Prof David Attwell

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Personal Profile

Name: David Attwell Email: d.attwell@ucl.ac.uk
Title: Prof Tel: 020 7679 7342
Department: Neuro, Physiology & Pharmacology Fax: 020 7916 7968
Position: Jodrell Professor of Physiology Address: Physiology, Andrew Huxley Building, UCL, Gower Street, London, WC1E 6BT
Research Domain: Basic Life Sciences, Cardiometabolic Science, Human Wellbeing, Neuroscience, Personalised Medicine, Stem Cells & Regenerative Medicine (Frontier Disciplines) Web Page: Personal Web Page

Profile

Research Description

Overview: In my lab we are interested in signalling between neurons and glial cells (oligodendrocytes, astrocytes and microglia), and in how the brain's energy supply is controlled and determines the computational power of the brain. Our studies of brain energy supply have characterized a new locus (in capillaries) for control of cerebral blood flow, have investigated how the amount of energy the brain receives determines the speed of the neural computations performed, and have studied the consequences of failure of the energy supply in conditions like stroke. Recent work on neural-glial signalling has focussed on how activation of glutamate and GABA receptors on oligodendrocytes may be responsible for the mental and physical disability occurring in white matter diseases such as cerebral palsy and spinal cord injury. Oligodendrocytes myelinate axons, and thus speed action potentials, but in pathological conditions like cerebral palsy, stroke, spinal cord injury and multiple sclerosis oligodendrocytes are killed, leading to mental and physical handicap. As for the neuronal death that occurs in stroke (see below), part of this oligodendrocyte death occurs as a result of glutamate being released by reversal of uptake transporters. We are using patch-clamping and immunocytochemistry to study the glutamate-evoked death of oligodendrocytes. Recent findings include the discovery of NMDA receptor mediated currents in oligodendrocytes which play a role in damaging these cells in pathological conditions. Other work is investigating the physiological function of these receptors in controlling the development of oligodendrocytes. All of this work is performed using patch-clamp, calcium imaging and oxygen electrode techniques applied to brain slices and isolated cells, and using mathematical modelling.

Keywords: Glutamate, Demyelination, Electrophysiology, fMRI, Microglia,
Mitochondria, Multiple Sclerosis, Neural signalling, Neurodegeneration, Neural
Circuits/Networks, Neuroimaging, Oligodendrocytes, Progenitors, Stem cells

Conditions: Cerebral palsy, Ischaemic stroke , Leukodystrophies, Multiple sclerosis, Spinal cord injury , Stroke, Transient ischaemic attack

Methods: Brain slice physiology, Calcium imaging, Confocal microscopy, Computational modeling, Electrophysiological recording techniques, fluorescence microscopy techniques, Genetic manipulation (including knockout/knockin), Image analysis, Immunohistochemistry, Patch-clamp recording, Time-lapse imaging, Transgenic mice



Research Activities

Brain energy supply

Cell biological mechanisms underlying neuronal excitability and synaptic plasticity

Neuron-glial interactions

Neuroscience

Education Description

I organise the 4 year PhD in Neuroscience at UCL, and give undergraduate lectures. Until recently I was Vice-Head of the Graduate School, the body overseeing graduate education at UCL, and I am currently on UCL's Council.

UCL Collaborators

Prof William Richardson; Prof Dmitri Rusakov

External Collaborators

Publications

    2014

    • O'Farrell FM, Attwell D (2014). A role for pericytes in coronary no-reflow. Nature Reviews Cardiology, 11(7), 427 - 432. doi:10.1038/nrcardio.2014.58
    • Mishra A, O'Farrell FM, Reynell C, Hamilton NB, Hall CN, Attwell D (2014). Imaging pericytes and capillary diameter in brain slices and isolated retinae.. Nat Protoc, 9(2), 323 - 336. doi:10.1038/nprot.2014.019
    • Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell DI (2014). Capillary pericytes regulate cerebral blood flow in health and disease. Nature, , - . doi:10.1038/nature13165
    • O'Farrell FM, Attwell D (2014). A role for pericytes in coronary no-reflow.. Nat Rev Cardiol, , - . doi:10.1038/nrcardio.2014.58
    • Arancibia-Carcamo IL, Attwell D (2014). The node of Ranvier in CNS pathology.. Acta Neuropathol, , - . doi:10.1007/s00401-014-1305-z
    • Arancibia-Carcamo IL, Attwell D (2014). The node of Ranvier in CNS pathology. Acta Neuropathologica, 128(2), 161 - 175. doi:10.1007/s00401-014-1305-z
    • Mishra A, O'Farrell FM, Reynell C, Hamilton NB, Hall CN, Attwell D (2014). Corrigendum: Imaging pericytes and capillary diameter in brain slices and isolated retinae.. Nat Protoc, 9(10), 2513 - . doi:10.1038/nprot1014-2513b

