I am Senior Research Associate and joined the Molecular Nociception Lab in 2008. My main interests are in the field of the ion channels, receptor trafficking and developing transgenic models to study various pain conditions. During my work in the lab I developed the inducible sensory neuron specific deletor model. This model is used to study the role of specific genes in various pain modalities. My current work is focused on the role of the neurons expressing Nav1.7 sodium channel in various pain conditions. I am also working on the developing of transgenic models to study the wiring of sensory neurons.
Telephone:020 7679 6722, e-Mail: email@example.com
My study is focused on sensory transduction and transmission in peripheral nervous system, especially in pain signalling. I use gene targeting in/transgenic mice as a model, combining molecular biochemistry, electrophysiology and behavioural approaches to identify the genes or molecules involved and to understand the molecular, cellular physiological and pathological mechanisms involved. Currently I am investigating 1) the trafficking of sodium channel Nav1.7, 2) the role of BDNF in chronic pain, 3) the function of microRNA in pain signalling and 4) the role of sodium channel Nav1.8 in cardiac conduction.
Telephone:020 7679 6722, e-Mail: firstname.lastname@example.org
I am a MRC Research Career Development Fellow focussing on the genetic basis of human pain. We study families with rare inherited pain disorders (either with pain insensitivity or chronic pain conditions). By sequencing the genome of our patients with pain disorders we aim to identify novel gene mutations. This enables us to highlight genes and pathways that are critical for normal pain sensation and potentially reveal new analgesic drug targets..
Telephone:020 7679 6704, e-Mail: email@example.com
The long term goal of our study is to develop better pain killers. To this end, we study families with extreme forms of pain-sensing disorders. I am currently investigating candidate and/or new genes and pathways that we recently identified using human genetics and a variety of in vivo, in vitro and biochemical approaches. This investigation is carried out in close collaboration with Dr James Cox. We plan to expand and develop these novel observations with a view to improving our understanding of the molecular mechanisms underlying pain sensing. .
Telephone:020 7679 6704, e-Mail: firstname.lastname@example.org
I am investigating the involvement of TRP channels, particularly TRPC channels, in mechanosensation and hearing. I am using cell expression systems and transgenics to look at the function and mechanism of TRP channels in order to enhance our understanding of mechanotransduction.
Telephone:020 7679 6722, e-Mail: email@example.com
Dr Jeffrey Vernon
My experiments have focused on ion channels and receptors in the nervous system, and the way they contribute to signalling and behaviour. Currently I am working on a gene delivery method for in vivo overexpression or knockdown studies. In this way I will test the role of expression or mutation of candidate genes in susceptibility or insensitivity to pain.
Telephone:020 7679 6725, e-Mail: firstname.lastname@example.org
As a medical doctor, I am training to become a specialist in anaesthesia, intensive care, emergency and pain medicine. Being funded by the German Research Foundation (DFG), I was given the chance to focus on research with a full-time post for two years. In general, I am interested in spinal and peripheral mechanisms of pain and touch perception. In particular, I am investigating the effects of local and general anaesthetics on chronic pain development. In previous projects I focused on the neurotoxic effects of local and general anaesthetics as well as on new techniques in regional anaesthesia and interventional pain medicine.
Telephone:020 7679 6722, e-Mail: email@example.com
Dr Stephane Lolignier
I work on the understanding of mechanotransduction, the basis of touch and mechanical pain (joint pain, pressure-induced pain etc.), within peripheral sensory neurons. I work mostly in vitro, looking for the genes and pathways that lead to the sense of pressure at the cellular level using electrophysiological recordings in cell lines or cultured sensory neurons, with the help of molecular cloning and pharmacology.
Telephone:020 7679 0793, e-Mail: firstname.lastname@example.org
Dr Minee-Liane Choi
I joined the molecular nociception group and now work on exploring a mysterious channel in mechanosensation which is particularly responsible for noxious stimuli. I am also interested in understanding the disease condition in which patients are suffering from the aberrant pain sense such as Fabry disease. Calcium imaging, in-vitro cellular transfection and animal behavioural assessment are the most frequently used laboratory techniques for my current research..
Telephone:020 7679 6722, e-Mail email@example.com