Prof David Hunt

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Personal Profile

Name: David Hunt Email: d.hunt@ucl.ac.uk
Title: Prof Tel: 020 7608 6820
Department: Inst Ophthalmology - Visual Neuroscience Fax: 020 7608 6863
Position: Emeritus Professor of Molecular Genetics Address: UCL Institute of Ophthalmology, 11-43 Bath Street, , London, EC1V 9EL
Research Domain: Basic Life Sciences, Neuroscience Web Page: Personal Web Page

Profile

Research Description

I have a long-standing interest in inherited retinal disease and the fundamental processes of phototransduction. One focus of this work is the spectral tuning of visual pigments, with studies of many visual systems including the origin and evolution of trichromacy in primates, the tuning of rod pigments in photon-limited environments, and the molecular basis for the shifts in the peak spectral sensitivity of the shortwave-sensitive pigment class from UV to violet sensitive. We are also investigating the origin of the vertebrate visual system through studies on an ancient vertebrate, the lamprey. These animals possess a full complement of visual pigments for day light or photopic vision but appear to lack pigments for vision in dim light, indicating that the latter evolved in the jawed vertebrate lineage only after it split from the jawless vertebrates about 450 million years ago.

In addition, I have an extensive programme of work directed towards the understanding of mutant gene function in inherited retinal diseases. Major achievements have been the demonstration that a form of dominant cone-rod dystrophy arises from mutations in the gene for retinal guanylyl cyclase (GC) type 1 and we were subsequently able to demonstrate in functional assays using recombinant proteins that the major consequence of mutation was an altered Ca2+ sensitivity of the cyclase. We have also established the functional effects of a mutation in the activator of GC (GCAP1). Animal models with knock-in mutations in retGC1 and GCAP1 have now been developed and are currently being analysed. Another form of cone-rod dystrophy was shown to be caused by mutations in RIMS1 and functional studies on the mechanism of action of mutations in splicing factor genes in the development of retinitis pigmentosa have clarified the disease mechanism. We have also contributed to the molecular analysis of a number of other retinal disorders, most recently, the identification of the mutations in KCNV2 which underlie cone dystrophy with supernormal rod ERG.

Research Activities

Epilepsy - developmental malformations, pathology, drug resistance, population genetics

Inherited Eye Disease

Neuronal migration

Visual function and disease

Education Description

UCL Collaborators

Prof Shomi Bhattacharya; Dr Martin Stocker; Prof Sanjay Sisodiya; Prof Robin Ali; Prof Tom Salt; Prof Tony Moore; Prof Glen Jeffery; Prof Andrew Webster; Prof John Duncan; Dr Maria Thom; Prof Ley Sander; Prof Jim Bowmaker

External Collaborators

Publications

    2013

    • Knott B, Davies WIL, Carvalho LS, Berg ML, Buchanan KL, Bowmaker JK, Bennett ATD, Hunt DM (2013). How parrots see their colours: novelty in the visual pigments of Platycercus elegans. JOURNAL OF EXPERIMENTAL BIOLOGY, 216(23), 4454 - 4461. doi:10.1242/jeb.094136
    • McClements M, Davies WI, Michaelides M, Carroll J, Rha J, Mollon JD, Neitz M, MacLaren RE, Moore AT, Hunt DM (2013). X-linked cone dystrophy and colour vision deficiency arising from a missense mutation in a hybrid L/M cone opsin gene.. Vision Res, 80, 41 - 50. doi:10.1016/j.visres.2012.12.012
    • McClements M, Davies WI, Michaelides M, Young T, Neitz M, MacLaren RE, Moore AT, Hunt DM (2013). Variations in opsin coding sequences cause x-linked cone dysfunction syndrome with myopia and dichromacy.. Invest Ophthalmol Vis Sci, 54(2), 1361 - 1369. doi:10.1167/iovs.12-11156

    2012

    • Carroll J, Dubra A, Gardner JC, Mizrahi-Meissonnier L, Cooper RF, Dubis AM, Nordgren R, Genead M, Connor TB, Stepien KE, Sharon D, Hunt DM, Banin E, Hardcastle AJ, Moore AT, Williams DR, Fishman G, Neitz J, Neitz M, Michaelides M (2012). The effect of cone opsin mutations on retinal structure and the integrity of the photoreceptor mosaic.. Invest Ophthalmol Vis Sci, 53(13), 8006 - 8015. doi:10.1167/iovs.12-11087
    • Carvalho LS, Davies WL, Robinson PR, Hunt DM (2012). Spectral tuning and evolution of primate short-wavelength-sensitive visual pigments.. Proc Biol Sci, 279(1727), 387 - 393. doi:10.1098/rspb.2011.0782
    • Davies WI, Wilkie SE, Cowing JA, Hankins MW, Hunt DM (2012). Anion sensitivity and spectral tuning of middle- and long-wavelength-sensitive (MWS/LWS) visual pigments.. Cell Mol Life Sci, 69(14), 2455 - 2464. doi:10.1007/s00018-012-0934-4
    • Smith KE, Wilkie SE, Tebbs-Warner JT, Jarvis BJ, Gallasch L, Stocker M, Hunt DM (2012). Functional Analysis of Missense Mutations in Kv8.2 causing Cone Dystrophy with Supernormal Rod Electroretinogram. Journal of Biological Chemistry, , - .

    2011

    • Hogg C, Neveu M, Stokkan KA, Folkow L, Cottrill P, Douglas R, Hunt DM, Jeffery G (2011). Arctic reindeer extend their visual range into the ultraviolet. J EXP BIOL, 214(12), 2014 - 2019. doi:10.1242/jeb.053553
    • Carvalho LS, Knott B, Berg ML, Bennett AT, Hunt DM (2011). Ultraviolet-sensitive vision in long-lived birds.. Proc Biol Sci, 278(1702), 107 - 114. doi:10.1098/rspb.2010.1100
    • Buch PK, Mihelec M, Cottrill P, Wilkie SE, Pearson RA, Duran Y, West EL, Michaelides M, Ali RR, Hunt DM (2011). Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene.. PLoS One, 6(3), e18089 - . doi:10.1371/journal.pone.0018089

    2010

    • Michaelides M, Gaillard MC, Escher P, Tiab L, Bedell M, Borruat FX, Barthelmes D, Carmona R, Zhang K, White E, McClements M, Robson AG, Holder GE, Bradshaw K, Hunt DM, Webster AR, Moore AT, Schorderet DF, Munier FL (2010). The PROM1 mutation p.R373C causes an autosomal dominant bull's eye maculopathy associated with rod, rod-cone, and macular dystrophy.. Invest Ophthalmol Vis Sci, 51(9), 4771 - 4780. doi:10.1167/iovs.09-4561
    • Robson AG, Webster AR, Michaelides M, Downes SM, Cowing JA, Hunt DM, Moore AT, Holder GE (2010). "Cone dystrophy with supernormal rod electroretinogram": a comprehensive genotype/phenotype study including fundus autofluorescence and extensive electrophysiology.. Retina, 30(1), 51 - 62. doi:10.1097/IAE.0b013e3181bfe24e
    • Hunt DM, Buch P, Michaelides M (2010). Guanylate cyclases and associated activator proteins in retinal disease.. Mol Cell Biochem, 334(1-2), 157 - 168. doi:10.1007/s11010-009-0331-y
    • Palacios AG, Bozinovic F, Vielma A, Arrese CA, Hunt DM, Peichl L (2010). Retinal Photoreceptor Arrangement, SWS1 and LWS Opsin Sequence, and Electroretinography in the South American Marsupial Thylamys elegans (Waterhouse, 1839). J COMP NEUROL, 518(9), 1589 - 1602. doi:10.1002/cne.22292
    • Mohun SM, Davies WL, Bowmaker JK, Pisani D, Himstedt W, Gower DJ, Hunt DM, Wilkinson M (2010). Identification and characterization of visual pigments in caecilians (Amphibia: Gymnophiona), an order of limbless vertebrates with rudimentary eyes.. J Exp Biol, 213(Pt 20), 3586 - 3592. doi:10.1242/jeb.045914

