UCL CfMR7

View our CfMR interactive map

If you are at UCL and interested in working with the CfMR, please email Michael Duchen


Dr Richard Orrell

Photo

Personal Profile

Name: Richard Orrell Email: r.orrell@ucl.ac.uk
Title: Dr Tel: 020 7830 2387
Department: Clinical Neuroscience Fax: 020 7472 6829
Position: Senior Clinical Lecturer Address: Department of Clinical Neurosciences, UCL Institute of Neuro, Rowland Hill Street, London, NW3 2PF
Research Domain: Basic Life Sciences, Experimental Medicine, Neuroscience, Personalised Medicine Web Page:  

Profile

Research Description

My research theme is focussed on neuromuscular disorders, neurodegenerative disorders, and neurogenetics. Within neuromuscular disorders I am interested in motor neuron disease / amyotrophic lateral sclerosis, muscular dystrophies, neuropathies, and related conditions. Current research projects include mitochondrial function in ALS, the neurotrophic effects of mechanogrowth factor (MGF) in ALS and other disorders, and genetic analysis of ALS. In addition to laboratory research, I provide a clinical service in neuromuscular disorders, including my role as Co-Director of the Motor Neuron Disease Care and Research Centre at the National Hospital for Neurology and Neurosurgery, and motor neuron disease, muscle and nerve disorder clinics at the Royal Free Hospital. I perform muscle and nerve biopsies, and EMG, and contribute to the reporting of peripheral nerve biopsies. As co-lead for motor neuron disease in the North Thames Department of Health funded Dementia and Neurodegenerative Diseases Research Network (DeNDRoN), I am developing a structure for clinical and other research projects. I am lead of the UCL Motor Neuron Disease Research Interest Group.


Research Activities

Neuromuscular and Neurodegenerative Disorders

Protein biomarker

Education Description

UCL Collaborators

Prof Alan Thompson; Prof John Hardy; Prof Jason Warren; Dr Axel Petzold; Prof Elizabeth Fisher; Prof Linda Greensmith; Dr Shi-Yu Yang; Prof Martin Rossor; Prof Francesco Muntoni

External Collaborators

Publications

    2015

    • Banerji CRS, Teschendorff AE, Severini S, Knopp P, Moyle LA, Zammit PS, Orrell RW (2015). β-catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy. Journal of the Royal Society Interface, 12(102), - . doi:10.1098/rsif.2014.0797

    2014

    • Meininger V, Pradat PF, Corse A, Al-Sarraj S, Rix Brooks B, Caress JB, Cudkowicz M, Kolb SJ, Lange D, Leigh PN, Meyer T, Milleri S, Morrison KE, Orrell RW, Peters G, Rothstein JD, Shefner J, Lavrov A, Williams N, Overend P, Price J, Bates S, Bullman J, Krull D, Berges A, Abila B, Meno-Tetang G, Wurthner J (2014). Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial.. PLoS One, 9(5), e97803 - . doi:10.1371/journal.pone.0097803
    • Lu CH, Petzold A, Topping J, Allen K, Macdonald-Wallis C, Clarke J, Pearce N, Kuhle J, Giovannoni G, Fratta P, Sidle K, Fish M, Orrell R, Howard R, Greensmith L, Malaspina A (2014). Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study.. J Neurol Neurosurg Psychiatry, , - . doi:10.1136/jnnp-2014-307672
    • Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, Chiò A, Traynor BJ (2014). Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.. Nat Neurosci, , - . doi:10.1038/nn.3688
    • Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, Heverin M, Howard RS, Huisman MH, Keren N, Leigh PN, Mazzini L, Mora G, Orrell RW, Rooney J, Scott KM, Scotton WJ, Seelen M, Shaw CE, Sidle KS, Swingler R, Tsuda M, Veldink JH, Visser AE, van den Berg LH, Pearce N (2014). Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study.. Lancet Neurol, 13(11), 1108 - 1113. doi:10.1016/S1474-4422(14)70219-4
    • Fratta P, Polke JM, Newcombe J, Mizielinska S, Lashley T, Poulter M, Beck J, Preza E, Devoy A, Sidle K, Howard R, Malaspina A, Orrell RW, Clarke J, Lu CH, Mok K, Collins T, Shoaii M, Nanji T, Wray S, Adamson G, Pittman A, Renton AE, Traynor BJ, Sweeney MG, Revesz T, Houlden H, Mead S, Isaacs AM, Fisher EM (2014). Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion.. Neurobiol Aging, , - . doi:10.1016/j.neurobiolaging.2014.07.037
    • Johnson JO, Renton AE, Pliner HA, Marangi G, Traynor BJ, Pioro EP, Boehringer A, Bowser R, Chia R, Abramzon Y, Cookson MR, Feit H, Winborn BJ, Taylor JP, Gibbs JR, Morgan S, Shoai M, Hardy J, Pittman A, Sidle KC, Nalls MA, Singleton AB, Orrell RW, Malaspina A, Fratta P, Harms MB, Pestronk A, Weihl CC, Baloh RH, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Chiò A, Rothstein JD, Drepper C, Sendtner M, Restagno G, Sabatelli M (2014). Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neuroscience, 17(5), 664 - 666. doi:10.1038/nn.3688

