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Prof Mervyn Singer

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Personal Profile

Name: Mervyn Singer Email: m.singer@ucl.ac.uk
Title: Prof Tel: 0207 679 6714
Department: Clinical Physiology Fax: 0207 679 6952
Position: Clinical Professor of Intensive Care Medicine Address: UCL, Cruciform Building, Gower Street, London, WC1E 6BT
Research Domain: Experimental Medicine, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description

1) Mechanisms of sepsis-induced multiple organ failure with particular emphasis on the role of mitochondrial dysfunction 2) Mechanisms of septic shock (and other shock states) with emphasis on the roles of nitric oxide, vasopressin, catecholamines and potassium channels 3) Management and diagnosis of infection (including infection control) in critical care 4) Haemodynamics including physiology and pathophysiology pertaining to shock states 5) Monitoring techniques to assess the macro- and microcirculation, and the adequacy of organ perfusion

Research Activities

Critical Care Medicine

Staphylococci

Understaning the cellular players and soluble medi

critical care

Education Description

UCL Collaborators

Dr Mike Grocott; Dr Geoffrey Bellingan; Prof Sir Salvador Moncada; Prof Mark Peters; Prof Quentin Pankhurst; Prof Tony Segal; Prof Derek Gilroy; Dr Sean Nair; Prof Hugh Montgomery; Prof John Martin; Prof Michael Duchen; Prof Arne Akbar; Prof Monty Mythen; Prof Ivan Parkin; Prof Mike Ehrenstein; Prof Lucie Clapp; Prof Steve Humphries; Prof Aroon Hingorani

External Collaborators

Publications

    2013

    • Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D'Egidio A, D'Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M (2013). Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock: A Randomized Clinical Trial.. JAMA, , - . doi:10.1001/jama.2013.278477
    • Dyson A, Simon F, Seifritz A, Zimmerling O, Matallo J, Calzia E, Radermacher P, Singer M (2013). Erratum to: Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges.. Intensive Care Med, 39(4), 797 - . doi:10.1007/s00134-013-2821-3
    • Rudiger A, Dyson A, Felsmann K, Carré JE, Taylor V, Hughes S, Clatworthy I, Protti A, Pellerin D, Lemm J, Claus RA, Bauer M, Singer M (2013). Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis.. Clin Sci (Lond), 124(6), 391 - 401. doi:10.1042/CS20120334
    • Umbrello M, Dyson A, Feelisch M, Singer M (2013). The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching.. Antioxid Redox Signal, 19(14), 1690 - 1710. doi:10.1089/ars.2012.4979
    • Arulkumaran N, Annear NM, Singer M (2013). Patients with end-stage renal disease admitted to the intensive care unit: systematic review.. Br J Anaesth, 110(1), 13 - 20. doi:10.1093/bja/aes401
    • Recknagel P, Gonnert FA, Halilbasic E, Gajda M, Jbeily N, Lupp A, Rubio I, Claus RA, Kortgen A, Trauner M, Singer M, Bauer M (2013). Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats.. Liver Int, 33(2), 283 - 293. doi:10.1111/liv.12012

    2012

    • Shankar-Hari M, Spencer J, Sewell WA, Rowan KM, Singer M (2012). Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective. CRITICAL CARE, 16(2), - . doi:10.1186/cc10597
    • Hill NE, Murphy KG, Singer M (2012). Ghrelin, appetite and critical illness.. Curr Opin Crit Care, 18(2), 199 - 205. doi:10.1097/MCC.0b013e3283514b01
    • Needleman I, Hyun-Ryu J, Brealey D, Sachdev M, Moskal-Fitzpatrick D, Bercades G, Nagle J, Lewis K, Agudo E, Petrie A, Suvan J, Donos N, Singer M (2012). The impact of hospitalization on dental plaque accumulation: an observational study.. J Clin Periodontol, 39(11), 1011 - 1016. doi:10.1111/j.1600-051X.2012.01939.x
    • Dyson A, Cone S, Singer M, Ackland GL (2012). Microvascular and macrovascular flow are uncoupled in early polymicrobial sepsis.. Br J Anaesth, 108(6), 973 - 978. doi:10.1093/bja/aes093
    • Chan YL, Orie NN, Dyson A, Taylor V, Stidwill RP, Clapp LH, Singer M (2012). Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis. Critical Care Medicine, 40(4), 1261 - 1268. doi:10.1097/CCM.0b013e31823da98d
    • Singer M (2012). Oesophageal Doppler monitoring: a not-so-NICE editorial.. Anaesthesia, 67(4), 428 - 430. doi:10.1111/j.1365-2044.2012.07111.x
    • Arulkumaran N, Montero RM, Singer M (2012). Management of the dialysis patient in general intensive care.. Br J Anaesth, 108(2), 183 - 192. doi:10.1093/bja/aer461
    • Singer M (2012). Management of fluid balance: a European perspective.. Curr Opin Anaesthesiol, 25(1), 96 - 101. doi:10.1097/ACO.0b013e32834e8150
    • Rudiger A, Singer M (2012). Acute kidney injury. LANCET, 380(9857), 1904 - 1904.
    • Atlas G, Brealey D, Dhar S, Dikta G, Singer M (2012). Additional hemodynamic measurements with an esophageal Doppler monitor: a preliminary report of compliance, force, kinetic energy, and afterload in the clinical setting. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 26(6), 473 - 482. doi:10.1007/s10877-012-9386-5
    • Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carré JE, Kortgen A, Krafft C, Popp J, Sponholz C, Fuhrmann V, Hilger I, Claus RA, Riedemann NC, Wetzker R, Singer M, Trauner M, Bauer M (2012). Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis.. PLoS Med, 9(11), e1001338 - . doi:10.1371/journal.pmed.1001338
    • Cuesta JM, Singer M (2012). The stress response and critical illness: a review.. Crit Care Med, 40(12), 3283 - 3289. doi:10.1097/CCM.0b013e31826567eb
    • Singer M, Rhodes A (2012). Obituary - David Bennett.. Crit Care, 16(2), 122 - . doi:10.1186/cc11234
    • Singer M, Rhodes A (2012). David bennett 1938-2012.. Intensive Care Med, 38(5), 910 - 911. doi:10.1007/s00134-012-2526-z
    • O'Brien AJ, Welch CA, Singer M, Harrison DA (2012). Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients.. Intensive Care Med, 38(6), 991 - 1000. doi:10.1007/s00134-012-2523-2
    • Dyson A, Simon F, Seifritz A, Zimmerling O, Matallo J, Calzia E, Radermacher P, Singer M (2012). Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges.. Intensive Care Med, 38(11), 1868 - 1876. doi:10.1007/s00134-012-2712-z

