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Prof Elizabeth Fisher

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Personal Profile

Name: Elizabeth Fisher Email: elizabeth.fisher@ucl.ac.uk
Title: Prof Tel: 020 3448 4439
Department: Neurodegenerative Diseases Fax: 020 7837 8047
Position: Professor of Neurogenetics Address: Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG
Research Domain: Genetics (Frontier Disciplines), Neuroscience Web Page: Personal Web Page

Profile

Research Description

We are interested in learning more of the genetic basis of two disorders that involve neurodegeneration in humans: motor neuron diseases and Down syndrome. We work with the mouse as a genetic model of humans.

Motor neuron diseases (MNDs) are common and incurable, and arise when the motor neurons that extend from the brain into the spinal cord and out to the muscles, degenerate and die. Spinal muscular atrophy, one form of MND is the biggest single genetic killer of children, and amyotrophic lateral sclerosis (ALS) is an adult form of MND that arises in mid-life. Although single genes are known that cause MNDs, it is not clear how the mutant genes exert their effects or what other genes can modify the pathways involved. Many different cellular systems are affected, including the transport of vesicles, organelles, molecules, in the axon and cell body. We are particularly interested in one transport complex, dynein, which transports many different cargoes from the synapse to the cell body and which moves vesicles around in the cell body. We are looking at the effects of mutant dynein and how this relates to motor neuron cell death.

We are also working with mouse models of Down syndrome. Down syndrome is the most common known genetic form of mental retardation. Down syndrome commonly results in the histopathology of Alzheimerâ??s disease in the brain, in the mid-30s (although not necessarily behavioural changes). Some form of neurodegeneration may be taking place, and, interestingly, there are also changes in axonal transport in Down syndrome. We are characterizing our mouse models in order to look specifically at axonal transport, and then to try to work out which genes are responsible for any changes we find, as such genes are likely to be important for neurodegeneration in the general population.


Research Activities

Neuromuscular and Neurodegenerative Disorders

The neurogenetics of neurodegenerative disease

Education Description

I am graduate tutor for my Department which entails keeping an eye on the progress of, currently, >30 PhD and MD and MRes students.  I send a questionnaire to all graduate students and their primary and secondary supervisors every six months to monitor progress and I see all new graduate students in January of the year they start.  In addition I regularly meet with graduate students – and occasionally supervisors - at their request to discuss academic or other aspects of their PhDs.  The questionnaire system also allows me to monitor supervisors and their approach to students.



Within my own research group, in addition to my own PhD students, I am secondary supervisor for a student from CRUK and two students from elsewhere within UCL and I am very active in meeting these students on a regular basis and being engaged in their PhDs. In addition I take rotation students from the UCL ION 4-year PhD course and Masters and undergradulate students from a variety of UCL courses, and, occasionally, outside courses.



I regularly undertake PhD vivas for UCL and external universities. 

I have taught at Imperial (where I am a Visiting Professor) on a Masters course and at Kings, and have taught on the UCL ION Neuroscience Masters course.



I am also pastoral supervisor for students on the UCL ION Neuroscience masters course. I note that the MRC Prion Unit is developing a 4-year PhD course (driven by Professor Parmjit Jat) and I will monitor the progress of this course. 



I sit on the UCL ION Neuroscience/Clinical Masters committee and on the Higher Degrees Sub-Committee for ION.



I am also the academic Mentor for a lecturer in my Department.

UCL Collaborators

Prof Alan Thompson; Prof John Hardy; Dr Richard Orrell; Prof Sebastian Brandner; Prof Michael Duchen; Prof Linda Greensmith; Dr Shi-Yu Yang; Prof Francesco Muntoni

External Collaborators

Publications

    2014

    • Bunton-Stasyshyn RK, Saccon RA, Fratta P, Fisher EM (2014). SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology: New and Renascent Themes.. Neuroscientist, , - . doi:10.1177/1073858414561795
    • Joyce PI, McGoldrick P, Saccon RA, Weber W, Fratta P, West SJ, Zhu N, Carter S, Phatak V, Stewart M, Simon M, Kumar S, Heise I, Bros-Facer V, Dick J, Corrochano S, Stanford MJ, Luong TV, Nolan PM, Meyer T, Brandner S, Bennett DL, Ozdinler PH, Greensmith L, Fisher EM, Acevedo-Arozena A (2014). A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity.. Hum Mol Genet, , - . doi:10.1093/hmg/ddu605
    • Watson-Scales S, Lana-Elola E, Williamson M, Slender A, Abucewicz D, Fisher E, Tybulewicz V (2014). A newly engineered high-resolution mapping panel to identify dosage-sensitive genes in Down syndrome-associated motor defects. TRANSGENIC RESEARCH, 23(5), 904 - 904.
    • Lana-Elola E, Watson-Scales S, Slender A, Abucewicz D, Martineau A, Douglas C, Mohun T, Fisher E, Tybulewicz V (2014). A newly engineered high-resolution mapping panel to identify dosage-sensitive genes in Down syndrome-associated heart defects. TRANSGENIC RESEARCH, 23(5), 905 - 905.
    • Ricketts T, McGoldrick P, Fratta P, de Oliveira HM, Kent R, Phatak V, Brandner S, Blanco G, Greensmith L, Acevedo-Arozena A, Fisher EM (2014). A Nonsense Mutation in Mouse Tardbp Affects TDP43 Alternative Splicing Activity and Causes Limb-Clasping and Body Tone Defects.. PLoS One, 9(1), e85962 - . doi:10.1371/journal.pone.0085962
    • Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IOC, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EMC, Partridge L, Isaacs AM (2014). C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science, , - . doi:10.1126/science.1256800
    • Garrett CA, Barri M, Kuta A, Soura V, Deng W, Fisher EM, Schiavo G, Hafezparast M (2014). DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.. Brain, 137(Pt 7), 1883 - 1893. doi:10.1093/brain/awu097
    • Fratta P, Nirmalananthan N, Masset L, Skorupinska I, Collins T, Cortese A, Pemble S, Malaspina A, Fisher EM, Greensmith L, Hanna MG (2014). Correlation of clinical and molecular features in spinal bulbar muscular atrophy.. Neurology, , - . doi:10.1212/WNL.0000000000000507
    • Fratta P, Polke JM, Newcombe J, Mizielinska S, Lashley T, Poulter M, Beck J, Preza E, Devoy A, Sidle K, Howard R, Malaspina A, Orrell RW, Clarke J, Lu CH, Mok K, Collins T, Shoaii M, Nanji T, Wray S, Adamson G, Pittman A, Renton AE, Traynor BJ, Sweeney MG, Revesz T, Houlden H, Mead S, Isaacs AM, Fisher EM (2014). Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion.. Neurobiol Aging, , - . doi:10.1016/j.neurobiolaging.2014.07.037

    2013

    • Cortese A, Plagnol V, Brady S, Simone R, Lashley T, Acevedo-Arozena A, de Silva R, Greensmith L, Holton J, Hanna MG, Fisher EM, Fratta P (2013). Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy.. Neurobiol Aging, , - . doi:10.1016/j.neurobiolaging.2013.12.029
    • Wiseman F, Barkus C, Sheppard O, Taylor A, Slender A, Choong X, Cleverley K, Pietrzyk J, Bannerman D, Tybulewicz V, Fisher EMC (2013). Trisomy of chromosome 21 modifies APP pathology in a mouse model.
    • Haas MA, Bell D, Slender A, Lana-Elola E, Watson-Scales S, Fisher EMC, Tybulewicz VLJ, Guillemot F (2013). Alterations to Dendritic Spine Morphology, but Not Dendrite Patterning, of Cortical Projection Neurons in Tc1 and Ts1Rhr Mouse Models of Down Syndrome. PLOS ONE, 8(10), - . doi:10.1371/journal.pone.0078561
    • Anstee QM, Knapp S, Maguire EP, Hosie AM, Thomas P, Mortensen M, Bhome R, Martinez A, Walker SE, Dixon CI, Ruparelia K, Montagnese S, Kuo YT, Herlihy A, Bell JD, Robinson I, Guerrini I, McQuillin A, Fisher EM, Ungless MA, Gurling HM, Morgan MY, Brown SD, Stephens DN, Belelli D, Lambert JJ, Smart TG, Thomas HC (2013). Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.. Nat Commun, 4, 2816 - . doi:10.1038/ncomms3816
    • Fratta P, Collins T, Pemble S, Nethisinghe S, Devoy A, Giunti P, Sweeney MG, Hanna MG, Fisher EM (2013). Sequencing analysis of the spinal bulbar muscular atrophy CAG expansion reveals absence of repeat interruptions.. Neurobiol Aging, , - . doi:10.1016/j.neurobiolaging.2013.07.015
    • Schiavo G, Greensmith L, Hafezparast M, Fisher EM (2013). Cytoplasmic dynein heavy chain: the servant of many masters.. Trends Neurosci, , - . doi:10.1016/j.tins.2013.08.001
    • Strydom A, Consortium L (2013). THE LONDOWNS CONSORTIUM - INVESTIGATING COGNITION AND ALZHEIMER'S DISEASE IN DOWN'S SYNDROME. JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 57(9), 801 - 801.
    • Fratta P, Hanna MG, Fisher EM, Sidle K (2013). An unusual presentation for SOD1-ALS: Isolated facial diplegia.. Muscle Nerve, , - . doi:10.1002/mus.23958
    • Fratta P, Poulter M, Lashley T, Rohrer JD, Polke JM, Beck J, Ryan N, Hensman D, Mizielinska S, Waite AJ, Lai MC, Gendron TF, Petrucelli L, Fisher EM, Revesz T, Warren JD, Collinge J, Isaacs AM, Mead S (2013). Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia.. Acta Neuropathol, , - . doi:10.1007/s00401-013-1147-0
    • Ahmed MM, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EM, Tybulewicz VL, Gardiner KJ (2013). Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.. Hum Mol Genet, 22(9), 1709 - 1724. doi:10.1093/hmg/ddt017
    • Gribble SM, Wiseman FK, Clayton S, Prigmore E, Langley E, Yang F, Maguire S, Fu B, Rajan D, Sheppard O, Scott C, Hauser H, Stephens PJ, Stebbings LA, Ng BL, Fitzgerald T, Quail MA, Banerjee R, Rothkamm K, Tybulewicz VLJ, Fisher EMC, Carter NP (2013). Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome. PLOS ONE, 8(4), - . doi:10.1371/journal.pone.0060482
    • Kara M, Groet J, Letourneau A, Guipponi M, Santoni F, Bena F, Bishop C, Canzonetta C, Murray A, Baldo C, Dagna-Bricarelli F, Ballard D, Syndercombe-Court D, Fusaki N, Hasegawa M, The LonDownS Consortium , Antonarakis S, Nizetic D (2013). AN INTACT GENOME, ISOGENIC HIPSC MODEL FROM A MOSAIC DOWN SYNDROME INDIVIDUAL REVEALS NEUROGENESIS AND MITOCHONDRIAL DEFECTS CAUSED BY TRISOMY 21.
    • Massand E, Karmiloff-Smith A, The LonDownS Consortium (2013). Understanding adult outcomes through infancy studies: Neuro-cognitive phenotypes of infants with Down syndrome may predict protective/risk markers for Alzheimer’s disease.
    • Stokholm J, Teasdale T, Johannsen P, Nielsen J, Nielsen T, Isaacs A, Brown J, Gade A, The FReJA Consortium (2013). Cognitive impairment in athe preclinical stage of dementia in FTD-3 CHMP2B mutation carriers: a longitudinal prospective study. Journal of Neurology, Neurosurgery and Psychiatry, (84), 170 - 176.
    • Ahmed , Dhanasekaran , Tong , Wiseman F, Fisher EMC, Tybulewicz V, Gardiner (2013). Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Molecular Genetics and Genomics: an international journal, , - .
    • Thorne T, Fratta P, Hanna M, Cortese A, Plagnol V, Fisher EMC, Stumpf M (2013). Graphical modelling of molecular networks underlying sporadic inclusion body myositis. Molecular Biosystems, , - .
    • Saccon R, Bunton-Stasyshyn R, Fisher EMC, Fratta P (2013). Is SOD1 loss of function involved in amyotrophic lateral sclerosis?. Brain: a journal of neurology, , - .
    • McGoldrick P, Joyce P, Fisher EMC, Greensmith L (2013). Rodent models of amyotrophic lateral sclerosis. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, , - .
    • Wiseman F, Sheppard O, Barkus C, Choong X, Slender A, Taylor A, Bannerman D, Tybulewicz V, Fisher EMC (2013). Trisomy of chromosome 21 modifies APP pathology in a mouse model.
    • Fisher EMC, Collins T, Sheppard O, Fratta P, Devoy A (2013). Working with mice to help understand motor neuron disease.
    • Fisher EMC, Wiseman F, Tybulewicz V (2013). Mouse models to understand Down syndrome and Alzheimer disease.
    • Holmes H, Wells J, O'Callaghan J, Richardson S, Siow B, Powell N, Ma D, Modat M, Colgan N, Oursellin S, Fisher EMC, Lythgoe M (2013). Morphometric Genomics: in vivo microMRI for 3D structural imaging of transgenic mice.
    • Holmes H, Powell N, Well J, O'Callaghan J, Colgan N, Siow B, Richardson S, O'Neill M, Collins C, Fisher EMC, Oursellin S, Lythgoe M (2013). Tensor-based morphometry as a sensitive biomarker of Alzheimer’s disease neuropathology in a Tau transgenic mouse (Tg4510).
    • Choong X, Raha A, Tybulewicz V, Wiseman F, Fisher EMC (2013). Identification of genes on Hsa21 influencing APP/A pathology using primary neuronal cultures from transgenic mice.
    • Fratta P, Cortese A, Plagnol V, Brady S, Lashley T, Simone R, de Silva R, Greensmith L, Holton J, Fisher EMC, Hanna M (2013). Alterations in RNA metabolism in sporadic inclusion body myositis.
    • McGoldrick P, Joyce P, Saccon R, Acevedo-Arozena A, Fisher EMC, Greensmith L (2013). An ENU-induced point mutation in mouse Sod1 causes aberrant mitochondrial function and axonal maintenance in primary motor neurons.
    • Choong X, Raha A, Tybulewicz V, Wiseman F, Fisher EMC (2013). Which genes on human chromosome 21, other than APP, influence Alzheimer neuropathology?.
    • Choong X, Raha A, Tybulewicz V, Wiseman F, Fisher EMC (2013). Using primary neurons from transgenic mice to identify genes on human chromosome 21 influencing Alzheimer neuropathology.
    • Crawford H, Wiseman F, Fisher EMC, Pocock J (2013). Clues to Down syndrome and Alzheimer’s disease: investigating microglial behaviour in the Tc1 mouse model.
    • Fratta P, Charnock J, Collins T, Devoy A, Howard R, Malaspina A, Orrell R, Sidle K, Clarke J, Shoai M, Lu CH, Hardy J, Plagnol V, Fisher EM (2013). Profilin1 E117G is a moderate risk factor for amyotrophic lateral sclerosis.. J Neurol Neurosurg Psychiatry, , - . doi:10.1136/jnnp-2013-306761