    2013

    • Docherty RJ, Ginsberg L, Jadoon S, Orrell RW, Bhattacharjee A (2013). TRPA1 insensitivity of human sural nerve axons after exposure to lidocaine.. Pain, , - . doi:10.1016/j.pain.2013.04.030
    • Docherty RJ, Jadoon S, Ginsberg L, Orrell RW, Bhattacharjee A (2013). TRPA1 insensitivity of human sural nerve axons after exposure to lidocaine. Pain, 154(9), 1569 - 1577. doi:10.1016/j.pain.2013.04.030
    • Mok K, Laaksovirta H, Tienari PJ, Peuralinna T, Myllykangas L, Chiò A, Traynor BJ, Nalls MA, Gurunlian N, Shatunov A, Restagno G, Mora G, Nigel Leigh P, Shaw CE, Morrison KE, Shaw PJ, Al-Chalabi A, Hardy J, Orrell RW (2013). Homozygosity analysis in amyotrophic lateral sclerosis.. Eur J Hum Genet, 21(12), 1429 - 1435. doi:10.1038/ejhg.2013.59
    • Beck J, Poulter M, Hensman D, Rohrer JD, Mahoney CJ, Adamson G, Campbell T, Uphill J, Borg A, Fratta P, Orrell RW, Malaspina A, Rowe J, Brown J, Hodges J, Sidle K, Polke JM, Houlden H, Schott JM, Fox NC, Rossor MN, Tabrizi SJ, Isaacs AM, Hardy J, Warren JD, Collinge J, Mead S (2013). Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.. Am J Hum Genet, 92(3), 345 - 353. doi:10.1016/j.ajhg.2013.01.011
    • Bartolome F, Wu HC, Burchell VS, Preza E, Wray S, Mahoney CJ, Fox NC, Calvo A, Canosa A, Moglia C, Mandrioli J, Chiò A, Orrell RW, Houlden H, Hardy J, Abramov AY, Plun-Favreau H (2013). Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels.. Neuron, 78(1), 57 - 64. doi:10.1016/j.neuron.2013.02.028
    • Fratta P, Charnock J, Collins T, Devoy A, Howard R, Malaspina A, Orrell R, Sidle K, Clarke J, Shoai M, Lu CH, Hardy J, Plagnol V, Fisher EM (2013). Profilin1 E117G is a moderate risk factor for amyotrophic lateral sclerosis.. J Neurol Neurosurg Psychiatry, , - . doi:10.1136/jnnp-2013-306761
    • Bartolome F, Wu H-C, Burchell VS, Preza E, Wray S, Houlden H, Hardy J, Abramov AY, Plun-Favreau H, Mahoney CJ, Fox NC, Orrell RW, Calvo A, Canosa A, Moglia C, Chiò A, Mandrioli J (2013). Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels. Neuron, 78(1), 57 - 64. doi:10.1016/j.neuron.2013.02.028
    • Hobson EV, McGeachan A, Al-Chalabi A, Chandran S, Crawley F, Dick D, Donaghy C, Ealing J, Ellis CM, Gorrie G, Hanemann CO, Harrower T, Jung A, Majeed T, Malaspina A, Morrison K, Orrell RW, Pall H, Pinto A, Talbot K, Turner MR, Williams TL, Young CA, Shaw PJ, McDermott CJ (2013). Management of sialorrhoea in motor neuron disease: a survey of current UK practice.. Amyotroph Lateral Scler Frontotemporal Degener, 14(7-8), 521 - 527. doi:10.3109/21678421.2013.790452
    • Al-Chalabi A, Allen C, Counsell C, Farrin A, Dickie B, Kelly J, Leigh PN, Murphy CL, Payan C, Reynolds G, Shaw P, Steen IN, Thornhill M, Waters J, Zajicek J, Shaw PJ, Young CA, Morrison KE, Dhariwal S, Hornabrook R, Savage L, Burn DJ, Khoo TK, Kelly J, Murphy CL, Dougherty A, Wijesekera L, Ellis CM, O'Hanlon K, Panicker J, Pate L, Ray P, Wyatt L, Copeland L, Ealing J, Hamdalla H, Leroi I, Murphy C, O'Keeffe F, Oughton E, Partington L, Paterson P, Rog D, Sathish A, Sexton D, Smith J, Vanek H, Dodds S, Williams TL, Clarke J, Eziefula C, Howard R, Orrell R, Sidle K, Sylvester R, Barrett W, Merritt C, Talbot K, Turner MR, Whatley C, Williams C, Williams J, Cosby C, Hanemann CO, Imam I, Phillips C, Timings L, Crawford SE, Hewamadduma C, Hibberd R, Hollinger H, McDermott C, Mills G, Rafiq M, Taylor A, Waines E, Walsh T, Addison-Jones R, Birt J, Hare M, Majid T (2013). Lithium in patients with amyotrophic lateral sclerosis (LiCALS): A phase 3 multicentre, randomised, double-blind, placebo-controlled trial. The Lancet Neurology, 12(4), 339 - 345. doi:10.1016/S1474-4422(13)70037-1

    2012

    • Lane RJ, Roncaroli F, Charles P, McGonagle DG, Orrell RW (2012). Acetylcholine receptor antibodies in patients with genetic myopathies: clinical and biological significance.. Neuromuscul Disord, 22(2), 122 - 128. doi:10.1016/j.nmd.2011.06.751
    • Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, Restagno G, Nicolaou N, Simon-Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O, Chromosome 9-ALS/FTD Consortium , French research network on FTLD/FTLD/ALS , ITALSGEN Consortium , Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E, Borghero G, Floris GL, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu CS, Yeh TH, Ishiura H, Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shaw P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering-Brown S, Traynor BJ (2012). Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study.. Lancet Neurol, 11(4), 323 - 330. doi:10.1016/S1474-4422(12)70043-1
    • Mok K, Traynor BJ, Schymick J, Tienari PJ, Laaksovirta H, Peuralinna T, Myllykangas L, Chiò A, Shatunov A, Boeve BF, Boxer AL, DeJesus-Hernandez M, Mackenzie IR, Waite A, Williams N, Morris HR, Simón-Sánchez J, van Swieten JC, Heutink P, Restagno G, Mora G, Morrison KE, Shaw PJ, Rollinson PS, Al-Chalabi A, Rademakers R, Pickering-Brown S, Orrell RW, Nalls MA, Hardy J (2012). Chromosome 9 ALS and FTD locus is probably derived from a single founder.. Neurobiol Aging, 33(1), 209.e3 - 209.e8. doi:10.1016/j.neurobiolaging.2011.08.005
    • Orrell RW (2012). Diagnosing and managing muscular dystrophy. Practitioner, 256(1754), 21 - 24.