    2011

    • Townsend W, Holroyd A, Pearce RM, Mackinnon S, Goldstone AH, Linch DC, Peggs KS, Thomson K, Singer M, Naik P, Howell D, Morris E (2011). A Simple Prognostic Score to Predict Short and Long-Term Survival Following ICU Admission in Critically III Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients: Improved Survival Following Reduced Intensity Conditioning.
    • Singer M (2011). Oesophageal Doppler monitoring: should it be routine for high-risk surgical patients?. Curr Opin Anaesthesiol, 24(2), 171 - 176. doi:10.1097/ACO.0b013e32834452b2
    • Polito A, Sonneville R, Guidoux C, Barrett L, Viltart O, Mattot V, Siami S, de la Grandmaison GL, Chretien F, Singer M, Gray F, Annane D, Brouland J-P, Sharshar T (2011). Changes in CRH and ACTH Synthesis during Experimental and Human Septic Shock. PLOS ONE, 6(11), - . doi:10.1371/journal.pone.0025905
    • Moreno R, Sprung CL, Annane D, Chevret S, Briegel J, Keh D, Singer M, Weiss YG, Payen D, Cuthbertson BH, Vincent J-L (2011). Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study. INTENSIVE CARE MEDICINE, 37(11), 1765 - 1772. doi:10.1007/s00134-011-2334-x
    • Adlakha A, Pavlou M, Walker DA, Copas AJ, Dufty N, Batson S, Edwards SG, Singer M, Miller RF (2011). Survival of HIV-infected patients admitted to the intensive care unit in the era of highly active antiretroviral therapy.. Int J STD AIDS, 22(9), 498 - 504. doi:10.1258/ijsa.2011.010496
    • Singer M, Matthay MA (2011). Clinical review: Thinking outside the box--an iconoclastic view of current practice.. Crit Care, 15(4), 225 - . doi:10.1186/cc10245
    • Singer M, Brealey D (2011). Another nail in the hammer's coffin?. Crit Care, 15(4), 179 - . doi:10.1186/cc10311
    • Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RA, Saeed S, Carré JE, Singer M, Gems D, Hartley RC, Partridge L, Murphy MP (2011). Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix.. Cell Metab, 13(3), 340 - 350. doi:10.1016/j.cmet.2011.02.003
    • Dyson A, Singer M (2011). Tissue oxygen tension monitoring: will it fill the void?. Curr Opin Crit Care, 17(3), 281 - 289. doi:10.1097/MCC.0b013e328344f1dc
    • O'Brien AJ, Terala D, Orie NN, Davies NA, Zolfaghari P, Singer M, Clapp LH (2011). BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis.. Shock, 35(5), 485 - 491. doi:10.1097/SHK.0b013e31820860f5
    • Wilson AP, Smyth D, Moore G, Singleton J, Jackson R, Gant V, Jeanes A, Shaw S, James E, Cooper B, Kafatos G, Cookson B, Singer M, Bellingan G (2011). The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals.. Crit Care Med, 39(4), 651 - 658. doi:10.1097/CCM.0b013e318206bc66
    • Sprung CL, Annane D, Singer M, Moreno R, Keh D, Grp CORTICUSS (2011). Glucocorticoids in sepsis: dissecting facts from fiction. CRITICAL CARE, 15(5), - . doi:10.1186/cc10428
    • Vincent J-L, Rhodes A, Perel A, Martin GS, Della Rocca G, Vallet B, Pinsky MR, Hofer CK, Teboul J-L, de Boode W-P, Scolletta S, Vieillard-Baron A, De Backer D, Walley KR, Maggiorini M, Singer M (2011). Clinical review: Update on hemodynamic monitoring - a consensus of 16. CRITICAL CARE, 15(4), - . doi:10.1186/cc10291
    • Fullerton JN, Singer M (2011). Organ Failure in the ICU: Cellular Alterations. SEMIN RESP CRIT CARE, 32(5), 581 - 586. doi:10.1055/s-0031-1287866
    • Gonnert FA, Westermann M, Felsmann K, Claus RA, Singer M, Trauner M, Bauer M (2011). Protection against sepsis-associated cholestaiss despite aggravated hepatocellular injury by selective knock-out of phosphoinositide 3-kinase gamma. SHOCK, 36, 28 - 28.
    • Miller R, Edwards S, Singer M (2011). 12 Intensive care.. HIV Med, 12 Suppl 2, 109 - 111. doi:10.1111/j.1468-1293.2011.00944_13.x
    • Dyson A, Bryan NS, Fernandez BO, Garcia-Saura MF, Saijo F, Mongardon N, Rodriguez J, Singer M, Feelisch M (2011). An integrated approach to assessing nitroso-redox balance in systemic inflammation.. Free Radic Biol Med, 51(6), 1137 - 1145. doi:10.1016/j.freeradbiomed.2011.06.012
    • Dyson A, Rudiger A, Singer M (2011). Temporal changes in tissue cardiorespiratory function during faecal peritonitis.. Intensive Care Med, 37(7), 1192 - 1200. doi:10.1007/s00134-011-2227-z
    • Prowle JR, Heenen S, Singer M (2011). Infection in the critically ill--questions we should be asking.. J Antimicrob Chemother, 66 Suppl 2, ii3 - i10. doi:10.1093/jac/dkq517
    • Dyson A, Bezemer R, Legrand M, Balestra G, Singer M, Ince C (2011). Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia.. Shock, 36(1), 83 - 89. doi:10.1097/SHK.0b013e3182169d5a
    • Singer M, Jones AM (2011). Bench-to-bedside review: the role of C1-esterase inhibitor in sepsis and other critical illnesses.. Crit Care, 15(1), 203 - . doi:10.1186/cc9304
    • Brealey DA, Singer M, Terblanche M (2011). Potential metabolic consequences of statins in sepsis.. Crit Care Med, 39(6), 1514 - 1520. doi:10.1097/CCM.0b013e31820eb74f
    • Corona A, Singer M (2011). An epistemological dilemma: is ertapenem adequate to treat severe infections in critically ill patients?. MINERVA ANESTESIOLOGICA, 77(11), 1027 - 1029.

    2010

    • Adlakha AG, Pavlou M, Walker D, Copas AJ, Batson S, Edwards SG, Singer M, Miller RF (2010). SURVIVAL OF HIV-INFECTED PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT. doi:10.1136/thx.2010.150938.33
    • Protti A, Russo R, Tagliabue P, Vecchio S, Singer M, Rudiger A, Foti G, Rossi A, Mistraletti G, Gattinoni L (2010). Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication. CRIT CARE, 14(1), - . doi:10.1186/cc8885
    • Ackland GL, Yao ST, Rudiger A, Dyson A, Stidwill R, Poputnikov D, Singer M, Gourine AV (2010). Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats.. Crit Care Med, 38(2), 388 - 394. doi:10.1097/CCM.0b013e3181c03dfa
    • Ackland GL, Del Arroyo AG, Yao ST, Stephens RC, Dyson A, Klein NJ, Singer M, Gourine AV (2010). Low molecular weight polyethylene glycol improves survival in experimental sepsis.. Critical Care Medicine, 38, 629 - 636.
    • Brame AL, Singer M (2010). Stressing the obvious? An allostatic look at critical illness.. Crit Care Med, 38(10 Suppl), S600 - S607. doi:10.1097/CCM.0b013e3181f23e92
    • Singer M, Matthay MA (2010). Thinking outside the box: Introduction.. Crit Care Med, 38(10 Suppl), S511 - . doi:10.1097/CCM.0b013e3181f3250f
    • Vincent JL, Singer M, Marini JJ, Moreno R, Levy M, Matthay MA, Pinsky M, Rhodes A, Ferguson ND, Evans T, Annane D, Hall JB (2010). Thirty years of critical care medicine. CRIT CARE, 14(3), - . doi:10.1186/cc8979
    • Vincent JL, Singer M (2010). Critical Care 3 Critical care: advances and future perspectives. LANCET, 376(9749), 1354 - 1361. doi:10.1016/S0140-6736(10)60575-2
    • del Arroyo AG, Singer M, Ackland GL (2010). NEURO-IMMUNOMODULATION OF HUMAN CD14+CD16+NEUTROPHILS IN SEPSIS.
    • Barnes SJ, Singer M, Ackland GL (2010). DOBUTAMINE STRESS ECHOCARDIOGRAPHY UNMASKS MYOCARDIAL DYSFUNCTION IN EARLY RODENT POLYMICROBIAL SEPSIS.
    • Nash R, Carre JE, Dyson A, Singer M (2010). TISSUE PGC-1A MRNA LEVELS IN A RODENT MODEL OF SEPSIS.
    • Ackland GL, Dyson A, Singer M (2010). Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest.. JAMA, 304(13), 1440 - . doi:10.1001/jama.2010.1396
    • Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M, Hobbs AJ (2010). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A.. Br J Pharmacol, 160(8), 2045 - 2054. doi:10.1111/j.1476-5381.2010.00830.x
    • Mongardon N, Singer M (2010). The evolutionary role of nutrition and metabolic support in critical illness.. Crit Care Clin, 26(3), 443 - viii. doi:10.1016/j.ccc.2010.04.001
    • Singer M (2010). A plea for balanced reporting Response. CRIT CARE, 14(2), - .
    • Reade M, Huang DT, Bell D, Coats TJ, Cross AM, Moran JL, Peake SL, Singer M, Yealy DM, Angus DC (2010). Variability in management of early sepsis. Emergency Medicine Journal, 27, 110 - 115.
    • Carré JE, Orban JC, Re L, Felsmann K, Iffert W, Bauer M, Suliman HB, Piantadosi CA, Mayhew TM, Breen P, Stotz M, Singer M (2010). Survival in critical illness is associated with early activation of mitochondrial biogenesis.. Am J Respir Crit Care Med, 182(6), 745 - 751. doi:10.1164/rccm.201003-0326OC
    • Sonneville R, Guidoux C, Barrett L, Viltart O, Mattot V, Polito A, Siami S, de la Grandmaison GL, Blanchard A, Singer M, Annane D, Gray F, Brouland JP, Sharshar T (2010). Vasopressin Synthesis by the Magnocellular Neurons is Different in the Supraoptic Nucleus and in the Paraventricular Nucleus in Human and Experimental Septic Shock. BRAIN PATHOL, 20(3), 613 - 622. doi:10.1111/j.1750-3639.2009.00355.x
    • Singer M (2010). A plea for balanced reporting.. Crit Care, 14(2), 414 - . doi:10.1186/cc8942
    • Corona A, Bertolini G, Lipman J, Wilson AP, Singer M (2010). Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC).. J Antimicrob Chemother, 65(6), 1276 - 1285. doi:10.1093/jac/dkq088
    • Corona A, Singer M (2010). Antibiotic prophylaxis to prevent surgical site infections: should it be prolonged or just perioperative and efficacious?. MINERVA ANESTESIOL, 76(6), 389 - 391.