    2013

    • Young KM, Psachoulia K, Tripathi RB, Dunn SJ, Cossell L, Attwell D, Tohyama K, Richardson WD (2013). Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling.. Neuron, 77(5), 873 - 885. doi:10.1016/j.neuron.2013.01.006
    • Attwell D, Jolivet R, Harris JJ, Klein-Fluegge M, Hall CN (2013). Energy use and supply in CNS grey and white matter.
    • Madry C, Jolivet R, Eder C, Attwell D (2013). MICROGLIAL P2Y RECEPTOR-MEDIATED CURRENTS AND ATP RELEASE IN SITU.
    • Attwell D, Clarke L, Young K, Hamilton NB, Tripathi R, Burzomato V, Arancibia L, Richardson WD (2013). DIVERSITY OF NG2 CELL NUMBER AND PROPERTIES.
    • Jolivet R, Madry C, Attwell D (2013). MICROGLIAL P2Y RECEPTOR-MEDIATED MOTILITY IN SITU.
    • Evans K, Lundgaard I, Luzhynskaya A, Stockley JH, Wang Z, Ffrench-Constant C, Attwell D, Karadottir RT (2013). THE GROWTH FACTOR NRG INDUCES NMDA RECEPTOR DEPENDENT MYELINATION BY OLIGODENDROCYTES, EMPLOYING AKT AND CREB SIGNALLING.
    • Hamilton NB, Kolodziejczyk K, Attwell D (2013). K+ FFECTS ON OLIGODENDROCYTES IN ISCHAEMIA.
    • Harris JJ, Attwell D (2013). Is myelin a mitochondrion?. J Cereb Blood Flow Metab, 33(1), 33 - 36. doi:10.1038/jcbfm.2012.148
    • Lundgaard I, Luzhynskaya A, Stockley JH, Wang Z, Evans KA, Swire M, Volbracht K, Gautier HO, Franklin RJ, Ffrench-Constant C, Attwell D, Káradóttir RT (2013). Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes.. PLoS Biol, 11(12), e1001743 - . doi:10.1371/journal.pbio.1001743

    2012

    • Howarth C, Gleeson P, Attwell D (2012). Updated energy budgets for neural computation in the neocortex and cerebellum.. J Cereb Blood Flow Metab, 32(7), 1222 - 1232. doi:10.1038/jcbfm.2012.35
    • Harris JJ, Attwell D (2012). The energetics of CNS white matter.. J Neurosci, 32(1), 356 - 371. doi:10.1523/JNEUROSCI.3430-11.2012
    • Clarke LE, Attwell D (2012). An astrocyte TRP switch for inhibition.. Nat Neurosci, 15(1), 3 - 4. doi:10.1038/nn.3010
    • Harris JJ, Attwell D (2012). The energetics of CNS white matter. Journal of Neuroscience, 32(1), 356 - 371. doi:10.1523/JNEUROSCI.3430-11.2012
    • Howarth C, Gleeson P, Attwell D (2012). Updated energy budgets for neural computation in the neocortex and cerebellum. Journal of Cerebral Blood Flow and Metabolism, 32(7), 1222 - 1232. doi:10.1038/jcbfm.2012.35
    • Harris JJ, Jolivet R, Attwell D (2012). Synaptic energy use and supply.. Neuron, 75(5), 762 - 777. doi:10.1016/j.neuron.2012.08.019
    • Hall CN, Klein-Fluegge MC, Howarth C, Attwell D (2012). Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing. The Journal of Neuroscience, 32(26), 8940 - 8951.
    • Clarke LE, Young KM, Hamilton NB, Li H, Richardson WD, Attwell D (2012). Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse.. J Neurosci, 32(24), 8173 - 8185. doi:10.1523/JNEUROSCI.0928-12.2012

    2011

    • Tripathi RB, Clarke LE, Burzomato V, Kessaris N, Anderson PN, Attwell D, Richardson WD (2011). Dorsally and ventrally derived oligodendrocytes have similar electrical properties but myelinate preferred tracts.. J Neurosci, 31(18), 6809 - 6819. doi:10.1523/JNEUROSCI.6474-10.2011
    • Rinholm JE, Hamilton NB, Kessaris N, Richardson WD, Bergersen LH, Attwell D (2011). Regulation of oligodendrocyte development and myelination by glucose and lactate.. J Neurosci, 31(2), 538 - 548. doi:10.1523/JNEUROSCI.3516-10.2011
    • Bakiri Y, Káradóttir R, Cossell L, Attwell D (2011). Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum.. J Physiol, 589(Pt 3), 559 - 573. doi:10.1113/jphysiol.2010.201376
    • Harris JJ, Reynell C, Attwell D (2011). The physiology of developmental changes in BOLD functional imaging signals. Developmental Cognitive Neuroscience, 1(3), 199 - 216. doi:10.1016/j.dcn.2011.04.001
    • Gammelsaeter R, Coppola T, Marcaggi P, Storm-Mathisen J, Chaudhry FA, Attwell D, Regazzi R, Gundersen V (2011). A role for glutamate transporters in the regulation of insulin secretion.. PLoS One, 6(8), e22960 - . doi:10.1371/journal.pone.0022960