    2011

    • Orrell RW (2011). Facioscapulohumeral dystrophy and scapuloperoneal syndromes.. Handb Clin Neurol, 101, 167 - 180. doi:10.1016/B978-0-08-045031-5.00013-X
    • Orrell RW (2011). GPs have key role in managing motor neurone disease.. Practitioner, 255(1743), 19 - 2.
    • Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M, ITALSGEN Consortium , Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ (2011). A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.. Neuron, 72(2), 257 - 268. doi:10.1016/j.neuron.2011.09.010

    2010

    • Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink JH, van Es MA, van den Berg LH, Robberecht W, Van Damme P, Hardiman O, Farmer AE, Lewis CM, Butler AW, Abel O, Andersen PM, Fogh I, Silani V, Chiò A, Traynor BJ, Melki J, Meininger V, Landers JE, McGuffin P, Glass JD, Pall H, Leigh PN, Hardy J, Brown RH, Powell JF, Orrell RW, Morrison KE, Shaw PJ, Shaw CE, Al-Chalabi A (2010). Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.. Lancet Neurol, 9(10), 986 - 994. doi:10.1016/S1474-4422(10)70197-6
    • Wain LV, Shrine NRG, Shaw C, Powell JF, Hardy J, Shaw P, Morrison KE, Brown RH, Orrell R, Mok B, Palmer LJ, Hui J, James AL, Musk B, Al-Chalabi A, Tobin MD (2010). The Role of Common Copy Number Variation in Amyotrophic Lateral Sclerosis (ALS).
    • Evans RM, Harridge SDR, Velloso CP, Yang SY, Goldspink G, Orrell RW (2010). Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches. AMYOTROPH LATERAL SC, 11(1-2), 172 - 177. doi:10.3109/17482960903089775
    • Lu C, Petzold A, Kalmar B, Orrell R, Malaspina A, Greensmith L (2010). Plasma neurofilament heavy chain levels as a disease biomarker in SOD1 mice..
    • Kearney M, Orrell RW, Fahey M, Pandolfo M (2010). Antioxidants and other pharmacological treatment for Friedreich ataxia.
    • Scott KM, Abhinav K, Wijesekera L, Ganesalingam J, Goldstein LH, Janssen A, Dougherty A, Willey E, Stanton BR, Turner MR, Ampong MA, Sakel M, Orrell R, Howard R, Shaw CE, Nigel Leigh P, Al-Chalabi A (2010). The association between ALS and population density: A population based study.. Amyotroph Lateral Scler, 11(5), 435 - 438. doi:10.3109/17482961003754552
    • Lu C, Malaspina A, Orrell R, Kalmar B, Petzold A, Greensmith L (2010). PLASMA NEUROFILAMENT HEAVY CHAIN LEVELS AS A DISEASE BIOMARKER IN THE SOD1 MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS. doi:10.1136/jnnp.2010.226340.179
    • Orrell RW (2010). Motor neuron disease: systematic reviews of treatment for ALS and SMA.. Br Med Bull, 93, 145 - 159. doi:10.1093/bmb/ldp049
    • Orrell RW (2010). What is the clinical significance of SOD1 mutations in amyotrophic lateral sclerosis?. Journal of Neurology, Neurosurgery and Psychiatry, 81(5), 473 - .
    • Orrell RW, Copeland S, Rose MR (2010). Scapular fixation in muscular dystrophy. Cochrane Database of Systematic Reviews, Issue 1, CD003278 - . doi:10.1002/14651858.CD003278.pub2

    2009

    • Scott KM, Abhinav K, Stanton BR, Johnston C, Turner MR, Ampong MA, Sakel M, Orrell RW, Howard R, Shaw CE, Leigh PN, Al-Chalabi A (2009). Geographical clustering of amyotrophic lateral sclerosis in South-East England: a population study.. Neuroepidemiology, 32(2), 81 - 88. doi:10.1159/000177032
    • King RHM, Nourallah M, Muddle JR, Orrell RW (2009). Ultrastructural studies of peripheral nerves in NDRG1 mutant mice.
    • Riddoch-Contreras J, Yang SY, Dick JRT, Goldspink G, Orrell RW, Greensmith L (2009). Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. Experimental Neurology, 215(2), 281 - 289. doi:10.1016/j.expneurol.2008.10.014
    • Bradley LJ, Taanman JW, Kallis C, Orrell RW (2009). Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues. Experimental Neurology, 218(1), 92 - 97. doi:10.1016/j.expneurol.2009.04.007
    • Kearney M, Orrell RW, Fahey M, Pandolfo M (2009). Antioxidants and other pharmacological treatments for Friedreich ataxia. Cochrane Database of Systematic Reviews, (2), - . doi:10.1002/14651858.CD007791
    • Ciccarelli O, Behrens TE, Johansen-Berg H, Talbot K, Orrell RW, Howard RS, Nunes RG, Miller DH, Matthews PM, Thompson AJ, Smith SM (2009). Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics.. Human Brain Mapping, 30(2), 615 - 624. doi:10.1002/hbm.20527
    • Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La BV, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ (2009). A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.. Hum Mol Genet, 18(8), 1524 - 1532. doi:10.1093/hmg/ddp059
    • Kearney M, Orrell RW, Fahey M, Pandolfo M (2009). Antioxidants and other pharmacological treatments for Friedreich ataxia. Cochrane Database of Systematic Reviews, CD007791, - .