    2009

    • Collin SP, Davies WL, Hart NS, Hunt DM (2009). The evolution of early vertebrate photoreceptors. PHILOS T R SOC B, 364(1531), 2925 - 2940. doi:10.1098/rstb.2009.0099
    • Hunt DM, Carvalho LS, Cowing JA, Davies WL (2009). Evolution and spectral tuning of visual pigments in birds and mammals.. Philos Trans R Soc Lond B Biol Sci, 364(1531), 2941 - 2955. doi:10.1098/rstb.2009.0044
    • Minogue PJ, Tong JJ, Arora A, Russell-Eggitt I, Hunt DM, Moore AT, Ebihara L, Beyer E, Berthoud VM (2009). A Mutant Connexin50 with Enhanced Hemichannel Function Leads to Cell Death. Invest Ophthalmol.Vis.Sci., , - .
    • Hunt DM, Chan J, Carvalho LS, Hokoc JN, Ferguson MC, Arrese CA, Beazley LD (2009). Cone visual pigments in two species of South American marsupials. Gene, 433(1-2), 50 - 55.
    • Davies WL, Collin SP, Hunt DM (2009). Adaptive gene loss reflects differences in the visual ecology of basal vertebrates. Mol.Biol.Evol., , - .
    • Metlapally R, Michaelides M, Bulusu A, Li YJ, Schwartz M, Rosenberg T, Hunt DM, Moore AT, Zuchner S, Rickman CB, Young TL (2009). Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies. Invest Ophthalmol.Vis.Sci., 50(4), 1552 - 1558.
    • Davies WL, Cowing JA, Bowmaker JK, Carvalho LS, Gower DJ, Hunt DM (2009). Shedding light on serpent sight: the visual pigments of henophidian snakes. J.Neurosci., 29(23), 7519 - 7525.
    • Cottril P, Davis W, Semo M, Bowmaker J, Hunt D, Jeffery G (2009). Developmental dynamics of cone photoreceptors in the eel. BMC Developmental Biology, ebub, - .
    • Davies WL, Carvalho LS, Tay BH, Brenner S, Hunt DM, Venkatesh B (2009). Into the blue: gene duplication and loss underlie color vision adaptations in a deep-sea chimaera, the elephant shark Callorhinchus milii. Genome Res., 19(3), 415 - 426.

    2008

    • Arora A, Minogue PJ, Liu X, Addison PK, Russel-Eggitt I, Webster AR, Hunt DM, Ebihara L, Beyer EC, Berthoud VM, Moore AT (2008). A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. J.Med.Genet., 45(3), 155 - 160.
    • Moradi P, Mackay D, Hunt DM, Moore AT (2008). Focus on molecules: retinol dehydrogenase 12 (RDH12). Exp.Eye Res., 87(3), 160 - 161.
    • Audo I, Michaelides M, Robson AG, Hawlina M, Vaclavik V, Sandbach JM, Neveu MM, Hogg CR, Hunt DM, Moore AT, Bird AC, Webster AR, Holder GE (2008). Phenotypic variation in enhanced S-cone syndrome. Invest Ophthalmol.Vis.Sci., 49(5), 2082 - 2093.
    • Yang ZL, Chen YL, Lillo C, Chien J, Yu ZY, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen HY, Zhao C, Chen YH, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li CM, Johnson S, Frederick JM, Zhao Y, Wang CG, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K (2008). Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J CLIN INVEST, 118(8), 2908 - 2916. doi:10.1172/JCI35891
    • Wilkie SE, Vaclavik V, Wu H, Bujakowska K, Chakarova CF, Bhattacharya SS, Warren MJ, Hunt DM (2008). Disease mechanism for retinitis pigmentosa (RP11) caused by missense mutations in the splicing factor gene PRPF31. Mol.Vis., 14, 683 - 690.
    • Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K (2008). Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J.Clin.Invest, 118(8), 2908 - 2916.
    • Yang Z, Tong Z, Chorich LJ, Pearson E, Yang X, Moore A, Hunt DM, Zhang K (2008). Clinical characterization and genetic mapping of North Carolina macular dystrophy. Vision Res., 48(3), 470 - 477.
    • Brindley AA, Pickersgill RW, Partridge JC, Dunstan DJ, Hunt DM, Warren MJ (2008). Enzyme sequence and its relationship to hyperbaric stability of artificial and natural fish lactate dehydrogenases. PLoS.ONE., 3(4), e2042 - .
    • Shand J, Davies WL, Thomas N, Balmer L, Cowing JA, Pointer M, Carvalho LS, Trezise AE, Collin SP, Beazley LD, Hunt DM (2008). The influence of ontogeny and light environment on the expression of visual pigment opsins in the retina of the black bream, Acanthopagrus butcheri. J.Exp.Biol., 211(Pt 9), 1495 - 1503.
    • Bowmaker JK, Semo M, Hunt DM, Jeffery G (2008). Eel visual pigments revisited: the fate of retinal cones during metamorphosis. Vis.Neurosci., 25(3), 249 - 255.
    • Cowing JA, Arrese CA, Davies WL, Beazley LD, Hunt DM (2008). Cone visual pigments in two marsupial species: the fat-tailed dunnart (Sminthopsis crassicaudata) and the honey possum (Tarsipes rostratus). Proc.Biol.Sci., 275(1642), 1491 - 1499.

    2007

    • Hunt DM, Carvalho LS, Cowing JA, Parry JW, Wilkie SE, Davies WL, Bowmaker JK (2007). Spectral tuning of shortwave-sensitive visual pigments in vertebrates.. Photochem Photobiol, 83(2), 303 - 310. doi:10.1562/2006-06-27-IR-952
    • Carvalho LS, Cowing JA, Wilkie SE, Bowmaker JK, Hunt DM (2007). The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments. Mol.Biol.Evol., 24(8), 1843 - 1852.
    • Carvalho LS, Cowing JA, Wilkie SE, Bowmaker JK, Hunt DM (2007). The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments.. Mol Biol Evol, 24(8), 1843 - 1852. doi:10.1093/molbev/msm109
    • Hunt DM, Carvalho LS, Cowing JA, Parry JW, Wilkie SE, Davies WL, Bowmaker JK (2007). Spectral tuning of shortwave-sensitive visual pigments in vertebrates. Photochem.Photobiol., 83(2), 303 - 310.
    • Davies WL, Cowing JA, Carvalho LS, Potter IC, Trezise AE, Hunt DM, Collin SP (2007). Functional characterization, tuning, and regulation of visual pigment gene expression in an anadromous lamprey. FASEB J., 21(11), 2713 - 2724.
    • Davies WL, Carvalho LS, Cowing JA, Beazley LD, Hunt DM, Arrese CA (2007). Visual pigments of the platypus: a novel route to mammalian colour vision. current biology, 17(5), R161 - R163. doi:10.1016/j.cub.2007.01.037
    • Pointer MA, Carvalho LS, Cowing JA, Bowmaker JK, Hunt DM (2007). The visual pigments of a deep-sea teleost, the pearl eye Scopelarchus analis. J.Exp.Biol., 210(Pt 16), 2829 - 2835.
    • Hart NS, Hunt DM (2007). Avian visual pigments: characteristics, spectral tuning, and evolution. Am.Nat., 169 Suppl 1, S7 - 26.
    • Davies WL, Carvalho LS, Hunt DM (2007). SPLICE: a technique for generating in vitro spliced coding sequences from genomic DNA. Biotechniques, 43(6), 785 - 789.
    • Sisodiya SM, Thompson PJ, Need A, Harris SE, Weale ME, Wilkie SE, Michaelides M, Free SL, Walley N, Gumbs C, Gerrelli D, Ruddle P, Whalley LJ, Starr JM, Hunt DM, Goldstein DB, Deary IJ, Moore AT (2007). Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation. Journal of medical genetics, 44(6), 373 - 380. doi:10.1136/jmg.2006.047407