    2010

    • Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA (2010). Glial and neuronal control of brain blood flow.. Nature, 468(7321), 232 - 243. doi:10.1038/nature09613
    • Madry C, Haglerød C, Attwell D (2010). The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells.. Brain, 133(Pt 12), 3755 - 3763. doi:10.1093/brain/awq284
    • Burzomato V, Frugier G, Pérez-Otaño I, Kittler JT, Attwell D (2010). The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes.. J Physiol, 588(Pt 18), 3403 - 3414. doi:10.1113/jphysiol.2010.195503
    • Hamilton NB, Attwell D (2010). Do astrocytes really exocytose neurotransmitters?. Nat Rev Neurosci, 11(4), 227 - 238. doi:10.1038/nrn2803
    • Kolodziejczyk K, Attwell D, Saab AS, Nave K-A (2010). Why do oligodendrocyte lineage cells express glutamate receptors?. F1000 Biology Reports, 2(1), - . doi:10.3410/B2-57
    • Howarth C, Peppiatt-Wildman CM, Attwell D (2010). The energy use associated with neural computation in the cerebellum.. J Cereb Blood Flow Metab, 30(2), 403 - 414. doi:10.1038/jcbfm.2009.231
    • Hamilton NB, Attwell D, Hall CN (2010). Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease.. Front Neuroenergetics, 2, - . doi:10.3389/fnene.2010.00005
    • Kolodziejczyk K, Saab AS, Nave KA, Attwell D (2010). Why do oligodendrocyte lineage cells express glutamate receptors?. F1000 Biol Rep, 2, 57 - . doi:10.3410/B2-57
    • Hamilton NB, Attwell D (2010). Do astrocytes really exocytose neurotransmitters?. Nat Rev Neurosci, 11(4), 227 - 238. doi:10.1038/nrn2803

    2009

    • Bakiri Y, Attwell D, Káradóttir R (2009). Electrical signalling properties of oligodendrocyte precursor cells.. Neuron Glia Biol, 5(1-2), 3 - 11. doi:10.1017/S1740925X09990202
    • MacAskill AF, Rinholm JE, Twelvetrees AE, Arancibia-Carcamo IL, Muir J, Fransson A, Aspenstrom P, Attwell D, Kittler JT (2009). Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses. Neuron, 61(4), 541 - 555. doi:10.1016/j.neuron.2009.01.030
    • Kolodziejczyk K, Hamilton NB, Wade A, Káradóttir R, Attwell D (2009). The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes.. Brain, 132, 1496 - 1508.
    • Bakiri Y, Burzomato V, Frugier G, Hamilton N, Karadottir R, Attwell D (2009). Glutamatergic signaling in the brain's white matter. Neuroscience, 158, 266 - 274. doi:10.1016/j.neuroscience.2008.01.015
    • De Simoni A, Allen NJ, Attwell D (2009). Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current.. European Journal of Neuroscience, 28, 1146 - 1156.

    2008

    • Furness DN, Dehnes Y, Akhtar AQ, Rossi DJ, Hamann M, Grutle NJ, Gundersen V, Holmseth S, Lehre KP, Ullensvang K, Wojewodzic M, Zhou Y, Attwell D, Danbolt NC (2008). A QUANTITATIVE ASSESSMENT OF GLUTAMATE UPTAKE INTO HIPPOCAMPAL SYNAPTIC TERMINALS AND ASTROCYTES: NEW INSIGHTS INTO A NEURONAL ROLE FOR EXCITATORY AMINO ACID TRANSPORTER 2 (EAAT2). NEUROSCIENCE, 157(1), 80 - 94. doi:10.1016/j.neuroscience.2008.08.043
    • Káradóttir R, Hamilton NB, Bakiri Y, Attwell D (2008). Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter.. Nat Neurosci, 11(4), 450 - 456. doi:10.1038/nn2060
    • Bakiri Y, Hamilton NB, Káradóttir R, Attwell D (2008). Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter.. Glia, 56(2), 233 - 240. doi:10.1002/glia.20608
    • Scholvinck M, Howarth C, Attwell D (2008). The cortical energy needed for conscious perception. Neuroimage. Neuroimage, , - . doi:10.1016/j.neuroimage.2008.01.032
    • Káradóttir R, Hamilton NB, Bakiri Y, Attwell D (2008). Corrigendum: Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter (Nature Neuroscience (2008) 11, (450-456)). Nature Neuroscience, 11(7), 851 - 851. doi:10.1038/nn0708-851b
    • Hall CN, Attwell D (2008). Neuroscience: Brain power. Nature, 456, 715 - 716.
    • Bakiri Y, Hamilton N, Karadottir R, Attwell D (2008). Testing NMDA receptor block as a therapeutic strategy for reducing white matter damage to CNS white matter.. Glia, 56, 233 - 240.
    • Hall CN, Attwell D (2008). Assessing the physiological concentration and targets of nitric oxide in brain tissue.. The Journal of Physiology, 586(15), 3597 - 3615.

    2007

    • Marcaggi P, Attwell D (2007). Short- and long-term depression of rat cerebellar parallel fibre synaptic transmission mediated by synaptic crosstalk.. The Journal of Physiology, 578(2), 545 - 550. doi:10.1113/jphysiol.2006.115014
    • Karadottir R, Attwell D (2007). Neurotransmitter receptors in the life and death of oligodendrocytes.. Neuroscience, 145, 1426 - 1438. doi:10.1016/j.neuroscience.2006.08.070
    • Cavelier P, Attwell D (2007). Neurotransmitter depletion by bafilomycin is promoted by vesicle turnover.. Neuroscience Letters, 412, 95 - 100.