    2008

    • Sakel M, Chalabi A, Leigh N, Shaw C, Howard R, Orrell RW, Ampong M, Turner MR, Johnston C, Stanton B, Scott KM, Abhinav K (2008). Amyotrophic lateral sclerosis in South-East England: a population based study [South-East England Amyotrophic Lateral Sclerosis (SEALS) Registry]..
    • Bennett DLH, Groves M, Blake J, Holton JL, King RHM, Orrell RW, Ginsberg L, Reilly MM (2008). The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective study. Journal of Neurology, Neurosurgery and Psychiatry, 79(12), 1376 - 1381. doi:10.1136/jnnp.2008.151126
    • Orrell RW, Lane RJ, Ross M (2008). A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. Amyotrophic Lateral Sclerosis, 9(4), 195 - 211. doi:10.1080/17482960801900032
    • Bacsi AM, Ginsberg L, Orrell RW (2008). Reversible dysphagia in facioscapulohumeral dystrophy caused by myasthenia gravis.

    2007

    • Orrell RW, Lane RJM, Ross M (2007). Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database of Systematic Reviews, (1), - . doi:10.1002/14651858.CD002829.pub4
    • Orrell RW, Lane RJ, Ross M (2007). Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease.. Cochrane database of systematic reviews (Online), (1), - .
    • Orrell RW (2007). Endocrine myopathies. In Mastaglia FL, Hilton-Jones D (Ed.), Myopathies (pp. 343 - 355). : .
    • Orrell RW, Clarke J, Howard RS (2007). Standards of care in motor neuron disease.. In Kiernan MC (Ed.), The Motor Neurone Disease Handbook (pp. 74 - 88). : Australian Medical Publishing Company Limited.
    • Orrell RW, Lane RJM, Ross M (2007). Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease.. Cochrane Database of Systematic Reviews, (1), CD002829 - . doi:10.1002/14651858.CD002829.pub4
    • Irani SR, Mathias CJ, Orrell RW (2007). Pure autonomic failure followed by amyotrophy. Neurology, 68(10), 792 - 793.
    • Kasperaviciute D, Weale ME, Shianna KV, Banks GT, Simpson CL, Hansen VK, Turner MR, Shaw CE, Al-Chalabi A, Pall HS, Goodall EF, Morrison KE, Orrell RW, Beck M, Jablonka S, Sendtner M, Brockington A, Ince PG, Hartley J, Nixon H, Shaw PJ, Schiavo G, Wood NW, Goldstein DB, Fisher EMC (2007). Large-scale pathways-based association study in amyotrophic lateral sclerosis.. Brain, 130(Pt 9), 2292 - 2301. doi:10.1093/brain/awm055
    • Bennett DLH, Groves M, Blake J, Holton JL, King RHM, Orrell RW, Ginsberg L, Reilly MM (2007). The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5-year retrospective study of 53 cases.
    • Ates K, Yang SY, Orrell RW, Sinanan AC, Simons P, Solomon A, Beech S, Goldspink G, Lewis MP (2007). The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle.. FEBS Letters, 581(14), 2727 - 2732.
    • Orrell RW (2007). Understanding the causes of amyotrophic lateral sclerosis.. New England Journal of Medicine, 357(8), 822 - 823. doi:10.1056/NEJMe078146
    • Abhinav K, Stanton B, Johnston C, Hardstaff J, Orrell RW, Howard R, Clarke J, Sakel M, Ampong MA, Shaw CE, Leigh PN, Al-Chalabi A (2007). Amyotrophic lateral sclerosis in South-East England: A population-based study. The South-East England Register for Amyotrophic Lateral Sclerosis (SEALS Registry).. Neuroepidemiology, 29(1-2), 44 - 48.
    • King RHM, Blake J, Muddle JR, Orrell RW, Morahan G, Kalaydjieva L (2007). Pathological and electrophysiological studies of NDRG1 mutant mice.
    • Orrell RW (2007). Book review. Palliative care in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Pschiatry, 78, 778 - . doi:10.1136/jnnp.2007.115808

    2006

    • Demestre M, Howard RS, Orrell RW, Pullen AH (2006). Serine proteases purified from sera of patients with amyotrophic lateral sclerosis (ALS) induce contrasting cytopathology in murine motoneurones to IgG.. Neuropathology and Applied Neurobiology, 32(2), 141 - 156.
    • Solomon AM, Hoffman EP, Chimbovschi SD, Wang Z, Orrell RW, Goldspink G, Harridge SD, Bouloux PMG (2006). Molecular mechanisms of idiopathic muscle hypertrophy in humans.
    • Orrell RW (2006). AEOL-10150 (Aeolus).. Current Opinion in Investigational Drugs, 7, 70 - 80.
    • Pearson SJ, Cobbold M, Orrell RW, Harridge SDR (2006). Power output and muscle myosin heavy chain composition in young and elderly men.. Medicine and Science in Sports and Exercise, 38(9), 1601 - 1607. doi:10.1249/01.mss.0000227638.75983.9d
    • Pearson SJ, Cobbold M, Orrell RW, Harridge SDR (2006). Power output and muscle myosin heavy chain composition in young and elderly men. MED SCI SPORT EXER, 38(9), 1601 - 1607. doi:10.1249/01.mss.0000227638.75938.9d
    • Howard RS, Orrell RW (2006). Management of motor neurone disease.. In (Ed.), Neurology Reviews (pp. 155 - 168). : Radcliffe Publishing Limited.
    • Bradley LJ, Wilhelm T, King RH, Ginsberg L, Orrell RW (2006). Brachial plexus hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy.. Neuromuscular Disorders, 16(2), 126 - 131. doi:10.1016/j.nmd.2005.11.006
    • Ciccarelli O, Behrens TE, Altmann DR, Orrell RW, Howard RS, Johansen-Berg H, Miller DH, Matthews PM, Thompson AJ (2006). Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis. Brain, 129(7), 1859 - 1871.
    • Orrell RW (2006). AEOL-10150 aeolus. CURR OPIN INVEST DR, 7(1), 70 - 80.

