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Prof Patrick Maxwell

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Personal Profile

Name: Patrick Maxwell Email: p.maxwell@ucl.ac.uk
Title: Prof Tel: 020 7679 6351
Department: Div of Medicine Fax: 020 7679 6211
Position: Honorary Professor Address: The Rayne Institute, 5 University Street, LONDON, WC1E 6JF
Research Domain: Basic Life Sciences, Cancer, Cardiometabolic Science, Experimental Medicine, Neuroscience, Personalised Medicine Web Page:  

Profile

Research Description

I have worked for about 17 years on different aspects of regulation of gene expression by changes in oxygen - sparked by an initial interest in how the kidney and liver regulate production of the hormone erythropoietin (EPO). Early discoveries while working as an MRC Clinical Training Fellow in Peter Ratcliffe's lab in Oxford included identifying the EPO producing in the liver and kidney, and showing that the underlying oxygen sensing system appeared to operate in all mammalian cells. Considerable progress has been made since; the system involves activation of a transcription factor Hypoxia Inducible Factor-1 (HIF) and controls processes ranging from angiogenesis to cellular metabolism. Key discoveries included (1) establishing the role of the von Hippel Lindau (VHL) tumour suppressor gene in HIF alpha destruction (2) that prolyl hydroxylation provided the recognition signal for capture by VHL (3) identification of the PHD enzymes that hydroxylate HIF alpha subunits, acting as oxygen sensors. With others we have shown that congenital polycythaemia (erythrocytosis) in humans can be caused by homozygosity for a subtle defect in VHL, a heterozygous mutation in PHD2 or an activating mutation of HIF-2alpha. The current program is focused on the link between VHL loss and kidney cancer, and the therapeutic potential of potentiating HIF activation by inhibiting the hydroxylase enzymes. We have now generated mice lacking each of the three PHD enzymes which hydroxylate HIF, and shown that lack of PHD1 is protective from ischemic injury.

Research Activities

Nephro-Urology

Regulation and targeting of the hypoxia inducible factor (HIF) pathway

The VHL-HIF pathway

Education Description

Local: Ward based teaching on AAU for clinical medical students. 3 current PhD students as primary supervisor. National: Teaching on courses etc(1) Renal Association Advanced Nephrology Course. (2) Renal Association Medical Masterclass (3)Nephrology update course (Imperial College). (4) Royal College of Physicians Advanced Medicine course. Role in postgraduate medical education - eg Modernising Medical Careers Programme Board, NHS Medical Education England.

UCL Collaborators

Prof Barbara Pedley; Prof David Gems; Prof Tony Segal; Prof Dominic Withers; Prof Michael Duchen; Prof Steve Wilson; Prof Robert Unwin; Prof Chris Boshoff; Prof Stephen Caddick

External Collaborators

Publications

    2013

    • Voskarides K, Demosthenous P, Papazachariou L, Arsali M, Athanasiou Y, Zavros M, Stylianou K, Xydakis D, Daphnis E, Gale DP, Maxwell PH, Elia A, Pattaro C, Pierides A, Deltas C (2013). Epistatic role of the MYH9/APOL1 region on familial hematuria genes.. PLoS One, 8(3), e57925 - . doi:10.1371/journal.pone.0057925
    • Gale DP, Maxwell PH (2013). C3 glomerulonephritis and CFHR5 nephropathy.. Nephrol Dial Transplant, 28(2), 282 - 288. doi:10.1093/ndt/gfs441
    • Connor TM, Oygar DD, Gale DP, Steenkamp R, Nitsch D, Neild GH, Maxwell PH (2013). Incidence of end-stage renal disease in the Turkish-Cypriot population of Northern Cyprus: a population based study.. PLoS One, 8(1), e54394 - . doi:10.1371/journal.pone.0054394

    2012

    • Maxwell P (2012). Next generation sequencing and internal medicine in the NHS - too much information?.
    • Connor T, Oygar D, Nitsch D, Gale D, Steenkamp R, Neild GH, Maxwell P (2012). (sic)HIGH INCIDENCE OF END-STAGE RENAL DISEASE IN THE TURKISH-CYPRIOT POPULATION OF NORTHERN CYPRUS: A POPULATION BASED STUDY..
    • Stewart PM, Bryan S, Dukes P, van Oudheusden HL, Walker R, Maxwell PH (2012). What happens to clinical training fellows? A retrospective study of the 20 years outcome of a Medical Research Council UK cohort.. BMJ Open, 2(4), - . doi:10.1136/bmjopen-2012-001792
    • Maxwell PH (2012). Increasing evidence that genetic variation in complement factor H related 5 (CFHR5) causes disease: a commentary on 'Atypical haemolytic uremic syndrome and genetic aberrations in the complement factor-H-related 5 gene'.. J Hum Genet, 57(8), 473 - 474. doi:10.1038/jhg.2012.80
    • Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW (2012). Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.. Development, 139(13), 2340 - 2350. doi:10.1242/dev.070813
    • Xu J, Wang B, Xu Y, Sun L, Tian W, Shukla D, Barod R, Grillari J, Grillari-Voglauer R, Maxwell PH, Esteban MA (2012). Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.. Oncogene, 31(8), 1065 - 1072. doi:10.1038/onc.2011.305
    • Maxwell PH (2012). Aspiring to prevent colon cancer. NATURE MEDICINE, 18(1), 32 - 33.
    • Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS (2012). Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.. PLoS One, 7(1), e31034 - . doi:10.1371/journal.pone.0031034
    • Devuyst O, Antignac C, Bindels RJ, Chauveau D, Emma F, Gansevoort R, Maxwell PH, Ong AC, Remuzzi G, Ronco P, Schaefer F (2012). The ERA-EDTA Working Group on inherited kidney disorders.. Nephrol Dial Transplant, 27(1), 67 - 69. doi:10.1093/ndt/gfr764
    • Maxwell PH (2012). Tumor strengths and frailties: Aspiring to prevent colon cancer.. Nat Med, 18(1), 32 - 33. doi:10.1038/nm.2637
    • Yang J, Staples O, Thomas LW, Briston T, Robson M, Poon E, Simões ML, El-Emir E, Buffa FM, Ahmed A, Annear NP, Shukla D, Pedley BR, Maxwell PH, Harris AL, Ashcroft M (2012). Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression.. J Clin Invest, 122(2), 600 - 611. doi:10.1172/JCI58780
    • Mowat FM, Gonzalez F, Luhmann UF, Lange CA, Duran Y, Smith AJ, Maxwell PH, Ali RR, Bainbridge JW (2012). Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy.. Am J Pathol, 180(4), 1726 - 1739. doi:10.1016/j.ajpath.2011.12.033

