Neuromuscular MRI
MRC Centre for Neuromuscular Diseases

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Fat Fraction Map

Recent Neuromuscular MRI Publications

Journal Articles

Reproducibility, and age, body-weight and gender dependency of candidate skeletal muscle MRI outcome measures in healthy volunteers.
Morrow JM, Sinclair CD, Fischmann A, Reilly MM, Hanna MG, Yousry TA, Thornton JS.
European Radiology, 24, p1610-1620 (2014)
doi: 10.1007/s00330-014-3145-6 [pubmed]

Improved anatomical reproducibility in quantitative lower-limb muscle MRI
Arne Fischmann, Jasper M Morrow, Christopher D.J. Sinclair, Mary M Reilly, Michael G Hanna, Tarek Yousry, John S. Thornton
Journal of Magnetic Resonance Imaging, 39, p1033-8 (2014)
doi: 10.1002/jmri.24220 [pubmed]

Quantitative Magnetic Resonance Imaging in Limb-Girdle Muscular Dystrophy 2I: A Multinational Cross-Sectional Study
Willis TA, Hollingsworth KG, Coombs A, Sveen ML, Andersen S, Stojkovic T, Eagle M, Mayhew A, de Sousa PL, Dewar L, Morrow JM, Sinclair CD, Thornton JS, Bushby K, Lochmuller H, Hanna MG, Hogrel JY, Carlier PG, Vissing J, Straub V
PLoS One, 9, e90377 (2014)
doi: 10.1371/journal.pone.0090377 [pubmed]

Muscle MRI reveals distinct abnormalities in genetically proven non-dystrophic myotonias
Jasper M Morrow, Emma Matthews, Dipa L Raja Rayan, Arne Fischmann, Christopher DJ Sinclair, Mary M Reilly, John S Thornton, Michael G Hanna, Tarek A Yousry
Neuromuscular Disorders, 23, p637-46 (2013) [DOI] [pubmed]

Quantitative Muscle MRI as an Assessment Tool for Monitoring Disease Progression in LGMD2I: A Multicentre Longitudinal Study
Willis TA, Hollingsworth KG, Coombs A, Sveen ML, Andersen S, Stojkovic T, Eagle M, Mayhew A, de Sousa PL, Dewar L, Morrow JM, Sinclair CD, Thornton JS, Bushby K, Lochmüller H, Hanna MG, Hogrel JY, Carlier PG, Vissing J, Straub V
PLoS One, 8, e70993 (2013)
doi: 10.1371/journal.pone.0070993 [pubmed]

Seletal muscle MRI magnetisation transfer ratio reflects clinical severity in peripheral neuropathies
CDJ Sinclair, JM Morrow, MA Miranda, I Davagnanam, PC Cowley, H Mehta, MG Hanna, M Koltzenburg, TA Yousry, MM Reilly, JS Thornton
Journal of Neurology, Neurosurgery & Psychiatry, 83, p29 (2012)
doi:10.1136/jnnp.2011.246116 [pubmed]

Correcting RF Inhomogeneity Effects in Skeletal Muscle Magnetization Transfer Maps
CDJ Sinclair, JM Morrow, MG Hanna, MM Reilly, TA Yousry, X Golay, JS Thornton
NMR in Biomedicine, 25, 262–270 (2011)
doi: 10.1002/nbm.1744 [pubmed]

Simultaneous T2 and Lipid Quantitation using IDEAL-CPMG
Robert L. Janiczek, Giulio Gambarota, Christopher D. J. Sinclair, Tarek A. Yousry, John S. Thornton, Xavier Golay, Rexford D. Newbould
Magnetic Resonance in Medicine, 66,  p1293-1302   (2011)
DOI: 10.1002/mrm.22916 [pubmed]