    2009

    • O'Brien A, Stidwill RP, Clapp LH, Singer M (2009). Variable effects of inhibiting inducible nitric oxide synthase and closing the vascular ATP-sensitive potassium channel via its pore-forming and sulfonylurea receptor subunits in endotoxic shock.. Shock, 31(5), 535 - 541.
    • O'Brien A, Stidwill RP, Clapp LH, Singer M (2009). Variable effects of inhibiting inducible nitric oxide synthase and closing the vascular ATP-sensitive potassium (KATP) channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock. Shock, 31, 535 - 541.
    • Mongardon N, Dyson A, Singer M (2009). Is MOF an outcome parameter or a transient, adaptive state in critical illness?. Curr Opin Crit Care, 15(5), 431 - 436. doi:10.1097/MCC.0b013e3283307a3b
    • Zolfaghari P, Singer M, Duchen MR (2009). UNCOUPLING PROTEIN-3 MEDIATES THE LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL IN SEVERE SEPSIS.
    • Carre JE, Re L, Orban JC, Felsmann K, Suliman H, Stotz M, Breen P, Bellingan G, Piantadosi C, Bauer M, Singer M (2009). MITOCHONDRIAL BIOGENESIS RESPONSE IS ASSOCIATED WITH POSITIVE OUTCOME IN CRITICALLY ILL PATIENTS.
    • Dyson A, Legrand M, Bezemer R, Balestra G, Singer M, Ince C (2009). SIMULTANEOUS ASSESSMENT OF RENAL MICROVASCULAR AND INTERSTITIAL OXYGEN TENSION DURING ENDOTOXAEMIA.
    • O'Brian A, Singer M, Harrison D, Welsh C (2009). LIVER CIRRHOSIS AND INTENSIVE CARE, UNHAPPY BEDFELLOWS? AN ANALYSIS OF ADMISSIONS TO ICU WITH CIRRHOSIS OVER A 12 YEAR PERIOD FROM THE INTENSIVE CARE NATIONAL AUDIT & RESEARCH CENTRE (ICNARC) DATABASE.
    • Hari MS, Shovel L, Singer M, O'Brian A (2009). DESCRIPTIVE EVALUATION OF CIRRHOTIC PATIENTS ADMITTED TO A GENERAL INTENSIVE CARE UNIT WITH ACUTE DECOMPENSATION OF CHRONIC LIVER DISEASE.
    • Sprung CL, Annane D, Singer M, Cuthbertson BH, Briegel J (2009). Steroids in Patients With Septic Shock. CHEST, 136(1), 323 - 324. doi:10.1378/chest.09-0329
    • Singer M (2009). Oesophageal Doppler.. Curr Opin Crit Care, 15(3), 244 - 248. doi:10.1097/MCC.0b013e32832b7083
    • Holroyd A, Townsend W, Naik P, Mackinnon S, Howell D, Goldstone A, Linch D, Peggs K, Thomson K, Singer M, Morris E (2009). Favourable outcome for haematopoietic transplant recipients requiring intensive therapy unit admission: a 10-year single-centre experience.
    • Zolfaghari PS, Packer S, Singer M, Nair SP, Bennett JH, Street C, Wilson M (2009). In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent. BMC Microbiology, 9, 1 - 8. doi:10.1186/1471-2180-9-27
    • Holroyd A, Townsend W, Naik P, Mackinnon S, Howell D, Goldstone A, Linch D, Peggs K, Thomson K, Singer M, Morris E (2009). Favourable outcome for allogeneic haematopoietic transplant recipients requiring intensive therapy unit admission with improved survival following reduced intensity conditioning.
    • Mongardon N, Dyson A, Singer M (2009). Pharmacological optimization of tissue perfusion.. Br J Anaesth, 103(1), 82 - 88. doi:10.1093/bja/aep135
    • Briegel J, Sprung CL, Annane D, Singer M, Keh D, Moreno R, Mohnle P, Weiss Y, Avidan A, Brunkhorst FM, Fiedler F, Vogeser M, CORTICUS Study Grp (2009). Multicenter comparison of cortisol as measured by different methods in samples of patients with septic shock. INTENS CARE MED, 35(12), 2151 - 2156. doi:10.1007/s00134-009-1627-9
    • Cuthbertson BH, Sprung CL, Annane D, Chevret S, Garfield M, Goodman S, Laterre PF, Vincent JL, Freivogel K, Reinhart K, Singer M, Payen D, Weiss YG (2009). The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. INTENS CARE MED, 35(11), 1868 - 1876. doi:10.1007/s00134-009-1603-4
    • Mongardon N, Singer M (2009). Etomidate versus ketamine for sedation in acutely ill patients. LANCET, 374(9697), 1240 - 1240.
    • Dyson A, Stidwill R, Taylor V, Singer M (2009). The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage.. Intensive Care Med, 35(10), 1783 - 1791. doi:10.1007/s00134-009-1577-2
    • Squara P, Cecconi M, Rhodes A, Singer M, Chiche JD (2009). Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. INTENS CARE MED, 35(10), 1801 - 1808. doi:10.1007/s00134-009-1570-9
    • Kidd IM, Down J, Nastouli E, Shulman R, Grant PR, Howell DC, Singer M (2009). H1N1 pneumonitis treated with intravenous zanamivir.. Lancet, 374(9694), 1036 - . doi:10.1016/S0140-6736(09)61528-2
    • Wang Z, Taylor V, Stidwill R, Leiper JM, Singer M (2009). A NOVEL DDAH1 INHIBITOR IMPROVES SURVIVAL IN A LONG TERM CONSCIOUS MODEL OF SEPTIC SHOCK.
    • Wang Z, Taylor V, Stidwill R, Leiper JM, Singer M (2009). COMPARISON OF DDAH-1 INHIBITION AND NOS INHIBITIOR L-NMMA IN AN ENDOTOXAEMIC RAT MODEL.
    • Wang Z, Taylor V, Stidwill R, Leiper JM, Singer M (2009). LOW DOSE L-NMMA IMPROVES SURVIVAL IN A LONG-TERM RAT MODEL OF SEPTIC SHOCK.
    • Smyth D, Bellingan G, Singer M, Moore G, Singleton J, Jackson R, Jeanes A, James E, Shaw S, Cooper B, Wilson P (2009). DOES HIGH INTENSITY OF CLEANING OF THE ICU ENVIRONMENT REDUCE COLONISATION AND HEALTHCARE-ACQUIRED INFECTION: A RANDOMISED MULTICENTRE CROSS-OVER COHORT STUDY?.
    • Zolfaghari P, Stidwill R, Singer M (2009). MYOCARDIAL DYSFUNCTION IN A 24 HOUR MOUSE MODEL OF SEPSIS.
    • Chan YL, Taylor V, Stidwill R, Clapp LH, Singer M (2009). SYMPATHETIC TONE AND VASCULAR KATP CHANNEL ACTIVITY.
    • O'Brian A, Terala D, Orie N, Singer M, Clapp LH (2009). NULL MICE FOR THE CALCIUM ACTIVATED POTASSIUM CHANNEL ARE NOT RESISTANT TO HYPOTENSION AND SURVIVAL IS NOT IMPROVED COMPARED TO THEIR WILD TYPE LITTER MATES IN A FLUID RESUSCITATED MODEL OF FECAL PERITONITIS.
    • Mongardon N, Dyson A, Taylor V, Stidwill R, Singer M (2009). EFFECTS OF SODIUM HYDROGEN SULPHIDE DURING ENDOTOXAEMIA.
    • O'Brian AJ, Clapp LH, Singer M (2009). CHARACTERISATION OF A FLUID RESUSCITATED MODEL OF FECAL PERITONITIS WITH CONTINUOUS BLOOD PRESSURE MONITORING IN A CONSCIOUS MOUSE.
    • Tritapepe L, De Santis V, Vitale D, Guarracino F, Pellegrini F, Pietropaoli P, Singer M (2009). Levosimendan pre-treatment improves outcomes in patients undergoing coronary artery bypass graft surgery. BRIT J ANAESTH, 102(2), 198 - 204. doi:10.1093/bja/aen367
    • Dyson A, Singer M (2009). Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting?. Crit Care Med, 37(1 Suppl), S30 - S37. doi:10.1097/CCM.0b013e3181922bd3
    • Brealey D, Singer M (2009). Hyperglycemia in critical illness: a review.. J Diabetes Sci Technol, 3(6), 1250 - 1260.