    2006

    • Howarth C, Attwell D (2006). Transports of Delight. Neuron, 52(2), 224 - 225. doi:10.1016/j.neuron.2006.09.002
    • Owe SG, Marcaggi P, Attwell D (2006). The ionic stoichiometry of the GLAST glutamate transporter in salamander retinal glia.. The Journal of Physiology, 577(2), 591 - 599.
    • Karadottir R, Attwell D (2006). Combining patch-clamping of cells in brain slices with immunocytochemical labelling to define cell type and developmental stage.. Nature Protocols, , - .
    • Peppiatt C, Howarth C, Mobbs P, Attwell D (2006). Bidirectional control of CNS capillary diameter by pericytes.. Nature, 443(7112), 700 - 7004. doi:10.1038/nature05193

    2005

    • Karadottir R, Cavelier P, Bergersen L, Attwell D (2005). NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature, 438, 1162 - 1166. doi:10.1038/nature04302
    • Marcaggi P, Hirji N, Attwell D (2005). Release of L-aspartate by reversal of glutamate transporters.. Neuropharmacology, 49(6), 843 - 849.
    • Hamann M, Rossi DJ, Mohr C, Andrade AL, Attwell D (2005). The electrical response of cerebellar Purkinje neurons to simulated ischaemia.. Brain, 128(10), 2408 - 2420.
    • Marcaggi P, Attwell DI (2005). Endocannabinoid signaling depends on the spatial pattern of synapse activation. Nature Neuroscience, 8(6), 776 - 781. doi:10.1038/nn1458
    • Cavelier P, Hamann M, Rossi D, Mobbs P, Attwell D (2005). Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences.. Progress in Biophysics and Molecular Biology, 87(1), 3 - 16.
    • Allen NJ, Karadottir R, Attwell D (2005). A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells.. Journal of Neuroscience, 25(4), 848 - 859.
    • Attwell D, Gibb A (2005). Neuroenergetics and the kinetic design of excitatory synapses. Nature Reviews Neuroscience, 6(11), 841 - 849.
    • Cavelier P, Hamann M, Rossi D, Mobbs P, Attwell D (2005). Tonic excitation and inhibition of neurons: Ambient transmitter sources and computational consequences. Progress in Biophysics and Molecular Biology, 87(1 SPEC. ISS.), 3 - 16. doi:10.1016/j.pbiomolbio.2004.06.001
    • Cavelier P, Attwell D (2005). Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices.. The Journal of Physiology, 564(2), 397 - 410.

    2004

    • Allen NJ, Attwell D (2004). The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus.. The Journal of Physiology, 561(2), 485 - 498.
    • Allen NJ, Karadottir R, Attwell D (2004). Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy.. Pflügers Archiv European Journal of Physiology, 449(2), 132 - 142.
    • Peppiatt C, Attwell D (2004). Feeding the brain. Nature, 431(7005), 137 - 138. doi:10.1038/431137a
    • Marcaggi P, Attwell D (2004). Role of glial amino acid transporters in synaptic transmission and brain energetics.. Glia, 47(3), 217 - 225. doi:10.1002/glia.20027
    • Allen NJ, Rossi DJ, Attwell D (2004). Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices.. Journal of Neuroscience, 24(15), 3837 - 3849.
    • Peppiatt C, Attwell D (2004). Neurobiology: feeding the brain.. Nature, 431(7005), 137 - 138.

    2003

    • Billups D, Attwell D (2003). Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse.. European Journal of Neuroscience, 18(11), 2975 - 2980.
    • Marcaggi P, Billups D, Attwell D (2003). The role of glial glutamate transporters in maintaining the independent operation of juvenile mouse cerebellar parallel fibre synapses.. The Journal of Physiology, 552(1), 89 - 107. doi:10.1113/jphysiol.2003.044263
    • Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM (2003). The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. Journal of Biological Chemistry, 278, 1220 - 1228.
    • Attwell D (2003). Interaction of low frequency electric fields with the nervous system: the retina as a model system.. Radiation Protection Dosimetry, 106, 341 - 348.
    • Rossi DJ, Hamann M, Attwell D (2003). Multiple modes of GABAergic inhibition of rat cerebellar granule cells.. The Journal of Physiology, 548(1), 97 - 110.

    2002

    • Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (2002). The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Molecular and Cellular Neuroscience, 19(2), 152 - 164.
    • Attwell D, Iadecola C (2002). The neural basis of functional brain imaging signals. Trends in Neurosciences, 25(12), 621 - 625.
    • Allen NJ, Attwell D (2002). Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. The Journal of Physiology, 543(2), 521 - 529.
    • Billups D, Attwell D (2002). Control of intracellular chloride concentration and GABA response polarity in rat retinal ON bipolar cells. The Journal of Physiology, 545(1), 183 - 198.
    • Hamann M, Rossi DJ, Marie H, Attwell D (2002). Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia. European Journal of Neuroscience, 15(2), 308 - 314.
    • Hamann M, Rossi DJ, Attwell DI (2002). Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. Neuron, 33(4), 625 - 633. doi:10.1016/S0896-6273(02)00593-7

    2001

    • Gray C, Boyde A, Jones S, Attwell D (2001). Reply: The curious incident of the [silent] dog in the night-time. J BONE MINER RES, 16(9), 1731 - 1732.
    • Allen NJ, Attwell D (2001). A chemokine-glutamate connection. Nature Neuroscience, 4(7), 676 - 678.
    • Gray C, Marie H, Arora M, Tanaka K, Boyde A, Jones S, Attwell D (2001). Glutamate does not play a major role in controlling bone growth. Journal of Bone and Mineral Research, 16(4), 742 - 749.
    • Mort D, Marcaggi P, Grant J, Attwell D (2001). Effect of acute exposure to ammonia on glutamate transport in glial cells isolated from the salamander retina. Journal of Neurophysiology, 86(2), 836 - 844.
    • Attwell D, Laughlin SB (2001). An energy budget for signaling in the grey matter of the brain. Journal of Cerebral Blood Flow and Metabolism, 21(10), 1133 - 1145.

