neurology, 479(4), 360 - 373.
    • Dittgen T, Nimmerjahn A, Komai S, Licznerski P, Waters J, Margrie TW, Helmchen F, Denk W, Brecht M, Osten P (2004). Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo.. Proceedings of the National Academy of Sciences of the United States of America, 101(52), 18206 - 18211.
    • Abraham NM, Spors H, Carleton A, Margrie TW, Kuner T, Schaefer AT (2004). Maintaining accuracy at the expense of speed: stimulus similarity defines odor discrimination time in mice.. Neuron, 44(5), 865 - 876. doi:10.1016/j.neuron.2004.11.017
    • Brecht M, Schneider M, Sakmann B, Margrie TW (2004). Whisker movements evoked by stimulation of single pyramidal cells in rat motor cortex.. Nature, 427(6976), 704 - 710.
    • Brecht M, Fee MS, Garaschuk O, Helmchen F, Margrie TW, Svoboda K, Osten P (2004). Novel approaches to monitor and manipulate single neurons in vivo.. Journal of Neuroscience, 24(42), 9223 - 9227.
    • Chadderton P, Margrie TW, Häusser M (2004). Integration of quanta in cerebellar granule cells during sensory processing.. Nature, 428(6985), 856 - 860. doi:10.1038/nature02442

    2003

    • Margrie TW, Meyer AH, Caputi A, Monyer H, Hasan MT, Schaefer AT, Denk W, Brecht M (2003). Targeted whole-cell recordings in the mammalian brain in vivo.. Neuron, 39(6), 911 - 918. doi:10.1016/j.neuron.2003.08.012

    2002

    • Margrie TW, Brecht MAS, B (2002). Whole-cell recordings from neurons of the anaesthetized and awake mammalian brain in vivo. Pflügers Archiv European Journal of Physiology, 444(4), 491 - 498.

    • Chadderton P, Agapiou JP, McAlpine, D, Margrie TW (). The synaptic representation of sound source location in primary auditory cortex. The Journal of Neuroscience, 2009, 14127 - 14135.