    2008

    • Chan YL, Orie NN, Singer M, Clapp LH (2008). Enhanced expression of vascular K-ATP channels in an in vitro model of sepsis.
    • Panayiotou CM, Stidwill R, Taylor V, Singer M, Hobbs AJ (2008). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. FASEB JOURNAL, 22, - .
    • Harvey SE, Welch CA, Harrison DA, Rowan KM, Singer M (2008). Post hoc insights from PAC-Man - The UK pulmonary artery catheter trial. CRIT CARE MED, 36(6), 1714 - 1721. doi:10.1097/CCM.0b013e318174315d
    • Sprung CL, Singer M, Annane D, CORTICUS Study Grp (2008). Corticosteroids for septic shock - Reply. NEW ENGL J MED, 358(19), 2070 - 2071.
    • Corona A, Cislaghi F, Raimondi F, Singer M (2008). Italy versus the United Kingdom: differing styles for treating bacteremia in the critically ill patient, but who's right?. MINERVA ANESTESIOL, 74(5), 157 - 165.
    • Rudiger A, Carre J, Singer M, Felsmann K, Bauer M (2008). RELATIONSHIP BETWEEN EARLY SEPSIS-INDUCED CARDIAC DYSFUNCTION AND EVENTUAL OUTCOME..
    • Rudiger A, Stotz M, Singer M (2008). Cellular processes in sepsis. SWISS MED WKLY, 138(43-44), 629 - 634.
    • Barrett L, Taylor V, Clapp L, Singer M (2008). DIFFERENT CALCIUM MOBILISATION PATHWAYS UNDERLIE THE CHANGES IN VASCULAR REACTIVITY TO NOREPINEPHRINE AND VASOPRESSIN IN SEPTIC SHOCK. J INFECTION, 57(5), 429 - 430.
    • Carre JE, Singer M (2008). Cellular energetic metabolism in sepsis. doi:10.1016/j.bbabio.2008.05.171
    • Singer M (2008). Cellular dysfunction in sepsis.. Clin Chest Med, 29(4), 655 - ix. doi:10.1016/j.ccm.2008.06.003
    • Corona A, Cislaghi F, Raimondi F, Singer M (2008). Italy versus the United Kingdom: differing styles for treating bacteremia in the critically ill patient, but who's right?. Minerva Anestesiol., 74, 155 - 161.
    • Marik PE, Pastores SM, Annane D, Meduri GU, Sprung CL, Arlt W K, D B, J B, A D, I T, S S, M C, G P ZG, Bokhari F, Vogeser MACOCCM (2008). Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine.. Critical Care Medicine, 36, 1937 - 1949.
    • Harvey SE, Welch CA, Harrison DA, Rowan KM, Singer M (2008). Post hoc insights from PAC-Man - the U.K. pulmonary artery catheter trial.. Critical Care Medicine, 36(1714), 1721 - .
    • Carré JE, Singer M (2008). Cellular energetic metabolism in sepsis: the need for a systems approach. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777(7-8), 763 - 771. doi:10.1016/j.bbabio.2008.04.024
    • Corona A, Cislaghi F, Singer M (2008). Timely selection of adequate antifungal therapy for candidemia in the critically ill: Don't let the yeast rise!. CRIT CARE MED, 36(11), 3097 - 3098. doi:10.1097/CCM.0b013e31818b9375

    2007

    • Lipiner-Friedman D, Sprung CL, Laterre PF, Weiss Y, Goodman SV, Vogeser M, Briegel J, Keh D, Singer M, Moreno R B, E A, Group DCS (2007). Adrenal function in sepsis: the retrospective Corticus cohort study.. Critical Care Medicine, 35, 1012 - 1018.
    • Protti A, Singer M (2007). Strategies to modulate cellular energetic metabolism during sepsis.. Novartis Found Symp, 280, 7 - 16.
    • Gibot S, Massin F, Marcou M, Taylor V, Stidwill R, Wilson P, Bellingan G (2007). TREM-1 promotes survival during septic shock in mice.. European Journal of Immunology, 37(2), 456 - 466.
    • Harrison DA, Singer M (2007). The Pancreatitis Outcome Prediction (POP) score: How about hematocrit and leukopenia?. Crit Care Med, 35(11), 2671 - 2672. doi:10.1097/01.CCM.0000288116.76928.B2
    • Engelhardt T, Ahlers O, Sprung CL, Briegel J, Volk HD, Annane D, Moreno R, Singer M, Gerlach , Keh D (2007). Immune effects of hydrocortisone in septic shock - results from the CORTICUS Berlin Study Group. INFECTION, 35, 19 - 19.
    • Abraham EA, Singer M (2007). Mechanisms of sepsis-induced organ dysfunction.. Critical Care Medicine, 35, 2408 - 2416.
    • Belikova I, Lukaszewicz AC, Faivre V, Damoisel C, Singer M, Payen D (2007). Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis.. Critical Care Medicine, 35, 2702 - 2708.
    • Dyson A, Stidwill R, Taylor V, Singer M (2007). Tissue oxygen monitoring in rodent models of shock.. American Journal of Physiology - Heart and Circulatory Physiology, 293, H526 - H533.
    • Dickson SJ, Batson S, Copas AJ, Edwards SG, Singer M, Miller RF (2007). Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy. Thorax, 62(11), 964 - 968. doi:10.1136/thx.2006.072256
    • Wilson AP, Hayman S, Whitehouse T, Cepeda J, Kibbler C, Shaw S, Zelaya C, Cookson B, Singer M, Bellingan G (2007). Importance of the environment for patient acquisition of methicillin-resistant Staphylococcus aureus in the intensive care unit: a baseline study.. Critical Care Medicine, 35(10), 2275 - 2279. doi:10.1097/01.CCM.0000284504.89948.6E
    • Barrett LK, Singer M, Clapp LH (2007). Vasopressin: mechanisms of action on the vasculature in health and in septic shock. Critical Care Medicine, 35(1), 33 - 40.
    • Barrett LK, Orie NN, Taylor V, Stidwill RP, Clapp LH, Singer M (2007). Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis. Critical Care Medicine, 35(10), 2337 - 2343.
    • Harrison DA, D'Amico G, Singer M (2007). Case mix, outcome, and activity for admissions to UK critical care units with severe acute pancreatitis: a secondary analysis of the ICNARC Case Mix Programme Database.. Critical Care, 11, S1 - .
    • Singer M (2007). Powering up failed organs. American Journal of Respiratory and Critical Care Medicine, 176, 733 - 734.
    • Singer M (2007). Mitochondrial function in sepsis: acute phase versus multiple organ failure.. Critical Care Medicine, 35, S441 - S448.
    • Singer M (2007). Why aren't we practising homogenized medicine?. Critical Care, 11, 157 - 158.
    • Protti A, Carré J, Frost MT, Taylor V, Stidwill R, Rudiger A, Singer M (2007). Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle.. Critical Care Medicine, 35, 2150 - 2155.
    • Singer M (2007). Catecholamine treatment for shock-equally good or bad?. The Lancet, 370, 636 - 637.
    • Singer M, Protti A (2007). Oxidative stress and critical illness. Minerva Anestesiol., 73, 255 - 257.
    • Harrison DA, D'Amico G, Singer M (2007). The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis.. Critical Care Medicine, 35, 1703 - 1708.
    • Yassin J, Singer M (2007). Fundamentals of oxygen delivery.. Contributions to Nephrology, 156, 119 - 132.
    • Rudiger A, Singer M (2007). Mechanisms of sepsis-induced cardiac dysfunction.. Critical Care Medicine, 35, 1599 - 1608.
    • Singer M (2007). System interactions. Novartis Found Symp, 280, 252 - 260.
    • Hayman S, Wilson AP, Singer M, Bellingan G (2007). Effect of linezolid and teicoplanin on skin staphylococci.. Journal of Antimicrobial Chemotherapy, 59(6), 1281 - 1282.