    2006

    • Nickle B, Wilkie SE, Cowing JA, Hunt DM, Robinson PR (2006). Vertebrate opsins belonging to different classes vary in constitutively active properties resulting from salt-bridge mutations. BIOCHEMISTRY-US, 45(23), 7307 - 7313. doi:10.1021/bi060234g
    • Spady TC, Parry JWL, Robinson PR, Hunt DM, Bowmaker JK, Carleton KL (2006). Evolution of the cichlid visual palette through ontogenetic subfunctionalization of the opsin gene arrays. Molecular Biology and Evolution, 23(8), 1538 - 1547. doi:10.1093/molbev/msl014
    • Arora A, Minogue PJ, Liu X, Reddy MA, Ainsworth JR, Bhattacharya SS, Webster AR, Hunt DM, Ebihara L, Moore AT, Beyer EC, Berthoud VM (2006). A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract. J.Med.Genet., 43(1), e2 - .
    • Wilkie SE, Morris KJ, Bhattacharya SS, Warren MJ, Hunt DM (2006). A study of the nuclear trafficking of the splicing factor protein PRPF31 linked to autosomal dominant retinitis pigmentosa (ADRP).. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1762(3), 304 - 311.
    • Bowmaker JK, Parry JWL, Spady T, Seehausen O, Hunt DM, Carleton KL (2006). Divergent evolution and adaptation in cone visual pigments: Mix and match collour vision in African cichlid fish. PERCEPTION, 35, 116 - 117.
    • Collin SP, Hunt DM, Davies WL, Potter IC, Bailes HJ, Hart NS, Trezise AEO (2006). Ancient vertebrate photoreceptors: The evolution and function of rods and cones. PERCEPTION, 35, 116 - 116.
    • Bowmaker JK, Hunt DM (2006). Evolution of vertebrate visual pigments.. Curr Biol, 16(13), R484 - R489. doi:10.1016/j.cub.2006.06.016
    • Hunt DM, Bowmaker JK, Cowing JA, Carvalho LDS, Parry JWL, Wilkie SE, Davies WL (2006). Spectral tuning of vertebrate visual pigments. PERCEPTION, 35, 167 - 167.
    • Spady TC, Parry JWL, Robinson PR, Hunt DM, Bowmaker JK, Carleton KL (2006). Evolution of the cichlid visual palette through ontogenetic subfunctionalization of the opsin gene arrays. MOL BIOL EVOL, 23(8), 1538 - 1547. doi:10.1093/molbev/msl014
    • Carvalho LD, Cowing JA, Wilkie SE, Bowmaker JK, Hunt DM (2006). Shortwave visual sensitivity in tree and flying squirrels reflects changes in lifestyle. CURR BIOL, 16(3), R81 - R83.
    • Hunt DM, Bowmaker JK (2006). Visual pigments and visual communication in deepwater environments. In Ladich F, Collin SP, Moller P, Kapoor BG (Ed.), Communication in Fishes (pp. 453 - 479). : Science Publishers, Inc., USA..
    • Hunt DM, Bowmaker JK (2006). Visual pigments and visual communication in deepwater environments.. In Ladich F, Collin SP, Moller P, Kapoor BG (Ed.), Communication in Fishes (pp. 457 - 483). : New Hampshire: Science Publishers..
    • Nickle B, Wilkie SE, Cowing JA, Hunt DM, Robinson PR (2006). Vertebrate opsins belonging to different classes vary in constitutively active properties resulting from salt-bridge mutations. Biochemistry, 45(23), 7307 - 7313.
    • Arrese CA, Beazley LD, Ferguson MC, Oddy A, Hunt DM (2006). Spectral tuning of the long wavelength-sensitive cone pigment in four Australian marsupials. Gene, 381, 13 - 17.
    • Michaelides M, Hardcastle AJ, Hunt DM, Moore AT (2006). Progressive cone and cone-rod dystrophies: phenotypes and underlying molecular genetic basis. Survey of Ophthalmology, 51(3), 232 - 258.
    • Hunt DM, Bowmaker JK (2006). Spectral tuning of visual pigments and its role in visual communication.. In Ladich F, Collin SP, Moller P, Kapoor BG (Ed.), Communication in Fishes (pp. 453 - 479). : New Hampshire: Science Publishers..
    • Wu H, Cowing JA, Michaelides M, Wilkie SE, Jeffery G, Jenkins SA, Nazari MMY, Mester V, Bird AC, Robson AG, Holder GE, Moore AT, Hunt DM, Webster AR (2006). Mutation in the gene KCNV2, encoding a voltage-gated potassium channel subunit cause “cone dystrophy with a supernormal rod electroretinogram” in humans.. The American Journal of Human Genetics, 79(3), 574 - 579.