    2012

    • Holmes H, Wells J, O'Callaghan J, Richardson S, Siow B, Powell N, Da M, Modat M, Colgan N, Oursellin S, Fisher EMC, Lythgoe M (2012). Morphometric genomics: in vivo midro MRI for 3D structural imaging of transgenic mice.
    • Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK (2012). Altered regulation of tau phosphorylation in a mouse model of down syndrome aging.. Neurobiol Aging, 33(4), 828.e31 - 828.e44. doi:10.1016/j.neurobiolaging.2011.06.025
    • Fratta P, Mizielinska S, Nicoll AJ, Zloh M, Fisher EM, Parkinson G, Isaacs AM (2012). C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes.. Sci Rep, 2, 1016 - . doi:10.1038/srep01016
    • Fratta P, Malik B, Gray A, La Spada A, Hanna MG, Fisher EMC, Greensmith L (2012). FUS is not dysregulated by the spinal bulbar muscular atrophy androgen receptor polyglutamine repeat expansion. Neurobiology of Aging, , - .
    • Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante E, Wenborn A, Fizet J, Poulter M, Wiseman F, Fisher EMC, Tybulewicz V, Brandner S, Colllinge J, Lloyd S (2012). Over-expression of Hspa13 (Stch) reduces prion disease incubation time in mice. Proc Natl Acad Sci U S A, 09(34):13722-7. Epub 2012 Aug 6, - .
    • Tolstrup Nielsen T, Mizielinska S, Hasholt L, Isaacs A, Nielsen J, the FReJA Consortium (2012). Reversal of pathology in CHMP2B-mediated frontotemporal dementia patient cells using RNA interference. J Gene Med., , - .
    • Ingram CJ, Weale ME, Plaster CA, Morrison KE, Goodall EF, Pall HS, Beck M, Jablonka S, Sendtner M, Fisher EM, Bradman N, Kasperavičiūtė D (2012). Analysis of European case-control studies suggests that common inherited variation in mitochondrial DNA is not involved in susceptibility to amyotrophic lateral sclerosis.. Amyotroph Lateral Scler, 13(4), 341 - 346. doi:10.3109/17482968.2012.654394
    • McGoldrick P, Joyce P, Acevedo-Arozena A, Fisher E, Greensmith L (2012). Investigating new mutant models of MND.
    • Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, O'Malley C, Farmer M, Parkinson N, Fisher EM, Asante EA, Brandner S, Collinge J, Isaacs AM (2012). Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.. Brain, 135(Pt 3), 819 - 832. doi:10.1093/brain/aws006
    • Rishal I, Kam N, Perry RB-T, Shinder V, Fisher EMC, Schiavo G, Fainzilber M (2012). A Motor-Driven Mechanism for Cell-Length Sensing. CELL REPORTS, 1(6), 608 - 616. doi:10.1016/j.celrep.2012.05.013
    • Wiggins LM, Kuta A, Stevens JC, Fisher EMC, von Bartheld CS (2012). A novel phenotype for the dynein heavy chain mutation, Loa: Altered dendritic morphology, organelle density, and reduced numbers of trigeminal motoneurons. The Journal of Comparative Neurology, , - .
    • Saccon R, Joyce P, Fratta P, Greensmith L, Acevedo A, Fisher EMC (2012). Characterisation of a unique SOD1 mouse model for ALS.
    • Devoy A, Bunton-Stasyshyn RK, Tybulewicz VL, Smith AJ, Fisher EM (2012). Genomically humanized mice: technologies and promises.. Nat Rev Genet, 13(1), 14 - 20. doi:10.1038/nrg3116
    • Sheppard O, Wiseman FK, Ruparelia A, Tybulewicz VL, Fisher EM (2012). Mouse models of aneuploidy.. ScientificWorldJournal, 2012, 214078 - . doi:10.1100/2012/214078
    • Lunau L, Mourisdsen K, Rodell A, Ostergaard L, Nielsen JE, Isaacs A, Johannsen P, The FReJA Consortium (2012). Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI. BMJ: British Medical Journal, , - .
    • Haas M, Watson-Scales S, Slender A, Fisher EMC, Tybulewicz V, Guillemot F (2012). Understanding Down syndrome using the Tc1 mouse model.
    • Wiseman F, Sheppard O, Barkus C, Choong X, Slender A, Taylor A, Bannerman D, Tybulewicz V, Fisher EMC (2012). Trisomy of chromosome 21 modifies APP pathology in a mouse model.

    2011

    • Duchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VLJ, Fisher EMC, Herault Y (2011). The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. BEHAV BRAIN RES, 217(2), 271 - 281. doi:10.1016/j.bbr.2010.10.023
    • Cleary JO, Wiseman FK, Norris FC, Price AN, Choy M, Tybulewicz VL, Ordidge RJ, Brandner S, Fisher EM, Lythgoe MF (2011). Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain.. Neuroimage, 56(3), 974 - 983. doi:10.1016/j.neuroimage.2011.01.082
    • Isaacs AM, Johannsen P, Holm I, Nielsen JE, FReJA consortium (2011). Frontotemporal dementia caused by CHMP2B mutations.. Curr Alzheimer Res, 8(3), 246 - 251.
    • Deng W, Garrett C, Dombert B, Soura V, Banks G, Fisher EMC, van der Brug MP, Hafezparast M (2011). Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions.. J Biol Chem, 285(51), 39922 - 39932.
    • Norris FC, Cleary JO, Modat M, Sinclair B, Mccue K, Wells JA, Martinez-Barbera JP, Brander S, Fisher E, Scambler PJ, Ourselin S, Lythgoe MF (2011). Mouse phenotyping using high resolution 3D microscopic magnetic resonance imaging.
    • Stevens JC, Fisher EM, Mead S (2011). How does the genetic assassin select its neuronal target?. Mamm Genome, 22(3-4), 139 - 147. doi:10.1007/s00335-011-9319-5
    • Lana-Elola E, Watson-Scales SD, Fisher EM, Tybulewicz VL (2011). Down syndrome: searching for the genetic culprits.. Dis Model Mech, 4(5), 586 - 595. doi:10.1242/dmm.008078
    • Joyce PI, Fratta P, Fisher EM, Acevedo-Arozena A (2011). SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.. Mamm Genome, 22(7-8), 420 - 448. doi:10.1007/s00335-011-9339-1
    • Acevedo-Arozena A, Kalmar B, Essa S, Ricketts T, Joyce P, Kent R, Rowe C, Parker A, Gray A, Hafezparast M, Thorpe JR, Greensmith L, Fisher EM (2011). A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis.. Dis Model Mech, 4(5), 686 - 700. doi:10.1242/dmm.007237
    • Banks GT, Haas MA, Line S, Shepherd HL, Alqatari M, Stewart S, Rishal I, Philpott A, Kalmar B, Kuta A, Groves M, Parkinson N, Acevedo-Arozena A, Brandner S, Bannerman D, Greensmith L, Hafezparast M, Koltzenburg M, Deacon R, Fainzilber M, Fisher EM (2011). Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.. J Neurosci, 31(14), 5483 - 5494. doi:10.1523/JNEUROSCI.5244-10.2011
    • Johannsen P, Frahm-Falkenberg S, Law I, Jennum P, Isaacs A, Brown J, Nielsen JE, FReJA Collaboration (2011). CHANGES IN CEREBRAL GLUCOSE METABOLISM IN EARLY SYMPTOMATIC FRONTOTEMPORAL DEMENTIA LINKED TO CHROMOSOME 3 (FTD-3).

    2010

    • De Vita S, Canzonetta C, Mulligan C, Delom F, Groet J, Baldo C, Vanes L, Dagna-Bricarelli F, Hoischen A, Veltman J, Fisher EMC, Tybulewicz VLJ, Nizetic D (2010). Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome. ONCOGENE, 29(46), 6102 - 6114. doi:10.1038/onc.2010.351
    • El-Kadi AM, Bros-Facer V, Deng WH, Philpott A, Stoddart E, Banks G, Jackson GS, Fisher EMC, Duchen MR, Greensmith L, Moore AL, Hafezparast M (2010). The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease. J BIOL CHEM, 285(24), 18627 - 18639. doi:10.1074/jbc.M110.129320
    • Dunlevy L, Bennett M, Slender A, Lana-Elola E, Tybulewicz VL, Fisher EM, Mohun T (2010). Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse.. Cardiovasc Res, 88(2), 287 - 295. doi:10.1093/cvr/cvq193
    • Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EMC, Tybulewicz VLJ, Hart IR, Hodivala-Dilke KM (2010). Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. NATURE, 465(7299), 813 - U13. doi:10.1038/nature09106
    • Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, Dickson DW, Rademakers R, Graff-Radford NR, Parisi JE, Petersen RC, Hatanpaa KJ, White CL, Weiner MF, Geser F, Van Deerlin VM, Trojanowski JQ, Miller BL, Seeley WW, van der Zee J, Kumar-Singh S, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bigio EH, Deng HX, Halliday GM, Kril JJ, Munoz DG, Mann DM, Pickering-Brown SM, Doodeman V, Adamson G, Ghazi-Noori S, Fisher EMC, Holton JL, Revesz T, Rossor MN, Collinge J, Mead S, Isaacs AM, FReJA Consortium (2010). FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. ACTA NEUROPATHOL, 120(1), 33 - 41. doi:10.1007/s00401-010-0698-6
    • Alford KA, Slender A, Vanes L, Li Z, Fisher EMC, Nizetic D, Orkin SH, Roberts I, Tybulewicz VLJ (2010). Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. BLOOD, 115(14), 2928 - 2937. doi:10.1182/blood-2009-06-227629
    • Richardson S, Siow B, Wells J, Fisher EMC, Schiavo G, Lythgoe MF (2010). MRI detection of axonal transport via tetanus neurotoxin bound ixide nanoparticles..
    • Ruparelia A, Wiseman F, Sheppard O, Kuta A, Tybulewicz VLJ, Schiavo G, Fisher EMC (2010). Axonal transport in a panel of mice that model Down syndrome..
    • Urwin H, Authier A, Nielsen JE, Metcalf D, Powell C, Froud K, Malcolm DS, Holm I, Johannsen P, Brown J, Fisher EMC, van der Zee J, Bruyland M, Van Broeckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM, FReJA Consortium (2010). Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations. HUM MOL GENET, 19(11), 2228 - 2238. doi:10.1093/hmg/ddq100
    • McGoldrick P, Dick J, Ricketts T, Acevedo-Arozena A, Fisher E, Greensmith L (2010). Investigating novel mutant mouse models of motor neuron disease.
    • Miller G, Neilan M, Chia R, Gheryani N, Holt N, Charbit A, Wells S, Tucci V, Lalanne Z, Denny P, Fisher EMC, Cheeseman M, Askew GN, Dear TN (2010). ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2. PLOS ONE, 5(2), - . doi:10.1371/journal.pone.0009137
    • Joyce P, Ricketts T, Fratta P, Greensmith L, Acevedo A, Fisher EMC (2010). A new mouse model of ALS carrying a point mutation in the mouse Sod1 gene.
    • Ruparelia A, Wiseman F, Sheppard O, Tybulewicz VLJ, Fisher EMC (2010). Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.. J Biomed. Res., 24, 87 - .
    • Stevens JC, Chia R, Hendriks WT, Bros-Facer V, van Minnen J, Martin JE, Jackson GS, Greensmith L, Schiavo G, Fisher EMC (2010). Modification of Superoxide Dismutase 1 (SOD1) Properties by a GFP Tag - Implications for Research into Amyotrophic Lateral Sclerosis (ALS). PLOS ONE, 5(3), A8 - A17. doi:10.1371/journal.pone.0009541
    • Kuta A, Deng W, Morsi El-Kadi A, Banks GT, Hafezparast M, Pfister KK, Fisher EM (2010). Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.. PLoS One, 5(7), e11682 - . doi:10.1371/journal.pone.0011682
    • van de Leemput J, Wavrant-De Vrièze F, Rafferty I, Bras JM, Giunti P, Fisher EM, Hardy JA, Singleton AB, Houlden H (2010). Sequencing analysis of the ITPR1 gene in a pure autosomal dominant spinocerebellar ataxia series.. Mov Disord, 25(6), 771 - 773. doi:10.1002/mds.22970
    • Chia R, Tattum MH, Jones S, Collinge J, Fisher EMC, Jackson GS (2010). Superoxide Dismutase 1 and tgSOD1(G93A) Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis. PLOS ONE, 5(5), - . doi:10.1371/journal.pone.0010627
    • Wiseman FK, Sheppard O, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM (2010). Generation of a panel of antibodies against proteins encoded on human chromosome 21.. J Negat Results Biomed, 9, 7 - . doi:10.1186/1477-5751-9-7

    2009

    • Holm IE, Isaacs AM, Mackenzie IRA, FReJA-Consortium (2009). Absence of FUS-immunoreactive pathology in frontotemporal dementia linked to chromosome 3 (FTD-3) caused by mutation in the CHMP2B gene. Acta Neuropathologica, 118, 719 - 720.
    • Rohrer JD, Ahsan RL, Isaacs AM, Neilsen JE, Ostergaard L, Scahill R, Warren JD, Rossor MN, Fox NC, Johannsen P, FReJA-Consortium (2009). Presymptomatic generalised brain atrophy in frontotemporal dementia caused by CHMP2B mutation.. Dement. Geriatr. Cogn. Disord., 27, 182 - 186.
    • Fisher EMC, Lana-Elola E, Watson SD, Vassiliou G, Tybulewicz VLJ (2009). New approaches for modelling sporadic genetic disease in the mouse. DIS MODEL MECH, 2(9-10), 446 - 453. doi:10.1242/dmm.001644
    • Wills AM, Cronin S, Slowik A, Kasperaviciute D, Van Es MA, Morahan JM, Valdmanis PN, Meininger V, Melki J, Shaw CE, Rouleau GA, Fisher EMC, Shaw PJ, Morrison KE, Pamphlett R, Van den Berg LH, Figlewicz DA, Andersen PM, Al-Chalabi A, Hardiman O, Purcell S, Landers JE, Brown RH (2009). A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. NEUROLOGY, 73(1), 16 - 24. doi:10.1212/WNL.0b013e3181a18674
    • AlQatari M, Vastani N, Bros-Facer V, Groves M, Greensmith L, Fisher EM, Koltzenburg M (2009). A MUTATION OF THE CYTOPLASMIC DYNEIN HEAVY CHAIN GENE Dync1h1 CAUSES A SEVERE SENSORY NEUROPATHY.
    • Achilli F, Bros-Facer V, Williams HP, Banks GT, AlQatari M, Chia R, Tucci V, Groves M, Nickols CD, Seburn KL, Kendall R, Cader MZ, Talbot K, van Minnen J, Burgess RW, Brandner S, Martin JE, Koltzenburg M, Greensmith L, Nolan PM, Fisher EMC (2009). An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy. DIS MODEL MECH, 2(7-8), 359 - 373. doi:10.1242/dmm.002527
    • Wiseman FK, Alford KA, Tybulewicz VLJ, Fisher EMC (2009). Down syndrome-recent progress and future prospects. HUM MOL GENET, 18, R75 - R83. doi:10.1093/hmg/ddp010
    • Becker EBE, Olivera PL, Glitsch MD, Banks GT, Achilli F, Hardy A, Nolan PM, Fisher EMC, Davies KE (2009). A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. P NATL ACAD SCI USA, 106(16), 6706 - 6711. doi:10.1073/pnas.0810599106
    • Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ (2009). A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.. Hum Mol Genet, 18(8), 1524 - 1532. doi:10.1093/hmg/ddp059
    • Philpott A, Bros V, Flenniken A, Schiavo G, Fisher EMC, Greensmith L, Hafezparast M (2009). Cellular and molecular characterization of abnormal rear leg (Arl) - a new mouse strain with a point mutation in cytoplasmic dynein.
    • Galante M, Jani H, Vanes L, Daniel H, Fisher EMC, Tybulewicz VLJ, Bliss TVP, Morice E (2009). Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. HUM MOL GENET, 18(8), 1449 - 1463. doi:10.1093/hmg/ddp055
    • Wang Y, Mulligan C, Denyer G, Delom F, Dagna-Bricarelli F, Tybulewicz VLJ, Fisher EMC, Griffiths WJ, Nizetic D, Groet J (2009). Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Molecular and Cellular Proteomics, 8(4), 585 - 595. doi:10.1074/mcp.M800256-MCP200
    • Zinyuk LE, Tybulewicz VLJ, Fisher EMC, Jones MW (2009). Understanding higher brain function and complex disorders using rodent models..
    • Rohrer JD, Ahsan RL, Isaacs AM, Nielsen JE, Ostergaard L, Scahill R, Warren JD, Rossor MN, Fox NC, Johannsen P (2009). Presymptomatic generalized brain atrophy in frontotemporal dementia caused by CHMP2B mutation. Dementia and Geriatric Cognitive Disorders, 27(2), 182 - 186. doi:10.1159/000200466
    • Need AC, Ge DL, Weale ME, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, Kasperaviciute D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Cola PA, McEvoy JP, Keefe RSE, Fisher EMC, St Jean PL, Giegling I, Hartmann AM, Moller HJ, Ruppert A, Fraser G, Crombie C, Middleton LT, St Clair D, Roses AD, Muglia P, Francks C, Rujescu D, Meltzer HY, Goldstein DB (2009). A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia. PLOS GENET, 5(2), - . doi:10.1371/journal.pgen.1000373
    • Banks GT, Bros-Facer V, Williams HP, Chia R, Achilli F, Bryson JB, Greensmith L, Fisher EMC (2009). Mutant Glycyl-tRNA Synthetase (Gars) Ameliorates SOD1(G93A) Motor Neuron Degeneration Phenotype but Has Little Affect on Loa Dynein Heavy Chain Mutant Mice. PLOS ONE, 4(7), - . doi:10.1371/journal.pone.0006218
    • Stevens JC, Bros-Facer V, Hendriks W, van Minnen J, Greensmith L, Martin JE, Fisher EMC (2009). HOW DOES A DYNEIN MUTATION SLOW MOTOR NEURONE DISEASE?. doi:10.1136/jnnp.2009.191759b