    2006

    • Buckley JF, Singer M, Clapp LH (2006). Role of K-ATP channels in sepsis. CARDIOVASC RES, 72(2), 220 - 230. doi:10.1016/j.cardiores.2006.07.011
    • Protti A, Singer M (2006). Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure.. Crit Care, 10(5), 228 - . doi:10.1186/cc5014
    • Singer M (2006). The FTc is not an accurate marker of left ventricular preload. Reply to the comment by Chemla and Nitenberg. INTENS CARE MED, 32(9), 1456 - 1457. doi:10.1007/s00134-006-0280-9
    • Singer M (2006). The FTc is not an accurate marker of left ventricular preload. INTENS CARE MED, 32(7), 1089 - 1089. doi:10.1007/s00134-006-0157-y
    • Buckley JF, Singer M, Clapp LH (2006). Role of KATP channels in sepsis. Cardiovas. Res., , - .
    • Buckley JF, Singer M, Clapp LH (2006). The role of KATP channels in sepsis. Cardiovas. Res., 72, 220 - 230.
    • Whitehouse T, Stotz M, Taylor V, Stidwill R, Singer M (2006). Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion. American Journal of Physiology - Renal Physiology, 291(3), F647 - F653.
    • Tritapepe L, De Santis V, Vitale D, Santulli M, Morelli A, Nofroni I, Puddu PE, Singer M, Pietropaoli P (2006). Preconditioning effects of levosimendan in coronary artery bypass grafting--a pilot study.. British Journal of Anaesthesia, 96(6), 694 - 700.
    • Svistunenko DA, Davies N, Brealey D, Singer M, Cooper CE (2006). Mitochondrial dysfunction in patients with severe sepsis: an EPR interrogation of individual respiratory chain components.. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1757(4), 262 - 272.
    • Wilson AP, Hayman S, Cepeda JA, Singer M, Bellingan G (2006). Screening for MRSA and GISA in the intensive care unit.. Journal of Hospital Infection, 64(1), 85 - 86.
    • Wilson AP, Hayman S, Folan P, Ostro PT, Birkett A, Batson S, Singer M, Bellingan G (2006). Computer keyboards and the spread of MRSA. Journal of Hospital Infection, 62(3), 390 - 392.
    • Corona A, Wilson AP, Grassi M, Singer M (2006). Short-course monotherapy strategy for treating bacteremia in the critically ill.. Minerva Anestesiol., 72(10), 841 - 857.
    • Miller RF, Allen E, Copas A, Singer M, Edwards SG (2006). Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy.. Thorax, 61(8), 716 - 721. doi:10.1136/thx.2005.055905
    • Alves JD, Clapp BR, Stidwill R, Chen PP, Hingorani AD, Singer M, Isenberg DA (2006). Human monoclonal IgG anticardiolipin antibodies induce nitric oxide synthase expression.. Atherosclerosis, 185(2), 246 - 253. doi:10.1016/j.atherosclerosis.2005.06.044
    • Singer M (2006). The key advance in the treatment of sepsis in the last 10 years...doing less.. Crit Care, 10(1), 122 - . doi:10.1186/cc4849
    • Wilson AP, Cepeda JA, Hayman S, Whitehouse T, Singer M, Bellingan G (2006). In vitro susceptibility of Gram-positive pathogens to linezolid and teicoplanin and effect on outcome in critically ill patients.. Journal of Antimicrobial Chemotherapy, 58(2), 470 - 473.
    • Protti A, Singer M (2006). Bench-to-bedside review: Potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure.. Critical Care, 10(5), e228 - .
    • Singer M (2006). The Surviving Sepsis guidelines: evidence-based ... or evidence-biased?. Critical Care and Resuscitation, 8(3), 244 - 245.
    • Harvey S, Singer M (2006). Managing critically ill patients with a pulmonary artery catheter.. British Journal of Hospital Medicine, 67(8), 421 - 426.
    • (2006). An evaluation of the clinical and cost-effectiveness of pulmonary artery catheters in patient management in intensive care: a systematic review and a randomised controlled trial.. Health Technol Assess, 10(29), 1 - 15.
    • Singer M (2006). The FTc is not an accurate marker of left ventricular preload.. Intensive Care Medicine, 32(7), 108 - 108.
    • Vincent JL, Fink MP, Marini JJ, Pinsky MR, Sibbald WJ, Singer M, Suter PM, Cook D, Pepe PE, Evans T (2006). Intensive care and emergency medicine: progress over the past 25 years.. Chest, 129(4), 1061 - 1067.
    • Corona A, Raimondi F, Singer M (2006). Statin use and mortality in the bacteremic critically ill patient.. Critical Care Medicine, 34(4), 1270 - 1272.
    • Singer M (2006). The key advance in the treatment of sepsis in the last 10 years... doing less.. Critical Care, 10(1), e122 - .
    • Carré J, Singer M, Moncada S (2006). Nitric oxide.. In Abraham E, Singer M (Ed.), Mechanisms of sepsis-induced organ dysfunction and recovery (pp. 77 - 95). : Springer-Verlag.
    • Whitehouse T, Stotz M, Taylor V, Stidwill R, Singer M (2006). Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion. AM J PHYSIOL-RENAL, 291(3), F647 - F653. doi:10.1152/ajprenal.00475.2005.

    2005

    • Miller RF, Singer M, Edwards SG (2005). Improving survival from HIV associated Pneumocystis jirovecii pneumonia admitted to the intensive care unit.
    • Singer M (2005). Sepsis-induced mitochondrial inhibition - A mechanism for multiorgan failure.. and for long-term survival?.
    • Harvey S, Harrison DA, Singer M, Ashcroft J, Jones CM, Elbourne D, Brampton W, Williams D, Young D, Rowan K, PAC-Man Study Collaboration (2005). Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. LANCET, 366(9484), 472 - 477.
    • Ng J, Finney SJ, Shulman R, Bellingan GJ, Singer M, Glynne PA (2005). Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil?. British Journal of Anaesthesia, 94(6), 774 - 777.
    • Singer M, Glynne P (2005). Treating critical illness: the importance of first doing no harm.. PLOS Medicine, , - .
    • Ng J, Finney SJ, Shulman R, Bellingan GJ, Singer M, Glynne PA (2005). Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil?. Br J Anaesth, 94(6), 774 - 777. doi:10.1093/bja/aei114
    • Wilson APR, Bellingan G, Singer M (2005). Isolation of patients with MRSA infection - Reply. LANCET, 365(9467), 1304 - 1305.
    • Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, Hayman S, Cookson B, Shaw S, Kibbler C, Singer M, Bellingan G, Wilson AP (2005). Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. The Lancet, 365(9456), 295 - 304. doi:10.1016/S0140-6736(05)17783-6
    • O'Brien AJ, Thakur G, Buckley JF, Singer M, Clapp LH (2005). The pore-forming subunit of the KATP channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro.. British Journal of Pharmacology, 144(3), 367 - 375.
    • Davies NA, Brealey DA, Stidwill R, Singer M, Svistunenko DA, Cooper CE (2005). Nitrosyl heme production compared in endotoxemic and hemorrhagic shock.. Free Radical Biology and Medicine, 38(1), 41 - 49. doi:10.1016/j.freeradbiomed.2004.09.026
    • Shulman R, Singer M, Goldstone J, Bellingan G (2005). Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit.. Critical Care, 9(5), R516 - R521.
    • Singer M, Coluzzi F, O'Brien AJ, Clapp LH (2005). Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide.. The Lancet, 365(9474), 1873 - 1875. doi:10.1016/S0140-6736(05)66619-6
    • Clapp BR, Hirschfield GM, Storry C, Gallimore JR, Stidwill RP, Singer M, Deanfield JE, MacAllister RJ, Pepys MB, Vallance P, Hingorani AD (2005). Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability. Circulation, 111(12), 1530 - 1536. doi:10.1161/01.CIR.0000159336.31613.31
    • Clapp BR, Hirschfield GM, Storry C, Gallimore JR, Stidwill RP, Singer M, Deanfield JE, MacAllister RJ, Pepys MB, Vallance P, Hingorani AD (2005). Inflammation and endothelial function: direct vascular effects of human c reactive protein on NO bioavailability. Circulation, (111), 1530 - 1536.
    • Whitehouse T, Cepeda JA, Shulman R, Aarons L, Nalda-Molina R, Tobin C, MacGowan A, Shaw S, Kibbler C, Singer M, Wilson AP (2005). Pharmacokinetic studies of linezolid and teicoplanin in the critically ill. Journal of Antimicrobial Chemotherapy, 55(3), 333 - 340.
    • Harvey S, Harrison , D A, Singer , M (2005). Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care. (PAC-Man): a randomised controlled trial.. The Lancet, 366, 472 - 477. doi:10.1016/S0140-6736(05)67061-4
    • Frost MT, Wang Q, Moncada S, Singer M (2005). Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages.. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 288(2), R394 - R400.
    • Morelli A, DeCatro S, Teboul JL, Singer M, Rocco M, Conti G, DeLuca L, Pietrapoli P (2005). Effects of levosimendan on systemic and regional haemodynamics in septic myocardial depression.. Intensive Care Medicine, 31(5), 638 - 644.
    • Nieminen MS, Bohm M, Cowie MR, Singer M, Singh S, Tendera M, Thygesen K (2005). Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. European Heart Journal, 26(4), 384 - 416.
    • Singer M (2005). Give oxygen, get a blood pressure... but don't overdo it.. Hospital Medicine, 66(2), 73 - 75.
    • Zerizer I, Chan WH, Singer M (2005). Intramural feeding: a complication of percutaneous endoscopic gastrostomy feeding.. European Journal of Gastroenterology and Hepatology, , - .
    • Corona A, Singer M (2005). Central venous catheter-related bacteraemia: Epidemiology, severity of illness and therapy.