    2005

    • Michaelides M, Wilkie SE, Jenkins S, Holder GE, Hunt DM, Moore AT, Webster AR (2005). Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy. OPHTHALMOLOGY, 112(8), 1442 - 1447. doi:10.1016/j.ophthta.2005.02.024
    • Michaelides M, Wilkie SE, Jenkins S, Holder GE, Hunt DM, Moore AT, Webster AR (2005). Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy. OPHTHALMOLOGY, 112(8), 1442 - 1447. doi:10.1016/j.ophtha.2005.02.024
    • Pointer MA, Cheng CH, Bowmaker JK, Parry JW, Soto N, Jeffery G, Cowing JA, Hunt DM (2005). Adaptations to an extreme environment: retinal organisation and spectral properties of photoreceptors in Antarctic notothenioid fish. Journal of Experimental Biology, 208(Pt 12), 2363 - 2376.
    • Michaelides M, Holder GE, Bradshaw K, Hunt DM, Moore AT (2005). Cone-rod dystrophy, intrafamilial variability, and incomplete penetrance associated with the R172W mutation in the peripherin/RDS gene. OPHTHALMOLOGY, 112(9), 1592 - 1598.
    • Michaelides M, Holder GE, Webster AR, Hunt DM, Bird AC, Fitzke FW, Mollon JD, Moore AT (2005). A detailed phenotypic study of "cone dystrophy with supernormal rod ERG". BR J OPHTHALMOL, 89(3), 332 - 339.
    • Parry JWL, Carleton KL, Spady T, Carboo A, Hunt DM, Bowmaker JK (2005). Mix and match color vision: Tuning spectral sensitivity by differential opsin gene expression in Lake Malawi Cichlids. CURR BIOL, 15(19), 1734 - 1739. doi:10.1016/j.cub.2005.08.010
    • Carleton KL, Parry JWL, Bowmaker JK, Hunt DM, Seehausen O (2005). Colour vision and speciation in Lake Victoria cichlids of the genus Pundamilia. MOL ECOL, 14(14), 4341 - 4353. doi:10.1111/j.1365-294X.2005.02735.x
    • Inglis-Broadgate SL, Ocaka L, Banerjee R, Gaasenbeek M, Chapple JP, Cheetham ME, Clark BJ, Hunt DM, Halford S (2005). Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Gene, 356, 19 - 31.
    • Arrese CA, Oddy AY, Runham PB, Hart NS, Shand J, Hunt DM, Beazley LD (2005). Cone topography and spectral sensitivity in two potentially trichromatic marsupials, the quokka (Setonix brachyurus) and quenda (Isoodon obesulus). Proceedings of the Royal Society B: Biological Sciences, 272(1565), 791 - 796.
    • Parry JW, Carleton KL, Spady T, Carboo A, Hunt DM, Bowmaker JK (2005). Mix and match color vision: tuning spectral sensitivity by differential opsin gene expression in Lake Malawi cichlids. Current biology, 15(19), 1734 - 1739. doi:10.1016/j.cub.2005.08.010
    • Michaelides M, Johnson S, Simunovic MP, Bradshaw K, Holder G, Mollon JD, Moore AT, Hunt DM (2005). Blue cone monochromatism: a phenotype and genotype assessment with evidence of progressive loss of cone function in older individuals. EYE, 19(1), 2 - 10.
    • Michaelides M, Johnson S, Bradshaw K, Holder GE, Simunovic MP, Mollon JD, Moore AT, Hunt DM (2005). X-linked cone dysfunction syndrome with myopia and protanopia. Ophthalmology, 112(8), 1448 - 1454. doi:10.1016/j.ophtha.2005.02.021
    • Hunt DM, Jacobs GH, Bowmaker JK (2005). The genetics and evolution of primate visual pigments. In Kremers J (Ed.), The Primate Visual System (pp. 73 - 97). : Wiley.
    • Ocaka L, Spalluto C, Wilson DI, Hunt DM, Halford S (2005). Chromosomal localisation, genomic organisation and evolution of the genes encoding phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3.. Cytogenetic and Genome Research, 108, 293 - 302.
    • Carleton KL, Parry JW, Bowmaker JK, Hunt DM, Seehausen O (2005). Colour vision and speciation in Lake Victoria cichlids of the genus Pundamilia. Molecular Ecology, 14(14), 4341 - 4353.
    • Michaelides M, Holder GE, Hunt DM, Fitzke FW, Bird AC, Moore AT (2005). A detailed study of the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with mutation in the gene for RIM1. BR J OPHTHALMOL, 89(2), 198 - 206.

    2004

    • Hunt DM, Cowing JA, Wilkie SE, Parry JW, Poopalasundaram S, Bowmaker JK (2004). Divergent mechanisms for the tuning of shortwave sensitive visual pigments in vertebrates.. Photochem Photobiol Sci, 3(8), 713 - 720. doi:10.1039/b314693f
    • Parry JW, Poopalasundaram S, Bowmaker JK, Hunt DM (2004). A novel amino acid substitution is responsible for spectral tuning in a rodent violet-sensitive visual pigment.. Biochemistry, 43(25), 8014 - 8020. doi:10.1021/bi049478w
    • Hunt DM, Cowing JA, Wilkie SE, Parry JW, Poopalasundaram S, Bowmaker JK (2004). Divergent mechanisms for the tuning of shortwave sensitive visual pigments in vertebrates.. Photochemical and Photobiological Sciences, 3(8), 713 - 720.
    • Michaelides M, Bloch-Zupan A, Holder GE, Hunt DM, Moore AT (2004). An autosomal recessive cone-rod dystrophy associated with amelogenesis imperfecta. Journal of Medical Genetics, 41(6), 468 - 473.
    • Michaelides M, Holder GE, Bradshaw K, Hunt DM, Mollon JD, Moore AT (2004). Oligocone trichromacy: a rare and unusual cone dysfunction syndrome.. British Journal of Ophthalmology, 88(4), 497 - 500.
    • Michaelides M, Aligianis IA, Ainsworth JR, Good P, Mollon JD, Maher ER, Moore AT, Hunt DM (2004). Progressive cone dystrophy associated with mutation in CNGB3.. Investigative Ophthalmology and Visual Science, 45(6), 1975 - 1982.
    • Michaelides M, Hunt DM, Moore AT (2004). The cone dysfunction syndromes.. British Journal of Ophthalmology, 88(2), 291 - 297.
    • Hunt DM, Wilkie SE, Newbold R, Deery E, Warren MJ, Bhattacharya SS, Zhang K (2004). Dominant cone and cone-rod dystrophies: functional analysis of mutations in retGC1 and GCAP1. Novartis Found Symp, 255, 37 - 49.
    • Gallon VA, Wilkie SE, Deery EC, Newbold RJ, Sohocki MM, Bhattacharya SS, Hunt DM, Warren MJ (2004). Purification, characterisation and intracellular localisation of aryl hydrocarbon interacting protein-like 1 (AIPL1) and effects of mutations associated with inherited retinal dystrophies.. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1690(2), 141 - 149.
    • Parry JW, Poopalasundaram S, Bowmaker JK, Hunt DM (2004). A novel amino acid substitution is responsible for spectral tuning in a rodent violet-sensitive visual pigment.. Biochemistry, 43(25), 8014 - 8020. doi:10.1021/bi049478w
    • Johnson S, Michaelides M, Aligianis IA, Ainsworth JR, Mollon JD, Maher ER, Moore AT, Hunt DM (2004). Achromatopsia caused by novel mutations in both CNGA3 and CNGB3.. Journal of Medical Genetics, 41(2), e20 - .

    2003

    • Michaelides M, Aligianis IA, Holder GE, Simunovic M, Mollon JD, Maher ER, Hunt DM, Moore AT (2003). Cone dystrophy phenotype associated with a frameshift mutation (M280fsX291) in the alpha-subunit of cone specific transducin (GNAT2). British Journal of Ophthalmology, 87(11), 1317 - 1320.
    • Chakarova CF, Vithana EN, Wilkie S, Hunt DM, Bhattacharya SS (2003). Functional studies of mutations in HPRP3 associated with autosomal dominant retinitis pigmentosa.
    • Collin SP, Knight MA, Davies WL, Potter IC, Hunt DM, Trezise AE (2003). Ancient colour vision: multiple opsin genes in the ancestral vertebrates. Current Biology, 13(22), R864 - R865.
    • Michaelides M, Hunt DM, Moore AT (2003). The genetics of inherited macular dystrophies. Journal of Medical Genetics, 40(9), 641 - 650.
    • Hunt DM, Arrese CA, von Dornum M, Rodger J, Oddy A, Cowing JA, Ager EI, Bowmaker JK, Beazley LD, Shand J (2003). The rod opsin pigments from two marsupial species, the South American bare-tailed woolly opossum and the Australian fat-tailed dunnart. Gene, 323, 157 - 162.
    • Vithana EN, Abu-Safieh L, Pelosini L, Winchester E, Hornan D, Bird AC, Hunt DM, Bustin SA, Bhattacharya SS (2003). Expression of PRPF31 mRNA in patients with autosomal dominant retinitis pigmentosa: a molecular clue for incomplete penetrance?. Investigative Ophthalmology and Visual Science, 44(10), 4204 - 4209.
    • Michaelides M, Johnson S, Poulson A, Bradshaw K, Bellmann C, Hunt DM, Moore AT (2003). An autosomal dominant bull's-eye macular dystrophy (MCDR2) that maps to the short arm of chromosome 4. Investigative Ophthalmology and Visual Science, 44(4), 1657 - 1662. doi:10.1167/iovs.02-0941
    • Francis PJ, Johnson S, Edmunds B, Kelsell RE, Sheridan E, Garrett C, Holder GE, Hunt DM, Moore AT (2003). Genetic linkage analysis of a novel syndrome comprising North Carolina-like macular dystrophy and progressive sensorineural hearing loss. British Journal of Ophthalmology, 87(7), 893 - 898.
    • Michaelides M, Johnson S, Tekriwal AK, Holder GE, Bellmann C, Kinning E, Woodruff G, Trembath RC, Hunt DM, Moore AT (2003). An early-onset autosomal dominant macular dystrophy (MCDR3) resembling North Carolina macular dystrophy maps to chromosome 5. Investigative Ophthalmology and Visual Science, 44(5), 2178 - 2183. doi:10.1167/iovs.02-1094
    • Douglas RH, Hunt DM, Bowmaker JK (2003). Spectral sensitivity tuning in the deep-sea. In Collin SP, Marshall NJ (Ed.), Sensory Processing in Aquatic Environments (pp. 323 - 342). : Springer-Verlag.
    • Johnson S, Halford S, Morris AG, Patel RJ, Wilkie SE, Hardcastle AJ, Moore AT, Zhang K, Hunt DM (2003). Genomic organisation and alternative splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7). Genomics, 81(3), 304 - 314. doi:10.1016/S0888-7543(03)00010-7