    2008

    • Alford KA, Vanes L, Li Z, Orkin SH, Fisher EMC, Tybulewicz VLJ (2008). A Myeloproliferative Disorder in the Tel Mouse Model of Down Syndrome..
    • Knapp S, Hosie AM, Anstee QM, Thomos P, Mortensen M, Martinez A, Tymowska-Lalanne Z, McQuillin A, Gurling HM, Morgan MY, Kuo YT, Herlihy A, Bell JD, Robinson I, Fisher E, Brown S, Stephens D, Smart TG, Thomas HC (2008). IDENTIFICATION OF A MODEL OF ALCOHOL PREFERENCE AND ITS SIMILARITY TO HUMAN ALCOHOLISM.
    • Wilson MD, Barbosa-Morais NL, Schmidt D, Conboy CM, Vanes L, Tybulewicz VLJ, Fisher EMC, Tavare S, Odom DT (2008). Species-specific transcription in mice carrying human chromosome 21. SCIENCE, 322(5900), 434 - 438. doi:10.1126/science.1160930
    • Canzonetta C, Mulligan C, Deutsch S, Ruf S, O'Doherty A, Lyle R, Borel C, Lin-Marq N, Delom F, Groet J, Schnappauf F, De Vita S, Averill S, Priestley JV, Martin JE, Shipley J, Denyer G, Epstein CJ, Fillat C, Estivill X, Tybulewicz VLJ, Fisher EMC, Antonarakis SE, Nizetic D (2008). DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. AM J HUM GENET, 83(3), 388 - 400. doi:10.1016/j.ajhg.2008.08.012
    • Lindquist SG, Braedgaard H, Svenstrup K, Isaacs AM, Nielsen JE (2008). Frontotemporal dementia linked to chromosome 3 (FTD-3)--current concepts and the detection of a previously unknown branch of the Danish FTD-3 family. Eur J Neurol, 15(7), 667 - 670.
    • Lindquist SG, Braendgaard H, Svenstrup K, Isaacs AM, Neilsen JE, The-FReJA-Consortium (2008). Frontotemporal dementia linked to chromosome 3 (FTD-3)– current concepts and the detection of a previously unknown branch of the Danish FTD-3 family.. Eu. J.Neurology, 15, 667 - 670.
    • Banks GT, Kuta A, Isaacs AM, Fisher EMC (2008). TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander. MAMM GENOME, 19(5), 299 - 305. doi:10.1007/s00335-008-9117-x
    • Banks GT, Fisher EM (2008). Cytoplasmic dynein could be key to understanding neurodegeneration.. Genome Biol, 9(3), 214 - . doi:10.1186/gb-2008-9-3-214
    • Ateh DD, Hussain IK, Mustafa AH, Price KM, Gulati R, Nickols CD, Bird MM, Greensmith L, Hafezparast M, Fisher EM, Baker CS, Martin JE (2008). Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease.. Neuropathol Appl Neurobiol, 34(1), 88 - 94. doi:10.1111/j.1365-2990.2007.00924.x
    • van der Zee J, Urwin H, Engelborghs S, Bruyland M, Vandenberghe R, Dermaut B, De Pooter T, Peeters K, Santens P, De Deyn PP, Fisher EM, Collinge J, Isaacs AM, Van Broeckhoven C (2008). CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro. HUM MOL GENET, 17(2), 313 - 322. doi:10.1093/hmg/ddm309
    • Morice E, Andreae LC, Cooke SF, Vanes L, Fisher EMC, Tybulewicz VLJ, Bliss TVP (2008). Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. LEARN MEMORY, 15(7), 492 - 500. doi:10.1101/lm.969608

    2007

    • Stevens JC, Banks GT, Festing MFW, Fisher EMC (2007). Quiet mutations in inbred strains of mice. TRENDS MOL MED, 13(12), 512 - 519. doi:10.1016/j.molmed.2007.10.001
    • Mensah A, Mulligan C, Linehan J, Ruf S, O'Doherty A, Grygalewicz B, Shipley J, Groet J, Tybulewicz V, Fisher E, Brandner S, Nizetic D (2007). An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.. BMC Dev Biol, 7, 131 - . doi:10.1186/1471-213X-7-131
    • Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerod L, Fisher EMC, Isaacs A, Brech A, Stenmark H, Simonsen A (2007). Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J CELL BIOL, 179(3), 485 - 500.
    • Holme IE, Englund E, Mackenzie IRA, Johannsen P, Isaacs AM, The-FReJA-Consortium (2007). A reassessment of the neuropathology of frontotemporal dementia linked to chromosome 3.. J. Neuropathol. Exp. Neurol, 66, 884 - 891.
    • Kasperaviciute D, Weale ME, Shianna KV, Banks GT, Simpson CL, Hansen VK, Turner MR, Shaw CE, Al-Chalabi A, Pall HS, Goodall EF, Morrison KE, Orrell RW, Beck M, Jablonka S, Sendtner M, Brockington A, Ince PG, Hartley J, Nixon H, Shaw PJ, Schiavo G, Wood NW, Goldstein DB, Fisher EM (2007). Large-scale pathways-based association study in amyotrophic lateral sclerosis.. Brain, 130(Pt 9), 2292 - 2301. doi:10.1093/brain/awm055
    • Hough TA, Polewski M, Johnson K, Cheeseman M, Nolan PM, Vizor L, Rastan S, Boyde A, Pritzker K, Hunter AJ, Fisher EMC, Terkeltaub R, Brown SDM (2007). Novel mouse model of autosomal semidominant adult Hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2. J BONE MINER RES, 22(9), 1397 - 1407.
    • Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Roos J, Hoyle A, Nickols CD, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, Franklin RJM, Revesz T, King RHM, Berninghausen O, Fisher EMC, Schiavo G, Martin JE (2007). The phagocytic capacity of neurones. EUR J NEUROSCI, 25(10), 2947 - 2955. doi:10.1111/j.1460-9568.2007.05554.x
    • Tybulewicz VLJ, O'Doherty A, Wiseman F, Broughton T, Ruf S, Mulligan C, Morice E, Cooke S, Vanes L, Dunlevy L, Mohun T, Sharpe PT, Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Fisher EMC (2007). Characterization of an aneuploid mouse with a human chromosome that models Down syndrome..

    2006

    • Fisher EMC, Tybulewicz VLJ (2006). Understanding Down Syndrome. Science and Public Affairs, 9, - .
    • Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE, Pall HS, Hardiman O, Collinge J, Shaw PJ, Fisher EM, MRC Proteomics in ALS Study , FReJA Consortium (2006). ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B).. Neurology, 67(6), 1074 - 1077. doi:10.1212/01.wnl.0000231510.89311.8b
    • Pfister KK, Shah PR, Hummerich H, Russ A, Cotton J, Annuar AA, King SM, Fisher EMC (2006). Genetic analysis of the cytoplasmic dynein subunit families. PLOS GENET, 2(1), 11 - 26. doi:10.1371/journal.pgen.0020001
    • Tybulewicz VL, Fisher EM (2006). New techniques to understand chromosome dosage: mouse models of aneuploidy.. Hum Mol Genet, 15 Spec No 2, R103 - R109. doi:10.1093/hmg/ddl179
    • Johannsen P, Holm I, Simon F, Eskildsen SF, Rodell A, Isaacs AM, Gade A, Nielsen J, Ostergard L, Fisher EMC, Collinge J, Brown J, The-FReJA-Consortium (2006). New imaging and pathology findings in FTD-3 patients and mutation carriers..
    • Ateh DD, Hussain I, Mustafa A, Price KM, Nickols CD, Bird MM, Greensmith L, Schiavo G, Hafezparast M, Fisher EMC, Baker CS, Martin JE (2006). Subcellular functional specificity of dynein-dynactin complex subunits - normal distribution and disturbances in neurodegenerative disease.
    • Johannsen P, Eskildsen SF, Nielsen J, Fisher EMC, Zeidler D, Rodell A, Ostergaard L, The-FReJA-Consortium (2006). Brain cortical thickness in a FTD3 patient and mutation carriers.. doi:10.1016/j.jalz.2006.05.246
    • Johannsen P, Eskildesen S, Neilsen J, Fisher EMC, Zeidler D, Rodell A, Ostergaard L (2006). Functional and structural imaging in FTD3..
    • Ateh DD, Hussain I, Mustafa A, Price KM, Nickols CD, Bird MM, Greensmith L, Schiavo G, Hafezparast M, Fisher EMC, Baker CS, Martin JE (2006). Normal subcellular distribution of dynein-dynactin complex subunits and disturbances in neurodegenerative disease.
    • Shah PR, Ahmad-Annuar A, Ahmadi KR, Russ C, Sapp PC, Horvitz HR, Brown RH, Goldstein DB, Fisher EMC (2006). No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: A tagging SNP approach. AMYOTROPH LATERAL SC, 7(1), 46 - 56. doi:10.1080/14660820500397057
    • Skibinski G, Parkinson N, Fisher E, Collinge J, Freja Consortium (2006). Mutations in the endosomal ESCRTIII complex subunit CHMP2B in frontotemporal dementia.

    2005

    • Chia R, Achilli F, Festing MFW, Fisher EMC (2005). The origins and uses of mouse outbred stocks. NAT GENET, 37(11), 1181 - 1186. doi:10.1038/ng1665
    • O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TV, Henderson DJ, Nizetic D, Tybulewicz VL, Fisher EM (2005). An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.. Science, 309(5743), 2033 - 2037. doi:10.1126/science.1114535
    • Skibinski G, Parkinson NJ, Brown JM, Chakrabarti L, Lloyd SL, Hummerich H, Nielsen JE, Hodges JR, Spillantini MG, Thusgaard T, Brandner S, Brun A, Rossor MN, Gade A, Johannsen P, Sørensen SA, Gydesen S, Fisher EM, Collinge J (2005). Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia.. Nat Genet, 37(8), 806 - 808. doi:10.1038/ng1609
    • Achilli F, Boyle S, Kieran D, Chia R, Hafezparast M, Martin JE, Schiavo G, Greensmith L, Bickmore W, Fisher EMC (2005). The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12. AMYOTROPH LATERAL SC, 6(2), 111 - 114. doi:10.1080/14660820510035351
    • Kieran D, Hafezparast M, Bohnert S, Dick JRT, Martin J, Schiavo G, Fisher EMC, Greensmith L (2005). A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J CELL BIOL, 169(4), 561 - 567. doi:10.1083/jcb.200501085
    • Hafezparast M, Brandner S, Linehan J, Martin JE, Collinge J, Fisher EMC (2005). Prion disease incubation time is not affected in mice heterozygous for a dynein mutation. BIOCHEM BIOPH RES CO, 326(1), 18 - 22. doi:10.1016/j.bbrc.2004.10.206
    • Morsi-El-Kadi A, Soura V, Bohnert S, Lo K, Pfister K, Wheatley S, Martin J, Ahmad-Annuar A, Fisher EMC, Greensmith L, Schiavo G, Hafezparast M (2005). Molecular analysis of motor neuron degeneration caused by mutant dynein..
    • Chia R, Achilli F, Festing MFW, Fisher EMC (2005). The origins and uses of mouse outbred stocks..
    • Achilli F, Boyle S, Kieran D, Chia R, Hafezparast M, Martin JE, Schiavo G, Greensmith L, Bickmore W, Fisher EMC (2005). The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12..
    • Shah PR, Ahmad-Annuar A, Ahmadi KR, Soranzo N, Russ C, Sapp PC, Kasperaviciute D, Horvitz HR, Brown RH, Goldstein DB, Fisher EMC (2005). Towards a systematic screen of cytoplasmic dynein-dynactin genes and other candidates for association with motor neuron degeneration disorders by tagging SNP analysis..
    • Pfister KK, Fisher EMC, Gibbons IR, Hays TS, Holzbaur ELF, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (2005). Cytoplasmic dynein nomenclature. J CELL BIOL, 171(3), 411 - 413. doi:10.1083/jcb.200508078

    2004

    • Hough T, Fisher E, Cheeseman M, Hunter J, Brown SDM (2004). Characterization and genetics of a mouse model of hypophosphatasia.
    • Lloyd SE, Thompson SR, Beck JA, Linehan JM, Wadsworth JD, Brandner S, Collinge J, Fisher EM (2004). Identification and characterization of a novel mouse prion gene allele.. Mamm Genome, 15(5), 383 - 389. doi:10.1007/s00335-004-3041-5
    • Tsipouri V, Curtin JA, Nolan PM, Vizor L, Parsons CA, Clapham CM, Latham ID, Rooke LJ, Martin JE, Peters J, Hunter AJ, Rogers D, Rastan S, Brown SDM, Fisher EMC, Spurr NK, Gray IC (2004). Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse. COMP FUNCT GENOM, 5(2), 123 - 127. doi:10.1002/cfg.382
    • Rastan S, Hough T, Kierman A, Hardisty R, Erven A, Gray IC, Voeling S, Isaacs A, Tsai H, Strivens M, Washbourne R, Thornton C, Greenaway S, Hewitt M, McCormick S, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Mburu P, Rogers D, Hagan J, Reavill C, Davies K, Glenister P, Fisher EMC, Martin J, Vizor L, Bouzyk M, Kelsell D, Guenet JL, Steel KP, Sheardown S, Spurr N, Gray I, Peters J, Nolan PM, Hunter AJ, Brown SDM (2004). Towards a mutant map of the mouse - new models of neurological, behavioural, deafness, bone, renal and blood disorders. GENETICA, 122(1), 47 - 49.
    • Gydesen S, Brown JM, Brun A, Chakrabarti L, Gade A, Johannsen P, Rossor M, Thusgaard T, Grove A, Fisher EMC, Collinge J, Sorensen SA (2004). Chromosome 3 linked frontotemporal dementia (FTD-3).. Dementia Review, (1/2004), - .
    • Brown J, Gydesen S, Johannsen P, Gade A, Skibinski G, Chakrabarti L, Brun A, Spillantini M, Yancopoulou D, Thusgaard T, Sorensen A, Fisher E, Collinge J, FReJA (Frontotemporal Dementia Research in Jutland Association) (2004). Frontotemporal dementia linked to chromosome 3.. Dement Geriatr Cogn Disord, 17(4), 274 - 276. doi:10.1159/000077153
    • Murdoch J, Quint E, Curtin J, Henderson D, Greene N, Arkell R, Bogani D, Gerrelli D, Doudney K, Paternotte C, Cattanach B, Nolan P, Spurr N, Fisher E, Stanier P, Gray I, Steel K, Brown S, Copp A (2004). Mechanisms regulating the initiation of neural tube closure.
    • Tsipouri V, Hough T, Curtin JA, Guionaud S, Fulleylove M, Vizor L, Hoult D, Scheib H, Brown SDM, Fisher EMC, Spurr NK, Gray IC (2004). An ENU-induced, low-cholesterol, low-HDL cholesterol mouse mutant carries an Abca1 point mutation and is a model for Tangier disease and familial hypoalphalipoproteinemia.. Comparative and Functional Genomics, 5, 123 - 127.