    2000

    • Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). GABAC receptor sensitivity is modulated by interaction with MAP1B.. J Neurosci, 20(23), 8643 - 8650.
    • Attwell D (2000). Brain uptake of glutamate: food for thought. Journal of Nutrition, 130(4S), 1023S - 1025S.
    • Attwell D (2000). Brain uptake of glutamate: Food for thought. Journal of Nutrition, 130(4 SUPPL.), - .
    • Warr O, Mort D, Attwell D (2000). Bilirubin does not modulate ionotropic glutamate receptors or glutamate transporters. Brain Research, 879(1), 13 - 16.
    • Attwell D (2000). How neurotoxic glutamate is released in stroke. Biomedicine and Pharmacotherapy, 54(4), 219 - 219.
    • Rawlins N, Akerman CJ, Andolina I, Blakemore SJ, Mrsic-Flogel T, Attwell D (2000). Four-year PhDs in neuroscience: an assessment after four years. Trends in Neurosciences, 23(7), 280 - 283.
    • Billups D, Hanley JG, Orme M, Attwell D, Moss SJ (2000). GABAc receptor sensitivity is modulated by interaction with MAP1B . Journal of Neuroscience, 20(23), 8643 - 8650.
    • Rossi DJ, Oshima T, Attwell D (2000). Glutamate release in severe brain ischaemia is mainly by reversed uptake. Nature, 403(6767), 316 - 321.
    • Auger C, Attwell D (2000). Fast removal of synaptic glutamate by postsynaptic transporters. Neuron, 28, 547 - 558.

    1999

    • Marie H, Attwell D (1999). C-terminal interactions modulate the affinity of GLAST glutamate transporters in salamander retinal glial cells. The Journal of Physiology, 520, 393 - 397.
    • Marie H, Bedford F, Moss S, Attwell D (1999). Looking for protein interactions with glutamate transporters. 1.Use of the yeast two-hybrid system to identify proteins that interact with the rat glutamate transporter GLT-1.
    • Marie H, Attwell D (1999). Looking for protein interactions with glutamate transporters. 2.Intracellular dialysis of isolated salamander retinal glia with C- and N-terminal peptides from the glutamate transporter GLAST.
    • Warr O, Takahashi M, Attwell D (1999). Modulation of extracellular glutamate concentration in rat brain slices by cystine-glutamate exchange. The Journal of Physiology, 514, 783 - 793.
    • Rossi D, Oshima T, Attwell D (1999). Simulating the anoxic depolarization and release of glutamate in chemical ischemia of rat hippocampal slices.
    • Hamann M, Rossi DJ, Attwell D (1999). Tonic activation of α6 subunit - containing GABAA receptors on granule cells in rat cerebellar slices decreases granule cell excitability.

    1998

    • Spiridon M, Kamm D, Billups B, Mobbs P, Attwell D (1998). Modulation by zinc of the glutamate transporters in glial cells and cones isolated from the tiger salamander retina.. The Journal of Physiology, 506(2), 363 - 376.
    • Levy LM, Attwell D, Hoover F, Ash JF, Bjoras M, Danbolt NC (1998). Erratum: Inducible expression of the GLT-1 glutamate transporter in a CHO cell line selected for low endogenous glutamate uptake (FEBS Letters 422 (1998) (339-342)). FEBS Letters, 427(1), 152 - 152.
    • Levy L, Attwell D, Hoover F, Ash JF, Bjoras M, Danbolt NC (1998). Inducible expression of the GLT-1 glutamate transport in a CHO cell line selected for low endogenous glutamate uptake. Federation of European Biochemical Societies Letters, 422, 339 - 342.
    • Billups B, Szatkowski M, Rossi D, Attwell D (1998). The use of patch-clamp, ion-sensing and glutamate-sensing techniques to study glutamate transport in isolated retinal glial cells. Methods in Enzymology, 296, 617 - 632.
    • Billups B, Rossi D, Oshima T, Warr O, Takahashi M, Sarantis M, Szatkowski M, Attwell D (1998). Physiological and pathological operation of glutamate transporters. Progress in Brain Research, 116, 45 - 58.
    • Levy LM, Warr O, Attwell D (1998). Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake. Journal of Neuroscience, 18, 9620 - 9628.
    • Takahashi M, Sarantis M, Attwell D (1998). Studying glutamate uptake in Purkinje cells in rat cerebellar slices. Methods in Enzymology, 296, 608 - 617.
    • Amato A, Billups B, Bouvier M, Szatkowski M, Attwell D (1998). pH changes associated with glutamate uptake. In Kaila K, Ransom BR (Ed.), pH and Brain Function (pp. 359 - 370). : Wiley.