    2005

    • Orrell RW, Lane JM, Ross MA (2005). Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD002829. Review. Update in:. Cochrane Database of Systematic Reviews, (1), CD002829 - .
    • Ng K, Orrell R (2005). Extensive heroin myelopathy associated with Adamkiewicz artery territory infarction.
    • Orrell RW (2005). Horizon programme. The Doctor who can make people walk again. Guardian Films / BBC TV.
    • Riddoch-Contreras J, Yang SY, Goldspink G, Orrell RW, Greensmith L (2005). Treatment with mechano-growth factor, an IGF-1 splice variant, rescues motoneurons and delays disease progression in SOD1 G93A mice..
    • Riddoch-Contreras J, Yang SY, Goldspink G, Orrell RW, Greensmith L (2005). Treatment with mechano-growth factor, an IGF-1 splice variant, rescues motoneurons and delays disease progression in SOD1 G93A mice..
    • Orrell RW, Lane RJ, Ross M (2005). Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease.. Cochrane Database Syst Rev, (1), CD002829 - . doi:10.1002/14651858.CD002829.pub3
    • Orrell RW (2005). Book review. Multiple Sclerosis: the history of a disease. Journal of the Royal Society of Medicine, 98(6), 289 - 289.
    • Orrell RW (2005). Book review. Atlas of neuromuscular disorders. Journal of Neurology, Neurosurgery and Psychiatry, 76, 1312 - . doi:10.1136/jnnp.2005.65920
    • Canepari M, Rossi R, Pellegrino MA, Orrell RW, Cobbold M, Harridge S, Bottinelli R (2005). Effects of resistance training on myosin function studied by the in vitro motility assay in young and older men.. Journal of Applied Physiology, 98(6), 2390 - 2395.
    • Demestre M, Pullen A, Orrell RW, Orth M (2005). ALS-IgG-induced selective motor neurone apoptosis in rat mixed primary spinal cord cultures. Journal of Neurochemistry, 94(1), 268 - 275.
    • Bradley M, Bradley L, de Belleroche J, Orrell RW (2005). Patterns of inheritance in familial ALS.. Neurology, 64(9), 1628 - 1631. doi:10.1212/01.WNL.0000160395.43761.AC

    2004

    • Orrell RW, Ross M, Lane RJM (2004). A systematic review of antioxidant treatment of amyotrophic lateral sclerosis. Cochrane Review.
    • Ginsberg L, Malik O, Kenton AR, Sharp P, Muddle JR, Davis MB, Winer JB, Orrell RW, King RHM (2004). Coexistent hereditary and inflammatory neuropathy. Brain, 127(1), 193 - 202. doi:10.1093/brain/awh017
    • Bradley LJ, Muddle JR, Taanman JW, Orrell RW (2004). Conflicting evidence for mitochondrial dysfunction in patients with amytrophic lateral sclerosis..
    • Orrell RW (2004). Facioscapulohumeral dystrophy. Practical Neurology, 4, 238 - 241.
    • Pullen AH, Demestre M, Howard RS, Orrell RW (2004). Passive transfer of purified IgG from patients with amyotrophic lateral sclerosis to mice results in degeneration of motor neurons accompanied by Ca2+ enhancement. Acta Neuropathologica, 107(1), 35 - 46.
    • Houlden H, King RHM, Muddle JR, Warner TT, Reilly MM, Orrell RW, Ginsberg L (2004). Ulcero-mutilating neuropathy: clinical, pathological and molecular genetic study of a family with a novel RAB7 mutation.
    • Orrell RW (2004). Book review. Fascioscapulohumeral dystrophy. Neuromuscular Disorders, 14(11), 775 - 775. doi:10.1016/j.nmd.2004.07.001
    • Majumdar A, Hartley L, Manzur AY, King RH, Orrell RW, Muntoni F (2004). A case of severe congenital chronic inflammatory demyelinating polyneuropathy with complete spontaneous remission.. Neuromuscular Disorders, 14(12), 818 - 821.
    • Orrell RW, Lane JM, Ross MA (2004). Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease.. Cochrane database of systematic reviews (Online), (4), - .
    • Orrell RW (2004). Book review. Neurological therapeutics: principles and practice. Volumes I and II.. Brain, 127(6), 1456 - 1457. doi:10.1093/brain/awh122
    • Bradley LJ, Wilhelm T, King RHM, Ginsberg L, Orrell RW (2004). Brachial plexus hypertrophy in chronic inflammatory demyelinating polyneuropathy..
    • Houlden H, King RHM, Muddle JR, Warner TT, Reilly MM, Orrell RW, Ginsberg L (2004). A novel RAB7 mutation associated with ulcero-mutilating neuropathy. Annals of Neurology, 56(4), 586 - 590. doi:10.1002/ana.20281
    • Orrell RW, Lane JM, Ross MA (2004). Antioxidant treatment for amyotrophic lateral sclerosis / motor neuron disease.. Cochrane Database of Systematic Reviews, (4), CD002829 - .
    • Bennett DLH, Groves M, King R, Orrell RW, Ginsberg L, Reilly MM (2004). The use of targeted nerve and muscle biopsy in the diagnosis of vasculitis.