    2011

    • International Consortium for Blood Pressure Genome-Wide Association Studies , Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL, Launer L, Zhao JH, Aulchenko Y, Heath S, Sõber S, Parsa A, Luan J, Arora P, Dehghan A, Zhang F, Lucas G, Hicks AA, Jackson AU, Peden JF, Tanaka T, Wild SH, Rudan I, Igl W, Milaneschi Y, Parker AN, Fava C, Chambers JC, Fox ER, Kumari M, Go MJ, van der Harst P, Kao WH, Sjögren M, Vinay DG, Alexander M, Tabara Y, Shaw-Hawkins S, Whincup PH, Liu Y, Shi G, Kuusisto J, Tayo B, Seielstad M, Sim X, Nguyen KD, Lehtimäki T, Matullo G, Wu Y, Gaunt TR, Onland-Moret NC, Cooper MN, Platou CG, Org E, Hardy R, Dahgam S, Palmen J, Vitart V, Braund PS, Kuznetsova T, Uiterwaal CS, Adeyemo A, Palmas W, Campbell H, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND, CARDIoGRAM consortium , CKDGen Consortium , KidneyGen Consortium , EchoGen consortium , CHARGE-HF consortium , Aspelund T, Garcia M, Chang YP, O'Connell JR, Steinle NI, Grobbee DE, Arking DE, Kardia SL, Morrison AC, Hernandez D, Najjar S, McArdle WL, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day IN, Lawlor DA, Beilby JP, Lawrence RW, Clarke R, Hopewell JC, Ongen H, Dreisbach AW, Li Y, Young JH, Bis JC, Kähönen M, Viikari J, Adair LS, Lee NR, Chen MH, Olden M, Pattaro C, Bolton JA, Köttgen A, Bergmann S, Mooser V, Chaturvedi N, Frayling TM, Islam M, Jafar TH, Erdmann J, Kulkarni SR, Bornstein SR, Grässler J, Groop L, Voight BF, Kettunen J, Howard P, Taylor A, Guarrera S, Ricceri F, Emilsson V, Plump A, Barroso I, Khaw KT, Weder AB, Hunt SC, Sun YV, Bergman RN, Collins FS, Bonnycastle LL, Scott LJ, Stringham HM, Peltonen L, Perola M, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Soler Artigas M, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, McKenzie CA, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Wichmann HE, Cho YS, Kim HL, Lee JY, Scott J, Sehmi JS, Zhang W, Hedblad B, Nilsson P, Smith GD, Wong A, Narisu N, Stančáková A, Raffel LJ, Yao J, Kathiresan S, O'Donnell CJ, Schwartz SM, Ikram MA, Longstreth WT, Mosley TH, Seshadri S, Shrine NR, Wain LV, Morken MA, Swift AJ, Laitinen J, Prokopenko I, Zitting P, Cooper JA, Humphries SE, Danesh J, Rasheed A, Goel A, Hamsten A, Watkins H, Bakker SJ, van Gilst WH, Janipalli CS, Mani KR, Yajnik CS, Hofman A, Mattace-Raso FU, Oostra BA, Demirkan A, Isaacs A, Rivadeneira F, Lakatta EG, Orru M, Scuteri A, Ala-Korpela M, Kangas AJ, Lyytikäinen LP, Soininen P, Tukiainen T, Würtz P, Ong RT, Dörr M, Kroemer HK, Völker U, Völzke H, Galan P, Hercberg S, Lathrop M, Zelenika D, Deloukas P, Mangino M, Spector TD, Zhai G, Meschia JF, Nalls MA, Sharma P, Terzic J, Kumar MV, Denniff M, Zukowska-Szczechowska E, Wagenknecht LE, Fowkes FG, Charchar FJ, Schwarz PE, Hayward C, Guo X, Rotimi C, Bots ML, Brand E, Samani NJ, Polasek O, Talmud PJ, Nyberg F, Kuh D, Laan M, Hveem K, Palmer LJ, van der Schouw YT, Casas JP, Mohlke KL, Vineis P, Raitakari O, Ganesh SK, Wong TY, Tai ES, Cooper RS, Laakso M, Rao DC, Harris TB, Morris RW, Dominiczak AF, Kivimaki M, Marmot MG, Miki T, Saleheen D, Chandak GR, Coresh J, Navis G, Salomaa V, Han BG, Zhu X, Kooner JS, Melander O, Ridker PM, Bandinelli S, Gyllensten UB, Wright AF, Wilson JF, Ferrucci L, Farrall M, Tuomilehto J, Pramstaller PP, Elosua R, Soranzo N, Sijbrands EJ, Altshuler D, Loos RJ, Shuldiner AR, Gieger C, Meneton P, Uitterlinden AG, Wareham NJ, Gudnason V, Rotter JI, Rettig R, Uda M, Strachan DP, Witteman JC, Harti (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.. Nature, 478(7367), 103 - 109. doi:10.1038/nature10405
    • Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK (2011). Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.. J Clin Invest, 121(3), 1053 - 1063. doi:10.1172/JCI43273
    • Shuib S, Wei W, Sur H, Morris MR, McMullan D, Rattenberry E, Meyer E, Maxwell PH, Kishida T, Yao M, Latif F, Maher ER (2011). Copy number profiling in von Hippel-Lindau disease renal cell carcinoma.. Genes Chromosomes Cancer, 50(7), 479 - 488. doi:10.1002/gcc.20865
    • Bond J, Gale DP, Connor T, Adams S, de Boer J, Gascoyne DM, Williams O, Maxwell PH, Ancliff PJ (2011). Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension.. Blood, 117(13), 3699 - 3701. doi:10.1182/blood-2010-12-327569
    • Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, Baban D, Nye E, Stamp GW, Wolhuter K, Stevens M, Fischer R, Carmeliet P, Maxwell PH, Pugh CW, Frizzell N, Soga T, Kessler BM, El-Bahrawy M, Ratcliffe PJ, Pollard PJ (2011). Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.. Cancer Cell, 20(4), 524 - 537. doi:10.1016/j.ccr.2011.09.006
    • Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M (2011). Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.. Nature, 479(7371), 122 - 126. doi:10.1038/nature10507
    • Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K, Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C (2011). Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.. J Am Soc Nephrol, 22(11), 2004 - 2015. doi:10.1681/ASN.2010121249
    • Marchbank T, Mahmood A, Harten S, Maxwell PH, Playford RJ (2011). Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms.. Lab Invest, 91(12), 1684 - 1694. doi:10.1038/labinvest.2011.129
    • Maxwell PH (2011). Seeing the smoking gun: a sensitive and specific method to visualize loss of the tumour suppressor, fumarate hydratase, in human tissues.. J Pathol, 225(1), 1 - 3. doi:10.1002/path.2950
    • Harten SK, Esteban MA, Shukla D, Ashcroft M, Maxwell PH (2011). Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.. Mol Cancer, 10, 89 - . doi:10.1186/1476-4598-10-89
    • Shively SB, Falke EA, Li J, Tran MG, Thompson ER, Maxwell PH, Roessler E, Oldfield EH, Lonser RR, Vortmeyer AO (2011). Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease.. Mod Pathol, 24(8), 1023 - 1030. doi:10.1038/modpathol.2011.61
    • Vernon KA, Gale DP, de Jorge EG, McLean AG, Galliford J, Pierides A, Maxwell PH, Taube D, Pickering MC, Cook HT (2011). Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant.. Am J Transplant, 11(1), 152 - 155. doi:10.1111/j.1600-6143.2010.03333.x
    • Formenti F, Beer PA, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas GS, Maher ER, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Pugh CW, Ratcliffe PJ, Smith TG, Talbot NP, Robbins PA (2011). Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation.. FASEB J, 25(6), 2001 - 2011. doi:10.1096/fj.10-177378
    • Khan MN, Bhattacharyya T, Andrikopoulos P, Esteban MA, Barod R, Connor T, Ashcroft M, Maxwell PH, Kiriakidis S (2011). Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.. Br J Cancer, 104(7), 1151 - 1159. doi:10.1038/bjc.2011.73
    • Bou-Gharios G, Amin F, Hill P, Nakamura H, Maxwell P, Fisk NM (2011). Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription.. Cells Tissues Organs, 193(6), 379 - 392. doi:10.1159/000321172
    • Evans , Maxwell PH (2011). Hypoxia and Upregulation of Hypoxia-Inducible Factor 1 alpha Stimulate Venous Thrombus Recanalization (vol 30, pg 2443, 2010). ARTERIOSCL THROM VAS, 31(2), E5 - E5. doi:10.1161/ATV.0b013e318209c861
    • Athanasiou Y, Voskarides K, Gale DP, Damianou L, Patsias C, Zavros M, Maxwell PH, Cook HT, Demosthenous P, Hadjisavvas A, Kyriacou K, Zouvani I, Pierides A, Deltas C (2011). Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees.. Clin J Am Soc Nephrol, 6(6), 1436 - 1446. doi:10.2215/CJN.09541010