    2004

    • Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, Hayman S, Shaw S, Kibbler C, Shulman R, Singer M, Wilson AP (2004). Linezolid versus teicoplanin in the treatment of Gram-positive infections in the critically ill: a randomized, double-blind, multicentre study. Journal of Antimicrobial Chemotherapy, 53(2), 345 - 355.
    • Rabuel C, Renaud E, Brealey D, Ratajczak P, Damy T, Alves A, Habib A, Singer M, Payen D, Mebazaa A (2004). Human septic myopathy: induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway.. Anesthesiology, 101(3), 583 - 590.
    • McKendry M, McGloin H, Saberi D, Caudwell L, Brady AR, Singer M (2004). Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery.. BMJ (Clinical Research Ed.), 329(7460), 258 - .
    • Brealey DA, Karyampudi S, Jaques TS, Stidwill R, Taylor V, Smolenski RT, Singer M (2004). Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure.. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 286(3), R491 - R497.
    • Singer M (2004). Anaesthetist or intensivist: continued debate.. Hospital Medicine, , - .
    • Corona A, Wilson APR, Grassi M, Singer M (2004). Could we treat bacteremia in the critically ill with a short strategy? Results of a 6 month prospective audit.. Internet Journal of Infectious Diseases, 3(2), - .
    • Singer M (2004). To transuse or not transfuse? That is the question.
    • Singer M, De Santis V, Vitale D, Jeffcoate W (2004). Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation.. The Lancet, 364(9433), 545 - 548.
    • Corona A, Raimondi F, Singer M (2004). Severe bloodstream infections from the community: risk factors and outcomes.. Critical Care Medicine, 32(4), 1083 - 1084.
    • Corona A, Wilson AP, Grassi M, Singer M (2004). Prospective audit of bacteraemia management in a university hospital ICU using a general strategy of short-course monotherapy. Journal of Antimicrobial Chemotherapy, 54(4), 809 - 817. doi:10.1093/jac/dkh416
    • Alves JD, Clapp BR, Stidwill R, Chen PP, Hingorani AD, Singer M, Isenberg DA (2004). Human monoclonal IGG anticardiolipin antibodies induce nitric oxide synthase expression.
    • Singer M (2004). Significance of mitochondrial dysfunction in the critically ill.
    • Singer M (2004). Protecting the mitochondria - When? How?.
    • Collins P, Singer M, Glynne P (2004). Modulation of hepatic uncoupling protein 2 expression by leptin in polymicrobial sepsis in vivo..

    2003

    • Brealey D, Singer M (2003). Mitochondrial Dysfunction in Sepsis. Current Infectious Disease Reports, 5(5), 365 - 371.
    • Wilson P, Andrews JA, Charlesworth R, Walesby R, Singer M, Farrell DJ, Robbins M (2003). Linezolid resistance in clinical isolates of Staphylococcus aureus.. Journal of Antimicrobial Chemotherapy, 51(1), 186 - 188.
    • Corona A, Bertolini G, Stella A, Rossi C, Wilson P, Singer M (2003). Differing strategies for antibiotic prescribing for bacteraemia in the critically ill patient.
    • Annane D, Briegel J, Keh D, Moreno R, Singer M, Sprung CL (2003). Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone. Critical Care Medicine, 31(8), 2250 - 2251.
    • Singer M (2003). ODM/CardioQ esophageal Doppler technology. Critical Care Medicine, 31(6), 1888 - 1889.
    • Brealey DA, Karyampudi S, Taylor V, Stidwill R, Singer M (2003). Mitochondrial dysfunction in a rodent model of sepsis and multi-organ dysfunction.
    • Hails J, Kwaku F, Wilson AP, Bellingan G, Singer M (2003). Large variation in MRSA policies, procedures and prevalence in English intensive care units: a questionnaire analysis. Intensive Care Medicine, (29), 481 - 483.
    • Norman JT, Stidwill R, Singer M, Fine LG (2003). Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action. Nephron Physiology, 94(2), 39 - 46.
    • Shulman RI, Singer M, Rock J (2003). Continuous renal replacement therapy. Keeping the circuit open: lessons from the lab. Blood Purification, 20(3), 275 - 281.
    • Wilson P, Andrews JA, Charlesworth R, Walesby R, Singer M, Farrell DJ, Robbins M (2003). Linezolid resistance in clinical isolates of Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 51(1), 186 - 188.
    • Norman JT, Stidwill R, Singer M, Fine LG (2003). Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action.. Nephron Physiol, 94(2), p39 - p46.
    • Cepeda JA, Whitehouse T, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, Hayman S, Shaw S, Kibbler C, Singer M, Bellingan G, Wilson APR (2003). Source isolation in intensive care units does not reduce spread of MRSA beyond that achieved by universal precautions: a prospective two-centre study.
    • Singer M, Bellingan G (2003). The use of oxygen in acute exacerbations of chronic obstructive pulmonary disease: a prospective audit of pre-hospital and hospital emergency management. Clinical Medicine, 3(2), 184 - 186.
    • Davies NA, Cooper CE, Stidwill R, Singer M (2003). Inhibition of mitochondrial respiration during early stage sepsis. Advances in Experimental Medicine and Biology, 530, 725 - 736.
    • Singer M (2003). What's in a beat?. INTENS CARE MED, 29(10), 1617 - 1620. doi:10.1007/s00134-003-1766-3
    • Corona A, Bertolini G, Rossi C, Stella A, Wilson P, Singer M (2003). Wide variation in prevalence of bacteraemia: Preliminary results of a multinational survey(basic-2).
    • Corona A, Bertolini G, Stella A, Rossi C, Wilson P, Singer M (2003). Basic (bacteraemia study in ICU) phase 2: Preliminary results of a prospective multicentre audit.
    • Cholley BP, Singer M (2003). Esophageal Doppler: noninvasive cardiac output monitor. Echocardiography, 20(8), 763 - 769.
    • Corona A, Bertolini G, Ricotta AM, Wilson AP, Singer M (2003). Variability of treatment duration for bacteraemia in the critically ill: a multinationalsurvey. Journal of Antimicrobial Chemotherapy, 52(5), 849 - 852.
    • Brealey DA, Karyampudi S, Jacques TS, Novelli M, Stidwill R, Taylor V, Smolenski RT, Singer M (2003). Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, , - .
    • Cepeda J, Hayman S, Whitehouse T, Kibbler CC, Livermore D, Singer M, Wilson AP (2003). Teicoplanin resistance in methicillin-resistant Staphylococcus aureus in an intensive care unit. Journal of Antimicrobial Chemotherapy, 50(3), 533 - 534.
    • Corona A, Wilson P, Singer M (2003). Short course therapy for gram-negative ICU-acquired bacteraemia in a mixed medical-surgical ICU.
    • O'Brien AJ, O'Brien AJ, Stidwill R, Arrigoni F, Singer M, Clapp L (2003). LPS induces inos in all layers of rat mesenteric artery in both in vitro and in vivo models.
    • Brealey DA, Hargreaves I, Heales S, Land J, Smolenski R, Singer M (2003). Recovery from organ failure is associated with improved mitochondrial function in septic patients.