    2003

    • Hough T, Fisher EMC, Cheeseman M, Hunter J, Brown SDM (2003). Characterisation and genetics of a mouse model of hypophospatasia..
    • Hafezparast M, Ahmad-Annuar A, Hummerich H, Shah P, Ford M, Baker C, Bowen S, Martin JE, Fisher EMC (2003). Paradigms for the identification of new genes in motor neuron degeneration. AMYOTROPH LATERAL SC, 4(4), 249 - 257. doi:10.1080/14660820310016084
    • Ahmad-Annuar A, Shah P, Hafezparast M, Goldstein DB, Fisher EMC (2003). Linkage disequilibrium and haplotype mapping of the human cytoplasmic dynein heavy chain 1 gene on chromosome 14q32.
    • Sangha HK, Robson JC, Bowen S, Nadarajan V, Ball S, Fisher EM, Nickols C, Peters J, Martin JE (2003). Deletion studies in the gammy mouse..
    • Doherty AMO, Fisher EMC (2003). Microcell-mediated chromosome transfer (MMCT): small cells with huge potential. MAMM GENOME, 14(9), 583 - 592. doi:10.1007/s00335-003-4002-0
    • Ahmad-Annuar A, Shah P, Hafezparast M, Hummerich H, Witherden AS, Morrison KE, Shaw PJ, Kirby J, Warner TT, Crosby A, Proukakis C, Wilkinson P, Orrell RW, Bradley L, Martin JE, Fisher EM (2003). No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders.. Amyotroph Lateral Scler Other Motor Neuron Disord, 4(3), 150 - 157.
    • Hafezparast M, Klocke R, Ruhrberg C, Marquardt A, Ahmad-Annuar A, Bowen S, Lalli G, Witherden AS, Hummerich H, Nicholson S, Morgan PJ, Oozageer R, Priestley JV, Averill S, King VR, Ball S, Peters J, Toda T, Yamamoto A, Hiraoka Y, Augustin M, Korthaus D, Wattler S, Wabnitz P, Dickneite C, Lampel S, Boehme F, Peraus G, Popp A, Rudelius M, Schlegel J, Fuchs H, de Angelis MH, Schiavo G, Shima DT, Russ AP, Stumm G, Martin JE, Fisher EMC (2003). Mutations in dynein link motor neuron degeneration to defects in retrograde transport. SCIENCE, 300(5620), 808 - 812.
    • Mead S, Stumpf MPH, Whitfield J, Beck JA, Poulter M, Campbell T, Uphill JB, Goldstein D, Alpers M, Fisher EMC, Collinge J (2003). Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics. SCIENCE, 300(5619), 640 - 643. doi:10.1126/science.1083320
    • Johannsen P, Gydesen S, Brown J, Gade A, Chakrabarti L, Skibinski G, Englund E, Brun A, Rossor M, Soerensen SA, Fisher E, Collinge J (2003). Chromosome 3 related frontotemporal dementia. INT PSYCHOGERIATR, 15, 81 - 81.
    • Skibinski G, Chakrabarti L, The-FReJA-Consortium (2003). Clinical and molecular characterisation of frontotemporal dementia linked to chromosome 3..
    • Kieran D, Hafezparast M, Martin JE, Fisher EMC, Greensmith L (2003). Delaying disease progression in mSOD transgenic mice..
    • Ahmad-Annuar A, Tabrizi SJ, Fisher EMC (2003). Mouse models as a tool for understanding neurodegenerative diseases. CURR OPIN NEUROL, 16(4), 451 - 458. doi:10.1097/01.wco.0000084221.82329.29
    • Hafezparast M, Ahmad-Annuar A, Wood NW, Tabrizi SJ, Fisher EMC (2003). Mouse models for neurological disease.. Adv Clin Neurosci, 13, 305 - .
    • Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, Nolan PM, Steel KP, Brown SD, Gray IC, Murdoch JN (2003). Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.. Curr Biol, 13(13), 1129 - 1133.
    • Baker CS, Price KM, Bowen S, Walker KE, Chana S, Fisher EMC, Martin JE (2003). Protein characterisation of the Loa mouse..
    • Fisher EMC (2003). The mouse: genetics and genome. Genetics Society Newsletter, 50, 7 - 9.
    • Hough T, Fisher EMC, Cheeseman M, Hunter J, Brown SDM (2003). Characterisation and genetics of a mouse model of hypophospatasia..

    2002

    • Skibinski G, Chakrabarti L, FReJA (2002). Clinical and molecular characterisation of Frontotemporal dementia linked to Human Chromosome 3.
    • Ramos VC, Vidal-Taboada J, Bergonon S, Egeo A, Fisher EMC, Scartezzini P, Oliva R (2002). Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21.. Biochim Biophys Acta, 1577(3), 377 - 383.
    • Robson JC, Bowen S, Ball S, Fisher EM, Gupta S, Nickols C, Parkinson LC, Peters J, Martin JE (2002). Gene dose effects in "Gammy": A mouse model of human club foot. J PATHOL, 198, 51A - 51A.
    • Mead S, Mahal S, Beck J, Farall M, Fisher EMC, Collinge J (2002). Identification of new prion disease susceptibility loci. J NEUROL NEUROSUR PS, 73(2), 223 - 223.
    • Martinez A, Jones L, Rosankiewicz J, Brown SDM, Thomas H, Fisher EMC (2002). Mapping, isolation and charactrization of gene(s) involved in ethanol preferences: Pilot study..
    • Hafezparast M, Ahmad-Annuar A, Wood NW, Tabrizi SJ, Fisher EMC (2002). Mouse models for neurological disease. LANCET NEUROL, 1(4), 215 - 224.
    • Hafezparast M, Ball S, Nicholson SJ, Witherden A, Arac D, Broadway N, Saggerson D, Cooper E, Naase M, Gokhale S, Quant P, Lascelles C, Nickols C, Baker CS, Peters J, Martin JE, Fisher EM (2002). A new mouse mutant, skijumper.. Mamm Genome, 13(7), 359 - 364.
    • Johannsen P, Gade A, Brown J, Chakrabarti L, Ghedde A, Gydesen S, Sorensen SA, The-FReJA-Group (2002). Extensive cerebral blood flow deficits in chromosome 3 frontotemporal dementia..
    • Witherden AS, Hafezparast M, Nicholson SJ, Ahmad-Annuar A, Bermingham N, Arac D, Rankin J, Iravani M, Ball S, Peters J, Martin JE, Huntley D, Hummerich H, Sergot M, Fisher EMC (2002). An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. GENE, 283(1-2), 71 - 82.
    • Gydesen S, Brown JM, Brun A, Chakrabarti L, Gade A, Johannsen P, Rossor M, Thusgaard T, Grove A, Yancopoulou D, Spillantini MG, Fisher EM, Collinge J, Sorensen SA (2002). Chromosome 3 linked frontotemporal dementia (FTD-3).. Neurology, 59(10), 1585 - 1594.
    • Lloyd SE, Uphill JB, Targonski P, Fisher EMC, Collinge J (2002). Identification of genetic loci affecting bovine spongiform encephalopathy incubation time in mice..
    • Lloyd SE, Uphill JB, Targonski PV, Fisher EMC, Collinge J (2002). Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice. NEUROGENETICS, 4(2), 77 - 81. doi:10.1007/s10048-002-0133-9
    • Hough TA, Nolan PM, Tsipouri V, Toye AA, Gray IC, Goldsworthy M, Moir L, Cox RD, Clements S, Glenister PH, Wood J, Selley RL, Strivens MA, Vizor L, McCormack SL, Peters J, Fisher EM, Spurr N, Rastan S, Martin JE, Brown SD, Hunter AJ (2002). Novel phenotypes identified by plasma biochemical screening in the mouse.. Mamm Genome, 13(10), 595 - 602. doi:10.1007/s00335-002-2188-1

    2001

    • Mead SH, Mahal SP, Farrall M, Fisher EMC, Collinge J (2001). Association of prion protein gene single nucleotide polymorphism haplotypes with Creutzfeldt-Jakob disease.. AM J HUM GENET, 69(4), 182 - 182.
    • Chakrabarti L, FReJA (2001). Clinical and molecular characterisation of frontotemporal dementia linked to human chromosome 3.. AMERICAN JOURNAL OF HUMAN GENETICS, 69(4), 278 - 278.
    • Mead S, Mahal SP, Beck J, Campbell T, Farrall M, Fisher E, Collinge J (2001). Sporadic - but not variant - Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP Exon 1. AM J HUM GENET, 69(6), 1225 - 1235.
    • O'Doherty A, Ruf S, Hernandez D, Tybulewicz V, Fisher EMC (2001). Generation of transchromosomal mice using ES cells containing freely segregating fragments of Hsa21: a model for human Down syndrome..
    • Johannsen P, Gade A, Brown J, Chakrabarti L, Gjedde A, Gydesen S, Sorensen SA, FReJA-Consortium (2001). Chromosome-3 linked frontotemporal dementia (FTD3) and cerebral blood flow..
    • Lloyd SE, Onwuazor ON, Beck JA, Mallinson G, Farrall M, Targonski P, Collinge J, Fisher EMC (2001). Identification of multiple quantitative trait loci linked to prion disease incubation period in mice. P NATL ACAD SCI USA, 98(11), 6279 - 6283.
    • Curtin JA, Tsipouri V, Latham I, Nolan P, Hardisty R, Vizor L, Sims MA, Parsons C, Naase MA, Doncaster K, Rastan S, Hunter AJ, Brown S, Fisher EMC, Gray IC, Spur NK (2001). Rapid genome scan reveals linkage to chromosome 15 for the ENU induced circling mouse mutant, spin cycle..
    • Witherden AS, Hafezparast M, Nicholson SJ, Bermingham NA, Peters J, Ball ST, Rogers DC, Martin JE, Fisher EMC (2001). Mapping of Loa, a mouse motor deficit mutation, to distal chromosome 12..
    • O'Doherty A, Ruf S, Hernandez D, Tybulewicz V, Fisher EMC (2001). Generation of transchromosomal mice using ES cells containing freely segregating fragments of human chromosome 21 (Hsa21): a model of human Down syndrome..

    2000

    • Witherden AS, Nicholson SJ, Hafezparast M, Peters J, Ball ST, Martin JE, Rogers JC, Fisher EMC (2000). Mapping of Loa, a mouse motor deficit gene, to distal mouse chromosome 12..
    • Lloyd SE, Onwuazor ON, Fisher EMC, Collinge J (2000). Quantitative trait locus analysis of prion disease incubation time..
    • Nolan PM, Peters J, Vizor L, Strivens M, Washbourne R, Hough T, Wells C, Glenister P, Thornton C, Martin J, Fisher E, Rogers D, Hagan J, Reavill C, Gray I, Wood J, Spurr N, Browne M, Rastan S, Hunter J, Brown SDM (2000). Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource. MAMM GENOME, 11(7), 500 - 506.
    • Isaacs AM, Davies KE, Hunter AJ, Nolan PM, Vizor L, Peters J, Gale DG, Kelsell DP, Latham ID, Chase JM, Fisher EMC, Bouzyk MM, Potter A, Masih M, Walsh FS, Sims MA, Doncaster KE, Parsons CA, Martin J, Brown SDM, Rastan S, Spurr NK, Gray IC (2000). Identification of two new Pmp22 mouse mutants using large-scale mutagenesis and a novel rapid mapping strategy. HUM MOL GENET, 9(12), 1865 - 1871.
    • Hunter AJ, Hagan JJ, Rogers D, Nolan P, Strivens M, Peters J, Brown SDM, Fisher EMC, Martin J (2000). The discovery of novel behavioural phenotypes via a genome wide mutagenesis programme. EUR J NEUROSCI, 12, 442 - 442.
    • Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MFW, Fisher EMC (2000). Genealogies of mouse inbred strains. NAT GENET, 24(1), 23 - +.
    • Mead S, Beck J, Dickinson A, Fisher EMC, Collinge J (2000). Examination of the human prion protein-like gene Doppel for genetic susceptibility to sporadic and variant Creutzfeldt-Jakob disease. NEUROSCI LETT, 290(2), 117 - 120.
    • Nolan PM, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray IC, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu XH, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson JA, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven H, Steel KP, Voegeling S, Guenet JL, Nickols C, Sadri R, Naase M, Isaacs A, Davies K, Browne M, Fisher EMC, Martin J, Rastan S, Brown SDM, Hunter J (2000). A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. NAT GENET, 25(4), 440 - 443.
    • Washbourne R, Nolan P, Peters J, Vizor L, Hewitt M, Sellley R, Strivens M, Martin J, Fisher E, Rogers D, Hagan J, Spurr N, Rastan S, Browne M, Hunter J, Brown S (2000). Identification of novel behavioural mutations using ENU mutagenesis.. EUR J NEUROSCI, 12, 235 - 235.

    1999

    • Hernandez D, Mee PJ, Martin JE, Tybulewicz VLJ, Fisher EMC (1999). Transchromosomal mouse embryonic stem cell lines that contain a freely segregating whole or partial human chromosome 21. Human Molecular Genetics, 8(5), 923 - 933.
    • Witherden AS, Hafezparast M, Nicholson SJ, Bermingham N, Ball S, Peters J, Rogers D, Martin JE, Fisher EMC (1999). Mapping of the mouse motor neurodegeneration gene Loa (legs at odd angles) and progress towards its cloning..
    • Hernandez D, Fisher EMC (1999). Mouse autosomal trisomy - two’s company, three’s a crowd. Trends in Genetics, 15, 241 - 247.
    • Ashworth A, Lloyd S, Brown J, Gydesen S, Sorensen SA, Brun A, Englund E, Humphreys C, Housman D, Badura M, Stanton V, Taylor K, Cameron J, Munroe D, Johansson J, Rossor M, Fisher EMC, Collinge J (1999). Molecular genetic characterisation of frontotemporal dementia on chromosome 3. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 10, 93 - 101.
    • Ward CL, Fisher EMC, Ball ST, Peters J, Martin JE (1999). Novel mouse mutant with motor dysfunction from phenotype to genotype. J PATHOL, 187, 23A - 23A.
    • Hafezparast M, Fisher EMC (1999). Polyglutamine diseases. Trend Genet, 15, 222 - .