MRI shows increased sciatic nerve cross sectional area in inherited and inflammatory neuropathies
Christopher D. J. Sinclair, Mario A. Miranda, Peter Cowley, Jasper M. Morrow, Indran Davagnanam, Hiten Mehta, Michael G. Hanna, Martin Koltzenburg, Mary M. Reilly, Tarek A. Yousry, and John S. Thornton
Journal of Neurology, Neurosurgery & Psychiatry 82: p1283-1286 (2010)
DOI:10.1136/jnnp.2010.211334  [pubmed] 

Quantitative magnetization transfer in in vivo healthy human skeletal muscle at 3T
Christopher D. J. Sinclair, Rebecca S. Samson, David L. Thomas, Nikolaus Weiskopf, Antoine Lutti, John S. Thornton and Xavier Golay
Magnetic Resonance in Medicine
, 64 (6): p1739-1748  (2010) [pubmed]

Review Articles

MR Neurography: Advances
Avneesh Chhabra, Lianxin Zhao, John A. Carrino, Eo Trueblood, Saso Koceski, Filip Shteriev, Lionel Lenkinski, Christopher D. J. Sinclair and Gustav Andreisek
Radiology Research and Practice, 809568 (2013) [doi]

Book Chapters

Atlas of topographical muscle anatomy
A. Fischmann and CDJ Sinclair
in Neuromuscular Imaging
Wattjes, Mike P., Fischer, Dirk (Eds.)
Springer  ISBN 978-1-4614-6551-5

Conference Proceedings

Texture Analysis of Muscle 3-Point Dixon Fat-Fraction: Changes Over 1 Year
Sinclair, Christopher; Morrow, Jasper M.; Fischmann, Arne; Hanna, Michael G.; Reilly, Mary M.; Yousry, Tarek; Thornton, John
Proc. Intl. Soc. Mag. Reson. Med. 22, 1595 (2014)

Upper Limb Muscle Fat-Water Quantification in Non-Ambulant Duchenne Muscular Dystrophy
Ricotti, Valeria; Evans, Matthew RB; Sinclair, Christopher; Morrow, Jasper M.; Butler, Jordan W.; Janiczek, Robert L.; Hanna, Michael G.; Matthews, Paul; Yousry, Tarek; Muntoni, Francesco; Thornton, John
Proc. Intl. Soc. Mag. Reson. Med. 22, 1220 (2014)

Upper limb muscle fat-water quantification MRI and clinical functional evaluation in non-ambulant Duchenne muscular dystrophy
Valeria Ricotti, Matthew Evans, Christopher Sinclair, Jasper Morrow, Jordan Butler, Robert Janiczek, Michael Hanna, Paul Matthews, Tarek Yousry, Francesco Muntoni, John Thornton
XIII International Congress on Neuromuscular Diseases PS4-439,361(2014)

Quantitative MRI in hypokalaemic periodic paralysis reveals age-dependent fat infiltration of lower limb muscles
J.M. Morrow, E. Rawah, C.D.J. Sinclair, M.R.B. Evans, S. Shah, M.G. Hanna, M.M. Reilly, J.S. Thornton, T.A. Yousry
XIII International Congress on Neuromuscular Diseases S4-433, 252 (2014)

Lower limb muscle MRI findings in X-linked Charcot-Marie-Tooth disease
A.L. Pelayo-Negro, M.R.B. Evans, J.M. Morrow, S. Shah, A.S. Carr, M.G. Hanna, T.A. Yousry, M.M. Reilly
XIII International Congress on Neuromuscular Diseases PS4-434, 255 (2014)

Upper limb muscle fat-water quantification MRI in non-ambulant Duchenne muscular dystrophy
V. Ricotti, M.R.B. Evans, C.D.J. Sinclair, J.M. Morrow, J.W. Butler, R.L. Janiczek, M.G. Hanna, P.M. Matthews, T.A. Yousry, F. Muntoni, J.S. Thornton
Neuromuscular Disorders, Volume 24, Supp 1, P35 (2014)