    2002

    • Hails J, Kwaku F, Wilson APR, Bellingan G, Singer M (2002). Large variation in MRSA policies, procedures, and prevalence in English intensive care units. A questionnaire analysis. BRIT J ANAESTH, 89(2), 354P - 355P.
    • Wilson AJ, Alis J, Singer M, Clapp LH (2002). The effects of lipopolysaccharide on levcromakalim- and forskolin-induced relaxation in endothelium-denuded rat aorta.
    • Brealey DA, Karyampudi S, Taylor V, Stidwill R, Singer M (2002). Mitochondrial dysfunction in a rodent model of sepsis and multi organ dysfunction.
    • Whitehouse T, Cepeda J, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, Shaw S, Kibbler C, Wilson P, Singer M (2002). Bacteraemia & LRTI treatment with linezolid in the critically ill: a randomized double-blind.
    • Robb SJ, Brealey D, Karyampudi S, Duchen MR, Bellingan G, Singer M (2002). Decrease in VO2 in renal tubules from septic rats relates to clinical severity and nitric oxide.
    • Robb SJ, Goss A, Duchen MR, Singer M (2002). Nitric oxide independent inhibition of the mitochondrial respiratory chain in HepG2 cells.
    • Naik P, Morris E, Mackinnon S, Singer M (2002). Do critically ill patients with haematological malignancy survive intensive care and beyond?. BRIT J ANAESTH, 89(2), 359P - 359P.
    • O'Brien AJ, Thakur G, Cui Y, Singer M, Clapp LH (2002). Inhibitors of the pore-forming subunit of the K-ATP channel partially reverses endotoxin-induced vascular hyporeactivity in rat superior mesenteric artery.
    • O'Brien AJ, Stidwill R, Clapp LH, Singer M (2002). A direct comparison between iNOS and KATP inhibition in an in vivo model of rat sepsis.
    • O'Brien AJ, O'Brien AJ, Stidwill R, Clapp LH, Singer M (2002). In vivo and in vitro differences in responses to catecholamines and vasopressin in rat models of LPS.
    • Corona A, Wilson P, Singer M (2002). Could SOFA score differentiate survivors from non-survivors in bacteraemic patients?.
    • Corona A, Bertolini G, Ricotta A, Singer M (2002). Antibiotic prescribing policies for bacteraemia: a North-South European divide.
    • Brealey D, Brand M, Hargreaves I, Heales S, Land JM, Smolenski R, Davies NA, Cooper CE, Singer M (2002). Association between mitochondrial dysfunction and severity and outcome of septic shock. The Lancet, 360(9328), 219 - 223. doi:10.1016/S0140-6736(02)09459-X
    • O'Brien A, Clapp L, Singer M (2002). Terlipressin for norepinephrine-resistant septic shock. The Lancet, 359(9313), 1209 - 1210. doi:10.1016/S0140-6736(02)08225-9
    • Shulman RI, Singer M, Rock J (2002). Continuous renal replacement therapy. Keeping the circuit open: lessons from the lab. Blood Purification, 20(3), 275 - 281.
    • Cepeda JA, Whitehouse T, Wilson APR, Singer M, Bellingan G, Kibbler C, Shaw S (2002). MRSA clearance during treatment with linezolid.
    • Cepeda JA, Whitehouse T, Tobin C, Zhang J, MacGowan A, Kibbler C, Shaw S, Wilson APR, Singer M (2002). The Pharmacokinetic Profiles of Linezolid and Teicoplanin in the critically ill..
    • Whitehouse T, Cepeda J, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, Shaw S, Kibbler C, Wilson APR, Singer M (2002). Treatment of bacteraemia and LRTI with linezolid in the critically ill patient: a randomized double-blind comparison against teicoplanin..
    • Shulman RI, Singer M, Rock J (2002). Keeping the circuit open: Lessons from the lab.
    • Singer M (2002). Terlipressin for haemodynamic support in septic patients: a double-edged sword? Reply. LANCET, 360(9341), 1251 - 1251.
    • Whitehouse T, Cepeda J, Cooper B, Hails J, Jones K, Kwaku F, Taylor L, Shaw S, Kibbler C, Wilson APR, Singer M (2002). Treatment of bacteraemia and LRTI with linezolid in the critically ill patient: a randomized double-blind comparison against teicoplanin.
    • Brealey DA, Rabuel C, Mebazaa A, Singer M (2002). iNOS expression and peroxynitrite production is associated with mitochondrial dysfunction in skeleta.
    • Corona A, Bertolini G, Ricotta A, Singer M (2002). UK vs Italy: Differing styles for treating bacteraemia.... But who's right?.
    • Corona A, Bertolini G, Ricotta A, Singer M (2002). Variation in antibiotic prescribing and influence of microbiologist for the treatment of bacteraemia.
    • Corona A, Wilson P, Singer M (2002). Central venous catheter-related bacteraemia: epidemiology, risk factors illness severity & therapy.
    • O'Brien AJ, O'Brien AJ, Singer M, Clapp LH (2002). Only KATP channel inhibitors binding to the pore-forming subunit reverse LPS-induced hyporeactivity.
    • Cepeda JA, Whitehouse T, Cooper B, Hails J, Hayman SJ, Jones K, Kwaku F, Taylor L, Shaw S, Kibbler C, Singer M, Wilson APR (2002). Linezolid versus teicoplanin in the treatment of Gram positive infections in the critically ill: a randomized, double-blind, multicentre study..
    • Coluzzi F, Brealey D, Brand M, Singer M (2002). Comparison of aconitase activity in patients and a rat model of septic shock. BRIT J ANAESTH, 89(2), 352P - 352P.

    2001

    • Corona A, Wilson P, Singer M (2001). Incidence of bacteraemia, severity of illness and outcome: a 6-month prospective audit. BRIT J ANAESTH, 87(2), 374P - 375P.
    • Brealey DA, Brand MP, Greaves IH, Heales SJR, Land JM, Singer M (2001). Septic shock and mitochondrial dysfunction. BRIT J ANAESTH, 87(2), 340P - 340P.
    • O'Brien AJ, Clapp LH, Singer M (2001). NO-cGMP pathway has a major role in endotoxin-induced vascular hyporeactivity in rat mesenteric artery.
    • Corona A, Wilson P, Singer M (2001). Predictive risk factors for colonization and infection of central venous catheters. INTENS CARE MED, 27, S245 - S245.
    • Corona A, Wilson P, Singer M (2001). Short course monotherapy for ICU-acquired gram-negative bacteraemia. INTENS CARE MED, 27, S139 - S139.
    • Park G, Coursin D, Ely EW, England M, Fraser GL, Mantz J, McKinley S, Ramsay M, Scholz J, Singer M, Sladen R, Vender JS, Wild L (2001). Commentary. Balancing sedation and analgesia in the critically ill. Critical Care Clinics, 17(4), 1015 - 1027.
    • Brealey D, Brand M, Hargreaves I, Heales S, Land J, Davies N, Cooper C, Singer M (2001). Mitochondrial inhibition is associated with the severity of human septic shock. BRIT J ANAESTH, 87(2), 340P - 341P.
    • Corona A, Wilson P, Singer M (2001). Central venous catheter-related bacteraemia: Epidemiology, severity of illness and therapy. INTENS CARE MED, 27, S245 - S245.
    • O'Brien AJ, Wilson AJ, Sibbald R, Singer M, Clapp LH (2001). Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model. British Journal of Pharmacology, 133(3), 351 - 360.
    • Corona A, Wilson P, Singer M (2001). Source, type, and resistance patterns of nosocomial bacteraemia in a teaching hospital ICU: a 6-month prospective audit. BRIT J ANAESTH, 87(2), 336P - 337P.
    • Corona A, Bertolini G, Ricotta AM, Singer M (2001). Major differences exist in bacteraemia management. INTENS CARE MED, 27, S237 - S237.
    • O'Brien AJ, Clapp LH, Singer M (2001). The use of glypressin in norepinephrine-resistant septic shock.
    • Morris E, Naik P, Goldstone A, Linch D, Mackinnon S, Singer M (2001). 5 year experience of intensive care for critically ill patients following chemotherapy or bone marrow transplantation: Who should go to ICU?. BLOOD, 98(11), 432A - 433A.
    • Brealey DA, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Singer M (2001). Mitochondrial inhibition is associated with the severity of human septic shock. INTENS CARE MED, 27, S137 - S137.
    • O'Brien AJ, Clapp LH, Singer M (2001). Vascular hyporeactivity in human colonic marginal artery is induced by a cytokine-endotoxin combination.

    2000

    • Brealey D, Singer M (2000). Multi-organ dysfunction in the critically ill: epidemiology, pathophysiology and management. Journal of the Royal College of Physicians of London, 34(5), 424 - 427.
    • Brealey D, Singer M (2000). Multi-organ dysfunction in the critically ill: effects on different organs. Journal of the Royal College of Physicians of London, 34(5), 428 - 431.
    • Penny JA, Anthony J, Shennan AH, De Swiet M, Singer M (2000). A comparison of hemodynamic data derived by pulmonary artery flotation catheter and the esophageal Doppler monitor in preeclampsia. American Journal of Obstetrics and Gynecology, 183(3), 658 - 661.
    • Singer M, Stidwill RP, Nathan A, Gainer JL (2000). Intravenous crocetinate prolongs survival in a rat model of lethal hypoxemia. Critical Care Medicine, 28(6), 1968 - 1972.
    • Wilson AW, O'Brien AJ, Singer M, Clapp LH (2000). Molecular and cellular mecahnisms in endotoxic shock: are potassium channels a novel therapeutic target. The Bulletin, 13, 4 - 9.