    2002

    • Hunt DM, Johnson S, Halford S, Morris AM, Patel R, Zhang K, Hardcastle A, Moore AT (2002). Genomic structure and pattern of alternate splicing for RIM1. A candidate gene for CORD7.
    • Cowing JA, Poopalasundaram S, Wilkie SE, Bowmaker JK, Hunt DM (2002). Spectral tuning and evolution of short wave-sensitive cone pigments in cottoid fish from Lake Baikal. Biochemistry, 41(19), 6019 - 6025. doi:10.1021/bi025656e
    • Chakarova CF, Hims MM, Bolz H, Abu-Safieh L, Patel RJ, Papaioannou MG, Inglehearn CF, Keen TJ, Willis C, Moore AT, Rosenberg T, Webster AR, Bird AC, Gal A, Hunt D, Vithana EN, Bhattacharya SS (2002). Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa. Human Molecular Genetics, 11(1), 87 - 92. doi:10.1093/hmg/11.1.87
    • Wilkie SE, Stinton I, Cottrill P, Deery E, Newbold R, Warren MJ, Bhattacharya SS, Hunt DM (2002). Characterisation of two genes for guanylate cyclase activator protein (GCAP1 and GCAP2) in the Japanese pufferfish, Fugu rubripes. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1577(1), 73 - 80. doi:10.1016/S0167-4781(02)00413-X
    • Pointer MA, Freedman AS, Hunt DM (2002). Molecular characterisation of the visual pigments in the deep-sea scopelarchid, Scopelarchus analis.
    • Newbold RJ, Deery EC, Payne AM, Wilkie SE, Hunt DM, Warren MJ (2002). Guanylate cyclase activating proteins, guanylate cyclase and disease. ADV EXP MED BIOL, 514, 411 - 438.
    • Wilkie SE, Deery E, Vithana EN, Chakarova C, Newbold RJ, Warren MJ, Bhattacharya SS, Hunt DM (2002). Functional characterisation of missense mutations in the splicing factor gene PRPF31 underlying autosomal dominant retinitis pigmentosa (RP11).
    • Cowing JA, Poopalasundaram S, Wilkie SE, Robinson PR, Bowmaker JK, Hunt DM (2002). The molecular mechanism for the spectral shifts between vertebrate ultraviolet- and violet-sensitive cone visual pigments.. Biochem J, 367(Pt 1), 129 - 135. doi:10.1042/BJ20020483
    • Cowing JA, Poopalasundaram S, Wilkie SE, Bowmaker JK, Hunt DM (2002). Spectral tuning and evolution of short wave-sensitive cone pigments in cottoid fish from Lake Baikal.. Biochemistry, 41(19), 6019 - 6025.
    • Aligianis IA, Forshew T, Johnson S, Michaelides M, Johnson CA, Trembath RC, Hunt DM, Moore AT, Maher ER (2002). Mapping of a novel locus for achromatopsia (ACHM4) to 1p and identification of a germline mutation in the alpha subunit of cone transducin (GNAT2). Journal of Medical Genetics, 39(9), 656 - 660.
    • Halford S, Inglis S, Gwilliam R, Spencer P, Mohamed M, Ebenezer ND, Hunt DM (2002). Genomic organization of human CDS2 and evaluation as a candidate gene for corneal hereditary endothelial dystrophy 2 on chromosome 20p13. Experimental Eye Research, 75(5), 619 - 623.
    • Newbold RJ, Deery EC, Payne AM, Wilkie SE, Hunt DM, Warren MJ (2002). Guanylate cyclase activating proteins, guanylate cyclase and disease. Advances in Experimental Medicine and Biology, 514, 411 - 438.
    • Ayton A, Morris AG, Tyson PJ, Hunt D, Mortimer AM, Cottrell D (2002). Early development and unstable genes in schizophrenia: preliminary results. European Psychiatry, 17(6), 332 - 338.
    • Deery EC, Vithana EN, Newbold RJ, Gallon VA, Bhattacharya SS, Warren MJ, Hunt DM, Wilkie SE (2002). Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing factor gene PRPF31. Human Molecular Genetics, 11(25), 3209 - 3219. doi:10.1093/hmg/11.25.3209
    • Cowing JA, Poopalasundaram S, Wilkie SE, Robinson PR, Bowmaker JK, Hunt DM (2002). The molecular mechanism for the spectral shifts between vertebrate ultraviolet- and violet-sensitive cone visual pigments. Biochemical Journal, 367(Pt 1), 129 - 135. doi:10.1042/BJ20020483