Texture analysis of muscle MRI changes over 1 year
C.D.J. Sinclair, J.M. Morrow, A. Fischmann, M.G. Hanna, M.M. Reilly, T.A. Yousry, J.S. Thornton
Neuromuscular Disorders, Volume 24, Supp 1, P36 (2014)

Muscle MRI in congenital myasthenics syndromes
P.M. Rodriguez Cruz, S. Finlayson, J.M. Morrow, T.A. Yousry, S. Jayawant, D. Beeson, J. Palace
Neuromuscular Disorders, Volume 24, Supp 1, P37 (2014)

MRI quantification of fixed myopathy in hypokalaemic periodic paralysis identifies potential therapeutic window
J.M. Morrow, E. Rawah, C.D.J. Sinclair, M.R.B. Evans, S. Shah, M.G. Hanna, M.M. Reilly, J.S. Thornton, T.A. Yousry
Neuromuscular Disorders, Volume 24, Supp 1, P38 (2014)

Quantitative lower limb muscle MRI in CMT1A demonstrates length-dependent fatty infiltration
M.R.B. Evans, J.M. Morrow, C.D.J. Sinclair, S. Shah, M.G. Hanna, M.M. Reilly, J.S. Thornton, T.A. Yousry
Neuromuscular Disorders, Volume 24, Supp 1, P39 (2014)

MRI quantification of lower limb muscle fat gradients in CMT1A
MRB Evans, JM Morrow, CDJ Sinclair, S Shah, E Rawah, MG Hanna, MM Reilly, JS Thornton, TA Yousry
Association of British Neurologists Annual Meeting 2014

Longitudinal Changes in Muscle 3-Point Dixon Fat-Fraction Texture Parameters Over 1 Year
CDJ Sinclair, JM Morrow, A Fischmann, MG Hanna, MM Reilly, TA Yousry, JS Thornton
19th Annual Scientific Meeting of the BC-ISMRM, P32, (2014)

Measuring the Unmeasurable: MRI Quantification of Disease Progression in CMT1A Over 12 Months
Morrow JM, Sinclair CDJ, Fischmann A, Hanna MG, Thornton JS, Yousry TA, Reilly MM
Journal of the Peripheral Nervous System 18, 75 (2013) [Link]

Multi-Parameter Quantitation of Coincident Fat and Water Skeletal Muscle Pathology
Christopher DJ Sinclair, Jasper M Morrow, Robert L Janiczek, Michael G Hanna, Mary M Reilly, Tarek A Yousry, Rebecca S Samson, Nikolaus Weiskopf,  Antoine Lutti, David L Thomas, Xavier Golay and John S Thornton
Proc. Intl. Soc. Mag. Reson. Med. 21, 691 (2013)

Diffusion Tensor Measurements in Healthy Human Sciatic Nerve
Christopher DJ Sinclair, Laura Mancini, and John S Thornton
Proc. Intl. Soc. Mag. Reson. Med. 21, 314 (2013)

Candidate Skeletal Muscle Outcome Measures for Therapy Trials: Dependence of MRI Measures Upon Age, Gender and Weight
Jasper M Morrow, Christopher DJ Sinclair, Arne Fischmann, Mary M Reilly, Michael G Hanna, Tarek A Yousry, and John S Thornton
Proc. Intl. Soc. Mag. Reson. Med. 21, 2115 (2013)

Diffusion Tensor MRI of the Sciatic Nerve
CDJ Sinclair, JM Morrow, L Mancini, MG Hanna, TA Yousry, MM Reilly and JS Thornton
6th UK neuromuscular Translational Research Conference, p52 (2013)

MRI provides sensitive quantification of disease progression in inclusion body myositis
Jasper M Morrow, Christopher DJ Sinclair, Arne Fischmann, John S Thornton, Mary M Reilly, Michael G Hanna, Tarek A Yousry
6th UK neuromuscular Translational Research Conference, p79 (2013)