    2003

    • Ginsberg L, King RHM, Orrell R (2003). Nerve biopsy - how to do it. Practical Neurology, 3(5), 306 - 313.
    • Orrell R, King RHM, Bowler JV, Ginsberg L (2003). Peripheral nerve granuloma in a patient with tubercolosis. Journal of Neurology, Neurosurgery and Psychiatry, (74), 410 - .
    • Figlewicz DA, Orrell R (2003). The genetics of motor neurone disease. ALS and other Motor Neuron Disorders, 4, 225 - 231.
    • Hameed M, Orrell RW, Cobbold M, Goldspink G, Harridge SDR (2003). Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise (vol 547, pg 247, 2003). J PHYSIOL-LONDON, 549(3), 995 - 995. doi:10.1113/jphysiol.2003.594001
    • Ahmad-Annuar A, Shah P, Hafezparast M, Hummerich H, Witherden AS, Morrison KE, Shaw PJ, Kirby J, Warner TT, Crosby A, Proukakis C, Wilkinson P, Orrell RW, Bradley L, Martin JE, Fisher EMC (2003). No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders.. Amyotroph Lateral Scler Other Motor Neuron Disord, 4(3), 150 - 157.
    • Houlden H, Lincoln S, Farrer M, Cleland PG, Hardy J, Orrell RW (2003). Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic. Neurology, 61(10), 1423 - 1426.
    • Hameed M, Orrell RW, Cobbold M, Goldspink G, Harridge SDR (2003). Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise.. The Journal of Physiology, 547(Pt 1), 247 - 254.
    • Toosy AT, Orrell RW, Werring DJ, Howard RS, King MD, Barker GJ, Miller DH, Thompson AJ (2003). Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in ALS..
    • Pullen AH, Demestre M, Orrell R, Schwaller B (2003). Ectopic expression of parvalbumin in motor neurons of mice attenuates development of cytopathology following passive transfer of purified and dialysed IgG from sera of patients with amyotrophic lateral sclerosis. ALS and Other Motor Neuron Disorders, 4S1(4S1), 131 - 132.
    • Hameed M, Orrell RW, Cobbold M, Goldspink G, Harridge SDR (2003). Erratum: (Journal of Physiology (2003) vol. 547 (247-254)). Journal of Physiology, 549(3), 995 - 995. doi:10.1113/jphysiol.2003.549001
    • Bradley LJ, Muddle JR, Taanman JW, Orrell R (2003). Investigation of intercellular differences of mitochondrial protein expression in amyotrophic lateral sclerosis. ALS and other Motor Neuron Disorders, 4S1, 87 - 88.
    • Orrell RW, Schapira AHV (2003). Mitochondria and amyotrophic lateral sclerosis. In Schapira AHV (Ed.), Mitochondrial Function and Dysfunction (pp. 411 - 424). : Academic Press.
    • Abalkhail H, Mitchell J, Habgood J, Orrell R, de Belleroche J (2003). A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2. The American Journal of Human Genetics, 73(2), 383 - 389.
    • Toosy AT, Werring DJ, Orrell RW, Howard RS, King MD, Barker GJ, Miller , D H T, A J (2003). Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 74(9), 1250 - 1257. doi:10.1136/jnnp.74.9.1250
    • Kimber TE, Orrell RW, King RH, Ginsberg L (2003). Pathological findings in a patient with ventilatory failure and chronic inflammatory demyelinating polyneuropathy. Journal of the Peripheral Nervous System, 8(1), 13 - 16.

    2002

    • Demestre M, Pullen AH, Orrell R, Howard RS (2002). Measurement of pro- and active forms of matrix metalloproteinase-9 (MMP9) in serum of patients with amyotrophic lateral sclerosis..
    • Bradley MD, Orrell RW, Clarke J, Davidson AC, Williams AJ, Kullmann DM, Hirsch N, Howard RS (2002). Outcome of ventilatory support for acute respiratory failure in motor neurone disease. Journal of Neurology, Neurosurgery and Psychiatry, 72(6), 752 - 756.
    • Orrell R, Schapira AH (2002). Mitochondria and amyotrophic lateral sclerosis. International Review of Neurobiology, 53, 411 - 424.
    • Orrell RW, Griggs RC (2002). Disorders of striated muscle. In Asbury AK, McKhann G (Ed.), Diseases of the Nervous System: Clinical Neuroscience and Therapeutic Principles (pp. 1163 - 1182). : Cambridge University Press.
    • Pearson SJ, Cobbold M, Orrell R, Harridge SDR (2002). A lesser proportion of fast myosin heavy chain isoforms in older men is closely related to a lower velocity at which peak power occurs during inertial sprint cycling.
    • Howard RS, Orrell RW (2002). Management of motor neurone disease. Postgraduate Medical Journal, 78(926), 736 - 741.
    • Orrell RW, Clark AJ (2002). ALADIN, but where's the genie?. Neurology, 58(6), 847 - 848.
    • Hameed M, Orrell R, Cobbold M, Goldspink G, Harridge SDR (2002). Weightlifting exercise increases the mRNA expression of a mechanosensitive IGF-I (MGF) in the muscles of young, but not old men.
    • Bajaj NPS, Waldman A, Orrell R, Wood NW, Bhatia KP (2002). Familial adult onset of Krabbe's disease resembling hereditary spastic paraplegia with normal neuroimaging. Journal of Neurology, Neurosurgery and Psychiatry, 72(5), 635 - 638.
    • Orrell RW, King RH, Bowler JV, Ginsberg L (2002). Peripheral nerve granuloma in a patient with tuberculosis. Journal of Neurology, Neurosurgery and Psychiatry, 73(6), 769 - 771.

