Research

Background 

We recognize the value of the MINAP data, certainly in improving patient care but also in its secondary use amongst others, for research. Therefore, in 2005 the MINAP Academic Group (MAG) was established to maximise the research potential of MINAP database and to establish processes for the safe distribution and return of sub-sets of MINAP data to research groups. The MAG is responsible for ensuring that data are only accessed by researchers with bona fide projects of high scientific probity who respect the conditions of confidentiality and security. MAG was delegated the responsibility for releasing MINAP data by the Health Quality Improvement Partnership (HQIP) through which MINAP is funded.

Current position

The last year has seen major developments driven by the MINAP Academic Group. We now have a truly nationwide programme incorporating many of the top cardiological and epidemiological research groups in the UK. In the last 12 months alone approvals have been given for data-sharing with researchers in London, Birmingham, Belfast, Leeds, Leicester, Edinburgh and Norwich. The academic fruits of earlier applications led to seven publications in major cardiovascular and general journals in 2010, more than ever before, with a further four publications to May 2011.

 Particularly significant has been the establishment of international collaborations with the SWEDEHEART investigators in Upsalla (Sweden) to complement the international collaborative analysis of pre-hospital thrombolysis previously undertaken in Europe and North America.

The development that will underpin research activity through the next decade and beyond has been the successful bid by the NICOR executive to take over custodianship of MINAP and five other national cardiovascular registries. Leaders within MINAP and MAG played a key role in securing the bid which will now allow a more hands on approach to the management and linkage of this unique data resource. Only in the UK are national registry data on this scale available providing opportunities for cardiovascular researchers that cannot be found elsewhere.  

MAG Membership

MINAP Academic Group reports to MINAP Steering Group and is chaired by Prof Adam Timmis (pictured). 

The MINAP Academic Group (MAG) meets twice a year to discuss the new applications, progress made and other related matters.
adamtimmis
Name Position Organisation
Prof Adam Timmis Chair, Deputy Director NIHR Cardiovascular Biomedical Research Unit, Professor of Clinical Cardiology Barts and the London NHS Trust Queen Mary & Westfield College, University of London, School of Medicine and Dentistry
Dr Clive Weston MINAP Clinical Lead, Consultant Cardiologist Singleton Hospital, Swansea University
Dr Mark de Belder Interventional Cardiologist South Tees Hospitals NHS Foundation Trust
Dr Chris Gale NICOR Research Committee Co-chair; NIHR Clinician Scientist Award Associate Professor of Cardiovascular Health Research , Honorary Reader of UCL and Honorary Consultant Cardiologist University of Leeds,  York Teaching Hospital
Dr Iain Squire Professor of Cardiovascular Medicine University of Leicester
Prof Harry Hemingway Professor of Clinical Epidemiology University College London
Dr Paul Wilkinson Reader in Environmental Epidemiology London School of Hygiene & Tropical Medicine 
Dr Spiros Denaxas CALIBER Data Manager University College London
Emmanuel Lazarides NICOR Senior Analyst NICOR, University College London
Prof Tom Quinn Associate Dean - Health and Medical Strategy and Clinical Lead, NICE Evidence Resources University of Surrey
Dr Owen Nicholas NICOR Senior Analyst NICOR, University College London
Tracy Whittaker MINAP Project Manager NICOR, University College London

Points to consider

We recommend that researchers consider carefully the challenges of analysing large complex observational data which have been routinely collected by healthcare professionals. Researchers may wish to consider the implications of using incomplete and incorrect data and that of reporting unadjusted outcomes. For example, researchers may incorporate statistical methods to allow more efficient inferences without the distractions of missing data and to consider modelling strategies to adjust for confounders.

You may wish to refer to:

'Multiple imputation for completion of a national clinical audit dataset'. Cattle BA, Baxter PD, Greenwood DC, Gale CP, West RM. Stat Med. 2011 Sep 30;30(22):2736-53. doi: 10.1002/sim.4314. Epub 2011 Jul 22.

'Impact of missing data on standardised mortality ratios for acute myocardial infarction: evidence from the Myocardial Ischaemia National Audit Project (MINAP) 2004-7'. Gale CP, Cattle BA, Moore J, Dawe H, Greenwood DC, West RM. Heart. 2011 Feb 28. [Epub ahead of print]

Cost

MINAP now contains over 1 million records and has had 100% participation since 2003. Its data have been available for research through application to MINAP Academic Group since 2005. The currently available dataset spans from 2003 to 2013 including vital status and an interval to death. MINAP receives no funding from HQIP for the research it supports. Data sharing with researchers attracts a fee that has been calculated to meet the costs of data management, processing of applications and preparation of extracts.