    1999

    • Nathan AT, Singer M (1999). The oxygen trail: tissue oxygenation. British Medical Bulletin, 55(1), 96 - 108.
    • Venn RM, Bradshaw CJ, Spencer R, Brealey D, Caudwell E, Naughton C, Vedio A, Singer M, Feneck R, Treacher D, Willatts SM, Grounds RM (1999). Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia, 54(12), 1136 - 1142. doi:10.1046/j.1365-2044.1999.01114.x
    • Poeze M, Ramsay G, Greve JW, Singer M (1999). Prediction of postoperative cardiac surgical morbidity and organ failure within 4 hours of intensive care unit admission using esophageal Doppler ultrasonography [see comments]. Critical Care Medicine, 27(7), 1288 - 1294.
    • Cardigan RA, McGloin H, Mackie IJ, Machin SJ, Singer M (1999). Activation of the tissue factor pathway occurs during continuous venovenous hemofiltration.. Kidney Int, 55(4), 1568 - 1574. doi:10.1046/j.1523-1755.1999.00397.x
    • Begg N, Cartwright KA, Cohen J, Kaczmarski EB, Innes JA, Leen CL, Nathwani D, Singer M, Southgate L, Todd WT, Welsby PD, Wood MJ (1999). Consensus statement on diagnosis, investigation, treatment and prevention of acute bacterial meningitis in immunocompetent adults. British Infection Society Working Party. The Journal of Infectious Diseases, 39(1), 1 - 15.
    • Brealey D, Nathan A, Davies N, Cooper C, Heales S, Land J, Singer M (1999). Mitochondrial dysfunction in human septic shock. BRIT J ANAESTH, 82(5), 786P - 786P.
    • Davies N, Brealey D, Singer M, Heales S, Cooper C (1999). Abnormal mitochondrial respiratory chain activity and glutathione levels in human septic shock. FREE RADICAL BIO MED, 27, S19 - S19.
    • Cardigan RA, McGloin H, Mackie IJ, Machin SJ, Singer M (1999). Activation of the tissue factor pathway occurs during continuous venovenous hemofiltration. Kidney International, 55(4), 1568 - 1574.
    • Singer M, Brealey D (1999). Mitochondrial dysfunction in sepsis.. Biochem Soc Symp, 66, 149 - 166.
    • McGloin H, Adam SK, Singer M (1999). Unexpected deaths and referrals to intensive care of patients on general wards. Are some cases potentially avoidable?. Journal of the Royal College of Physicians of London, 33(3), 255 - 259.
    • Singer M, Little R (1999). ABC of intensive care - Cutting edge. BRIT MED J, 319(7208), 501 - 504.

    1998

    • Stidwill RP, Rosser DM, Singer M (1998). Cardiorespiratory, tissue oxygen and hepatic NADH responses to graded hypoxia. INTENSIVE CARE MED, 24(11), 1209 - 1216.
    • Singer M (1998). Cardiac output in 1998. HEART, 79(5), 425 - 428.
    • Singer M (1998). Management of multiple organ failure: guidelines but no hard-and-fast rules. J ANTIMICROB CHEMOTHER, 41 Sup, 103 - 112.
    • Cardigan R, McGloin H, Mackie I, Machin S, Singer M (1998). Endothelial dysfunction in critically ill patients: the effect of haemofiltration. Intensive Care Medicine, 24(12), 1264 - 1271.
    • Cardigan RA, Singer M, McGloin H, Mackle IJ, Machin SJ (1998). Endothelial dysfunction in intensive care patients: The effect of haemofiltration. BRIT J HAEMATOL, 102(1), 357 - 357.
    • Poeze M, Ramsay G, Grieve JWM, Singer M (1998). Stroke volume versus cardiac output as a marker for predicting postoperative morbidity. BRIT J SURG, 85(6), 868 - 869.

    1997

    • Sinclair S, James S, Singer M (1997). Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial [see comments]. BMJ, 315(7113), 909 - 912.
    • Montgomery H, Sumeray M, Carr C, Singer M (1997). Sinus arrest and severe peripheral vasodilation following cardiopulmonary bypass in a patient taking nicorandil. CARDIOVASC DRUG THER, 11(1), 81 - 81.
    • Salmon J, Cardigan R, Mackie I, Cohen SL, Machin S, Singer M (1997). Continuous venovenous haemofiltration using polyacrylonitrile filters does not activate contact system and intrinsic coagulation pathways. INTENSIVE CARE MED, 23(1), 38 - 43.
    • Cardigan RA, Purdy G, Mackie IJ, Singer M, Machin SJ (1997). FVII is activated during continuous veno-venous haemofiltration (CVVH). THROMB HAEMOSTASIS, , PS431 - PS431.
    • Kong R, Singer M (1997). Insertion of a pulmonary artery flotation catheter: how to do it.. Br J Hosp Med, 57(9), 432 - 435.

    1996

    • Carr CS, Ling KD, Boulos P, Singer M (1996). Randomised trial of safety and efficacy of immediate postoperative enteral feeding in patients undergoing gastrointestinal resection.. BMJ, 312(7035), 869 - 871.
    • Singer M, Millar C, Stidwill R, Unwin R (1996). Bladder epithelial oxygen tension--a new means of monitoring regional perfusion? Preliminary study in a model of exsanguination/fluid repletion.. Intensive Care Med, 22(4), 324 - 328.
    • Rosser DM, Stidwill RP, Jacobson D, Singer M (1996). Cardiorespiratory and tissue oxygen dose response to rat endotoxemia. AM J PHYSIOL-HEART C, 40(3), H891 - H895.
    • Rosser DM, Stidwill RP, Jacobson D, Singer M (1996). Cardiorespiratory and tissue oxygen dose response to rat endotoxemia.. Am J Physiol, 271(3 Pt 2), H891 - H895.

    1995

    • SINCLAIR S, SINGER M (1995). PERIOPERATIVE HEMODYNAMIC MONITORING AND FLUID MANAGEMENT - NCEPOD REVISITED. BRIT J HOSP MED, 53(4), 166 - 168.
    • Singer M, Rosser D, Stidwill R (1995). Bladder epithelial oxygen tension as a marker of organ perfusion.. Acta Anaesthesiol Scand Suppl, 107, 77 - 80.
    • Sinclair S, Singer M (1995). Perioperative haemodynamic monitoring and fluid management--NCEPOD revisited. National Confidential Enquiry into Perioperative Deaths.. Br J Hosp Med, 53(4), 166 - 168.
    • Thompson FJ, Singer M (1995). High dependency units in the UK: variable size, variable character, few in number.. Postgrad Med J, 71(834), 217 - 221.
    • Rosser DM, Stidwill RP, Millar CG, Singer M (1995). The effect of norepinephrine and dobutamine on bladder epithelial oxygen tension.. Chest, 108(5), 1368 - 1372.
    • Rosser DM, Stidwill RP, Jacobson D, Singer M (1995). Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis.. J Appl Physiol (1985), 79(6), 1878 - 1882.

    1994

    • MILLAR CGM, SINGER M, STIDWILL R, UNWIN RJ, NEILD GH (1994). BLADDER EPITHELIAL OXYGEN-TENSION (BEPO2) IS AN INDEX OF RENAL PERFUSION. J AM SOC NEPHROL, 5(3), 608 - 608.
    • SINGER M (1994). CARDIORESPIRATORY EFFECTS OF POSITIVE END-EXPIRATORY PRESSURE - REPLY. CHEST, 106(1), 327 - 328.
    • Singer M, McNally T, Screaton G, Mackie I, Machin S, Cohen SL (1994). Heparin clearance during continuous veno-venous haemofiltration.. Intensive Care Med, 20(3), 212 - 215.
    • Singer M, Vermaat J, Hall G, Latter G, Patel M (1994). Hemodynamic effects of manual hyperinflation in critically ill mechanically ventilated patients.. Chest, 106(4), 1182 - 1187.
    • Singer M, Myers S, Hall G, Cohen SL, Armstrong RF (1994). The cost of intensive care: a comparison on one unit between 1988 and 1991.. Intensive Care Med, 20(8), 542 - 549.

    1993

    • Sinclair S, Singer M (1993). Intensive care.. Postgrad Med J, 69(811), 340 - 358.