    2001

    • Pullen AH, Howard R, Orrell R (2001). Necrotic and apoptotic-like degeneration in motor neurons following passive transfer of ALS/MND derived IgG..
    • Orrell RW, Guiloff RJ (2001). Myopathies: ethics, outcome variables and clinical scales. In (Ed.), Neurological Disease (pp. 505 - 513). : Springer.
    • Schapira AHV, Orrell R (2001). Young onset stroke. In Schapira AHV, Rowland LP (Ed.), Clinical cases in neurology (pp. 177 - 182). : Butterworth-Heinemann.
    • Bradley MD, Orrell RW, Williams AJ, Davidson C, Kullmann D, Hirsch N, Howard RS (2001). The management of motor neurone disease presenting with acute respiratory failure..
    • Orrell R, Schapira AHV (2001). Muscle weakness and dysphagia. In Schapira AHV, Rowland LP (Ed.), Clinical cases in neurology (pp. 99 - 106). : Butterworth-Heinemann.
    • Orrell RW, Figlewicz DA (2001). Clinical implications of the genetics of ALS and other motor neuron diseases. Neurology, 57(1), 9 - 17.
    • Orrell R, Schapira AHV (2001). Asymmetric muscle weakness. In Schapira AHV, Rowland LP (Ed.), Clinical cases in neurology (pp. 239 - 245). : Butterworth-Heinemann.
    • Bajaj NPS, Waldman AD, Orrell RW, Bhatia KP (2001). A unique family with adult onset Krabbe disease and normal neuroimaging.

    2000

    • Orrell RW (2000). Amyotrophic lateral sclerosis: copper/zinc superoxide dismutase (SOD1) gene mutations. Neuromuscular Disorders, 10(1), 63 - 68.
    • Mitchell J, Habgood JJ, Orrell RW, Kaushik N, Malaspina A, Gardiner IM, Greenwood JS, de Belleroche JS (2000). Identifying gene defects in motor neurone disease /amyotrophic lateral sclerosis families that lack Cu/Zn superoxide dismutase mutations.. EUR J NEUROSCI, 12, 226 - 226.
    • Malik O, Sharp D, King RHM, Orrell R, Ginsberg L (2000). Coexistent hereditary and inflammatory neuropathy. Journal of Neurology, Neurosurgery and Psychiatry, 69(3), - .

    1998

    • Orrell RW, Jurkat-Rott K, Lehmann-Horn F, Lane RJ (1998). Familial cramp due to potassium-aggravated myotonia.. Journal of Neurology, Neurosurgery and Psychiatry, 65(4), 569 - 572.
    • Orrell RW, Johnston HM, Gibson C, Cass RM, Griggs RC (1998). Case of the month - Spontaneous abdominal hematoma in dermatomyositis.

    1997

    • Orrell RW, Habgood JJ, Shepherd DI, Donnai D, deBelleroche J (1997). A novel mutation of SOD-1 (Gly 108 Val) in familial amyotrophic lateral sclerosis. EUR J NEUROL, 4(1), 48 - 51.

    1996

    • Orrell RW, Lane RJM (1996). Myoglobinuria.. In Lane RJM (Ed.), Handbook of Muscle Disease (pp. 607 - 611). : Marcel Dem.
    • Orrell RW, Shakir R, Lane RJM, Kennard C, Wade JPH, Poser CM (1996). Distinguishing acute disseminated encephalomyelitis from multiple sclerosis. British Medical Journal, 313(7060), 802 - 804.
    • Orrell RW, Shakir R, Lane RJM, Kennard C, Wade JPH, Poser CM (1996). Grand rounds - Hammersmith Hospitals - Distinguishing acute disseminated encephalomyelitis from multiple sclerosis - Genetic predisposition may differ. BRIT MED J, 313(7060), 802 - 804.

    1995

    • Orrell RW, Amrolia PJ, Heald A, Cleland PG, Owen JS, Morgan-Hughes JA, Harding AE, Marsden CD (1995). Acanthocytosis, retinitis pigmentosa, and pallidal degeneration: a report of three patients, including the second reported case with hypoprebetalipoproteinemia (HARP syndrome).. Neurology, 45(3), 487 - 492.
    • Shaunak S, Orrell RW, O'Sullivan E, Hawken MB, Lane RJ, Henderson L, Kennard C (1995). Oculomotor function in amyotrophic lateral sclerosis: evidence for frontal impairment.. Annals of Neurology, 38(1), 38 - 44.
    • Enayat ZE, Orrell RW, Claus A, Ludolph A, Bachus R, Brockmuller J, Ray-Chaudhuri K, Radunovic A, Shaw C, Wilkinson J, et AL (1995). Two novel mutations in the gene for copper zinc superoxide dismutase in UK families with amyotrophic lateral sclerosis.. Human Molecular Genetics, 4(7), 1239 - 1240.
    • Orrell RW, Peatfield RC, Collins CE, Woodrow DF, Moss J, Press M, Lane RJ (1995). Myopathy in acquired partial lipodystrophy.. Clinical Neurology and Neurosurgery, 97(2), 181 - 186.
    • Orrell RW, James-Galton M, Stevens JM, Rossor MN (1995). Cerebral achromatopsia as a presentation of Trousseau's syndrome.. Postgraduate Medical Journal, 71(831), 44 - 46.
    • Orrell RW, King AW, Hilton DA, Campbell MJ, Lane RJ, de Belleroche JS (1995). Familial amyotrophic lateral sclerosis with a point mutation of SOD-1: intrafamilial heterogeneity of disease duration associated with neurofibrillary tangles.. Journal of Neurology, Neurosurgery and Psychiatry, 59(3), 266 - 270.
    • Orrell RW, Woodrow DF, Barrett MC, Press M, Dick DJ, Rowe RC, Lane RJ (1995). Testosterone deficiency myopathy.. Journal of the Royal Society of Medicine, 88(8), 454 - 456.
    • Orrell RW, King AW, Lane RJ, de Belleroche JS (1995). Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis.. Journal of the Neurological Sciences, 132(2), 126 - 128.
    • ORRELL RW, DEBELLEROCHE J, MARKLUND SL, BOWE FA, HALLEWELL RA (1995). TOXIC MUTANTS IN CHARCOTS SCLEROSIS - REPLY. NATURE, 378(6555), 343 - 343.