    2010

    • Gale DP, Maxwell PH (2010). The role of HIF in immunity.. Int J Biochem Cell Biol, 42(4), 486 - 494. doi:10.1016/j.biocel.2009.10.012
    • Evans CE, Humphries J, Mattock K, Waltham M, Wadoodi A, Saha P, Modarai B, Maxwell PH, Smith A (2010). Hypoxia and upregulation of hypoxia-inducible factor 1{alpha} stimulate venous thrombus recanalization.. Arterioscler Thromb Vasc Biol, 30(12), 2443 - 2451. doi:10.1161/ATVBAHA.110.215038
    • Ashby DR, Gale DP, Busbridge M, Murphy KG, Duncan ND, Cairns TD, Taube DH, Bloom SR, Tam FW, Chapman R, Maxwell PH, Choi P (2010). Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin.. Haematologica, 95(3), 505 - 508. doi:10.3324/haematol.2009.013136
    • Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ, Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Ferrucci L, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Melander O, Munroe PB, Nordfors L, Parsa A, Peltonen L, Penninx BW, Perucha E, Pouta A, Prokopenko I, Roderick PJ, Ruokonen A, Samani NJ, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Shuldiner AR, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Tanaka T, Ubink-Veltmaat LJ, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Mooser V, Abecasis GR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS (2010). Genetic loci influencing kidney function and chronic kidney disease.. Nat Genet, 42(5), 373 - 375. doi:10.1038/ng.566
    • Lou T, Zhang J, Gale DP, Rees AJ, Rhodes B, Feehally J, Li C, Li Y, Li R, Huang W, Hu B, Leung JC, Lam MF, Lai KN, Wang Y, Maxwell PH (2010). Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients.. Nephrol Dial Transplant, 25(7), 1 - . doi:10.1093/ndt/gfq312
    • Feehally J, Farrall M, Boland A, Gale DP, Gut I, Heath S, Kumar A, Peden JF, Maxwell PH, Morris DL, Padmanabhan S, Vyse TJ, Zawadzka A, Rees AJ, Lathrop M, Ratcliffe PJ (2010). HLA has strongest association with IgA nephropathy in genome-wide analysis.. J Am Soc Nephrol, 21(10), 1791 - 1797. doi:10.1681/ASN.2010010076
    • Gale DP, de Jorge EG, Cook HT, Martinez-Barricarte R, Hadjisavvas A, McLean AG, Pusey CD, Pierides A, Kyriacou K, Athanasiou Y, Voskarides K, Deltas C, Palmer A, Frémeaux-Bacchi V, de Cordoba SR, Maxwell PH, Pickering MC (2010). Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis.. Lancet, 376(9743), 794 - 801. doi:10.1016/S0140-6736(10)60670-8
    • Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT (2010). Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.. Gastroenterology, 139(6), 2093 - 2101. doi:10.1053/j.gastro.2010.06.068
    • Van de Veire S, Stalmans I, Heindryckx F, Oura H, Tijeras-Raballand A, Schmidt T, Loges S, Albrecht I, Jonckx B, Vinckier S, Van Steenkiste C, Tugues S, Rolny C, De Mol M, Dettori D, Hainaud P, Coenegrachts L, Contreres JO, Van Bergen T, Cuervo H, Xiao WH, Le Henaff C, Buysschaert I, Masouleh BK, Geerts A, Schomber T, Bonnin P, Lambert V, Haustraete J, Zacchigna S, Rakic JM, Jimenez W, Noel A, Giacca M, Colle I, Foidart JM, Tobelem G, Morales-Ruiz M, Vilar J, Maxwell P, Vinores SA, Carmeliet G, Dewerchin M, Claesson-Welsh L, Dupuy E, Van Vlierberghe H, Christofori G, Mazzone M, Detmar M, Collen D, Carmeliet P (2010). Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease. CELL, 141(1), 178 - 190. doi:10.1016/j.cell.2010.02.039
    • Mowat FM, Luhmann UF, Smith AJ, Lange C, Duran Y, Harten S, Shukla D, Maxwell PH, Ali RR, Bainbridge JW (2010). HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.. PLoS One, 5(6), e11103 - . doi:10.1371/journal.pone.0011103
    • Schneider M, Van Geyte K, Fraisl P, Kiss J, Aragones J, Mazzone M, Mairbaurl H, De Bock K, Jeoung NH, Mollenhauer M, Georgiadou M, Bishop T, Roncal C, Sutherland A, Jordan B, Gallez B, Weitz J, Harris RA, Maxwell P, Baes M, Ratcliffe P, Carmeliet P (2010). Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury. GASTROENTEROLOGY, 138(3), 1143 - U438. doi:10.1053/j.gastro.2009.09.057
    • Harten SK, Ashcroft M, Maxwell PH (2010). Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection.. Antioxid Redox Signal, 12(4), 459 - 480. doi:10.1089/ars.2009.2870
    • Vernon KA, Gale DP, de Jorge EG, McLean AG, Maxwell PH, Pickering MC, Cook HT (2010). Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant. doi:10.1016/j.molimm.2010.05.024
    • Hedborg F, Fischer-Colbrie R, Ostlin N, Sandstedt B, Tran MGB, Maxwell PH (2010). Differentiation in Neuroblastoma: Diffusion-Limited Hypoxia Induces Neuro-Endocrine Secretory Protein 55 and Other Markers of a Chromaffin Phenotype. PLOS ONE, 5(9), - . doi:10.1371/journal.pone.0012825
    • Cantley J, Grey ST, Maxwell PH, Withers DJ (2010). The hypoxia response pathway and beta-cell function. DIABETES OBES METAB, 12, 159 - 167. doi:10.1111/j.1463-1326.2010.01276.x
    • Ashrafian H, O'Flaherty L, Adam J, Steeples V, Chung YL, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, Spencer-Dene B, Yusuf M, Volpi E, Maxwell PH, Stamp G, Poulsom R, Pugh CW, Costa B, Bardella C, Di Renzo MF, Kotlikoff MI, Launonen V, Aaltonen L, El-Bahrawy M, Tomlinson I, Pollard PJ (2010). Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.. Cancer Res, 70(22), 9153 - 9165. doi:10.1158/0008-5472.CAN-10-1949
    • Xu J, Li H, Wang B, Xu Y, Yang J, Zhang X, Harten SK, Shukla D, Maxwell PH, Pei D, Esteban MA (2010). VHL inactivation induces HEF1 and Aurora kinase A.. J Am Soc Nephrol, 21(12), 2041 - 2046. doi:10.1681/ASN.2010040345
    • Lou T, Zhang J, Gale DP, Rees AJ, Rhodes B, Feehally J, Li C, Li Y, Li R, Huang W, Hu B, Leung JC, Lam MF, Lai KN, Wang Y, Maxwell PH (2010). Variation in IGHMBP2 is not associated with IgA nephropathy in independent studies of UK Caucasian and Chinese Han patients.. Nephrol Dial Transplant, 25(5), 1547 - 1554. doi:10.1093/ndt/gfp661

