NMR Experiments

In addition to standard one- and two-dimensional spectra used on daily basis, there are several NMR experiments used for specific tasks, such as measurements of ¹³C-¹H coupling constants or nuclear Overhauser effects (NOEs). These experiments can be run in automated mode under Iconnmr, although some of them may require additional acquisition parameters.

• Measurements of J(C,H) Couplings
• NOE Experiments
• Carbon-Carbon Correlations
• Non Uniform Sampling
• Concentration Measurements
• Solvent Suppression Experiments
• HSQC-TOCSY
• HSQC-HECADE
• ADEQUATE
• Fast COSY
• Pure Shift
• Diffusion ordered spectroscopy (DOSY)
• Relaxation time measurements
• Saturation Transfer and Water-LOGSY
• Metabonomics
• SNR-controlled Experiments

 The 300 MHz instrument is equipped with a QNP probe, allowing automated acquisition of ¹H, ¹³C, ¹⁹F and ³¹P spectra using the BACS60 sample changer. Standard experiments added into the auto-acquisition list under Iconnmr include:

• Quantitative proton NMR for determining concentrations of samples
• Multiple solvent suppression experiments
• High-temperature measurements
• Proton NMR with ¹⁹F or ³¹P decoupling and optional solvent suppression
• 2D ¹H-¹⁹F and ¹H-³¹P HMBC experiments for multiple bond correlations
• 2Dexperiments for measurements of ¹H-¹⁹F heteronuclear Overhauser effects (HOE)