    1994

    • Orrell RW, Marsden CD (1994). The neck-tongue syndrome. Journal of Neurology, Neurosurgery and Psychiatry, 57(3), 348 - 352.
    • Orrell RW, deBelleroche JS (1994). Superoxide dismutase and ALS.. Lancet, 344(8938), 1651 - 1652.
    • KING AW, ORRELL RW, LANE R, DEBELLEROCHE JS (1994). MORE THAN ONE LOCUS FOR FAMILIAL AMYOTROPHIC-LATERAL-SCLEROSIS - ABSENCE OF LINKAGE TO THE SMA LOCUS.
    • Orrell RW, Lane RJ, Guiloff RJ (1994). Recent developments in the drug treatment of motor neurone disease.. BMJ (Clinical Research Ed.), 309(6948), 140 - 141.
    • Orrell RW, Lane RJ, Maitland J, Leslie RD (1994). Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus.. Lancet, 344(8917), 267 - 267.
    • Orrell RW, Lane RJ, Maitland J, Leslie RD (1994). Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus. The Lancet, 344, 267 - .

    1993

    • Orrell RW, Johnson MM (1993). Plasma viscosity and the diagnosis of giant cell arteritis. British Journal of Clinical Practice, 47, 71 - 72.

    1991

    • Orrell RW, Tromans AM, Burt AA (1991). Myotonic dystrophy and traumatic quadriplegia: case report.. Paraplegia, 29(6), 419 - 422. doi:10.1038/sc.1991.57
    • Orrell RW, Tromans AM, Burt AA (1991). Myotonic dystrophy and traumatic quadriplegia. Paraplegia, 29, 419 - 422.
    • Orrell RW (1991). Sodium valproate in pregnancy.. BMJ, 303(6793), 56 - 57.
    • Orrell RW, Guthrie JA, Lamb JT (1991). Nose Blowing and CSF rhinorrhoea. The Lancet, , 804 - .
    • Orrell RW, Omer S, Burt AA, Galvin M (1991). Pseudotumour cerebri and paraproteinaemia. Leukemia and Lymphoma, 5, 211 - 213.

    1990

    • Orrell RW, Lilford RJ (1990). Chorionic villus sampling and rare side effects. Will a randomised controlled trial detech them?. International Journal of Gynecology and Obstetrics, 32(1), 29 - 34.

    • Jaffer F, Reilly MM, Quinlivan R , Muntoni F, Orrell R, Wraige E, Radunovic A, Mummery C, Hanna MG (). Avoiding unplanned admissions in patients with neuromuscular diseases: a regional collaborative audit of hospital admissions 2009-2011.
    • Manjaly Z, Scott K, Abhinav K, Wijesekera L, Ganesalingam J, Goldstein L, Janssen A, Dougherty A, Willey E, Stanton B, Turner M, Ampong M-A, Sakel M, Orrell R, Howard R, Shaw C, Leigh N, Al-Chalabi A (). The sex ratio in amyotrophic lateral sclerosis: a population-based study.. Amyotrophic Lateral Sclerosis, , - .
    • Orrell RW (). What is the clinical significance of SOD1 mutations in amytrophic lateral sclerosis?. Journal of Neurology, Neurosurgery and Psychiatry, , - .
    • Orrell RW (). Facioscapulohumeral dystrophy.. In Amato A, Griggs RC (Ed.), Muscular dystrophy. (pp. - ). : Elsevier.
    • Scott KM, Abinav KM, Wijesekera L, Ganesalingam J, Goldestein LH, Janssen A, Dougherty A, Willey E, Stanton BR, Turner MR, Ampong MA, Sakel M, Orrell RW, Howard R, Shaw CE, Leigh PN, Al-Chalabi A (). The sex ratio in amyotrophic lateral sclerosis: a population based study. Amyotrophic Lateral Sclerosis, , - .
    • Bradley LJ, Taanman J-W, Kallis C, Orrell RW (). Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues.. Experimental Neurology, , - .
    • Evans RM, Harridge SDR, Velloso CP, Yang SY, Goldspink G, Orrell RW (). Investigation of MGF mRNA expression in patients with amyotrophic lateral sclerosis using parallel in vivo and in vitro approaches. Amyotrophic Lateral Sclerosis, , - .
    • Orrell RW (). Motor Neuron Disease: Systematic reviews of treatment for ALS and SMA. British Medical Bulletin.. British Medical Bulletin, , - .
    • Orrell RW (). HARP syndrome. In Kompoliti K, Verhagen L (Ed.), Encyclopedia of Movement Disorders. (pp. - ). : Elsevier.