    2009

    • Tuthill M, Barod R, Pyle L, Cook T, Chew S, Gore M, Maxwell P, Eisen T (2009). A report of succinate dehydrogenase B deficiency associated with metastatic papillary renal cell carcinoma: successful treatment with the multi-targeted tyrosine kinase inhibitor sunitinib.. BMJ Case Rep, 2009, - . doi:10.1136/bcr.08.2008.0732
    • Chambers JC, Zhang WH, Li Y, Sehmi J, Wass MN, Zabaneh D, Hoggart C, Bayele H, McCarthy MI, Peltonen L, Freimer NB, Srai SK, Maxwell PH, Sternberg MJE, Ruokonen A, Abecasis G, Jarvelin MR, Scott J, Elliott P, Kooner JS (2009). Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. NAT GENET, 41(11), 1170 - 1172. doi:10.1038/ng.462
    • Formenti F, Beer P, Croft QPP, Dorrington KL, Gale DP, Lappin TRJ, Lucas G, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Smith TG, Talbot NP, Robbins PA (2009). A 'GAIN-OF-FUNCTION' MUTATION IN THE HYPOXIA-INDUCIBLE FACTOR 2 alpha GENE DOES NOT REDUCE EXERCISE CAPACITY IN HUMANS. J PHYSIOL SCI, 59, 357 - 357.
    • Volke M, Gale DP, Maegdefrau U, Schley G, Klanke B, Bosserhoff AK, Maxwell PH, Eckardt KU, Warnecke C (2009). Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.. PLoS One, 4(11), e7875 - . doi:10.1371/journal.pone.0007875
    • Maxwell PH (2009). Oxygen availability sHIFts the cell cycle.. Cell Cycle, 8(9), 1307 - .
    • Barod R, Domin J, Eccles S, Ashcroft M, O'Brien TS, Maxwell PH (2009). PTEN can function as a tumour suppressor in clear cell renal carcinoma.
    • Lim S, Ong SG, Shukla DH, Maxwell P, Hausenloy DJ, Yellon DM (2009). ACTIVATING HYPOXIA INDUCIBLE FACTOR IN THE HEART BY GENETIC INACTIVATION OF VON HIPPEL LINDAU PROTEIN REDUCES MYOCARDIAL INFARCT SIZE.
    • Ashby DR, Gale DP, Busbridge M, Maxwell PH, Choi P (2009). Hepcidin levels in patients with renal disease Response. KIDNEY INT, 76(6), 680 - 681. doi:10.1038/ki.2009.240
    • de Jorge EG, Gale DP, Cook HT, Martinez-Barricarte R, Hadjisavvas A, Pusey CD, Palmer A, Fremeaux-Bacchi V, de Cordoba SR, Maxwell PH, Pickering MC (2009). A mutant complement factor H-related 5 protein is associated with familial C3 glomerulonephritis. doi:10.1016/j.molimm.2009.05.198
    • Ashby DR, Gale DP, Busbridge M, Maxwell PH, Choi P (2009). Response to 'The utility of multivariate analysis in the study of hepcidin'. KIDNEY INT, 76(8), 912 - 913. doi:10.1038/ki.2009.277
    • Ashby DR, Gale DP, Busbridge M, Singh SK, Maxwell PH, Choi P (2009). Response to 'Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease'. KIDNEY INT, 76(10), 1116 - 1116. doi:10.1038/ki.2009.337
    • Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ (2009). Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.. Journal of Clinical Investigation, 119(1), 125 - 135. doi:10.1172/JCI26934
    • Harten SK, Esteban MA, Maxwell PH (2009). Identification of novel VHL regulated genes by transcriptomic analysis of RCC10 renal carcinoma cells.. Adv Enzyme Regul, 49(1), 43 - 52. doi:10.1016/j.advenzreg.2008.12.005
    • Harten SK, Shukla D, Barod R, Hergovich A, Balda MS, Matter K, Esteban MA, Maxwell PH (2009). Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin.. Mol Biol Cell, 20(3), 1089 - 1101. doi:10.1091/mbc.E08-06-0566
    • Barod R, Domin J, Eccles S, O' Brien TS, Ashcroft M, Maxwell PH (2009). PTEN CAN FUNCTION AS A TUMOUR SUPPRESSOR IN CLEAR CELL RENAL CARCINOMA. EUR UROL SUPPL, 8(4), 377 - 377.
    • Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, de Almodovar CR, De Smet F, Vinckier S, Aragones J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P (2009). Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization. CELL, 136(5), 839 - 851. doi:10.1016/j.cell.2009.01.020
    • Ma DQ, Lim T, Xu J, Tang H, Wan YJ, Zhao HL, Hossain M, Maxwell PH, Maze M (2009). Xenon Preconditioning Protects against Renal Ischemic-Reperfusion Injury via HIF-1 alpha Activation. J AM SOC NEPHROL, 20(4), 713 - 720. doi:10.1681/ASN.2008070712
    • Barod R, Domin J, Eccles S, Ashcroff M, O'Brien TS, Maxwell PH (2009). PTEN CAN FUNCTION AS A TUMOR SUPPRESSOR IN CLEAR CELL RENAL CARCINOMA.
    • Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, Kanopka A, Gorlach A, Gasmann M, Harris AL, Maxwell P, Scozzafava A (2009). Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. J ENZYM INHIB MED CH, 24, 1 - 39. doi:10.1080/14756360902784425
    • Ashby DR, Gale DP, Busbridge M, Murphy KG, Duncan ND, Cairns TD, Taube DH, Bloom SR, Tam FWK, Chapman RS, Maxwell PH, Choi P (2009). Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. KIDNEY INT, 75(9), 976 - 981. doi:10.1038/ki.2009.21
    • Wiesener MS, Maxwell PH, Eckardt KU (2009). Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression. J MOL MED-JMM, 87(9), 871 - 877. doi:10.1007/s00109-009-0504-x
    • Brooks JTS, Elvidge GP, Glenny L, Gleadle JM, Liu C, Ragoussis J, Smith TG, Talbot NP, Winchester L, Maxwell PH, Robbins PA (2009). Variations within oxygen-regulated gene expression in humans. J APPL PHYSIOL, 106(1), 212 - 220. doi:10.1152/japplphysiol.90578.2008

    2008

    • Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008). Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.. Nature Genetics, 40(2), 170 - 180. doi:10.1038/ng.2007.62
    • Hill P, Shukla D, Tran MG, Aragones J, Cook HT, Carmeliet P, Maxwell PH (2008). Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.. Journal of the American Society of Nephrology, 19(1), 39 - 46.
    • Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M, Robbins PA (2008). Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology.. Advances in Experimental Medicine and Biology, 605, 51 - 56.
    • Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P (2008). Role of Gas6 in erythropoiesis and anemia in mice.. Journal of Clinical Investigation, 118(2), 583 - 596. doi:10.1172/JCI30375
    • Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P (2008). Role of Gas6 in erythropoiesis and anemia in mice.. J Clin Invest, 118(2), 583 - 596. doi:10.1172/JCI30375
    • Ashby D, Smith C, Hurril R, Maxwell P, Brown E (2008). Dialysis survivors: clinical status of patients on treatment for more than 10 years.. Nephron Clinical Practice, 108(3), c207 - 212. doi:10.1159/000119094
    • Lutz J, Luong LA, Strobl M, Deng MH, Huang H, Anton M, Zakkar M, Enesa K, Chaudhury H, Haskard DO, Baumann M, Boyle J, Harten S, Maxwell PH, Pusey C, Heemann U, Evans PC (2008). The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. J MOL MED-JMM, 86(12), 1329 - 1339. doi:10.1007/s00109-008-0405-4
    • Mikhaylova O, Ignacak ML, Barankiewicz TJ, Harbaugh SV, Yi Y, Maxwell PH, Schneider M, Van Geyte K, Carmeliet P, Revelo MP, Wyder M, Greis KD, Meller J, Czyzyk-Krzeska MF (2008). The von hippel-lindau tumor suppressor protein and Egl-9-type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. MOL CELL BIOL, 28(8), 2701 - 2717. doi:10.1128/MCB.01231-07
    • Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, Diez-Juan A, Lopez-Barneo J, Channon KM, Maxwell PH, Pugh CW, Davies AM, Carmeliet P, Ratcliffe PJ (2008). Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.. Mol Cell Biol, 28(10), 3386 - 3400. doi:10.1128/MCB.02041-07
    • Rajatapiti P, van der Horst IWJM, de Rooij JD, Tran MGB, Maxwell PH, Tibboel D, Rottier R, de Krijger RR (2008). Expression of hypoxia-inducible factors in normal human lung development. PEDIATR DEVEL PATHOL, 11(3), 193 - 199. doi:10.2350/07-04-0257.1
    • Gale DP, Harten SK, Reid CD, Tuddenham EG, Maxwell PH (2008). Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.. Blood, 112(3), 919 - 921. doi:10.1182/blood-2008-04-153718
    • Mehta GU, Shively SB, Duong H, Tran MG, Moncrief TJ, Smith JH, Li J, Edwards NA, Lonser RR, Zhuang Z, Merrill MJ, Raffeld M, Maxwell PH, Oldfield EH, Vortmeyer AO (2008). Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease.. Neoplasia, 10(10), 1146 - 1153.
    • Barod R, Esteban M, O'Brien TS, Domin J, Maxwell P (2008). Inactivation of the phosphatase and tensin homolog (PTEN) tumor suppressor contributes to tumor characteristics of 786-O clear cell renal carcinoma cells.