Type of research Fee
Academic £5,000
Commercial ≥£10,000 plus VAT (by negotiation)
Annual update including vital statistics £1,000 plus VAT

Note: additional cost will apply for applications requiring cross-registry linkage depending on the complexity of the work involved. 

Fees are not applicable to any non-research applications.

How to apply

An application pack and more information about accessing NICOR data can be downloaded from the NICOR Research webpages. The required fields should be clearly indicated in the master dataset available in the link below and submitted with the completed application form. 

MINAP Academic Group meets twice a year however the applications can be reviewed in between the meetings if necessary. NICOR are currently only making MINAP data available up to September 2013.

Submission date Review date
28 January 2014 11 February 2014
2 September 2014 16 September 2014

For more information on how to make or submit an application for MINAP data please email Tracy Whittaker, MINAP Project Manager at t.whittaker[at]ucl.ac.uk.

MINAP Publications

Since the establishment of the MINAP Academic Group  approximately 95 approved applications resulted in over 65 papers being published in the high impact journals like The Lancet, BMJ, Heart, European Heart Journal, and more. 

The table below highlights just a few...

Myint PK, Kwok CS, O Bachmann, et al. Prognostic value of troponins in acute coronary syndrome depends upon patient age.Heart.June 2014.doi:10.1136 /heartjnl-2014-305533 [e-pub]
Zaman MJ, Stirling, S, Shepstone L et al. The association between older age and receipt of care and outcomes in patients with acute coronary syndromes: a cohort study of the Myocardial Ischaemia National Audit Project (MINAP). European Heart Journal. doi:10.1093/eurheartj/ehu039 
Crowe F, Appleby PN, Travis RC at al. Risk of hospitalization or death from ischemic heart disease among British vegetarians and nonvegetarians: results from the EPIC-Oxford cohort study. Eur Heart J 2013 34: 1527-1531
Laut KG, Gale CP, Lash TL, et al.  Determinants and patterns of utilization of primary percutaneous coronary intervention across 12 European countries: 2003-2008.  Int J Cardiol. 2013 Apr; doi: 10.1016/j.ijcard.2013.03.085.
Simms AD, Baxter PD, Cattle BA, et al. An assessment of composite measures of hospital performance and associated mortality for patients with acute myocardial infarction. Analysis of individual hospital performance and outcome for the National Institute for Cardiovascular Outcomes Research (NICOR). European Heart Journal: Acute Cardiovascular Care, March 2013; 2, 1: 9-18
Boggon R, Timmis A, Hemingway H,et al. Smoking cessation interventions following acute coronary syndrome: a missed opportunity? Eur J Prev Cardiol. 2013 Jan 10. [Epub ahead of print]
Tonne C, Wilkinson P. Long-term exposure to air pollution is associated with survival following acute coronary syndrome. Eur Heart J. 2013 May;34(17):1306-11. doi: 10.1093/eurheartj/ehs480. Epub 2013 Feb 19.
Herrett E, Shah AD, Boggon R, et al. Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study. BMJ. 2013 May 20;346:f2350. doi: 10.1136/bmj.f 2350
 Herrett E, George J, Denaxas S, et al. Type and timing of heralding in ST-elevation and non-ST-elevation myocardial infarction: an analysis of prospectively collected electronic healthcare records linked to the national registry of acute coronary syndromes. European Heart Journal: Acute Cardiovascular Care, September 2013; 2, 3: 235-245
Zaman MJ, Philipson P, Chen R, et al. South Asians and coronary disease: is there discordance between effects on incidence and prognosis? Heart. 2013;99(10):729-36
Noman A, Zaman A, Schechter C, et al. Early discharge after primary percutaneous coronary intervention for ST-elevation myocardial infarction.  European Heart Journal: Acute Cardiovascular Care, September 2013; 2, 3: 262-269
Puymirat E, Battler A, Birkhead J, et al. Euro Heart Survey 2009 Snapshot: regional variations in presentation and management of patients with AMI in 47 countries. European Heart Journal: Acute Cardiovascular Care. 2013 Aug. DOI: 10.1177/2048872613497341. Epub 2013 Aug 20
Wilkinson, P MINAP – the first decade. Cardiology News. Volume 15, number 3. Feb/March 2012
Gale CP, Cattle BA, Woolston A, et al. Resolving inequalities in care? Reduced mortality in the elderly after acute coronary syndromes. The Myocardial Ischaemia National Audit Project 2003-2010. Eur Heart J. 2012 Mar;33(5):630-9. doi: 10.1093/eurheartj/ehr381. Epub 2011 Oct 18.
Gholap NN, Mehta RL, Ng L,et al. Is admission blood glucose concentration a more powerful predictor of mortality after myocardial infarction than diabetes diagnosis? A retrospective cohort study. BMJ Open. 2012 Sep 25;2(5). doi:pii: e001596. 10.1136/bmjopen-2012-001596. Print 2012.
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