    1998

    • Fisher EMC, Telling G, Collinge J (1998). Prions and the prion disorders. Mamm Genome, 9(7), 497 - 502.
    • Fisher EMC (1998). Modelling motor neuron degenerative disease. Neuropathol. Appl. Neurobiol., 24, 90 - .
    • Vidal-Taboada JM, Bergonon S, Sanchez M, Lopez-Acdeo C, Groet J, Nizetic D, Katsanis N, Fisher EMC, Delabar JM, Oliva R (1998). A 342kb ready-to-sequence PAC and cosmid contig with full EcoRI/SMAI restriction map between markers ACTL5 and D21S268 within the Down syndrome region-2.. Biochem. Biophys. Res. Comm., 243, 572 - .
    • Katsanis N, Fisher EMC (1998). A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. Genomics, 47, 294 - 299.
    • Katsanis N, Fisher EMC (1998). Identification, expression and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homolog of the Saccharomyces cerevisiae Ubc7 gene.. Genomics, 51, 128 - .
    • (1998). Methods in Mouse Genetics and Genome Mapping.
    • Katsanis N, Ives JH, Groet J, Nizetic D, Fisher EMC (1998). Localisation of Receptor Interacting Protein 140 (RIP140) within 100kb of D21S13 on 21q11, a gene-poor region of the human genome. Hum Genet, 102, 221 - .
    • Prasher V, Farrer MJ, Kessling AM, Fisher EMC, West RJ, Barber PC, Butler AC (1998). Molecular mapping of Alzheimer- type dementia in Down syndrome.. Ann. Neurol, 43, 380 - .
    • Nickols CD, Peters J, Fisher EMC, Martin JE (1998). Muscle and nerve morphology in the affected hindlimb of the mouse mutant 'gammy' (gam) a model of human club foot..
    • Bermingham NA, Rauf S, Katsanis N, Martin JE, Hunter AJ, Fisher EMC (1998). The immunophilin FKBP4 (FKBP52/FKBP59) maps to the distal short arm of human chromosome 12.. Mamm Genome, 9, 268 - .
    • Hafezparast M, Fisher EMC (1998). Wasted by an elongation factor. Trends Genet, 14, 215 - 217.
    • Martin JE, Shaw GLCF, Donnithorne JC, Peters J, Rogers DC, Fisher EMC (1998). Validation of the SHIRPA protocol for phenotype analysis of normal, mutant and gene targeted mice - age, sex, weight and the effects of repeat testing. J PATHOL, 186, 4A - 4A.

    1997

    • Hoyle J, Tan KH, Fisher EMC (1997). Localization of genes encoding two human one domain members of the AAA family: PSMC5 (the thyroid hormone receptor interacting protein, TRIP1) and PSMC3 (the Tat binding protein, TBP1).. Hum Genet, 99, 285 - 288.
    • Hoyle J, Tan KH, Fisher EMC (1997). Mapping human and mouse valosin containing protein (VCP) sequences. Mamm. Genome, 8, 778 - 780.
    • Rogers DC, Fisher EMC, Brown SDM, Peters J, Hunter AJ, Martin JE (1997). Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. MAMM GENOME, 8(10), 711 - 713.
    • Mileham P, Fisher EMC, Neal L, Peters J, Martin JE (1997). Genetic mapping of the gammy (gam) mutation - a putative model of human congenital club foot..
    • Nickols CK, Peters J, Fisher EMC, Martin JE (1997). Phenotypic analysis of the mouse mutant gammy (gam) and the effects of laterality on scoring in the SHIRPA protocol..
    • Fisher EMC, Martin JE (1997). Phenotypic and genotypic characterisation of feeble..
    • Martin JE, Fisher EMC, Peters J, Hunter J, Brown SDM, Rogers D (1997). SHIRPA - Phenotypic assessment of neurological function.
    • Nickols CD, Peters J, Fisher EMC, Martin JE (1997). A closer look at the mouse mutant 'gammy' (gam), a proposed model for human club foot..
    • Katsanis N, Yaspo M, Fisher EMC (1997). Identification and mapping of a novel human gene, PRMT2, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene.. Mamm Genome, 8, 526 - 529.
    • Witherden AS, Nicholson SJ, Fisher EMC (1997). The value of mouse mutants. Mouse Genome, 95, 856 - 874.
    • Fisher EMC (1997). The contribution of the mouse to advances in human genetics.. Advances in Genetics, 35, 155 - 205. doi:10.1016/S0065-2660(08)60450-2
    • Ballabio A, Brown SDM, Fisher EMC (1997). Strategies for disease identification. In (Ed.), Genome Analysis: A laboratory manual (pp. - ). : Cold Spring Harbor Laboratory Press.
    • Martin JE, Fisher EMC (1997). Phenotypic analysis - making the most of your mouse.. Trends Genet., 13, 254 - .
    • Katsanis N, Beck JA, Fisher EMC (1997). Mapping of a novel SH3 domain protein and two proteins of unknown function to human chromosome 21.. Hum Genet, 100, 477 - 480.
    • Hernandez D, Tybulewicz V, Fisher EMC (1997). Modelling aspects of Down syndrome in mice..

    1996

    • Bermingham N, Martin JE, Fisher EMC (1996). The mouse lysosomal membrane protein 1 gene as a candidate for the motorneuron degeneration (mnd) locus.. Genomics, 32, 266 - 271.
    • Bermingham N, McKay T, Hoyle J, Hernandez D, Martin JE, Fisher EMC (1996). The gene encoding tripeptidyl peptidase II maps to chromosome 1 in the mouse. Mamm Genome, 7, 390 - .
    • Katsanis N, Fisher EMC (1996). The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome.. Hum Genet, 98, 497 - .
    • Katsanis N, Fitzgibbon J, Fisher EMC (1996). Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci. Genomics, 35, 101 - 108.
    • Hoyle J, Fisher EMC (1996). Genomic organization and mapping of the mouse P26s4 ATPase gene: a member of the remarkably conserved AAA gene family.. Genomics, 31, 115 - 118.
    • Matthews D, Fry L, Powles A, Weber J, McCarthy M, Fisher EMC, Davies K, Williamson R (1996). Evidence for a locus for familial psoriasis mapping to chromosome 4q.. Nature genetics, 14, 231 - 233.
    • Hernandez D, Fisher EMC (1996). Down syndrome genetics: unravelling a multifactorial disorder. Hum Mol Genet, 5, 1411 - 1416.
    • Hoyle J, Yulug IG, Johnstone K, Scambler PJ, Fisher EMC (1996). Characterisation of a short interspersed repeat (Mermaid) which has family members on human chromosome 21 and elsewhere in the human genome.. Hum Genet, 97, 117 - 120.
    • Moran TH, Reeves RH, Rogers D, Fisher EMC (1996). Ain't misbehavin' - it's genetic.. Nature Genetics, 12, 115 - 116.
    • Hoyle J, Phelan JP, Bermingham N, Fisher EMC (1996). Localization of human and mouse N-ethylmaleimide-sensitive factor (NSF) gene: a two domain member of the AAA family which is involved in membrane fusion.. Mamm Genome, 7, 850 - .
    • Delabar JM, Creau N, Antonarakis SE, Brahe C, Estivill X, Pritchard M, Fisher EMC, Kessling A, Yaspo ML, Lehrach H, Nizetic D, Oliva R, Petersen M, Potier MC, Roizes G, Van-Broeckhoven C, Lutfalla G (1996). Towards an integrated chromosome 21 map: progress of the European chromosome 21 consortium..

    1995

    • Katsanis N, Yaspo ML, Fisher EMC (1995). cDNA selection from human chromosome 21..
    • Yulug IG, Katsanis N, de-Belleroche J, Collinge J, Fisher EMC (1995). An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon 4.. Hum Mol Genet, 4, 1101 - 1104.
    • Fisher EMC (1995). Why aren't we all bacteria. Immunology News, 2, 100 - 103.
    • Hoyle J, Smith DJ, Connolly JAC, Fisher EMC (1995). Characterisation of the S4 gene, a member of a highly conserved gene family involved in ubiquitinated degradation of proteins..
    • Yulug IG, Killary AM, Sandhu AK, Athwal RS, Fox M, Fisher EMC (1995). Gene expression in response to retinoic acid in novel human chromosome 21 monochromosomal cell hybrids. SOMAT CELL MOLEC GEN, 21(5), 357 - 365.
    • Hernandez D, Pannett A, Tybulewicz V, Fisher EMC (1995). Highly polymorphic sequence at D21S1448 mapping close to D21S55.. Hum Genet, 95, 721 - 722.
    • Yulug IG, Egan SE, See CG, Fisher EMC (1995). Mapping human SHC, a gene that encodes an adaptor protein and identifying and mapping a SHC related sequence.. Hum. Genet., 96, 245 - 248.
    • Bermingham N, Hernandez D, Balfour A, Gilmour F, Martin JE, Fisher EMC (1995). Mapping TNNC1, the gene which encodes cardiac troponin I in the human and the mouse.. Genomics, 30, 620 - 622.
    • Yulug IG, See CG, Fisher EMC (1995). The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14.. Genomics, 26, 433 - 435.
    • Yulug IG, Fisher EMC (1995). The frequency and position of Alu repeats in cDNAs, as determined by database searching.. Genomics, 27, 544 - 548.
    • Wang W, Fisher EMC, Jia Q, Dunn JM, Porfiri E, Downward J, Egan SE (1995). The Grb2 binding domain of mSos1 is not required for downstream signal transduction.. Nature Genetics, 10, 294 - 299.
    • Bermingham N, Gilmour F, Martin JE, Fisher EMC (1995). Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5.. Hum Genet, 96, 671 - 673.

    1994

    • Egan SE, Fisher EMC, Downward J (1994). Transformation by the mSos1 Ras exchange protein..
    • Hernandez D, Yulug IG, Egan SE, Fisher EMC (1994). Mapping the gene which encodes phosphatidylinositol specific phospholipase C-g 2 in the human and the mouse.. Genomics, 23, 504 - 507.
    • Schmitt K, Lazzeroni LC, Vollrath D, Foote S, Fisher EMC, Goradia TM, Lange K, Page DC, Arnheim N (1994). Multipoint linkage map of the human pseudoautosomal region based on single sperm typing: Do double crossovers occur during male meiosis?. Am. J. Hum. Genet., 55, 423 - 430.
    • Yulug IG, Killary A, Athwal R, Fisher EMC (1994). Creating somatic cell hybrids which respond to the morphogen retinoic acid..
    • Fisher EMC (1994). Genetics, molecular and cell biology. In Kumar PJ, Clark ML (Ed.), Clinical Medicine (pp. - ). : Balliere Tindall.
    • Fisher EMC, Scambler PJ (1994). Human haploinsufficiency - one for sorrow, two for joy.. Nature Genetics, 7, 5 - 7.
    • Yulug IG, Egan SE, See CG, Fisher EMC (1994). Mapping GRB2, a signal transduction gene in the human and the mouse.. Genomics, 22, 313 - 318.
    • Hernandez D, Tybulewicz V, Fisher EMC (1994). Modelling Down syndrome in mouse..
    • Hoyle J, Yulug IG, Egan SE, Fisher EMC (1994). The gene which encodes the phosphatidylinositol-3 kinase regulatory subunit (p85a) maps to chromosome 13 in the mouse.. Genomics, 24, 400 - 402.
    • Yulug IG, Hillermann R, Fisher EMC (1994). The SHB adaptor protein maps to human chromosome 9.. Genomics, 24, 615 - 617.

    1993

    • Schmitt K, Vollrath D, Foote S, Fisher EMC, Page DC, Arnheim N (1993). Four PCR-based polymorphisms in the pseudoautosomal region of the human X and Y chromosomes.. Hum Mol Genet, 2, 1978 - .
    • Yulug IG, Egan SE, Pollock PM, Fisher EMC (1993). A homologue of the Drosophila Son of Sevenless gene maps to mouse chromosome 17.. Genomics, 18, 733 - 734.
    • Fisher EMC (1993). Much ado about cloning. BMJ, 307(6911), 1074 - 1075.
    • Zinn AR, Page DC, Fisher EMC (1993). Turner syndrome: the case of the missing sex chromosome.. Trends Genet, 9, 90 - 93.
    • Fisher EMC (1993). Working with the media. Physiological Society Magazine, 8, 25 - 25.

    1992

    • Hamvas RMJ, Zinn A, Keer JT, Fisher EMC, Beer-Romero P, Brown SDM, Page D (1992). Rps4 maps near the inactivation center on the mouse X chromosome.. Genomics, 12, 363 - 367.

    1991

    • Fisher EMC (1991). On air. Science and Public Affairs, 1, 5 - 6.

    1990

    • Fisher EMC, Beer-Romero P, Brown LG, Ridley A, McNeil JA, Bentley-Lawrence J, Willard HF, Bieber F, Page DC (1990). Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome.. Cell, 63, 1205 - 1218.
    • Page DC, Fisher EMC, McGillivray B, Brown LG (1990). Additional deletion in sex-determining region of human Y chromosome resolves paradox of X,t(Y;22) female.. Nature, 346, 279 - 281.
    • NASIR J, FISHER EMC, BROCKDORFF N, DISTECHE C, LYON MF, BROWN SDM (1990). UNUSUAL MOLECULAR CHARACTERISTICS OF A REPEAT SEQUENCE ISLAND WITHIN A GIEMSA POSITIVE BAND ON THE MOUSE X-CHROMOSOME. GENET RES, 55(2), 126 - 126.
    • Fisher EMC, Alitalo T, Luoh SW, de-la-Chapelle A, Page DC (1990). Human sex-chromosome-specific repeats within a region of pseudoautosomal/Yq homology.. Genomics, 7, 625 - 628.
    • Nasir J, Fisher EMC, Brockdorff N, Disteche CM, Lyon MF, Brown SDM (1990). Unusual molecular characteristics of a repeat sequence island within a Giemsa positive bankd on the mouse X chromosome..
    • Nasir J, Fisher EMC, Brockdorff N, Disteche CM, Lyon MF, Brown SDM (1990). Unusual molecular characteristics of a repeat sequence island within a Giemsa positive band on the mouse X chromosome.. Proc. Natl. Acad. Sci. (USA), 87, 399 - .

    1988

    • NASIR J, FISHER EMC, BROCKDORFF N, LYON MF, BROWN SDM (1988). A NOVEL REPEAT SEQUENCE ISLAND ON THE MOUSE X-CHROMOSOME. GENET RES, 52(1), 69 - 69.
    • BROCKDORFF N, FISHER EMC, ORKIN SH, LYON MF, BROWN SDM (1988). LOCALIZATION OF THE HUMAN X-LINKED GENE FOR CHRONIC GRANULOMATOUS-DISEASE TO THE MOUSE X-CHROMOSOME - IMPLICATIONS FOR X-CHROMOSOME EVOLUTION. CYTOGENET CELL GENET, 48(2), 124 - 125.
    • BROWN SDM, BROCKDORFF N, CAVANNA JS, FISHER EMC, GREENFIELD AJ, LYON MF, NASIR J (1988). THE LONG-RANGE MAPPING OF MAMMALIAN CHROMOSOMES. CURR TOP MICROBIOL, 137, 3 - 12.

    1987

    • BROCKDORFF N, FISHER EMC, CAVANNA J, LYON MF, BROWN SDM (1987). THE MOLECULAR MAPPING OF THE MOUSE X-CHROMOSOME. GENET RES, 49(3), 258 - 258.
    • BROCKDORFF N, FISHER EMC, CAVANNA JS, LYON MF, BROWN SDM (1987). CONSTRUCTION OF A DETAILED MOLECULAR MAP OF THE MOUSE X-CHROMOSOME BY MICROCLONING AND INTERSPECIFIC CROSSES. EMBO J, 6(11), 3291 - 3297.
    • Page DC, Mosher R, Simpson EM, Fisher EMC, Mardon G, Pollack J, McGillivray B, de-la-Chapelle A, Brown LG (1987). The sex determining region of the human Y chromosome encodes a finger protein.. Cell, 51, 1091 - 1104.
    • Brockdorff N, Cross GS, Cavanna JS, Fisher EMC, Lyon MF, Davies KE, Brown SDM (1987). The mapping of a cDNA from the human X linked Duchenne muscular dystrophy gene to the mouse X chromosome.. Nature, 328, 166 - 168.