    2007

    • Hoogewijs D, Terwilliger NB, Webster KA, Powell-Coffman JA, Tokishita S, Yamagata H, Hankeln T, Burmester T, Rytkönen KT, Nikinmaa M, Abele D, Heise K, Lucassen M, Fandrey J, Maxwell PH, Påhlman S, Gorr TA (2007). From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia.. Integr Comp Biol, 47(4), 552 - 577. doi:10.1093/icb/icm072
    • Mahmood A, Marchbank T, Harten SK, Maxwell PH, Ghosh S, Playford RJ (2007). Administration of dimethyloxalylglycine as a novel gastrointestinal repair strategy.
    • Kiriakidis S, Esteban MA, Maxwell PH (2007). Genetic insights into the hypoxia-inducible factor (HIF) pathway.. Advances in Enzyme Regulation, 47, 288 - 306.
    • Boutet A, Esteban MA, Maxwell PH, Nieto MA (2007). Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?. Cell Cycle, 6(6), 638 - 642.
    • Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP (2007). Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.. Cancer Cell, 11(4), 311 - 319. doi:10.1016/j.ccr.2007.02.005
    • Mahmood A, Marchbank T, Harten S, Maxwell PH, Ghosh S, Playford RJ (2007). Administration of dimethyloxalylglycine (Dmog) as a novel gastrointestinal repair strategy.
    • Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, Rieker C, Collen D, Conway SJ, Conway EM (2007). Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.. Blood, 109(11), 4742 - 4752.
    • Black C, Maxwell P, Marshall M, Rees M, Dolphin T (2007). MTAS: which way now? Interview by Rebecca Coombes.. BMJ (Clinical Research Ed.), 334(7607), 1300 - . doi:10.1111/j.1542-4758.2007.00213.x
    • Black C, Maxwell P, Marshall M, Rees M, Dolphin T (2007). MTAS: which way now? Interview by Rebecca Coombes.. BMJ, 334(7607), 1300 - . doi:10.1136/bmj.39252.407350.68
    • Coombes R, Maxwell P, Marshall M, Black C, Rees M (2007). MTAS: Which way now?. BRIT MED J, 334(7607), 1300 - 1300.
    • Pepper RJ, Gale DP, Wajed J, Bommayya G, Ashby D, McLean A, Laffan M, Maxwell PH (2007). Inadvertent postdialysis anticoagulation due to heparin line locks.. Hemodial Int, 11(4), 430 - 434. doi:10.1111/j.1542-4758.2007.00213.x
    • Wiesener MS, Mà nchenhagen P, Glà ser M, Sobottka BA, Knaup KX, Jozefowski K, Jà rgensen JS, Roigas J, Warnecke C, Grà ne HJ, Maxwell PH, Willam C, Eckardt KU (2007). Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia.. International Journal of Cancer, 121(11), 2434 - 2442.

    2006

    • Du Roure C, Takà cs K, Maxwell PH, Roberts I, Dazzi F, Cannella L, Merkenschlager M, Fisher AG (2006). Correction of severe anaemia using immuno-regulated gene therapy is achieved by restoring the early erythroblast compartment.. British Journal of Haematology, 132(5), 608 - 614.
    • Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'brien TS, Maxwell PH (2006). Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.. Cancer Research, 66(7), 3567 - 3575.
    • Alexakis C, Maxwell P, Bou-Gharios G (2006). Organ-specific collagen expression: implications for renal disease.. Nephron Exp Nephrol, 102(3-4), e71 - e75. doi:10.1159/000089684
    • Percy MJ, Zhao Q, Flores A, Harrison C, Lappin TR, Maxwell PH, McMullin MF, Lee FS (2006). A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.. Proceedings of the National Academy of Sciences of the United States of America, 103(3), 654 - 659.
    • Walmsley SR, Cowburn AS, Clatworthy MR, Morrell NW, Roper EC, Singleton V, Maxwell P, Whyte MK, Chilvers ER (2006). Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis.. Blood, 108(9), 3176 - 3178. doi:10.1002/path.2062
    • Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J, Nieto MA (2006). Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney.. The EMBO Journal, 25(23), 5603 - 5613.
    • Walmsley SR, Cowburn AS, Clatworthy MR, Morrell NW, Roper EC, Singleton V, Maxwell P, Whyte MKB, Chilvers ER (2006). Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis. BLOOD, 108(9), 3176 - 3178. doi:10.1182/blood-2006-04-018796
    • Vortmeyer AO, Tran MG, Zeng W, Glà sker S, Riley C, Tsokos M, Ikejiri B, Merrill MJ, Raffeld M, Zhuang Z, Lonser RR, Maxwell PH, Oldfield EH (2006). Evolution of VHL tumourigenesis in nerve root tissue.. The Journal of Pathology, 210(3), 374 - 382.
    • Maxwell PH (2006). The VHL tumor suppressor gene and oxygen sensing.
    • Glà sker S, Tran MG, Shively SB, Ikejiri B, Lonser RR, Maxwell PH, Zhuang Z, Oldfield EH, Vortmeyer AO (2006). Epididymal cystadenomas and epithelial tumourlets: effects of VHL deficiency on the human epididymis.. The Journal of Pathology, 210(1), 32 - 41.
    • Chen SQ, Zhou Y, Li XH, Labu , Huang S, Huang WJ, Zhou CL, Maxwell PH, Wang YM (2006). Genetic and structural analyses suggest that a novel SPG3A mutation causes severe phenotypes of hereditary spastic paraplegia. CHINESE SCI BULL, 51(16), 2038 - 2040. doi:10.1007/s11434-006-2086-0
    • Bernhardt WM, Cramer T, Rohwer N, Klanke B, Wiesener MS, Maxwell PH, Eckardt KU (2006). Expression and distribution of hypoxia inducible transcription factors in mouse liver, heart and kidney.
    • Willam C, Maxwell PH, Nichols L, Lygate C, Tian YM, Bernhardt W, Wiesener M, Ratcliffe PJ, Eckardt KU, Pugh CW (2006). HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.. Journal of Molecular and Cellular Cardiology, 41(1), 68 - 77.
    • Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M, Robbins PA (2006). Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.. PLoS Medicine, 3(7), e290 - .
    • Esteban MA, Harten SK, Tran MG, Maxwell PH (2006). Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein.. Journal of the American Society of Nephrology, 17(7), 1801 - 1806.
    • Koumenis C, Maxwell PH (2006). Low oxygen stimulates the intellect. Symposium on hypoxia and development, physiology and disease.. EMBO Reports, 7(7), 679 - 684.
    • Wang SJ, Voisin MB, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L, Nourshargh S (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J EXP MED, 203(6), 1519 - 1532. doi:10.1081/jem.20051210
    • Tran MGB, Esteban MA, Shukla D, Chandra A, O'Brien TS, Maxwell PH (2006). The cell of origin of clear cell renal carcinoma - Revisited.
    • Xia Y, Li Y, Du Y, Yang N, Li C, Leung JC, Lam MF, Huang W, Chen S, Maxwell PH, Lai KN, Wang Y (2006). Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy.. Nephrology Dialysis Transplantation, 21(6), 1570 - 1574.
    • Kinderlerer AR, Steinberg R, Johns M, Harten SK, Lidington EA, Haskard DO, Maxwell PH, Mason JC (2006). Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.. Arthritis Research and Therapy, 8(4), R130 - .
    • Maxwell PH, Wang Y (2006). Genetic studies of IgA nephropathy.. Nephron Experimental Nephrology, 102(3), e76 - e80.
    • Tran MGB, Esteban MA, Shukla D, Barod R, Chandra A, O'Brien TS, Maxwell PH (2006). The identity of the angiogenic switch in renal cancer.
    • Percy MJ, Zhao Q, Floresw A, Harrisonz C, Lappin TRJ, Maxwell PH, Mcmullin MF, Lee FS (2006). A novel mutation in the HIF prolyl hydroxylase, PHD2, associated with familial erythrocytosis.