    2001

    • Deery EC, Newbold RJ, Wilkie SE, Graham CE, Zang K, Hunt DM, Bhattacharya SS, Warren MJ (2001). Comparison and analysis of different human GCAP1 mutants.. INVEST OPHTH VIS SCI, 42(4), S653 - S653.
    • Newbold RJ, Deery EC, Walker CE, Wilkie SE, Srinivasan N, Hunt DM, Bhattacharya SS, Warren MJ (2001). The destabilization of human GCAP1 by a proline to leucine mutation might cause cone-rod dystrophy. Human Molecular Genetics, 10(1), 47 - 54.
    • Hunt DM, Dulai KS, Partridge JC, Cottrill P, Bowmaker JK (2001). The molecular basis for spectral tuning of rod visual pigments in deep- sea fish. Journal of Experimental Biology, 204(Pt 19), 3333 - 3344.
    • Ramamurthy V, Tucker C, Wilkie SE, Daggett V, Hunt DM, Hurley JB (2001). Interactions within the coiled-coil domain of RetGC-1 guanylyl cyclase are optimized for regulation rather than for high affinity. J BIOL CHEM, 276(28), 26218 - 26229.
    • Johnson S, Halford S, Mollon JD, Moore AT, Hunt DM (2001). Molecular basis of cone dystrophy associated with protanopia.. INVEST OPHTH VIS SCI, 42(4), S640 - S640.
    • Vithana EN, Abu-Safieh L, Allen MJ, Carey A, Papaioannou M, Chakarova C, Al-Maghtheh M, Ebenezer ND, Willis C, Moore AT, Bird AC, Hunt DM, Bhattacharya SS (2001). A human homologue of yeast pre mRNA-splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11).. AM J HUM GENET, 69(4), 229 - 229.
    • Halford S, Bellingham J, Ocaka L, Fox M, Johnson S, Foster RG, Hunt DM (2001). Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids.. Cytogenet Cell Genet, 95(3-4), 234 - 235.
    • Hunt DM, Wilkie SE, Bowmaker JK, Poopalasundaram S (2001). Vision in the ultraviolet.. Cell Mol Life Sci, 58(11), 1583 - 1598.
    • Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM (2001). Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43.. Genomics, 72(2), 203 - 208. doi:10.1006/geno.2001.6469
    • Hunt DM (2001). Seeing rainbows. BIOLOGIST (LONDON), 48(2), 67 - 71.
    • Downes SM, Payne AM, Kelsell RE, Fitzke FW, Holder GE, Hunt DM, Moore AT, Bird AC (2001). Autosomal dominant cone-rod dystrophy with mutations in the guanylate cyclase 2D gene encoding retinal guanylate cyclase-1. Archives of Ophthalmology, 119(11), 1667 - 1673.
    • Vithana EN, Abu-Safieh L, Allen MJ, Carey A, Papaioannou M, Chakarova C, Al Maghtheh M, Ebenezer ND, Willis C, Moore AT, Bird AC, Hunt DM, Bhattacharya SS (2001). A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11). Molecular Cell, 8(2), 375 - 381. doi:10.1016/S1097-2765(01)00305-7
    • Wilkie SE, Li Y, Deery EC, Newbold RJ, Garibaldi D, Bateman JB, Zhang H, Lin W, Zack DJ, Bhattacharya SS, Warren MJ, Hunt DM, Zhang K (2001). Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy. The American Journal of Human Genetics, 69(3), 471 - 480.
    • Ramamurthy V, Tucker C, Wilkie SE, Daggett V, Hunt DM, Hurley JB (2001). Interactions within the coiled-coil domain of RetGC-1 guanylyl cyclase are optimized for regulation rather than for high affinity. Journal of Biological Chemistry, 276(28), 26218 - 26229.
    • Payne AM, Morris AG, Downes SM, Johnson S, Bird AC, Moore AT, Bhattacharya SS, Hunt DM (2001). Clustering and frequency of mutations in the retinal guanylate cyclase (GUCY2D) gene in patients with dominant cone-rod dystrophies. Journal of Medical Genetics, 38(9), 611 - 614.
    • Halford S, Freedman MS, Bellingham J, Inglis SL, Poopalasundaram S, Soni BG, Foster RG, Hunt DM (2001). Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. Genomics, 72(2), 203 - 208.
    • Hunt DM, Wilkie SE, Bowmaker JK, Poopalasundaram S (2001). Vision in the ultraviolet. Cellular and Molecular Life Sciences, 58(11), 1583 - 1598.

    2000

    • (2000). A cluster of single nucleotide polymorphisms in the 5'-leader of the human dopamine D3 receptor gene (DRD3) and its relationship to schizophrenia. Neuroscience Letters, 279(1), 13 - 16.
    • (2000). Functional characterization of missense mutations at codon 838 in retinal guanylate cyclase correlates with disease severity in patients with autosomal dominant cone-rod dystrophy. Human Molecular Genetics, 9(20), 3065 - 3073.
    • Lee BB, Silveira LCL, Yamada ES, Hunt DM, Kremers J, Martin PRT, J B DS-F, M (2000). Visual responses of ganglion cells of a New-World primate, the capuchin monkey, Cebus apella.. The Journal of Physiology, 528, 573 - 590.
    • (2000). Spectral tuning of avian violet- and ultraviolet-sensitive visual pigments. Biochemistry, 39(27), 7895 - 7901.
    • Inglis SL, Halford S, Hunt DM (2000). Characterisation of murine CDP-diacyclglycerol synthase (CDS1 & CDS2) genes.. AM J HUM GENET, 67(4), 187 - 187.
    • Halford S, Bellingham J, Freedman MS, Inglis SL, Poopalasundaram S, Foster R, Hunt DM (2000). Characterization of the Human NMO-1 gene at 1q43 and genomic organisation of the region. NMO-1.. AM J HUM GENET, 67(4), 187 - 187.
    • (2000). Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nature Genetics, 25(3), 306 - 310.
    • Gregory-Evans K, Gregory-Evans CY, Holder GE, Hunt DM, Bird AC, Moore AT (2000). Negative b-wave electroretinogram suggests a novel mechanism of photoreceptor cell death in human GUCY2D-mutant cone-rod retinal dystrophy.. INVEST OPHTH VIS SCI, 41(4), S889 - S889.
    • Cowing JA, Wilkie SE, Poopalasundaram S, Bowmaker JK, Hunt DM (2000). Spectral tuning of blue cone pigments in cottoid fish from Lake Baikal. INVEST OPHTH VIS SCI, 41(4), S610 - S610.
    • Wilkie SE, Robinson PR, Cronin TW, Poopalasundaram S, Bowmaker JK, Hunt DM (2000). Spectral tuning of avian violet/UV visual pigments.. INVEST OPHTH VIS SCI, 41(4), S609 - S609.
    • Wilkie SE, Robinson PR, Cronin TW, Poopalasundaram S, Bowmaker JK, Hunt DM (2000). Spectral tuning of avian violet- and ultraviolet-sensitive visual pigments.. Biochemistry, 39(27), 7895 - 7901.
    • (2000). Autosomal dominant cone-rod retinal dystrophy (CORD6) from heterozygous mutation of GUCY2D, which encodes retinal guanylate cyclase. Ophthalmology, 107(1), 55 - 61.
    • (2000). Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids. Cytogenetics and Cell Genetics, 88(3-4), 217 - .
    • Visvanathan R, Wilkie SE, Warren MJ, Hunt DM, Hurley JB (2000). Role of dimerization domain in activation of human retinal guanylyl cyclase-1 (RetGC-1) and dominant cone-rod dystrophy (CORD).. INVEST OPHTH VIS SCI, 41(4), S533 - S533.

    1999

    • (1999). The evolution of trichromatic colour vision by opsin gene duplication in New World and Old World primates. Genome Research, 9, 629 - 638.
    • Silveira LCL, Lee BB, Yamada ES, Kremers J, Hunt DM, Martin PR, Gomes FL (1999). Ganglion cells of a short wavelength sensitive cone pathway in New World monkeys: morphology and physiology.. Visual Neuroscience, 16, 333 - 343.
    • Bowmaker JK, Hunt DM (1999). Molecular biology of photoreceptor spectral sensitivity. In Archer SN, Djamgoz MBA, Leow ER, Partridge JC, Valerga S (Ed.), Adaptive Mechanisms in the Ecology of Vision (pp. 439 - 462). : Kluwer Academic Publishers.
    • Small KW, Yelchits S, Udar N, Klein R, Garcia C, Gallardo G, Puech B, Puech V, Saperstein D, Lin J, Flaxel C, Weber B, Sauer C, Kelsell RE, Hunt DM, Evans K, Lennon F, Pericak-Vance M (1999). North Carolina macular dystrophy (MCDR1) locus: a fine resolution genetic map and haplotype analysis.. Molecular Vision, 5, 38 - .
    • (1999). Estimating relatedness in a population of grey squirrels, Sciurus carolinensis. Acta Theriologica, 44, 3 - .
    • Douglas RH, Partridge JC, Dulai KS, Hunt DM, Mullineaux CW, Hynninen PH (1999). Enhanced retinal longwave sensitivity using a chlorophyll-derived photosensitiser in Malacosteus niger, a deep-sea dragon fish with far red bioluminescence. Vision Research, 39, 2817 - 2832.
    • (1999). High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice. Cell Death and Differentiation, 5(2), 156 - 162.
    • Bowmaker JK, Wilkie SE, Hunt DM (1999). Photoreceptors and molecular genetics of visual pigments in birds. In Adams NJ, Slotow RH (Ed.), Proceedings of the 22nd International Ornithological Congress, Durban (pp. 2729 - 2742). : BirdLife South Africa.
    • (1999). Visual pigments and oil droplets in the retina of a passerine bird, the canary Serinus canaria: microspectrophotometry and opsin sequences. Vision Research, 39, 2801 - 2815.
    • Das D, Wilkie SE, Hunt DM, Bowmaker JK (1999). Visual pigments and oil droplets in the retina of a passerine bird, the canary Serinus canaria: microspectrophotometry and opsin sequences.. Vision Res, 39(17), 2801 - 2815.