    1986

    • FISHER EMC, CAVANNA JS, BROCKDORFF N, LYON MF, BROWN SDM (1986). THE MOLECULAR MAPPING OF THE MOUSE X-CHROMOSOME. HEREDITY, 57, 286 - 286.

    1985

    • Fisher EMC, Cavanna JS, Brown SDM (1985). Microdissection and microcloning of the mouse X chromosome.. Proc. Natl. Acad. Sci., 82, 5846 - 5849.

    • Ma S (). Automatic Structural Parcellation of Mouse Brain MRI Using Multi-Atlas Label Fusion. PLoS ONE, 9, e86576 - e86576. doi:10.1371/journal.pone.0086576
    • Tybulewicz VLJ, O'Doherty A, Ruf S, Mulligan C, Morice E, Cooke S, Vanes L, Dunlevy L, Mohun T, Sharpe PT, Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Fisher EMC (). An aneuploid mouse with a human chromosome modelling Down syndrome..
    • Hunter J, Rogers D, Hagan J, Peters J, Nolan P, Vizor L, Thornton C, Glenister P, Greenaway S, Hewitt M, Selley R, Strivens M, Martin J, Fisher EMC, Rastan S, Browne M, Brown S (). A comprehensive ENU mutagenesis programme for the mouse genome..
    • Brown S, Peters J, Nolan P, Vizor L, Thornton C, Glenister P, Greenaway S, Hewitt M, Selley R, Strivens M, Martin J, Fisher EMC, Rogers D, Hagan J, Rastan S, Browne M, Hunter J (). A comprehensive ENU mutagenesis programme for the mouse genome..
    • Brown S, Peters J, Vizor L, Thornton C, Glenister P, Greenaway S, Nolan P, Hewitt M, Selley R, Strivens M, Martin J, Fisher EMC, Rogers D, Hagan J, Rastan S, Browne M, Hunter J (). A comprehensive ENU mutagenesis programme for the mouse genome..
    • Peters J, Vizor L, Thornton C, Glenister P, Middlehurst P, Selley R, Strivens M, Brown S, Martin J, Fisher EMC, Rogers D, Hagan J, Rastan S, Browne M, Hunter J (). A comprehensive ENU mutagenesis programme for the mouse genome..
    • Hunter AJ, Hagan JJ, Rogers D, Nolan P, Strivens M, Peters J, Brown SDM, Martin J, Fisher EMC (). A comprehensive ENU mutagenesis programme has produced novel neurological and behavioural phenotypes..
    • Hunter AJ, Hagan JJ, Rogers D, Nolan P, Strivens M, Peters J, Brown SDM, Fisher EMC, Martin JE (). A comprehensive ENU mutagenesis programme has produced novel neurological and behavioural phenotypes..
    • Banks G, Fisher EMC (). A functional dissection of the dynein complex by genetic screening in mice..
    • Martin J, Bermingham N, Mileham P, Peters J, Fisher EMC (). A model of neurological disease with anterior horn cell degeneration - legs at odd angles..
    • Acevedo-Arozena A, Ricketts T, Kalmar B, Kent R, Greensmith L, Fisher EMC (). A mutagenesis strategy to find SOD1 ALS modifiers in the mouse..
    • Acevedo-Arozena A, Rowe C, Fisher EMC (). A mutagenesis strategy to find SOD1 ALS modifiers in the mouse..
    • Isaacs AM, Skibinski G, Parkinson NJ, Brown JM, Nielsen JE, Thusgaard T, Brun A, Gade A, Johannsen P, Gydesen S, Fisher EMC, Collinge J, FReJA-Consortium (). A mutation in CHMP2B is the likely cause of frontotemporal dementia in a large Danish kindred..
    • Kieran D, Hafezparast M, Bohnert S, Dick J, Martin J, Schiavo G, Fisher EMC, Greensmith L (). A mutation in dynein rescules defects in retrograde axonal transport and delays disease progression in SOD1G93A mice..
    • Isaacs AM, Skibinski G, Parkinson NJ, Brown JM, Nielsen JE, Thusgaard T, Brun A, Gade A, Johannsen P, Gydesen S, Fisher EMC, Collinge J, The-FReJA-Consortium (). A mutation in the endosomal gene CHMP2B in frontotemporal dementia..
    • Alford KA, Vanes L, Fisher EMC, Tybulewicz VLJ (). A myeloproliferative disorder in the Tc1 mouse model of Down syndrome.
    • Joyce P, Fratta P, Phatac V, McGoldrick P, Greensmith L, Fisher EMC, Acevedo-Arozena A (). A new mouse model of ALS carrying a point mutation in the mouse Sod1 gene.
    • Joyce P, Fratta P, Phatak V, McGoldrick P, Greensmith L, Fisher EMC, Acevedo-Arozena A (). A new mouse model of ALS carrying a point mutation in the mouse Sod1 gene.
    • Joyce P, Fratta P, Phatak V, McGoldrick P, Greensmith L, Fisher EMC, Acevedo-Arozena A (). A new mouse model of ALS carrying a point mutation in the mouse Sod1 gene..
    • Joyce P, Fratta P, Phatac V, McGoldrick P, Greensmith L, Fisher EMC, Acevedo-Arozena A (). A new mouse model of ALS carrying a point mutation in the mouse Sod1 gene..
    • Bros-Facer V, Banks GT, Williams H, Greensmith L, Fisher EMC (). A novel mutation in glycine tRNA synthetase ameliorates SOD1G93A motor neuron degeneration..
    • Fisher EMC, Grimmett WJ, Johnstone K, McKie J, Pollock PM, Strutt P, Yulug IG (). A PCR approach to cloning genes from Chromosome 21..
    • Soura V, Morsi-Ed-Kadi A, Kuta A, Deng W, Stoddart E, Fisher EMC, Schiavo G, Hafezparast M (). A point mutation in cytoplasmic dynein impairs receptor tyrosine kinase (RTK) endocytic transport in the Legs at odd angles (Loa) mouse model..
    • Kieran D, Hafezparast M, Bohnert S, Dick JRT, Martin J, Schiavo G, Fisher EMC, Greensmith L (). A point mutation in dynein delays disease progression in SOD1G93A mice, a model of amyotrophic lateral sclerosis..
    • Shah PR, Mead S, Poulter M, Campbell T, Uphill J, Adamson G, Beck J, Whitfield J, Alpers M, Fisher EMC, Collinge J (). A Search for acquired prion disease susceptibility loci: genetic investigations in kuru.
    • Bunton-Stasyshyn R, Devoy A, Tybulewicz V (). A SOD1 humanising knock-in mouse model fo ALS with conditional point mutation.
    • Bunton-Stasyshyn R, Devoy A, Tybulewicz V, Fisher EMC (). A SOD1 humanising knock-in mouse model fo ALS with conditional point mutation.
    • Bunton-Stasyshyn R, Devoy A, Tybulewicz V, Fisher EMC (). A SOD1 humanising knock-in mouse model of ALS with conditional point mutation.
    • Bunton-Stasyshyn R, Devoy A, Tybulewicz V, Fisher EMC (). A SOD1 humanising knock-in mouse model of ALS with conditional point mutation.
    • Devoy A, Tybulewicz VLJ, Fisher EMC (). A SOD1 humansing knock-in mouse model of ALS with conditional point mutation.
    • Bunton-Stasyshyn R, Devoy A, Tybulewicz VLJ, Fisher EMC (). A SOD1 humansing knock-in mouse model of ALS with conditional point mutation.
    • Hafezparast M, Witherden AS, Nicholson SJ, Ahmad-Annuar A, Bermingham N, Arac D, Rankin J, Irvani M, Hummerich H, Ball S, Peters J, Martin JE, Huntley D, Sergot M, Fisher EMC (). A transcription map of distal chromosome 12 encompassing Loa: a gene involved in motor neuron degeneration..
    • Zinyuk LE, Popov VI, Padmashri R, Witton J, Tybulewicz VLJ, Fisher EMC, Randall A, Brown JT, Rusakov D, Stewart MG, Jones MW (). Abnormal dentate gyrus and CA3 connectivity and activity in the Tc1 mouse model of Down Syndrome..
    • Zinyuk LE, Popov VI, Ragunathan P, Witton J, Tybulewicz VLJ, Fisher EMC, Randall A, Brown JT, Rusakov D, Stewart MG, Jones MW (). Abnormal dentate gyrus and CA3 connectivity and activity in the Tc1 mouse model of Down syndrome..
    • Katsanis N, Fisher EMC (). Adding to the transcription map of HSA21..
    • Line SJ, Papaioannou D, Fisher EMC, Tybulewicz VJL, Bannerman DM, Deacon R (). An aneuploid mouse which models Down syndrome displays deficits in spatial working memory and motor coordination..
    • Tybulewicz VLJ, O'Doherty A, Ruf S, Morice E, Mulligan C, Cooke S, Vanes L, Dunlevy L, Sharpe PT, Brandner S, Henderson DJ, Nizetic D, Mohun T, Bliss TVP, Fisher EMC (). An aneuploid mouse with a human chromosome modelling Down syndrome.
    • O'Doherty A, Ruf S, Mulligan C, Cooke S, Vanes L, Hernandez D, Sharpe PT, Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Tybulwicz VLJ, Fisher EMC (). An aneuploid mouse with a human chromosome modelling Down syndrome..
    • Mulligan C, Ruf S, O'Doherty A, McElwaine S, Cotter FE, Mensah A, Burtscher I, Groet J, Tybulewicz VLJ, Fisher EMC, Nizetic D (). An embryonic stem cell approach to identify genes for lineage decisions in differentiating neruonal and haematopoetic cells in Down syndrome..
    • Katsanis N, Humphreys C, Sarner S, de-Belleroche J, Collinge J, Fisher EMC (). An improved protocol for the analysis of Sod1 gene mutations: screening of UK ALS families..
    • Bunton-Stasyshyn R, Devoy A, Fisher EMC (). An investigation into the role of endogenousmouse Sod1 in the disease course of transgenic SOD1mouse models of amyotrophic lateral sclerosis.
    • Stevens J, Hendriks W, Bros-Facer V, Greensmith L, Martin J, Schiavo G, Fisher EMC (). An investigation of SOD1 behaviour in amyotrophic lateral sclerosis.
    • Stevens J, Hendriks W, Bros-Facer V, Greensmith L, Martin J, Schiavo G, Fisher EMC (). An investigation of SOD1 behaviour in amyotrophic lateral sclerosis..
    • Tybulewicz VLJ, Wiseman F, Watson S, Lana-Elola E, Ruparelia A, Sheppard O, Fisher EMC (). An unusual mouse modeling aspects of Down syndrome.
    • Tybulewicz VLJ, Wiseman F, Watson S, Lana-Elola E, Ruparelia A, Sheppard O, Fisher EMC (). An unusual mouse modeling aspects of Down syndrome.
    • Tybulewicz VLJ, Wiseman F, Watson S, Lana-Elola E, Ruparelia A, Fisher EMC (). An unusual mouse modelling aspects of Down Syndrome..
    • Tybulewicz VLJ, Wiseman F, Watson S, Lana-Elola E, Ruparelia A, Fisher EMC (). An unusual mouse modelling aspects of Down syndrome..
    • Galante M, Jani H, Vanes L, Daniel H, Fisher EMC, Tybulewicz VLJ, Bliss TVP, Morice E (). Analysis of cerebellar function in the Tc1 mouse model of Down syndrome.
    • Airey J, Washbourne R, Peters J, Vizor L, Tymowska-Lalanne Z, Smythe S, Martin J, Fisher EMC, Rogers D, Hagan J, Rastan S, Browne M, Hunter J, Brown S, Nolan PM (). Analysis of ENU-induced mutations exhibiting an elevated acoustic startle response..
    • Katsanis N, Yulug I, Yaspo ML, Fisher EMC (). Analysis of expressed sequences from human chromosome 21..
    • Hafezparast M, Ahmad-Annuar A, Shah P, Martin JE, Fisher EMC (). Analysis of the cytoplasmic dynein heavy chain gene, which is mutated in the Loa mouse model of anterior horn cell degeneration..
    • Morsi A, Stoddart E, Bros C, Fisher EMC, Greensmith L, Hafezparast M (). Analysis of the role of cytoplasmic dynein in the toxicity of SOD1G93A..
    • Morsi A, Soura V, Chia R, Jackson G, Greensmith L, Fisher EMC, Hafezparast M (). Analysis of the role of dynein mutations in attenuating the phenotype of mutant-SOD1 transgenic mice..
    • Mead SH, Mahal SP, Farrall M, Fisher EMC, Collinge J (). Association of prion protein gene single nucleotide polymorphism haplotypes with Creutzfeldt-Jakob disease..
    • Sinclair B, Modat M, Cleary JO, Norris FC, Wiseman F, Fisher EMC, Lythgoe MF, Ourselin S (). Automated tensor based morphometry for phenotyping the Tc1 mouse model of Down syndrome..
    • Ruparelia A, Wiseman F, Sheppard O, Kuta A, Tybulewicz VLJ, Schiavo G, Fisher EMC (). Axonal transport in a panel of mice that model Down syndrome.
    • Dunlevey LPE, Fisher EMC, Tybulewicz VLJ, Mohun T (). Cardiac development in a mouse model of Down Syndrome (Tc1)..
    • Dunlevey LPE, Fisher EMC, Tybulewicz VLJ, Mohun T (). Cardiac development in a mouse model of Down syndrome (Tc1)..
    • Dunlevy L, Fisher EMC, Tybulewicz VLJ, Mohun T (). Cardiac development in a mouse model of Down Syndrome (Tc1)..
    • Katsanis N, Yulug IG, Yaspo ML, Hernandez D, Fisher EMC (). cDNA selection and isolation from human chromosome 21..
    • Fisher EMC, Johnstone K, McKie J, Scambler PJ (). Cell hybrids to isolate genes from human chromosome 21..
    • Lunau I, Mouridsen K, Rodell A, Nielsen J, Isaacs A, Brown J, Zeidler D, Ostergaard L, Eskildsen SF, Johannsen P, The-FReJA-Consortium (). Changes in cerebral blood flow in presymptomatic mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI..
    • FISHER E, Johannsen P, Fraham-Falkenberg S, Law I, Jennum P, Isaacs A, Brown J, Nielsen JE (). Changes in cerebral glucose metabolism in early symptomatic frontotemporal dementia linked to chromosome 3 (FTD-3).
    • Johannsen P, Fraham-Falkenberg S, Law I, Jennum P, Isaacs A, Brown J, Nielsen JE, FreJA collaboration (). Changes in cerebral glucose metabolism in early symptomatic frontotemporal dementia linked to chromosome 3 (FTD-3).
    • Fraham-Falkenbert S, Johannsen P, Law I, Jennum P, Isaacs A, Brown J, FReJA , Neilsen J (). changes in regional cerebral glucose metabolism in early symptomatic frontotemporal dementia linked to chromosome 3 (FTD3).
    • Fraham-Falkenbert S, Johannsen P, Law I, Jennum P, Isaacs A, Brown J, FReJA Collaboration , Neilsen J (). Changes in regional cerebral glucose metabolism in early symptomatic frontotemporal dementia linked to chromosome 3 (FTD3).
    • Saccon R, Joyce P, Fratta P, Greensmith L, Acevedo A, Fisher EMC (). Characterisation of a unique SOD1 mouse model for ALS.
    • Wiseman F, Fiegler H, Rajan D, Broughton T, Carter N, Fisher EMC, Tybulewicz VLJ (). Characterisation of an AnEUploid mouse which models Down Syndrome..
    • Hough T, Fisher EMC, Cheeseman M, Hunter AJ, Brown SDM (). Characterisation of mouse lines with abnormal levels of plasma alkaline phosphatase..
    • Ricketts T, Fratta P, Joyce P, McGoldrick P, Kent R, Line S, Greensmith L, Acevedo A, Fisher EMC (). Characterisation of mouse TDP43 point mutations generated by chemical mutagenesis.
    • Ricketts T, Fratta P, Joyce P, McGoldrick P, Kent R, Line S, Greensmith L, Acevedo A, Fisher EMC (). Characterisation of mouse TDP43 point mutations generated by chemical mutagenesis.