    2005

    • van der Schaft DW, Hillen F, Pauwels P, Kirschmann DA, Castermans K, Egbrink MG, Tran MG, Sciot R, Hauben E, Hogendoorn PC, Delattre O, Maxwell PH, Hendrix MJ, Griffioen AW (2005). Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia.. Cancer Research, 65(24), 11520 - 11528.
    • Summers SA, Laing C, Cook TH, Maxwell PH (2005). Is it rejection? Be on the lookout for 'decoys'.. Nephrology Dialysis Transplantation, 20(9), 2002 - 2004.
    • Glà sker S, Lonser RR, Tran MG, Ikejiri B, Butman JA, Zeng W, Maxwell PH, Zhuang Z, Oldfield EH, Vortmeyer AO (2005). Effects of VHL deficiency on endolymphatic duct and sac.. Cancer Research, 65(23), 10847 - 10853.
    • Percy MJ, Zhao Q, Flores A, Harrison CN, Lappin TRJ, Maxwell PH, McMullin MF, Lee FS (2005). Familial erythrocytosis associated with a mutation in the HIF prolyl hydroxylase, PHD2..
    • Maxwell PH (2005). Hypoxia-inducible factor as a physiological regulator.. Experimental Physiology, 90(6), 791 - 797.
    • Esteban MA, Maxwell PH (2005). HIF, a missing link between metabolism and cancer.. Nature Medicine, 11(10), 1047 - 1048.
    • Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P (2005). Genetic evidence for a tumor suppressor role of HIF-2alpha.. Cancer Cell, 8(2), 131 - 141.
    • Maxwell PH (2005). The HIF pathway in cancer.. Seminars in Cell and Developmental Biology, 16(4), 523 - 530.
    • Raval RR, Lau KW, Tran MGB, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ (2005). Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. MOL CELL BIOL, 25(13), 5675 - 5686. doi:10.1128/MCB.13.5675-5686.2005
    • Esteban MA, Maxwell PH (2005). Manipulation of oxygen tensions for in vitro cell culture using a hypoxic workstation.. Expert Review of Proteomics, 2(3), 307 - 314.
    • Tran MG, Esteban MA, Hill PD, Chandra A, O'Brien TS, Maxwell PH (2005). von Hippel-Lindau inactivation downregulates the cell-cell adhesion molecule E cadherin in renal cancer cells.
    • Wang SJ, Dangerfield J, Voisin MB, Tran M, Maxwell P, Sorokin L, Nourshargh S (2005). Pre-formed matrix protein "low expression" regions act as exit points for leukocytes migrating through the venular perivascular basement membrane.
    • Chen S, Song C, Guo H, Xu P, Huang W, Zhou Y, Sun J, Li CX, Du Y, Li X, Liu Z, Geng D, Maxwell PH, Zhang C, Wang Y (2005). Distinct novel mutations affecting the same base in the NIPA1 gene cause autosomal dominant hereditary spastic paraplegia in two Chinese families.. Human Mutation, 25(2), 135 - 141.
    • Maxwell PH (2005). A common pathway for genetic events leading to pheochromocytoma.. Cancer Cell, 8(2), 91 - 93.
    • van der Schaft DW, Hillen F, Pauwels P, Kirschmann DA, Castermans K, Egbrink MG, Tran MG, Sciot R, Hauben E, Hogendoorn PC, Delattre O, Maxwell PH, Hendrix MJ, Griffioen AW (2005). Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia.. Cancer Res, 65(24), 11520 - 11528. doi:10.1158/0008-5472.CAN-05-2468
    • Gläsker S, Lonser RR, Tran MG, Ikejiri B, Butman JA, Zeng W, Maxwell PH, Zhuang Z, Oldfield EH, Vortmeyer AO (2005). Effects of VHL deficiency on endolymphatic duct and sac.. Cancer Res, 65(23), 10847 - 10853. doi:10.1158/0008-5472.CAN-05-1104

    2004

    • Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin WJ, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP (2004). Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.. Cancer Research, 64(9), 3350 - 3356. doi:10.1164/rccm.200402-230OC
    • Jà rgensen JS, Rosenberger C, Wiesener MS, Warnecke C, Hà rstrup JH, Grà fe M, Philipp S, Griethe W, Maxwell PH, Frei U, Bachmann S, Willenbrock R, Eckardt KU (2004). Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium.. The FASEB Journal, 18(12), 1415 - 1417.
    • Angelillo-Scherrer A, Burnier L, Fish R, Plaisance S, Martinez-Soria E, Maxwell P, Collen D, Izui S, Conway EM, Carmeliet P (2004). Critical amplification by Gas6 of the Epo-dependent erythropoietic response to anemia: Novel opportunities for anemia treatment.
    • Kinderlerer AR, Mankoff R, Maxwell PH, Haskard DO, Mason JC (2004). UPREGULATION OF MEMBRANE-BOUND COMPLEMENT REGULATORY PROTEINS BY ATORVASTATIN PROTECTS VASCULAR ENDOTHELIUM AGAINST COMPLEMENT-MEDIATED INJURY DURING HYPOXIA-REOXYGENATION. RHEUMATOLOGY, 43, 8 - 8.
    • Maxwell PH (2004). HIF-1's relationship to oxygen: simple yet sophisticated.. Cell Cycle, 3(2), 156 - 159.
    • Wykoff CC, Sotiriou C, Cockman ME, Ratcliffe PJ, Maxwell P, Liu E, Harris AL (2004). Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene.. British Journal of Cancer, 90(6), 1235 - 1243. doi:10.1038/sj.bjc.6601657
    • Maxwell P (2004). Hypoxia-inducible factors and tumour pathways.
    • Li YJ, Du Y, Li CX, Guo H, Leung JC, Lam MF, Yang N, Huang F, Chen Y, Fang JQ, Maxwell PH, Lai KN, Wang Y (2004). Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene.. Journal of the American Society of Nephrology, 15(7), 1739 - 1743.
    • Willam C, Nicholls LG, Ratcliffe PJ, Pugh CW, Maxwell PH (2004). The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.. Advances in Enzyme Regulation, 44, 75 - 92.
    • Maxwell P, Salnikow K (2004). HIF-1: an oxygen and metal responsive transcription factor.. Cancer Biol Ther., 3(1), 29 - 35.

    2003

    • Wang YM, Du Y, Leung JCK, Li CX, Lam MF, Guo H, Xue C, Fang JQ, Maxwell PH, Lai N, Li YJ (2003). Megsin 2093TT genotype is associated with a protective role in IgA nephropathy..
    • Hedborg F, Ullerà s E, Grimelius L, Wassberg E, Maxwell PH, Hero B, Berthold F, Schilling F, Harms D, Sandstedt B, Franklin G (2003). Evidence for hypoxia-induced neuronal-to-chromaffin metaplasia in neuroblastoma.. The FASEB Journal, 17(6), 598 - 609.
    • Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P (2003). Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.. Journal of Clinical Investigation, 111(10), 1519 - 1527.
    • Brusselmans K, Compernolle V, Tjwa M, Wiesener MS, Maxwell PH, Collen D, Carmeliet P (2003). Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia.. J Clin Invest, 111(10), 1519 - 1527. doi:10.1172/JCI15496
    • Kinderlerer AR, Mankoff R, Maxwell PH, Haskard DO, Mason JC (2003). Atorvastatin protects vascular endothelium from complement-mediated ischaemia-reperfusion injury by upregulation of complement regulatory proteins.
    • Maxwell P (2003). HIF-1: an oxygen response system with special relevance to the kidney.. J Am Soc Nephrol, 14(11), 2712 - 2722.
    • Wiesener MS, Maxwell PH (2003). HIF and oxygen sensing; as important to life as the air we breathe?. Annals of Medicine, 35(3), 183 - 190.
    • Maxwell P (2003). Intracellular proteolysis controlling oxygen responsiveness.
    • Kinderlerer AR, Mankoff R, Maxwell PH, Haskard DO, Mason JC (2003). Upregulation of membrane-bound complement regulatory proteins by atorvastatin protects vascular endothelium against complement-mediated injury during hypoxia-reoxygenation..
    • Morris M, Ready SMJ, Wiesener M, Maxwell P, Howie A, Latif F, Maher ER (2003). Analysis of VHL tumour suppressor gene (TSG) targets in sporadic and familial renal cell carcinoma (RCC).