    1998

    • Douglas RH, Partridge JC, Dulai KS, Hunt DM, Mullineaux CW, Tauber AY, Hynninen PH (1998). Dragon fish see using chlorophyll. Nature, 393, 423 - 424.
    • Ali RR, Reichel MB, De Alwis M, Kanuga N, Kinnon C, Levinsky RJ, Hunt DM, Bhattacharya SS, Thrasher AJ (1998). Adeno-associated virus gene transfer to mouse retina.. Hum Gene Ther, 9(1), 81 - 86. doi:10.1089/hum.1998.9.1-81
    • Shyue S-K, Boissinot S, Schneider H, Sampaio I, Schneider MP, Abee CR, Williams L, Hewett-Emmett D, Sperling HG, Cowing JA, Dulai KS, Hunt DM, Li W-H (1998). Molecular genetics of spectral tuning in New World monkey color vision.. Journal of Molecular Evolution, 46, 697 - 702.
    • Reichel MB, Kelsell RE, Fan J, Gregory CY, Evans K, Moore AT, Hunt DM, Fitzke FW, Bird AC (1998). Phenotype of a British North Carolina macular dystrophy family linked to chromosome 6q.. British Journal of Ophthalmology, 82, 1162 - 1168.
    • Ali RR, Reichel MB, Kanuga N, Clarke AR, Luthert PJ, Bhattacharya SS, Hunt DM (1998). Gene therapy for inherited retinal degeneration.. British Journal of Ophthalmology, 81, 795 - 801.
    • Wilkie SE, Vissers PM, Das D, Degrip WJ, Bowmaker JK, Hunt DM (1998). The molecular basis for UV vision in birds: spectral characteristics, cDNA sequence and retinal localization of the UV-sensitive visual pigment of the budgerigar (Melopsittacus undulatus).. Biochemical Journal, 15, 541 - 547.
    • Ali RR, Reichel MB, Baker D, Byrnes AP, Kanuga N, Hunt DM, Bhattacharya SS (1998). Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally-mediated LacZ reporter gene expression in the mouse retina.. Gene Therapy, 5(11), 1561 - 1565.
    • Silveira LCL, Lee BB, Yamada ES, Kremers J, Hunt DM (1998). Post-receptoral mechanisms of colour vision in new world primates.. Vision Research, 38, 3329 - 3337.
    • Gehrig A, Felbor U, Kelsell RE, Hunt DM, Maumenee IH, Weber BHF (1998). Assessment of interphotoreceptor matrix proteoglycan-1 (IMPG1) gene localized to 6q13-q15 in autosomal dominant Stargardt-like disease (ADSTGD), progressive bifocal chorioretinal atrophy (PBCRA), and North Carolina macular dystrophy (MCDR1).. Journal of Medical Genetics, 35, 641 - 645.
    • Halford S, Dulai KS, Fitzgibbon J, Hunt DM (1998). Isolation and chromosomal localisation of two human CDP-diacylglycerol synthase (CDS) genes.. Genomics, 54, 140 - 144.
    • Bellingham J, Morris AG, Hunt DM (1998). The rhodopsin gene of the cuttlefish Sepia officinalis: sequence and spectral tuning.. J Exp Biol, 201(Pt 15), 2299 - 2306.
    • Wilkie SE, Vissers PM, Das D, Degrip WJ, Bowmaker JK, Hunt DM (1998). The molecular basis for UV vision in birds: spectral characteristics, cDNA sequence and retinal localization of the UV-sensitive visual pigment of the budgerigar (Melopsittacus undulatus).. Biochem J, 330 ( Pt 1), 541 - 547.
    • Ali RR, Reichel MB, Kanuga N, Munro PM, Alexander RA, Clarke AR, Luthert PJ, Bhattacharya SS, Hunt DM (1998). Absence of p53 delays apoptotic photoreceptor cell death in the rds mouse.. Curr Eye Res, 17(9), 917 - 923.
    • Röhl JCG, Warren MJ, Hunt DM (1998). Purple Secret. Genes,‘Madness’, and the Royal Houses of Europe..
    • Reichel MB, Ali RR, Thrasher AJ, Hunt DM, Bhattacharya SS, Baker D (1998). Immune responses limit adenovirally-mediated gene expression in the adult mouse eye.. Gene Therapy, 5(8), 1038 - 1046.
    • Reichel MB, Ali RR, D Esposito F, Clarke AR, Luthert PJ, Bhattacharya SS, Hunt DM (1998). High frequency of hyperplastic primary vitreous in p53-deficient mice.. Cell Death and Differentiation, 5, 156 - 162.
    • David-Gray ZK, Gurnell J, Hunt DM (1998). DNA fingerprinting reveals high levels of genetic diversity within British populations of the introduced non-native grey squirrel, Sciurus carolinensis.. Journal of Zoology, 246, 443 - 445.
    • Ali RR, Reichel MB, de Alwis M, Kanuga N, Kinnon C, Levinsky RJ, Hunt DM, Bhattacharya SS, Thrasher AJ (1998). Adeno-associated virus gene transfer to mouse retina. Human Gene Therapy. Human Gene Therapy, 9, 81 - 86.
    • Kelsell RE, Yang R-B, Gregory-Evans K, Payne AM, Kaplan J, Perrault I, Garbers DL, Bird AC, Moore AT, Hunt DM (1998). Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy.. Human Molecular Genetics, 7, 1179 - 1184.
    • Hunt DM, Dulai KS, Cowing JA, Julliot C, Mollon JD, Bowmaker JK, Li W-H, Hewett-Emmett D (1998). Molecular evolution of trichromacy in primates.. Vision Research, 38, 3299 - 3306.
    • Reichel MB, Ali RR, Hunt DM, Bhattacharya SS (1998). Gene therapy for retinal degeneration.. Ophthalmic Research, 29, 261 - 268.
    • Perrault I, Rozet J-M, Gerber S, Kelsell RE, Souied E, Cabot A, Hunt DM, Munnich A, Kaplan J (1998). A retGC-1 mutation in autosomal dominant cone-rod dystrophy.. The American Journal of Human Genetics, 63, 651 - 654.

