4 YEAR PhD IN NEUROSCIENCE
Dementia Research Centre (Institute of Neurology) Clinical neuroscience of complex sound
The key objective of my group is to identify mechanisms of neural network dysfunction and impaired information processing that link tissue pathology with clinical symptoms in neurodegenerative disease, using the paradigm of complex sounds (speech, environmental noises, and music) and associated sensory modalities. Our brain-behaviour focus is complementary to other translational and diagnostic biomarker and structural imaging work at the Dementia Research Centre. My group applies cognitive neuropsychology, morphometric and functional brain imaging and physiological (autonomic) techniques to the analysis of cognitive and behavioural deficits in the common dementias. We pursue two broad parallel research streams devoted to nonverbal and verbal mechanisms, respectively. The nonverbal stream addresses the cognition and anatomy of extra-linguistic concepts and codes, and how these map onto behavioural and emotional deficits in dementia diseases, including aberrant reward and social signal processing. The verbal stream is directed to the neurolinguistic, cognitive, behavioural and neuroanatomical characterisation of a key group of focal dementias: the primary progressive aphasias.
Currently available topics for lab projects include:
i) pathophysiology of aberrant reward processing in young onset dementias (using combined behavioural, physiological (pupillometric) and MRI tools to define a novel model ‘addictive’ behaviour, musicophilia); and
ii) phenotyping language network failure in young onset dementias (an integration of neurolinguistic data with MR connectivity measures of neural network disintegration).
Warren JD, Rohrer JD, Schott JM, Fox NC, Hardy J, Rossor MN. (2013) Molecular nexopathies: a new paradigm of neurodegenerative disease. Trends Neurosci. 36(10):561-9.
Fletcher PD, Downey LE, Witoonpanich P, Warren JD. (2013) The brain basis of musicophilia: evidence from frontotemporal lobar degeneration. Front Psychol. 4:347.
Mahoney CJ, Malone IB, Ridgway GR, Buckley AH, Downey LE, Golden HL, Ryan NS, Ourselin S, Schott JM, Rossor MN, Fox NC, Warren JD. (2013) White matter tract signatures of the progressive aphasias. Neurobiol Aging 34(6):1687-99.
Goll JC, Kim LG, Ridgway GR, Hailstone JC, Lehmann M, Buckley AH, Crutch SJ, Warren JD. (2012) Impairments of auditory scene analysis in Alzheimer's disease. Brain 135(Pt 1):190-200.
Goll JC, Ridgway GR, Crutch SJ, Theunissen FE, Warren JD. (2012) Nonverbal sound processing in semantic dementia: a functional MRI study. Neuroimage 61(1):170-80.