4 YEAR PhD IN NEUROSCIENCE
MRC Laboratory for Molecular Cell Biology and
Department of Neuroscience Physiology and Pharmacology
Transcriptional and epigenetic mechanisms in developing neurons
Within the nervous system, neurotrophic factors and activity regulate a wide range of processes including the proliferation of neuronal precursors, and the growth, survival, and synaptic connectivity of developing neurons. Many, if not all of the stimuli that contribute to such processes have the capacity to signal to the nucleus and influence gene expression. Our laboratory is interested in understanding the transcriptional and epigenetic mechanisms that regulate gene expression in neurons. We will use in vivo and in vitro models to address 1) the role of the transcription factor CREB in the adult and developing nervous system 2) characterize a novel signalling pathway that controls neuronal gene expression by inducing epigenetic changes 3) identify RNA transcripts locally translated in axons.
1) C. Andreassi, C. Zimmermann, R. Mitter, S. Fusco, S. De Vita, A. Saiardi and A.Riccio An NGF-responsive element targets Inositol Monophospatase 1 mRNA to sympathetic neuron axons Nature Neuroscience, 2010 (in press)
2) A. Riccio New endogenous regulators of ClassI histone deacetylases Science Signalling, 2010; 3:pe1
3) C. Andreassi and A. Riccio To localize or not to localize: mRNAs fate is in the 3’ UTR ends Trends in Cell Biology, 2009; 19(9): 465-74
4) A. Nott and A. Riccio Nitric Oxide-mediated epigenetic mechanisms in developing neurons Cell Cycle, 2009; 8(5): 725-730
5) A. Nott, P. M. Watson, J.D. Robinson, L. Crepaldi and A. Riccio S- nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons Nature, 2008; 455:411-5
6) A. Riccio, R.S Alvania, B.E. Lonze, N. Ramanan, T. Kim, Y. Huang, T. M. Dawson, S. H. Snyder and D.D. Ginty A nitric oxide signalling pathway controls CREB-mediated gene expression in neurons Mol Cell, 2006; 21(2): 283-94
7) B.E. Lonze, A. Riccio, S. Cohen and D. D. Ginty Apoptosis, axonal growth defects and degeneration of peripheral neurons in mice lacking CREB Neuron, 2002; 34: 371-385
8) A. Riccio, D. D. Ginty What a privilege to reside at the synapse: NMDA receptor signaling to CREB Nature Neuroscience, 2002 May;5(5):389-90.