Mutli-parameter quantification of coincident fat and water skeletal muscle pathology
CDJ Sinclair, JM Morrow, RL Janiczek, MG Hanna, MM Reilly, TA Yousry, RS Samson, N Weiskopf, A Lutti, DL Thomas, X Golay, JS Thornton
18th Annual Meeting of the British Chapter of the International Society for Magnetic Resonance in Medicine, p53 (2012)

MRI Quantification of Lower Limb Muscle Fatty Atrophy: A Potential Outcome Measure in Chronic Neuromuscular Diseases
Morrow J, Sinclair CDJ, Fischmann A, Thornton JS, Yousry TA, Reilly MM, Hanna MG
Journal of Neurology, Neurosurgery and Psychiatry. 83 (2012) e1 doi:10.1136/jnnp-2011-301993.32

MRI quantification of abnormal muscle water distribution in chronic neuromuscular diseases: a sensitive biomarker
J.M. Morrow, C.D.J. Sinclair, A. Fischmann, J.S. Thornton, M.M. Reilly, M.G. Hanna, T.A. Yousry
Neuromuscular Disorders, 22., S33, P93 (2012)

Novel muscle fat-fraction MRI metrics for quantifying neuromuscular pathology
C.D.J. Sinclair, J.M. Morrow, A. Fischmann, M.G. Hanna, M.M. Reilly, T.A. Yousry, X. Golay, J.S. Thornton
Neuromuscular Disorders, 22., S33, P94 (2012)

Relationships Between Fat -Fraction Metrics and Visual Assessment in Skeletal Muscle
CDJ Sinclair, JM Morrow, A Fischmann, MG Hanna, MM Reilly, TA Yousry, X Golay, JS Thornton
Fat-Water Separation: Insights, Applications & Progress in MR, ISMRM Workshop (2012)

Comparison of 3-Point Dixon fat-water quantification and functional measures in acquired and hereditary neuromuscular diseases
JM Morrow, CDJ Sinclair, A Fischmann, X Golay, TA Yousry, MM Reilly, MG Hanna, JS Thornton
Fat-Water Separation: Insights, Applications & Progress in MR, ISMRM Workshop (2012)

Quantitative Magnetic Resonance Imaging of Muscle in Charcot-Marie-Tooth Disease 1A-a Potential Outcome Measure
Morrow JM, Sinclair CDJ, Fischmann A, Thornton JS, Laura M, Yousry TA, Hanna MG, Reilly MM
Journal of the Peripheral Nervous System 16: S90-S90. 2011

Improved magnetization transfer MRI of skeletal muscle in myopathy and neuropathy
Sinclair CDJ, Morrow JM, Hanna MG, Reilly MM, Yousry TA, Golay X, Thornton JS
Neuromuscular Disorders 21: S29-S29. 2011

MRI shows increased tibial nerve size in CMT1A
Sinclair CDJ, Morrow JM, Fischmann A, Hanna MG, Reilly MM, Yousry TA, Golay X, Thornton JS
Neuromuscular Disorders 21: S28-S28. 2011

Magnetic resonance imaging in the non-dystrophic myotonias
Morrow JM, Matthews E, Rayan DLR, Amer I, Fischmann A, Sinclair CDJ, Thornton JS, Reilly MM, Yousry TA, Hanna MG
Neuromuscular Disorders 21: S5-S5. 2011

Skeletal muscle MRI-determined fat fraction and myometric strength in inclusion body myositis and Charcot-Marie-Tooth disease Type 1A
Sinclair CDJ, Morrow JM, Fischmann A, Hanna MG, Reilly MM, Yousry TA, Golay X, Thornton JS
Neuromuscular Disorders 21: S5-S5.  2011