    1997

    • Gaitonde EJ, Sivagnanasundaram S, Morris AG, McKenna PJ, Mollon JD, Hunt DM (1997). The number of triplet repeats in five brain-expressed loci with CAG repeats is not associated with schizophrenia. SCHIZOPHR RES, 25(2), 111 - 116.
    • Bellingham J, Wilkie SE, Morris AG, Bowmaker JK, Hunt DM (1997). Characterisation of the ultraviolet-sensitive opsin gene in the honey bee, Apis mellifera.. Eur J Biochem, 243(3), 775 - 781.
    • Kelsell RE, Evans K, Gregory CY, Moore AT, Bird AC, Hunt DM (1997). Localisation of a gene for dominant cone-rod dystrophy (CORD6) to chromosome 17p.. Hum Mol Genet, 6(4), 597 - 600.
    • Heath LA, Wilkie SE, Bowmaker JK, Hunt DM (1997). The rod and green cone opsins of two avian species, the budgerigar, Melopsittacus undulatus, and the mallard duck, Anas platyrhynchus.. Gene, 204(1-2), 121 - 126.
    • Ali RR, Reichel MB, Thrasher AJ, Kanuga N, Hunt DM, Bhattacharya SS (1997). Gene delivery to the RDS mouse. INVEST OPHTH VIS SCI, 38(4), 1194 - 1194.
    • Reichel MB, Ali RR, Baker D, Byrnes AP, DEsposito F, Kanuga N, Hunt DM, Bhattacharya SS (1997). Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally-mediated lacZ reporter gene expression in the mouse retina.. INVEST OPHTH VIS SCI, 38(4), 1198 - 1198.
    • Wilkie SE, Vissers PMAM, Das D, deGrip WJ, Bowmaker JK, Hunt DM (1997). Short-wave sensitive visual pigments from birds: The ultraviolet-sensitive opsin from budgerigar (Melopsittacus undulatus). INVEST OPHTH VIS SCI, 38(4), 1046 - 1046.
    • Hunt DM, Fitzgibbon J, Slobodyanyuk SJ, Bowmaker JK, Dulai KS (1997). Molecular evolution of the cottoid fish endemic to Lake Baikal deduced from nuclear DNA evidence.. Mol Phylogenet Evol, 8(3), 415 - 422. doi:10.1006/mpev.1997.0428
    • Felbor U, Gehrig A, Koehler M, Schmid M, Kelsell R, Hunt DM, Kuehn M, Hageman GS, Hussels IEM, Weber BHF (1997). Mapping, genomic organization and mutational analyses of a novel interphotoreceptor matrix gene (IPM150): A candidate for 6q-linked retinopathies?. AM J HUM GENET, 61(4), A333 - A333.
    • Morris AC, Sivagnanasundaram S, Gaitonde E, McKenna P, Mollon J, Hunt DM (1997). Repeat expansion detection (RED) of dynamic mutations in diseases exhibiting anticipation. J MED GENET, 34, SP08 - SP08.
    • Woodcock SC, Farber DB, Hunt DM, Warren MJ (1997). Expression of cone cGMP-phosphodiesterase (PDE6C) in E-coli. INVEST OPHTH VIS SCI, 38(4), 2740 - 2740.
    • Dulai KS, Partridge JC, Bowmaker JK, Hunt DM (1997). The rod opsin photopigment of deep-sea fishes.. INVEST OPHTH VIS SCI, 38(4), 2765 - 2765.
    • Halford S, Dulai KS, Fitzgibbon J, Hunt DM (1997). Cloning and characterization of the human and mouse homologues of the Drosophila CDP-diacylglycerol synthase (eye-CDS) gene.. INVEST OPHTH VIS SCI, 38(4), 5278 - 5278.
    • Cowing JA, Bowmaker JK, Hunt DM (1997). Sequence analysis of the promoter regions of the rod and rodlike green cone opsin genes in the goldfish. INVEST OPHTH VIS SCI, 38(4), 5308 - 5308.
    • Hope AJ, Partridge JC, Dulai KS, Hunt DM (1997). Mechanisms of wavelength tuning in the rod opsins of deep-sea fishes. P R SOC B, 264(1379), 155 - 163.
    • Bowmaker JK, Heath LA, Wilkie SE, Hunt DM (1997). Visual pigments and oil droplets from six classes of photoreceptor in the retinas of birds.. Vision Res, 37(16), 2183 - 2194.
    • Kelsell RE, Evans K, Gregory CY, Moore AT, Bird AC, Hunt DM (1997). A new gene for dominant cone-rod dystrophy is localised to chromosome 17p. INVEST OPHTH VIS SCI, 38(4), 3686 - 3686.

    1996

    • Hunt DM, Fitzgibbon J, Slobodyanyuk SJ, Bowmaker JK (1996). Spectral tuning and molecular evolution of rod visual pigments in the species flock of cottoid fish in Lake Baikal.. Vision Res, 36(9), 1217 - 1224.
    • Appukuttan B, Dulai KS, Hunt DM (1996). Isolation and characterisation of protein binding sites in the 5' flanking region of blue cone pigment (BCP) genes. INVEST OPHTH VIS SCI, 37(3), 1547 - 1547.
    • Bowmaker JK, Heath LA, Wilkie SE, Das D, Hunt DM (1996). Middle-wave cone and rod visual pigments in birds: Spectral sensitivity and opsin structure. INVEST OPHTH VIS SCI, 37(3), 3698 - 3698.
    • Ali RR, Reichel MB, Thrasher AP, Kanuga N, Hunt DM, Bhattacharya SS (1996). In vivo gene delivery to the mouse retina. INVEST OPHTH VIS SCI, 37(3), 41 - 41.
    • Morris AG, Gaitonde E, Mckenna PJ, Mollon JD, Hunt DM (1996). Association of CAG repeat expansions with clinical features of schizophrenia. SCHIZOPHR RES, 18(2-3), IXD1 - IXD1.
    • Hunt DM, Hope AJ, Partridge JC (1996). Molecular adaptations of rod opsin's in deep-sea fish. INVEST OPHTH VIS SCI, 37(3), 3697 - 3697.
    • Warren MJ, Jay M, Hunt DM, Elder GH, Röhl JC (1996). The maddening business of King George III and porphyria.. Trends Biochem Sci, 21(6), 229 - 234.
    • Ali RR, Reichel MB, Thrasher AJ, Levinsky RJ, Kinnon C, Kanuga N, Hunt DM, Bhattacharya SS (1996). Gene transfer into the mouse retina mediated by an adeno-associated viral vector.. Hum Mol Genet, 5(5), 591 - 594.
    • Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM (1996). Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.. FEBS Lett, 385(3), 185 - 188.

    1995

    • Morris AG, Gaitonde E, McKenna PJ, Mollon JD, Hunt DM (1995). CAG repeat expansions and schizophrenia: association with disease in females and with early age-at-onset.. Hum Mol Genet, 4(10), 1957 - 1961.

    1994

    • Fitzgibbon J, Appukuttan B, Gayther SA, Wells D, Delhanty J, Hunt DM (1994). Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32. Human Genetics, 93, 79 - 80.
    • FITZGIBBON J, PILZ A, GAYTHER S, APPUKUTTAN B, DULAI KS, DELHANTY JDA, HELMKAMP GM, YARBROUGH LR, HUNT DM (1994). LOCALIZATION OF THE GENE ENCODING HUMAN PHOSPHATIDYLINOSITOL TRANSFER PROTEIN (PITPN) TO 17P13.3 - A GENE SHOWING HOMOLOGY TO THE DROSOPHILA RETINAL DEGENERATION B-GENE (RDGB). CYTOGENET CELL GENET, 67(3), 205 - 207.

    1975

    • JOHNSON DR, HUNT DM (1975). ENDOCRINOLOGICAL FINDINGS IN STERILE PINK-EYED MICE. J REPROD FERTIL, 42(1), 51 - +.

    1974

    • JOHNSON DR, HUNT DM (1974). BIOCHEMICAL OBSERVATIONS ON CARTILAGE OF ACHONDROPLASTIC (CAN) MICE. J EMBRYOL EXP MORPH, 31(APR), 319 - 328.

    1973

    • JOHNSON DR, HUNT DM (1973). NEUROCHEMISTRY OF BRINDLED (MO-BR) AN ALLELE AT X-LINKED MOTTLED LOCUS IN MOUSE. TERATOLOGY, 8(2), 224 - 224.
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