    • Achilli F, Nolan P, Lalanne Z, Hardy A, Booker D, Strand K, Revesz T, Fisher EMC (). Characterisation of new locomotor mutants.
    • Achilli F, Nolan P, Fisher EMC (). Characterisation of new mice models of motor neuron disease..
    • Hoyle J, Smith DJ, Fisher EMC (). Characterisation of the S4 gene in mouse and human..
    • Hoyle J, Smith DJ, Fisher EMC (). Characterisation of the S4 gene, a member of a highly conserved gene family involved in the ubiquitin protein degradation pathway..
    • Bermingham N, Peters J, Martin JE, Fisher EMC (). Characterisation of three new mouse mutants with neuromuscular deficits..
    • Fisher EMC, Page DC (). Characterising the distal short arm of the human Y chromosome..
    • Ricketts T, Fratta P, Joyce P, McGoldrick P, Kent R, Line S, Greensmith L, Acevedo-Arozena A, Fisher EMC (). Chatacterisation of mouse TDP43 point mutations generated by chemical mutagenesis.
    • Gade S, Brown J, Chakrabarti L, Johannsen P, Gydesen S, Association FFRIJ (). Chromosome 3 frontotemporal dementia (FTD-3): clinical course and neuropsychology..
    • Johannsen P, Gade A, Brown J, Gydesen S, Chakrabarti L, Thusgaard T, Fisher EMC, Rossor M, Collinge J, Gjedde A, Sorensen SA (). Chromosome-3 frontotemporal dementia (FTD3) with global cerebral blood flow decreases..
    • Chakrabarti L, Association FFRIJ (). Clinical and molecular characterisation of Frontotemporal dementia linked to Human Chromosome 2..
    • Skibinski G, Chakrabarti L, FReJA (). Clinical and molecular characterisation of frontotemporal dementia linked to human chromosome 3..
    • Hough T, Nolan PM, Peters J, Fisher EMC, Martin J, Browne M, Rastan S, Vizor L, Brown SDM, Hunter AJ (). Clinical biochemistry screens can complement behavioural screens in mutagenised mice..
    • Brown J, The-FReJA-Consortium (). Clinical features of frontotemporal demential linked to chromosome 3 - FTD3.
    • Grimmett WJ, Johnstone K, McKie J, Strutt P, Yulug IG, Scambler PJ, Fisher EMC (). Cloning genes from chromosome 21..
    • O'Donnell H, Johnston K, McKie J, Strutt P, Yulug I, Scambler P, Fisher EMC (). Cloning genes from chromosome 21..
    • Haas M, Tybulewicz VLJ, Fisher EMC, Guillemot F (). Cortical development in the Tc1 mouse: a model of Down Syndrome..
    • Haas M, Tybulewicz VLJ, Fisher EMC, Guillemot F (). Cortical neurogenesis in the Tc1 mouse model of Down syndrome..
    • Haas M, Fisher EMC, Tybulewicz V, Guillemot F (). Cortical projection neuron dendrite morphology in the Tc1 mouse model of Down Syndrome..
    • Haas M, Fisher E, Tybulewicz VLJ, Guillemot F (). Cortical projection neuron morphology in the Tc1 and Ts1Rhr modele of Down syndrome..
    • Haas M, Fisher EMC, Tybulewicz VLJ, Guillemot F (). Cortical projection neuron morphology in the Tc1 and Ts1Rhr models of Down syndrome.
    • Hernandez D, Tybulwicz VLJ, Fisher EMC (). Creating as panel of 'transgenomic' mouse embryonic stem cell lines that contain freely segregating portions of human chromosome 21..
    • Hernandez D, Tybulewicz V, Fisher EMC (). Creating as panel of 'transgenomic' mouse embryonic stem cell lines that contain freely segregating portions of human chromosome 21..
    • O'Doherty A, Ruf S, Hernandez D, Tybulewicz V, Fisher EMC (). Creation of transchromosomal mice for the study of Down syndrome: issues related to germline transmission of Hsa21 in mouse ES cells..
    • Morsi-El-Kadi A, Schiavo G, Ahman-Annuar A, Martin J, Fisher EMC, Hafezparast M (). Defective retrograde axonal transport and motor neuron degeneration..
    • Hatcher JP, Rogers DC, Nolan P, Fisher EMC, Martin JE, Hunter AJ (). Development of SHIRPA to characterise the behavioural phenotype of transgenic and gene-targeted mice..
    • Rogers DC, Hunter AJ, Hockings PD, Martin JE, Peters J, Cattanach BM, Fisher EMC (). Development of the 'SHIRPA' procedure to characterise the phenotype of mouse mutation..
    • Kieran D, Hafezparast M, Bohnert S, Dick J, Martin J, Schiavo G, Fisher EMC, Greensmith L (). Disrupted axonal transport in SOD1G93A transgenics is restored by mutant dynein, so significantly extending lifespan..
    • Urwin H, Authier A, Nielsen JE, Metclaf D, Froud K, Holm I, Johannsen P, Brown J, Fisher EMC, van der Zee , The FReJA consortium , Van Broeckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM (). Disruption of endosomal trafficiking in frontotemporal dementia with CHMP2B mutations.
    • Urwin H, Authier A, Nielsen J, Holm I, Johannsen P, Brown J, Fisher EMC, Van-der-Zee J, The-FReJA-Consortium , Van-Broweckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM (). Disruption of endosomal trafficking and identification of a novel vacuolar pathology in Frontotemporal Dementia with CHMP2B mutations..
    • Urwin H, Authier A, Nielsen J, Holm I, Johannsen P, Brown J, Fisher EMC, Van-der-Zee J, The-FReJA-Consortium , Van-Broweckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM (). Disruption of endosomal trafficking in frontotemporal dementia with CHMP2B mutations..
    • Urwin H, Authier A, Nielsen J, Metcalf D, Froud K, Holm I, Johannsen P, Brown J, Fisher EMC, Van-der-Zee J, The-FReJA-Consortium , Van-Broeckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM (). Disruption of endosomes-lysosome fusion in frontotemporal dementia with CHMP2B mutations..
    • Urwin H, Authier A, Nielsen JE, Metcalf D, Froud K, Holm I, Johannsen P, Brown J, Fisher EMC, van-der-Zee J, The-FReJA-Consortium , Van-Brockhoven C, Collinge J, Brandner S, Futter C, Isaacs AM (). Disruption of lysosomal fusion events in frontotemporal dementia with CHMP2B mutations..
    • Stephens J, Greensmith L, Martin JE, Schiavo G, Fisher EMC (). Dissecting the mechanisms of motor neuron disease..
    • Stephens J, Greensmith L, Martin JE, Schiavo G, Fisher EMC (). Dissecting the molecular mechanisms of motor neuron disease..
    • Wiggins LM, Stevens JC, Kuta A, Fisher EMC, von Bartheld SC (). Effects of the dynein heavy chain mutation (Loa) on neuronal morphology and survival in cranial nerve nuclei of the heterozygote Loa mouse.
    • Wiggins LM, Stevens JC, Kuta A, Fisher EMC, von Bartheld SC (). Effects of the dynein heavy chain mutation (Loa) on neuronal morphology and survival in cranial nerve nuclei of the heterozygote Loa mouse.
    • Wiggins LM, Stevens JC, Kuta A, Fisher EMC, Van Bartheld CS (). Effects of the dynein heavy chain mutation (Loa) on neuronal morphology and survival in cranial nerve nuclei of the heterozygote Loa mouse..
    • Mensah A, Linehan J, Ruf S, O'Doherty A, Burtscher I, Mulligan C, Tybulewicz VLJ, Fisher EMC, Brandner S, Nizetic D (). Embryonic stem cell derived transchromosomal teratocarcinoams: an attempt to map human chromosome 21 gene-dose effects on tumour suppression and neuronal differentiation..
    • Ruparelia A, Wiseman F, Sheppard O, Kuta A, Slender A, Tybulewicz VLJ, FISHER E (). Endocytic trafficking in a panel of mice that model Down syndrome.
    • Ruparelia A, Wiseman F, Sheppard O, Kuta A, Tybulewicz VLJ, Schiavo G, Fisher EMC (). Endocytic trafficking in a panel of mice that model Down syndrome..
    • Ruparelia A, Wiseman F, Sheppard O, Kuta A, Slender A, Tybulewicz VLJ, Schiavo G, Fisher EMC (). Endocytic trafficking in a panel of mice that model Down syndrome. Models of dementia: the good the bad and the future.
    • Lana-Elola E, Watson-Scales S, Slender A, Dunlevy L, Bennett M, Mohun T, Fisher EMC, Tybulewicz V (). Engineering new mouse models to map dosage-sensitive genes in Down syndrome congenital heart defects.
    • Wiseman F, Watson S, Elola-Lana E, Sheppard O, Ruparelia A, Tybulewicz V, FISHER E (). Engineering new mouse models to understand Alzheimer disease and its relationship to Down syndrome.
    • Wiseman F, Watson S, Elola-Lana E, Sheppard O, Ruparelia A, Tybulewicz V, Fisher EMC (). Engineering new mouse models to understand Alzheimer disease and its relationship to Down syndrome. Models of dementia: the good the bad and the future.
    • (). Enjoy writing your science thesis or dissertation.
    • Hernandez D, Fisher EMC, Tybulewicz V (). Modelling Down syndrome..
    • Fisher EMC, Hafezparast M, Ahmad-Annuar A, Shah P, Martin JE (). Models of motor neuron degeneration..
    • Farrer MJ, Fisher EMC, Kessling AM (). Molecular genetic characterisation of six cases with partial chromosome 21 aneuploidy..
    • Nickols CD, Peters J, Fisher EMC, Martin JE (). Morphology of the nerve supply to the lower limb in the gammy (gam) mouse..
    • Morice E, Cooke SF, Vanes L, Fisher EMC, Tybulewicz VLJ, Bliss TVP (). Motor dysfunction and impairments in short-term memory and synaptic plasticity in a mouse model (Tc1) of Down syndrome..
    • Tybulewicz V, Fisher EMC (). Mouse models of Down Syndrome: why make them and what can we learn from them?.
    • Hough T, Nolan P, Tsipouri V, Toye A, Goldsworthy M, Moir L, Vizor L, Cox RD, Gray I, Peters J, Spurr N, Rastan S, Martin J, Fisher EMC, Hunter AJ, Brown SDM (). Mouse models of human metabolic disorders - characterisation of mutant lines with abnormal levels of plasma alkaline phosphatase..
    • Martin JE, Sadri R, Naase M, Vizor L, Nolan P, Fisher EMC (). Mouse models of motor neuron dysfunction arising from a large scale mutagenesis programme..
    • Norris FC, Cleary JO, Modat M, Sinclair B, McCue K, Wells JA, Martinez-Barbera JP, Brandner S, FISHER E, Scambler PJ, Oourselin S, Lythgoe MF (). Mouse phenotyping using high resolution 3D microscopic magnetic resonance imaging..
    • Norris FC, Cleary JO, Modat M, Sinclair B, McCue K, Wells JA, Martinez-Barbera JP, Brandner S, Fisher EMC, Scambler PJ, Lythgoe MF (). Mouse phtnotyping using high resolution 3D microscopic magenetic resonance imaging.
    • Richardson S, Menendez G, Siow B, Wells J, Fisher EMC, Schiavo G, Lythgoe MF (). MRI detection of axonal transport via tetanus neurotoxin bound iron oxide nanoparticles..
    • Fisher EMC (). Multiple mouse models for helping us understand ALS..
    • Van-de-Leemput J, Chandran J, Hardy J, Fisher EMC, Cai H, Singleton A (). Mutation in inositol 1,4,5-triphosphate receptor type 1 gene is underlying a server movement disorder in mice..
    • Van-de-Leemput J, Chandran J, Hardy J, Fisher EMC, Cai H, Singleton A (). Mutation in inositol 1,4,5-triphosphate receptor type 1 gene underlies a severe movement in disorder in mice..
    • Knapp S, Hosie AM, Thomas P, Martinez A, Mortensen M, Brown SDM, Fisher EMC, Smart TG, Thomas HC (). Mutation of the GABA a receptor b1 gene with ENU results in alcohol preference in mice..
    • Hafezparast M, Ruhrberg C, Ahmad-Annuar A, Bowen S, Lalli G, Preistley JV, Takashi T, Schiavo G, Shima DT, Martin JE, Fisher EMC (). Mutations in dynein link motor neuron degeneration to defects in retrograde transport..
    • Hafezparast M, Ruhrberg C, Ahmad-Annuar A, Bowen S, Achilli F, Lalli G, Ball S, Toda T, Peters J, Schiavo G, Shima D, Martin JE, Fisher EMC (). Mutations in dynein link motor neuron degeneration to defects in retrograde transport..
    • Brown JM, Isaacs A, Neilsen J, The-FReJA-Consortium (). Mutations in the endosomal ESCRT-III complex in frontotemporal dementia..
    • Isaacs AM, Skibinski G, Parkinson NJ, Brown JM, Nielsen JE, Thusgaard T, Brun A, Gade A, Johannsen P, Gydesen S, Fisher EMC, Collinge J, The-FReJA-Consortium (). Mutations in the endosomal gene CHMP2B in frontotemporal dementia..
    • Isaacs AM, Skibinski G, Parkinson NJ, Brown JM, Nielsen JE, Thusgaard T, Brun A, Gade A, Johannsen P, Gydesen S, Fisher EMC, Collinge J, The-FReJA-Consortium (). Mutations in the endosomal gene cHMP2B in frontotemporal dementia..
    • Hafezparast M, Kieran D, Bohnert S, Dick J, Martin JE, Fisher EMC, Schiavo G, Greensmith L (). Neurodegeneration as a result of defective retrograde axonal transport..
    • Haas M, Fisher EMC, Tybulewicz VLJ, Guillemot F (). Neurogenesis in the developing and adult Tc1 mouse, a model of human Down Syndrome..
    • Zinyuk LE, Tybulewicz VLJ, Fisher EMC, Jones MW (). Neurophysiological profile of the Tc1 mouse model of Down syndrome..
    • Sadri R, Fisher EMC, Martin J (). New animal models of motor neurone disease..
    • Johannsen P, Holm I, Eskildsen SF, Rodell A, Isaacs AM, Gade A, Nielsen J, Ostergaard L, Fisher EMC, Collinge J, Brown J, The-FReJA-Consortium (). New imaging and neuropathology findings in FRD-3 patients and mutation carriers..
    • Gray IC, Nolan PM, Peters J, Strivens M, Hough T, Vizor L, Glenister P, Tymowska-Lalanne Z, Roby P, Latham ID, Doncaster KE, Parsons CA, Tsipouri V, Curtin JA, Sims MA, Isaacs AM, Davies KE, Rogers DC, Hagan J, Fisher EMC, Martin J, Spurr NK, Rastan S, Hunter AJ, Brown SDM (). New mouse models of human disease..
    • Hough T, Hunter AJ, Nolan PM, Tsipouri V, Goldsworthy M, Moir L, Toye A, Vizor L, Gray IC, Peters J, Fisher EMC, Rastan S, Martin J, Spurr NK, Cox R, Brown SDM (). Novel phenotypes identified by plasma biochemical screening in the mouse..