    2002

    • Rosenberger C, Mandriota S, Jurgensen JS, Wiesener MS, Ratcliffe PJ, Maxwell P, Bachmann S, Eckardt KU (2002). Expression of hypoxia-inducible factors-1alpha and-2alpha in hypoxic and ischemic rat kidneys. FASEB J, 16(5), A887 - A888.
    • Onita T, Ji PG, Xuan JW, Sakai H, Kanetake H, Maxwell PH, Fong GH, Gabril MY, Moussa M, Chin JL (2002). Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer.. Clinical Cancer Research, 8(2), 471 - 480.
    • Maxwell PH, Ratcliffe PJ (2002). Oxygen sensors and angiogenesis.. Seminars in Cell and Developmental Biology, 13(1), 29 - 37.
    • Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH (2002). Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.. Advances in Enzyme Regulation, 42, 333 - 347.
    • Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH (2002). HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.. Cancer Cell, 1(5), 459 - 468.
    • Binley K, Askham Z, Iqball S, Spearman H, Martin L, De Alwis M, Thrasher AJ, Ali RR, Maxwell PH, Kingsman S, Naylor S (2002). Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy. BLOOD, 100(7), 2406 - 2413.
    • Pugh CW, Maxwell PH, Ratcliffe PJ (2002). Oxygen mediated gene regulation. NEPHROLOGY, 7, S21 - S25.
    • Turner KJ, Moore JW, Jones A, Taylor CF, Cuthbert-Heavens D, Han C, Leek RD, Gatter KC, Maxwell PH, Ratcliffe PJ, Cranston D, Harris AL (2002). Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.. Cancer Research, 62(10), 2957 - 2961.
    • Ang S, Stockton D, Hirota K, Gordeuk V, Jelinek J, Sergueeva A, Maxwell P, Semenza G, Prchal J (2002). Oxygen sensing and Chuvash Polycythemia. EXP HEMATOL, 30(6), 43 - 43.
    • McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ (2002). The use of dioxygen by HIF prolyl hydroxylase (PHD1).. Bioorganic and Medicinal Chemistry Letters, 12(12), 1547 - 1550.
    • Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY (2002). Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.. Nature, 417(6892), 975 - 978.
    • Maxwell PH (2002). Oxygen homeostasis and cancer: insights from a rare disease.. Clinical Medicine, 2(4), 356 - 362.
    • Rosenberger C, Mandriota S, JÃ rgensen JS, Wiesener MS, HÃ rstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU (2002). Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.. Journal of the American Society of Nephrology, 13(7), 1721 - 1732.
    • Willam C, Masson N, Tian YM, Mahmood SA, Wilson MI, Bicknell R, Eckardt KU, Maxwell PH, Ratcliffe PJ, Pugh CW (2002). Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis.. Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10423 - 10428.
    • Rinsch C, Dupraz P, Schneider BL, DÃ glon N, Maxwell PH, Ratcliffe PJ, Aebischer P (2002). Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia.. Kidney International, 62(4), 1395 - 1401.
    • Wiesener MS, Jurgensen JS, Rosenberger C, Scholze C, Horstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH, Eckardt KU (2002). Widespread, hypoxia-inducible expression of HIF-2 alpha in distinct cell populations of different organs. FASEB J, 16(14), 271 - +. doi:10.1096/fj.02-0445fje
    • Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL, Prchal JT (2002). Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia.. Nature Genetics, 32(4), 614 - 621.

    2001

    • Vaux EC, Wood SM, Cockman ME, Nicholls LG, Yeates KM, Pugh CW, Maxwell PH, Ratcliffe PJ (2001). Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor.. Journal of Biological Chemistry, 276(47), 44323 - 44330.
    • Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ (2001). C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.. Cell, 107(1), 43 - 54.
    • Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ (2001). Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.. The EMBO Journal, 20(18), 5197 - 5206.
    • Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER (2001). The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.. Oncogene, 20(36), 5067 - 5074.
    • Wiesener MS, Mà nchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, Jà rgensen JS, Gruber G, Maxwell PH, Là ning SA, Frei U, Maher ER, Grà ne HJ, Eckardt KU (2001). Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.. Cancer Research, 61(13), 5215 - 5222.
    • Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ (2001). Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.. IUBMB Life, 52(1), 43 - 47.
    • Maxwell PH, Pugh CW, Ratcliffe PJ (2001). Activation of the HIF pathway in cancer.. Current Opinion in Genetics and Development, 11(3), 293 - 299.
    • Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim AV, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ (2001). Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.. Science, 292(5516), 468 - 472.
    • Yap LB, Bowler IC, Maxwell PH (2001). Guiding hands of our teachers.. The Lancet, 357(9254), 480 - .
    • Wykoff CC, Pugh CW, Harris AL, Maxwell PH, Ratcliffe PJ (2001). The HIF pathway: implications for patterns of gene expression in cancer.. Novartis Found Symp, 240, 212 - 225.
    • Maxwell PH, Pugh CW, Ratcliffe PJ (2001). Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation.. Experimental Nephrology, 9(4), 235 - 240.
    • Maxwell PH, Buckley C, Gleadle JM, Mason PD (2001). Nasty shock after an anti-emetic.. Nephrology Dialysis Transplantation, 16(5), 1069 - 1072.
    • Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, Maher ER (2001). Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.. Human Molecular Genetics, 10(10), 1029 - 1038.
    • Pugh CW, Gleadle J, Maxwell PH (2001). Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways.. Breast Cancer Research, 3(5), 313 - 317.
    • Maxwell PH, Pugh CW, Ratcliffe PJ (2001). The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.. Advances in Experimental Medicine and Biology, 502, 365 - 376.
    • Brusselmans K, Bono F, Maxwell P, Dor Y, Dewerchin M, Collen D, Herbert JM, Carmeliet P (2001). Hypoxia-inducible factor-2alpha (HIF-2alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia.. Journal of Biological Chemistry, 276(42), 39192 - 39196. doi:10.1074/jbc.C100428200

    2000

    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL (2000). The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.. American Journal Of Pathology, 157(2), 411 - 421.
    • Pandit JJ, Maxwell PH (2000). New insights into the regulation of erythropoietin production.. British Journal of Anaesthesia, 85(2), 329 - 330.
    • Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, Lewis C, Harris A, Kingsman S, Naylor S (2000). The macrophage - a novel system to deliver gene therapy to pathological hypoxia.. Gene Ther, 7(3), 255 - 262. doi:10.1038/sj.gt.3301058
    • Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P LC, Harris A KS, Naylor S (2000). The macrophage - a novel system to deliver gene therapy to pathological hypoxia.. Gene Therapy, 7(3), 255 - 262. doi:10.1089/hum.2008.023
    • Ren X, Dorrington KL, Maxwell PH, Robbins PA (2000). Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans.. Journal of Applied Physiology, 89(2), 680 - 686.
    • Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ (2000). Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.. Oncogene, 19(54), 6297 - 6305.
    • Ratcliffe PJ, Pugh CW, Maxwell PH (2000). Targeting tumors through the HIF system.. Nature Medicine, 6(12), 1315 - 1316.
    • Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH (2000). Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.. Journal of Biological Chemistry, 275(33), 25733 - 25741.
    • Wykoff CC, Beasley NJ, Watson PH, Turner KJ, Pastorek J, Sibtain A, Wilson GD, Turley H, Talks KL, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL (2000). Hypoxia-inducible expression of tumor-associated carbonic anhydrases.. Cancer Research, 60(24), 7075 - 7083.

    1999

    • Maxwell P, Somerville J (1999). Aortic atresia: survival to adulthood without surgery.. British Heart Journal, 64(5), 336 - 337.
    • Pugh CW, Chang GW, Cockman M, Epstein AC, Gleadle JM, Maxwell PH, Nicholls LG, O'Rourke JF, Ratcliffe PJ, Raybould EC, Tian YM, Wiesener MS, Wood M, Wykoff CC, Yeates KM (1999). Regulation of gene expression by oxygen levels in mammalian cells.. Advances in Nephrology, 29, 191 - 206.
    • Peacock SJ, Curtis N, Berendt AR, Bowler IC, Winearls CG, Maxwell P (1999). Outcome following haemodialysis catheter-related Staphylococcus aureus bacteraemia.. Journal of Hospital Infection, 41(3), 223 - 228.
    • Ringrose TR, Mason PD, Winearls CG, Maxwell PH (1999). Tunnelled vascular catheters for haemodialysis: the Tesio catheter.. KIDNEY INT, 55(5), 2094 - 2094.
    • Clifford SC, Maxwell PH, Wiesener MS, Chang GW, Smallwood AV, Ratcliffe PJ, Maher ER (1999). Interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease causing pVHL mutants. J MED GENET, 36, S25 - S25.
    • Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.. Nature, 399(6733), 271 - 275.
    • Maher ER, Clifford SC, Maxwell PH, Wiesener MS, Chang GW, Ratcliffe PJ (1999). The interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease-causing pVHL mutants.. AM J HUM GENET, 65(4), A10 - A10.
    • Maxwell P, Ferguson D, Nicholls L, Johnson M, Ratcliffe P (1999). Fibroblast-like cells in renal injury show phenotypic changes and hare reduced potential for erythropoietin gene expression.. KIDNEY INT, 55(5), 2098 - 2098.