Assessing muscle pathology by MRI in LGMD2I
Willis T, Hollingsworth KG, Sveen ML, Morrow JM, Sinclair CDJ, Thornton JS, Vandenheede J, Strojkovic T, Eagle M, Mayhew A, et al. Bushby K, Lochmuller H, Hanna MG, Vissing J, Carliers P, Straub V
Neuromuscular Disorders. 21: S4-S5. 2011

Simultaneous T2 and Lipid Quantitation using IDEAL-CPMG
R. L. Janiczek, G. Gambarota, C. D. Sinclair T. A. Yousry, J. S. Thornton, X. Golay, and R. D. Newbould
Proc. Int. Soc. Mag. Res. Med.  19 (2011) p4365

Correcting RF Inhomogeneities in Skeletal Muscle Magnetization Transfer Maps
CDJ Sinclair, JM Morrow, MG Hanna, MM Reilly, TA Yousry, X Golay and JS Thornton
Proc. Int. Soc. Mag. Res. Med.  19 (2011) p3590

3Tesla gradient-echo 3-point Dixon imaging for robust water-only imaging of the extra-ocular muscles
CDJ Sinclair, R Pitceathly, I Davagnanam, MG Hanna, MM Reilly, TA Yousry, X Golay, JS Thornton
Proc. Int. Soc. Mag. Res. Med.  19 (2011) p3625

Quantitative Magnetization Transfer in In Vivo Healthy Human Skeletal Muscle at 3T
C.D.J. Sinclair, R.S. Samson, D.L. Thomas, N. Weiskopf, A. Lutti, J.S. Thornton, X. Golay
Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) p871

Test-Retest Reproducibility of MTR, T2 and 3-point Dixon Fat Quantification in Muscle MRI
C.D.J. Sinclair, J. M. Morrow, T.A. Yousry, X. Golay and J.S. Thornton
Proc. Intl. Soc. Mag. Reson. Med. 18 (2010) p852

Continuously Moving Table Whole-Body MRI using Variable Field of View.
Janiczek RL, Howard JW, Gambarota G, Thornton JS, Golay X, Newbould RD.
In Proc ISMRM Annual Meeting (2010), Stockholm, Sweden.

Extra-orbital muscle T2 relaxation time and clinical activity in thyroid eye disease
L Mancini, R. Rajendram, J Uddin, RW Lee, GE Rose, T Yousry, K Miszkiel, JS Thornton.
18th Scientific meeting of the ISMRM, Stockholm,Sweden, May 2010

Quantitative Magnetization Transfer MRI: A Potential New Source of Biomarkers in Skeletal Muscle?
C.D.J. Sinclair, R.S. Samson, D.L. Thomas, N. Weiskopf, A. Lutti, J.S. Thornton, X. Golay
United Kingdom Neuromuscular Translational Research Conference 2010, Oxford, England, 25Mar 2010 - 26 Mar 2010. Neuromuscular Disorders. Pergamon-Elsevier Science Ltd. 20: S28-S29. Mar 2010

Inter-Scan Reproducibility of Quantitative Neuromuscular MRI
C.D.J. Sinclair, J. M. Morrow, T.A. Yousry, M.M. Reilly, M.G. Hanna, X. Golay and J.S. Thornton
United Kingdom Neuromuscular Translational Research Conference 2010, Oxford, England, 25Mar 2010 - 26 Mar 2010. Neuromuscular Disorders. Pergamon-Elsevier Science Ltd. 20: S28-S28. Mar 2010

Quantitative Magnetization Transfer in In Vivo Healthy Human Skeletal Muscle at 3T
C.D.J. Sinclair, R.S. Samson, D.L. Thomas, N. Weiskopf, A. Lutti, J.S. Thornton, X. Golay
19th British Chapter ISMRM Annual Symposium, Kings College London, 2010 O14

Assessing the Inter-Scan Reproducibility of MTR, T2 and Fat Quantification in Muscle MRI
C.D.J. Sinclair, J. M. Morrow, M.M. Reilly, M.G. Hanna, T.A. Yousry, X. Golay and J.S. Thornton
19th British Chapter ISMRM Annual Symposium, Kings College London, 2010 P9