    1997

    • Mobbs P, Attwell D (1997). Retinal processing: visionary transgenics.. Current Biology, 7(8), 3 - 6.
    • Mobbs P, Attwell D (1997). Retinal processing: visionary transgenics.. Curr Biol, 7(8), R483 - R486.
    • Mobbs P, Attwell D (1997). Visionary transgenics. Current Biology, 7, - .
    • Warr O, Takahashi M, Billups B, Attwell D (1997). Cystine-glutamate exchange and the regulation of extracellular glutamate concentration, [glu]o in rat brain slices.
    • Takahashi M, Billups B, Rossi D, Sarantis M, Hamann M, Attwell D (1997). The role of glutamate transporters in glutamate homeostasis in the brain. Journal of Experimental Biology, 200, 401 - 409.
    • Oshima T, Rossi D, Attwell D (1997). Calcium-independent release of glutamate in simulated ischaemia, sensed by whole-cell clamping CA1 pyramidal cells in rat hippocampal slices.

    1996

    • Takahashi M, Sarantis M, Attwell D (1996). Postsynaptic glutamate uptake in rat cerebellar Purkinje cells.. J Physiol, 497 ( Pt 2), 523 - 530.
    • Billups B, Rossi D, Attwell D (1996). Anion conductance behavior of the glutamate uptake carrier in salamander retinal glial cells.. J Neurosci, 16(21), 6722 - 6731.
    • Attwell D, Boyd R (1996). Withdrawal of funding for intercalating BSc students.. Br Dent J, 181(6), 196 - .
    • Billups B, Attwell D (1996). Modulation of non-vesicular glutamate release by pH.. Nature, 379(6561), 171 - 174. doi:10.1038/379171a0
    • Hamann M, Attwell D (1996). Non-synaptic release of ATP by electrical stimulation in slices of rat hippocampus, cerebellum and habenula.. Eur J Neurosci, 8(7), 1510 - 1515.
    • Attwell D, Rawlins N (1996). The changing pattern of neuroscience PhDs in the UK.. Trends Neurosci, 19(2), 47 - 48.
    • Attwell D, Boyd R (1996). Withdrawal of medical research council funding for intercalated BSc students.. Lancet, 348(9021), 198 - .

    1995

    • ATTWELL D, BILLUPS B (1995). STOICHIOMETRY OF THE GLUTAMATE UPTAKE CARRIER IN MULLER CELLS OF THE TIGER SALAMANDER RETINA. INVEST OPHTH VIS SCI, 36(4), S649 - S649.
    • Takahashi M, Kovalchuk Y, Attwell D (1995). Pre- and postsynaptic determinants of EPSC waveform at cerebellar climbing fiber and parallel fiber to Purkinje cell synapses.. J Neurosci, 15(8), 5693 - 5702.

    1994

    • Amato A, Ballerini L, Attwell D (1994). Intracellular pH changes produced by glutamate uptake in rat hippocampal slices.. J Neurophysiol, 72(4), 1686 - 1696.
    • Amato A, Barbour B, Szatkowski M, Attwell D (1994). Counter-transport of potassium by the glutamate uptake carrier in glial cells isolated from the tiger salamander retina.. J Physiol, 479 ( Pt 3), 371 - 380.
    • Szatkowski M, Attwell D (1994). Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms.. Trends Neurosci, 17(9), 359 - 365.
    • Bouvier M, Amato A, Attwell D (1994). Molecular biology and physiology of glutamate transporters. Seminars in the Neurosciences, 6(2), 117 - 125. doi:10.1006/smns.1994.1015
    • Attwell D, Mobbs P (1994). Neurotransmitter transporters.. Curr Opin Neurobiol, 4(3), 353 - 359.
    • Kovalchuk Y, Miller B, Sarantis M, Attwell D (1994). Arachidonic acid depresses non-NMDA receptor currents.. Brain Res, 643(1-2), 287 - 295.
    • ATTWELL D (1994). NEUROBIOLOGY - GLIA AND NEURONS IN DIALOG. NATURE, 369(6483), 707 - 708.

    1993

    • Sarantis M, Ballerini L, Miller B, Silver RA, Edwards M, Attwell D (1993). Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic current.. Neuron, 11(3), 541 - 549.
    • ATTWELL D, MILLER B, SARANTIS M (1993). ARACHIDONIC-ACID AS A MESSENGER IN THE CENTRAL-NERVOUS-SYSTEM. SEMIN NEUROSCI, 5(3), 159 - 169.
    • Barbour B, Magnus C, Szatkowski M, Gray PT, Attwell D (1993). Changes in NAD(P)H fluorescence and membrane current produced by glutamate uptake into salamander Müller cells.. J Physiol, 466, 573 - 597.
    • Attwell D, Barbour B, Szatkowski M (1993). Nonvesicular release of neurotransmitter.. Neuron, 11(3), 401 - 407.