    1998

    • Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans , K , Dewerchin , M , Neeman , M , Bono , F , Abramovitch , R , Maxwell , P , Koch , CJ , Ratcliffe , P , Moons , L , Jain , RK , Collen , D , Keshert , E (1998). Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.. Nature, 394(6692), 485 - 490. doi:10.1038/28867
    • Maxwell P, Fitzpatrick R (1998). End stage renal failure and assessment of health related quality of life. Quality in Health Care, 7(42), 182 - .
    • Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E (1998). Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998). NATURE, 395(6701), 525 - 525.
    • Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, Maxwell PH (1998). Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.. Blood, 92(7), 2260 - 2268.
    • Maxwell P, Ratcliffe P (1998). Regulation of expression of the erythropoietin gene.. Current Opinion in Hematology, 5(3), 166 - 170.
    • Ratcliffe PJ, O'Rourke JF, Maxwell PH, Pugh CW (1998). Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.. Journal of Experimental Biology, 201(8), 1153 - 1162.
    • Wood SM, Wiesener MS, Yeates KM, Okada N, Pugh CW, Maxwell PH, Ratcliffe PJ (1998). Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.. Journal of Biological Chemistry, 273(14), 8360 - 8368.

    1997

    • Ratcliffe PJ, Ebert BL, Firth JD, Gleadle JM, Maxwell PH, Nagao M, O'Rourke JF, Pugh CW, Wood SM (1997). Oxygen regulated gene expression: erythropoietin as a model system.. Kidney International, 51(2), 514 - 526.
    • Raja KB, Maxwell PH, Ratcliffe PJ, Salisbury JR, Simpson RJ, Peters TJ (1997). Iron metabolism in transgenic mice with hypoplastic anaemia due to incomplete deficiency of erythropoietin.. British Journal of Haematology, 96(2), 248 - 253.
    • O'Rourke JF, Dachs GU, Gleadle JM, Maxwell PH, Pugh CW, Stratford IJ, Wood SM, Ratcliffe PJ (1997). Hypoxia response elements.. Oncology Research, 9(6), 327 - 332.
    • Maxwell PH, Winearls CG (1997). Recurrence of autonomous hyperparathyroidism in dialysis patients.. Nephrology Dialysis Transplantation, 12(10), 2195 - 2200.
    • Maxwell PH, Ferguson DJ, Nicholls LG, Johnson MH, Ratcliffe PJ (1997). The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression.. Kidney International, 52(3), 715 - 724.
    • Ratcliffe PJ, Maxwell PH, Pugh CW (1997). Beyond erythropoietin: the oxygen sensor.. Nephrology Dialysis Transplantation, 12(9), 1842 - 1848.
    • Abelson J, Maxwell PH, Maxwell RJ (1997). Do professions have a future? Perhaps, if they are not defensive or complacent. BRIT MED J, 315(7105), 382 - 382.
    • Abelson J, Maxwell PH, Maxwell RJ (1997). Do professions have a future?. BMJ (Clinical Research Ed.), 315(7105), 382 - .
    • Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ (1997). Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.. Proceedings of the National Academy of Sciences of the United States of America, 94(15), 8104 - 8109.
    • Ratcliffe PJ, Dachs G, Ebert BL, Firth JD, Gleadle JM, Maxwell PH, ORourke JF, Pugh CW, Stratford I, Wood SM (1997). Oxygen-regulated gene expression in mammalian cells. J PHYSIOL-LONDON, 499P, S13 - S14.
    • Maxwell PH, Ferguson DJ, Nicholls LG, Iredale JP, Pugh CW, Johnson MH, Ratcliffe PJ (1997). Sites of erythropoietin production.. Kidney International, 51(2), 393 - 401.

    1996

    • Maxwell PH, Ratcliffe PJ (1996). The erythropoietin-producing cells.. Experimental Nephrology, 4(6), 309 - 313.

    1995

    • Peacock SJ, Maxwell P, Stanton A, Jeffery KJ (1995). Two cases of infected atherosclerotic aneurysms and a comparison with infective endocarditis.. European Journal of Clinical Microbiology and Infectious Diseases, 14(11), 1004 - 1008.
    • Ratcliffe PJ, Ebert BL, Ferguson DJ, Firth JD, Gleadle JM, Maxwell PH, Pugh CW (1995). Regulation of the erythropoietin gene.. Nephrology Dialysis Transplantation, 10(2), 18 - 27.

    1994

    • Pugh CW, Ebert BL, Ebrahim O, Maxwell PH, Ratcliffe PJ (1994). Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines.. Ann N Y Acad Sci, 718, 31 - 39.
    • Maxwell PH, Ferguson DJ, Osmond MK, Pugh CW, Heryet A, Doe BG, Johnson MH, Ratcliffe PJ (1994). Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells.. Blood, 84(6), 1823 - 1830.
    • FERGUSON DJP, MAXWELL PH, RATCLIFFE PJ (1994). Ultrastructural characterization of erythropoietin producing cells in the kidney and liver using transgenic mice.
    • Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJ, Johnson MH, Ratcliffe PJ (1994). Erythropoietin-producing cells in transgenic mice expressing SV40 large T antigen directed by erythropoietin control sequences.. Annals of the New York Academy of Sciences, 718, 356 - 358.
    • FERGUSON DJP, MAXWELL PH, RATCLIFFE PJ (1994). Localisation of ecto-5'-nucleotidase in mouse kidney using immunoelectron microscopy.

    1993

    • Maxwell PH, Abbott J, Koffman CG, Dave J (1993). Haemophilus influenzae as a rare cause of CAPD peritonitis.. Journal of Infection, 26(3), 340 - 341.
    • Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJ, Johnson MH, Ratcliffe PJ (1993). Identification of the renal erythropoietin-producing cells using transgenic mice.. Kidney International, 44(5), 1149 - 1162.
    • PUGH CW, MAXWELL PH, NICHOLLS LG, EBRAHIM O, BARTLETT SM, RATCLIFFE PJ (1993). INDUCIBLE OPERATION OF THE ERYTHROPOIETIN 3' ENHANCER IN DIFFERENT CELL-LINES - EVIDENCE FOR A WIDESPREAD OXYGEN-SENSING MECHANISM IN MAMMALIAN-CELLS.
    • Maxwell PH, Pugh CW, Ratcliffe PJ (1993). Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.. Proceedings of the National Academy of Sciences of the United States of America, 90(6), 2423 - 2427.

    1992

    • Paterson-Brown S, Chappatte OA, Clark SK, Wright A, Maxwell P, Taub NA, Raju KS (1992). The significance of cone biopsy resection margins.. Gynecologic Oncology, 46(2), 182 - 185.

    1989

    • Maxwell P, Barker R (1989). Sarawak: our elective.. J R Soc Med, 82(8), 496 - 497.
    • Rosin MD, Ridley PD, Maxwell PH (1989). Rupture of a pseudoaneurysm of a saphenous vein coronary arterial bypass graft presenting with superior caval venous obstruction.. International Journal of Cardiology, 25(1), 121 - 123.

    1988

    • Barker RA, Maxwell PH, Hong CP, Cordery MC, Chrystie IL (1988). Paediatric gastroenteritis in the eastern Malaysian state of Sarawak: an epidemiological and clinical study.. Transactions of the Royal Society of Tropical Medicine and Hygiene, 82(6), 898 - 901.