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Multiscale Cardiovascular Engineering

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Multiscale Cardiovascular Engineering


We are a group working at the interface of cardiovascular science, mathematics and bioengineering and we apply multi-physics and multi-scale computational techniques to produce patient-specific simulations and to understand cardiovascular health and disease. For this, we use a combination of systems biology, ICT for health, imaging and biomechanics. The group is highly technical and we pride ourselves in tackling complex issues of robustness and uncertainty in multiscale models. 

The group's strong and unique selling point is our carefully considered, comprehensive and biologically meaningful way to model cardiovascular patho/physiology at multiple length and time scales and to use our models to test hypotheses and produce relevant and complex biological or clinical scenarios.  

Patient-specific aortic simulation

Figure taken from Development of a Patient-Specific Multi-Scale Model to Understand Atherosclerosis and Calcification Locations: Comparison with In vivo Data in an Aortic Dissection. Mona Alimohammadi, Cesar Pichardo-Almarza, Obiekezie Agu, Vanessa Díaz-Zuccarini (Frontiers in Physiology)

We believe we do this in a highly innovative, professional but also practical way and we are amongst the very few groups capable of tackling applications from the molecular to the organism level in the cardiovascular field.

The research we carry out goes from modelling and simulation of the formation of atherosclerotic plaque (using a combined systems biology-engineering approach), to the modelling and simulation of the ventricular dynamics, linking the cell level to the physiological level. Another area of interest also is the utilization of computational tools for the modelling and simulation of physiological systems, for example, heart valves and medical implants, for example, stents.

The group has important collaborations with vascular scientists and clinicians. We have tight links with the UCL hospitals, in particular with UCLH (Vascular Unit), The Royal Free Hospital and the Institute of Child Health, as well as other excellent research hospitals such as the General Infirmary of Leeds.

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We gratefully acknowledge our funders for supporting our work.

Funders April 2015

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