    1992

    • Bouvier M, Szatkowski M, Amato A, Attwell D (1992). The glial cell glutamate uptake carrier countertransports pH-changing anions.. Nature, 360(6403), 471 - 474. doi:10.1038/360471a0
    • Miller B, Sarantis M, Traynelis SF, Attwell D (1992). Potentiation of NMDA receptor currents by arachidonic acid.. Nature, 355(6362), 722 - 725. doi:10.1038/355722a0
    • Attwell D, Bouvier M (1992). Cloners quick on the uptake.. Curr Biol, 2(10), 541 - 543.

    1991

    • Bouvier M, Miller BA, Szatkowski M, Attwell D (1991). Electrogenic uptake of sulphur-containing analogues of glutamate and aspartate by Müller cells from the salamander retina.. J Physiol, 444, 441 - 457.
    • Barbour B, Brew H, Attwell D (1991). Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina.. J Physiol, 436, 169 - 193.
    • Szatkowski M, Barbour B, Attwell D (1991). The potassium-dependence of excitatory amino acid transport: resolution of a paradox.. Brain Res, 555(2), 343 - 345.

    1990

    • Szatkowski M, Barbour B, Attwell D (1990). Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake.. Nature, 348(6300), 443 - 446. doi:10.1038/348443a0
    • Nicholls D, Attwell D (1990). The release and uptake of excitatory amino acids.. Trends Pharmacol Sci, 11(11), 462 - 468.
    • Attwell D (1990). The photoreceptor output synapse. Progress in Retinal and Eye Research, 9(1), 337 - 362.
    • EVERETT K, SARANTIS M, ATTWELL D (1990). A PRESYNAPTIC ACTION OF GLUTAMATE ON CONE PHOTORECEPTORS.
    • BARBOUR B, BREW H, ATTWELL D (1990). PROPERTIES OF ELECTROGENIC GLUTAMATE UPTAKE IN RETINAL GLIA.
    • Sarantis M, Attwell D (1990). Glutamate uptake in mammalian retinal glia is voltage- and potassium-dependent.. Brain Res, 516(2), 322 - 325.

    1989

    • ATTWELL D, TESSIERLAVIGNE M (1989). DESIGNING SYNAPTIC CONNECTIONS IN THE OUTER RETINA.
    • Barbour B, Szatkowski M, Ingledew N, Attwell D (1989). Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells.. Nature, 342(6252), 918 - 920. doi:10.1038/342918a0

    1988

    • Barbour B, Brew H, Attwell D (1988). Electrogenic glutamate uptake in glial cells is activated by intracellular potassium.. Nature, 335(6189), 433 - 435. doi:10.1038/335433a0
    • Mobbs P, Brew H, Attwell D (1988). A quantitative analysis of glial cell coupling in the retina of the axolotl (Ambystoma mexicanum).. Brain Res, 460(2), 235 - 245.
    • Tessier-Lavigne M, Attwell D (1988). The effect of photoreceptor coupling and synapse nonlinearity on signal:noise ratio in early visual processing.. Proc R Soc Lond B Biol Sci, 234(1275), 171 - 197.
    • Tessier-Lavigne M, Attwell D, Mobbs P, Wilson M (1988). Membrane currents in retinal bipolar cells of the axolotl.. J Gen Physiol, 91(1), 49 - 72.
    • Sarantis M, Everett K, Attwell D (1988). A presynaptic action of glutamate at the cone output synapse.. Nature, 332(6163), 451 - 453. doi:10.1038/332451a0
    • Brew H, Attwell D (1988). Erratum: Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells (Nature (1987) 327, (707-709)). Nature, 328(6132), 742 - 742.
    • Attwell D, Lee JA (1988). A cellular basis for the primary long Q-T syndromes.. Lancet, 1(8595), 1136 - 1139.

    1987

    • ATTWELL D (1987). THE RETINA - AN APPROACHABLE PART OF THE BRAIN - DOWLING,JE. NATURE, 330(6147), 430 - 431.
    • Wilson M, Tessier-Lavigne M, Attwell D (1987). Noise analysis predicts at least four states for channels closed by glutamate.. Biophys J, 52(6), 955 - 960. doi:10.1016/S0006-3495(87)83288-5
    • Attwell D, Tessier-Lavigne M, Wilson M, Mobbs P (1987). Bipolar cell membrane currents and signal processing in the axolotl retina.. Neurosci Res Suppl, 6, S191 - S204.
    • Brew H, Attwell D (1987). Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells.. Nature, 327(6124), 707 - 709. doi:10.1038/327707a0
    • Attwell D, Mobbs P, Tessier-Lavigne M, Wilson M (1987). Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum.. J Physiol, 387, 125 - 161.
    • Attwell D, Borges S, Wu SM, Wilson M (1987). Signal clipping by the rod output synapse.. Nature, 328(6130), 522 - 524. doi:10.1038/328522a0

    1986

    • Attwell D (1986). The Sharpey-Schafer lecture. Ion channels and signal processing in the outer retina.. Q J Exp Physiol, 71(4), 497 - 536.
    • Brew H, Gray PT, Mobbs P, Attwell D (1986). Endfeet of retinal glial cells have higher densities of ion channels that mediate K+ buffering.. Nature, 324(6096), 466 - 468. doi:10.1038/324466a0