Magnetic Resonance Imaging and Sciatic Nerve Cross-sectional Area in Inherited and Inflammatory Neuropathies
C.D.J. Sinclair, J.M. Morrow, M.A. Miranda, P. Cowley, I. Davagnanam, H. Mehta, M.G. Hanna, M. Koltzenburg, M.M. Reilly, T.A. Yousry and J.S. Thornton
United Kingdom Neuromuscular Translational Research Conference 2010, Oxford, England, 25Mar 2010 - 26 Mar 2010. Neuromuscular Disorders. Pergamon-Elsevier Science Ltd. 20:S29-S29. Mar 2010

Magnetic Resonance Imaging and Sciatic Nerve Cross-sectional Area in Inherited and Inflammatory Neuropathies
J.M. Morrow, C.D.J. Sinclair, M.A. Miranda, P. Cowley, I. Davagnanam, H. Mehta, M.G. Hanna, M. Koltzenburg, M.M. Reilly, T.A. Yousry and J.S. Thornton
Joint British and Italian Peripheral Nerve Society Meeting, Trieste, 2010

Using MRI as a diagnostic tool in the skeletal muscle channelopathies
E. Mathews, R. Sud, R. Labrum, L. Strycharczuk, C.D.J. Sinclair, T.A. Yousry, M.G. Hanna
United Kingdom Neuromuscular Translational Research Conference2010, Oxford, England, 25Mar 2010 - 26 Mar 2010. Neuromuscular Disorders. Pergamon-Elsevier Science Ltd. 20: S29-S30. Mar 2010

The reliability of quantitative MRI measures in neuromuscular disease
J.M. Morrow, C.D.J Sinclair, M.M. Reilly, M.G. Hanna, T.A. Yousry, X. Golay, J.S. Thornton
XII International Congress on Neuromuscular Disorders, Naples, Italy, 2010 Acta Myologica 29 TW156 p279

Quantitative Magnetization Transfer MRI: A Potential New Source of Biomarkers in Skeletal Muscle?
C.D.J. Sinclair, R.S. Samson, D.L. Thomas, N. Weiskopf, A. Lutti, J.S. Thornton, X. Golay
XII International Congress on Neuromuscular Disorders, Naples, Italy, 2010 Acta Myologica 29 TW158 p280

Correlation between muscle magnetization transfer ratio and muscle strength in chronic inflammatory demyelinating polyneuropathy
Sinclair CD, Miranda MA, Cowley P, Reilly M, Thornton JS, Yousry TA.
Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, Hawaii, USA, 2009;17:3958.

Quantitative neuromuscular MRI: Correlation between magnetization transfer ratio and muscle strength in a peripheral neuropathy
C.D.J. Sinclair, M.A. Miranda, P. Cowley, M. Reilly, J.S. Thornton, T.A. Yousry
18th British Chapter ISMRM Annual Symposium, Imperial College London, 2009

Association between magnetization transfer ratio and muscle strength in chronic inflammatory demyelinating polyneuropathy
CDJ Sinclair, MA Miranda, P Cowley, M Reilly, M Koltzenburg, JS Thornton, TA Yousry
UK Neuromuscular Translational Research Conference, Newcastle-Upon-Tyne, 2009

Using MRI as a diagnostic tool in the skeletal muscle channelopathies
E. Mathews, R. Sud, R. Labrum, L. Strycharczuk, C. Sinclair, J. Thorpe, T. Yousry and M.G. Hanna
Muscle Study Group, Beaver Hollow, USA, 2009

Histogram segmentation using Dixon fat-fraction maps for characterizing skeletal muscle disease
C.D.J Sinclair, X. Golay and J.S. Thornton
15th Annual Meeting of the British Chapter of the ISMRM, Cardiff University, 2009 p61

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