    1985

    • Brew H, Attwell D (1985). Is the potassium channel distribution in glial cells optimal for spatial buffering of potassium?. Biophys J, 48(5), 843 - 847. doi:10.1016/S0006-3495(85)83843-1
    • Attwell D, Wilson M, Wu SM (1985). The effect of light on the spread of signals through the rod network of the salamander retina.. Brain Res, 343(1), 79 - 88.
    • Attwell D (1985). Phototransduction changes focus.. Nature, 317(6032), 14 - 15.
    • ATTWELL D (1985). VISION - PHOTOTRANSDUCTION CHANGES FOCUS. NATURE, 317(6032), 14 - 15.
    • Gray P, Attwell D (1985). Kinetics of light-sensitive channels in vertebrate photoreceptors.. Proc R Soc Lond B Biol Sci, 223(1232), 379 - 388.
    • ASHMORE JF, ATTWELL D (1985). MODELS FOR ELECTRICAL TUNING IN HAIR-CELLS. P ROY SOC LOND B BIO, 226(1244), 325 - 344.
    • Tessier-Lavigne M, Mobbs P, Attwell D (1985). Lead and mercury toxicity and the rod light response.. Invest Ophthalmol Vis Sci, 26(8), 1117 - 1123.

    1984

    • Nicol GD, Attwell D, Werblin FS (1984). Membrane potential affects photocurrent kinetics in salamander rods and cones.. Brain Res, 297(1), 164 - 168.
    • Attwell D, Wilson M, Wu SM (1984). A quantitative analysis of interactions between photoreceptors in the salamander (Ambystoma) retina.. J Physiol, 352, 703 - 737.

    1983

    • Wilson M, Attwell D (1983). A new method for obtaining isolated photoreceptors from the amphibian retina.. Pflugers Arch, 399(3), 238 - 240.
    • Attwell D, Werblin FS, Wilson M, Wu SM (1983). A sign-reversing pathway from rods to double and single cones in the retina of the tiger salamander.. J Physiol, 336, 313 - 333.
    • Attwell D, Wilson M (1983). The spatial frequency sensitivity of bipolar cells.. Biol Cybern, 47(2), 131 - 140.
    • Attwell D, Wilson M (1983). The spatial frequency sensitivity of bipolar cells. Biological Cybernetics, 48(2), 138 - 138. doi:10.1007/BF00344398
    • ATTWELL DI, WERBLIN FS, WILSON M, WU SM (1983). PROPERTIES OF DOUBLE CONES IN THE LARVAL SALAMANDER RETINA. J PHYSIOL-LONDON, 341(AUG), P74 - P74.

    1982

    • Attwell D, Werblin FS, Wilson M (1982). The properties of single cones isolated from the tiger salamander retina.. J Physiol, 328, 259 - 283.
    • Arnold L, Page J, Attwell D, Cannell M, Eisner DA (1982). The dependence on heart rate of the human ventricular action potential duration.. Cardiovasc Res, 16(10), 547 - 551.

    1981

    • Cohen I, Attwell D, Strichartz G (1981). The dependence of the maximum rate of rise of the action potential upstroke on membrane properties.. Proc R Soc Lond B Biol Sci, 214(1194), 85 - 98.
    • Attwell D, Cohen I, Eisner DA (1981). The effects of heart rate on the action potential of guinea-pig and human ventricular muscle.. J Physiol, 313, 439 - 461.
    • Cohen I, van der Kloot W, Attwell D (1981). The timing of channel opening during miniature end-plate currents.. Brain Res, 223(1), 185 - 189.

    1980

    • Attwell D, Dubois JM, Ojeda C (1980). Fully activated potassium current-voltage relationship in the Ranvier node: discrepancy between the results of two methods of analysis.. Pflugers Arch, 384(1), 49 - 56.
    • Attwell D, Wilson M (1980). Behaviour of the rod network in the tiger salamander retina mediated by membrane properties of individual rods.. J Physiol, 309, 287 - 315.

    1979

    • Attwell D, Cohen I, Eisner D (1979). Membrane potential and ion concentration stability conditions for a cell with a restricted extracellular space.. Proc R Soc Lond B Biol Sci, 206(1163), 145 - 161.
    • Attwell D, Iles JF (1979). Synaptic transmission: ion concentration changes in the synaptic cleft.. Proc R Soc Lond B Biol Sci, 206(1162), 115 - 131.
    • Attwell D, Cohen I, Eisner D, Ohba M, Ojeda C (1979). The steady state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres.. Pflugers Arch, 379(2), 137 - 142.
    • Attwell D, Eisner D, Cohen I (1979). Voltage clamp and tracer flux data: effects of a restricted extra-cellular space.. Q Rev Biophys, 12(3), 213 - 261.
    • Attwell D, Bergman C, Ojeda C (1979). The action of salicylate ions on the frog node of Ranvier.. J Physiol, 295, 69 - 81.

    1978

    • Attwell D, Jack J (1978). The interpretation of membrane current voltage relations: a Nernst-Planck analysis.. Prog Biophys Mol Biol, 34(2), 81 - 107.
    • Attwell D, Eisner D (1978). Discrete membrane surface charge distributions. Effect of fluctuations near individual channels.. Biophys J, 24(3), 869 - 875. doi:10.1016/S0006-3495(78)85426-5

    1977

    • Attwell D, Cohen I (1977). The voltage clamp of multicellular preparations.. Prog Biophys Mol Biol, 31(3), 201 - 245.