    • Holmes H, Wells J, Siow B, O'Callaghan J, Richardson S, Oursellin S, Powell N, Da M, Fisher EMC, Lythgoe MF (). Optimisation of the inv vivo sequence for structural imaging of a mouse model of Alsheimer disease.
    • Katsanis N, Yaspo ML, Fisher EMC (). Enrichment of the expressed sequence map of human chromosome 21.
    • Delabar JM, Creau N, Brahe C, Fisher EMC, Kessling A, Potier MC, Nizetic D, Petersen MB, Van-Broeckhoven C (). European chromosome 21 consortium: two years achievements..
    • Brown S, Peters J, Vizor L, Thornton C, Glenister P, Greenaway S, Hewitt M, Selley R, Strivens M, Nolan P, Martin J, Fisher EMC, Rogers D, Hagan J, Spurr N, Rastan S, Browne M, Hunter J (). Evaluation of neurological mouse mutants caused by ENU mutagenesis..
    • Levey PM, Bermingham NA, Fisher EMC, Martin JE (). Expression of lysosomal membrane glycoproteins LAMP-1 and LAMP-2 in the central nervous system.
    • Levey PM, Bermingham NA, Fisher EMC, Martin JE (). Expression of lysosomal membrane glycoproteins LAMP-1 and LAMP-2 in the central nervouse system..
    • Hoyle J, Wilkinson D, Fisher EMC (). Expression of the mouse P26S4 gene, an ATPase regulatory subunit of the 26S proteosome..
    • Johannsen P, Gade A, Brown J, Ghakrabarti K, Gjedde A, Gydesen S, Sorensen SA, PET-Centre-and-Dementia-Clinic A-U-H-A-O-S (). Extensive cerebral blood flow deficits in chromosome 2 frontotemporal dementia..
    • Ward C, Mileham P, Peters J, Fisher EMC, Martin JE (). Feeble - Failure to thrive..
    • Lloyd SE, Maytham ELG, Thompson S, Mott R, Fisher EMC, Collinge J (). Fine mapping prion disease incubation time QTL using heterogeneous stock mice..
    • Bermingham N, Martin JE, Fisher EMC (). Fine mapping the MND locus and mouse chromosome 8..
    • Brown J, Gydesen S, Johannsen P, Gade A, Skinbinski G, Chakrabarti L, Brun A, Spillantini M, Yancopoulou D, Thusgaard T, Sorensen A, Fisher EMC, Collinge J (). Frontotemporal dementia linked to chromosome 3 (FTD3)..
    • Isaacs AM, Urwin H, Authier A, Nielsen JE, Johannsen P, Holm I, Brown J, Metcalf D, Froud K, van-der-Zee J, Van-Broeckhoven C, Brandner S, Futter C, Fisher EMC, Collinge J, The-FReJA-Consortium (). Frontotemporal dementia-3 with CHMP2B mutations.
    • Urwin H, Neilsen J, Collinge J, FReJA-Consortium , Isaacs A (). Frontotemporal dementia-causing mutants produce enlarged endosoal phenotype and alter growth factor trafficking..
    • Urwin H, Neilsen J, Collinge J, Fisher EMC, The-FReJA-Consortium , Isaacs A (). Frontotemporal demential causing CHMP2B mutants mislocalise and lead to aberrant endosomal structures in cell culture..
    • Johannsen P, The-FReJA-Consortium (). FTD3 brain imaging.
    • Gade A, The-FReJA-Consortium (). FTD3 neuropsychology.
    • Ricketts T, Fratta P, Joyce P, McGoldrick P, Kent R, Greensmith L, Acevedo-Arozena A, Fisher EMC (). Functional characterization of mouse TDP-43 point mutations generated by chemical mutagenesis.
    • Ricketts T, Fratta P, Joyce P, McGoldrick P, Kent R, Greensmith L, Acevedo-Arozena A, Fisher EMC (). Functional characterization of mouse TDP-43 point mutations generated by chemical mutagenesis.
    • Ricketts T, Fratta P, Joyce P, McGoldrick P, Kent R, Greensmith L, Acevedo-Arozena A, Fisher E (). Functional characterization of mouse TDP-43 point mutations generated by chemical mutagenesis..
    • Nickols CD, Peters J, Saleem S, Fisher EMC, Martin JE (). Gammy - the mouse that limps..
    • Nickols C, Mileham P, Peters J, Fisher EMC, Martin JE (). Gammy - the mouse that limps..
    • Robson JC, Sangha HK, Gupta S, Bird MM, Bowen S, Ball S, Fisher EMC, Nickols C, Peters J, Thavapalasundaru J, Martin JE (). Gammy, a spectrum of skull defects..
    • Watson S, Lana-Elola E, Slender A, Fisher EMC, Tybulewicz VLJ (). Generation of a mapping panel of mouse strains to identify causative dosage-sensitive genes in Down syndrome.
    • Watson S, Lana-Elola E, Slender A, Fisher EMC, Tybulewicz VLJ (). Generation of a mapping panel of mouse strains to identify causative dosage-sensitive genes in Down syndrome..
    • Nolan PM, Peters J, Vizor L, Strivens M, Washbourne R, Hough T, Glenister PI, Thornton C, Greenaway S, Hewitt M, Liu X, McCormack S, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Martin J, Fisher EMC, Rogers D, Hagan J, Reavill C, Gray I, Wood J, Spurr N, Browne M, Rastan S, Hunter J, Brown SDM (). Genetic and functional studies of mutations identified in a large scale ENU mutagenesis screen..
    • Martin JE, Hafezparast M, Rurhberg C, Ahmad-Annuar A, Bowen S, Ball S, Morrison K, Shaw P, Schiavo G, Shima DT, Peters J, Fisher EMC (). Genetic characterisation of the Legs at odd angles locus, a new mutation causing motor neuron degeneration in a gene dose dependent manner..
    • Martin JE, Fisher EMC, Mackin J, Ball ST, Nicholson SJ, Witherden AS, Hafezparast M, ten-Ashbroek A, Peters J, Baas F (). Genetic localisation of the Legs at odd angles locus and analysis of the human syntenic region..
    • O'Doherty A, Ruf S, Tybulewicz VLJ, Fisher EMC (). Germline transmission of Hsa21 in the mouse: a model of human Down syndrome..
    • Zinyuk LE, Tybulewicz VLJ, Fisher EMC, Jones MW (). Hippocampal activity in the Tc1 mouse model of Down syndrome..
    • Zinyuk LE, Tybulewicz VLJ, Fisher EMC, Jones MW (). Hippocampal network activity in the Tc1 mouse model of Down syndrome.
    • Page DC, Fisher EMC, Beer-Romero P, Ridley A, Brown LG (). Homologous ribosomal protein genes on the human X and Y chromosomes may underlay the aploinsufficiency in Turner syndrome..
    • Stevens JC, Hendricks W, Martin JE, Greensmith L, Schiavo G, Fisher EMC (). How does a dynein mutation slow motor neuron disease..
    • Yulug IG, Pollock PJ, Hoyle J, Hernandez D, Scambler PJ, Fisher EMC (). Human chromosome 21: new cell lines and PCR products..
    • Katsanis N, Fisher EMC (). Identification and mapping single copy expressed sequences on human chromosome 21..
    • Lloyd S, Onwuazor O, Uphill J, Beck J, Farrall M, Targonski P, Collinge J, Fisher EMC (). Identification of multiple quantitative trait loci linked to prion disease incubation time..
    • Chia R, Tattum H, Clarke A, Fisher EMC, Jackson GS (). In vitro fibrillization of superoxide dismutatse type 1 (SOD1) suggests one possible mechanism by which mutations may lead to amyotrophic lateral sclerosis (ALS)..
    • Cooke SF, Errington ML, O'Doherty A, Sesay A, Ruf A, Vanes L, Bliss TVP, Tybulewicz VLJ, Fisher EMC (). Insertion of human chromosome 21 into the mouse genome leads to impairments of hippocampal LTP and memory.
    • Errington ML, Cooke SF, O'Doherty A, Ruf S, Vanes L, Bliss TVP, Tybulewicz VLJ, Fisher EMC (). Insertion of human chromosome 21 into the mouse genome leads to impairments of memory and hippocampal LTP..
    • Sheppard O, Plattner F, Rubin A, Slender A, Tybulewicz V, Fisher EMC (). International Conference Jerome Lejeune.
    • Yulug IG, Scambler P, Fisher EMC (). Introducing human chromosome 21 into a mouse embryonal carcinoma cell line by microcell mediated chromosome transfer..
    • Yulug IG, Grimmett WJ, Johnstone K, McKie J, Pollock PJ, Marrable A, Scambler PJ, Fisher EMC (). Introducing human chromosome 21 into a mouse embryonal carcinoma cell line..
    • McGoldrick P, Joyce P, Acevedo A, Fisher EMC, Greensmith L (). Investigating New Mutant Models of Amyotrophic Lateral Sclerosis.
    • McGoldrick P, Joyce P, Acevedo A, Fisher EMC, Greensmith L (). Investigating new mutant models of MND.
    • McGoldrick P, Dick J, Ricketts T, Acevedo-Arozena A, Fisher EMC, Greensmith L (). Investigating novel mutant mouse models of motor neuron disease.
    • McGoldrick P, Dick J, Ricketts T, Acevedo-Arozena A, Fisher E, Greensmith L (). Investigating novel mutant mouse models of motor neuron disease..
    • Fratta P, Joyce P, Ricketts T, Acevedo A, Fisher EMC (). Investigating specific transcriptomes in mouse models of amyotrophic lateral sclerosis.
    • Yulug IG, Grimmett WJ, Johnstone K, Scambler PJ, Fisher EMC (). Investigating the molecular genetics of trisomy 21 (Down syndrome)..
    • Ali-Morsi A, Stoddart E, Bros-Facer V, Fisher EMC, Greensmith L, Hafezparast M (). Investigating why dynein mutation ameliorates the SOD1 ALS phenotype and considerably extends lifespan..
    • Fisher EMC, Greensmith L (). Investigating why dynein mutation ameliorates the SOD1 ALS phenotype and considerably extends lifespan..
    • Yu Y, Kenny GD, Zhang L, Wells JA, Fisher EMC, Gaspar HB, Lythgoe MF (). Investigation of ventriculomegaly in mice deficient for adenosine deaminase using MRI.
    • Yu Y, Kenny GD, Zhang L, Fisher EMC, Gaspar HB, Lythgoe MF (). Investigation of ventriculomegaly in mice deficient for adenosine deaminase, using MRI.
    • Mileham P, Peters J, Martin J, Fisher EMC (). Investigations into the gammy (gam) mutation - a putative mouse model for human focal dystonic syndromes..
    • Page DC, Fisher EMC, Beer-Romero P, Ridley A, Brown LG (). Isolating genes from the human X and Y chromosome..
    • Nicholson S, Witherden A, Hafezparast M, Bermingham NA, Ball ST, Peters J, Martin JE, Fisher EMC (). Isolating the gene for Loa, a mouse model of dominant motor neuron degeneration..
    • Nicholson SJ, Bermingham NA, Ball ST, Peters J, Martin JE, Fisher EMC (). Isolating the gene for Loa, a mouse model of dominant motor neuron degeneration..
    • Hafezparast M, Hummerich H, Fisher EMC (). Isolation of the legs at odd angles (Loa) gene in a nutant mouse with motor neuron degeneration..
    • Hafezparast M, Ahmad-Annuar A, Lalli G, Shima DT, Schiavo G, Ball S, Peters J, Fisher EMC, Ruhrberg C (). Legs at odd angles - a mutation in dynein that impairs the navigation of motor neurons..
    • Ahmad-Annuar A, Hafezparast M, Witherden A, Ball S, Hummerich H, Peters J, Martin JE, Fisher EMC (). Legs at odd angles: a mouse mutant for motor neuron degeneration..
    • Ahmad-Annuar A, Hafezparast M, Witherden A, Ball S, Peters J, Martin JE, Fisher EMC (). Legs at odd angles: a mouse mutant with a neuronal deficit..
    • Schmitt K, Vollrath D, Foote S, Fisher EMC, Goradia T, Page D, Arnheim N (). Linkage analysis of human pseudoautosomal polymorphisms using single sperm typing: do double crossovers occur during male meiosis..
    • Ahmad-Annuar A, Shah P, Hafezparast M, Goldstein D, Fisher EMC (). Linkage disequilibrium and haplotype mapping of the human cytoplasmic dynein heavy chain 1 gene..
    • Hafezparast M, Nicholson SJ, Witherden AS, Bermingham N, Ball S, Peters J, Rogers DC, Martin JE, Fisher EMC (). Loa (Legs at odd angles) a mouse model of motor neurone dysfunction: mapping and progress towrds isolation of the causal gene..
    • Hafeparast M, Nicholson SJ, Witherden AS, Bermingham N, Ball S, Peters J, Rogers DC, Martin JE, Fisher EMC (). Loa (Legs at odd angles) a mouse model of motor neurone dysfuntion: mapping and progress towards isolation of the causal gene..
    • Devoy A, Fratta P, Fisher EMC (). Making new mouse models of ALS.
    • Devoy A, Bunton-Stasyshyn R, Tybulewicz VLJ, Fisher EMC (). Making new mouse models of ALS.
    • Tsipouri V, Curtin JA, Hough T, Nolan PM, Rooke LJ, Vizor L, Hunter AJ, Rogers D, Rastan S, Martin J, Brown SDM, Fisher EMC, Spurr NK, Gray IC (). Mapping an ENU mutagenesis derived, lov total cholesterol, low HDL-cholesterol mutant mouse to chromosome 4..
    • Nicholson S, Witherden A, Peters J, Ball S, Martin JE, Rogers D, Fisher EMC, Hafezparast M (). Mapping of a motor neuron disease gene, Loa, to the distal region of Mmu12..
    • Nicholson S, Witherden A, Peters J, Ball S, Martin J, Rogers D, EMC F, Hafezparast M (). Mapping of a mouse motor neuron disease gene, Loa..
    • Witherden AS, Nicholson SJ, Hafezparast M, Peters J, Ball ST, Martin JE, Rogers JC, Fisher EMC (). Mapping of Loa, a mouse motor deficit gene, to distal mouse chromosome 12..
    • Nicholson SJ, Witherden AS, Hafezparast M, Peters J, Martin JE, Rogers JC, Fisher EMC (). Mapping of Loa, a mouse motor deficit gene..
    • Witherden AS, Hafezparast M, Nicholson SJ, Bermingham NA, Peters J, Ball ST, Rogers DC, Martin JE, Fisher EMC (). Mapping of Loa, a mouse motor deficit mutation, to distal chromosome 12..
    • Tymowska-Lalanne Z, Nolan PM, Peters J, Vizor L, Strivens M, Washbourne R, Hough T, Glenister P, Thornton C, Greenaway S, Hewitt M, Liu X, McCormack S, Selley R, Wells C, Roby P, Martin J, Fisher EMC, Rogers D, Hagan J, Reaveill C, Gray I, Wood J, Spurr N, Browne M, Rastan S, Hunter J, Brown SDM (). Mapping of mutations from the UK mouse mutagenesis screen - towards a mutant map of the mouse..
    • Witherden AS, Nicholson SJ, Bermingham N, Ball S, Peters J, Rogers D, Martin JE, Fisher EMC, Hafezparast M (). Mapping of the mouse motor neurodegeneration gene Loa (legs at odd angles) and progress towards its cloning..
    • Yulug IG, Hernandez D, Hoyle J, Egan S, Fisher EMC (). Mapping signal transduction genes in mouse and human..
    • Fisher EMC, Brown LG, Page DC (). Mapping the human Y chromosome..
    • Martin JE, Nicholson SJ, Hafezparast M, Witherden A, Cooper E, Baker CS, Fisher EMC (). Mass spectrometry: a tool to screen mice for inborn errors of metabolism..
    • Fisher EMC, Greenfield A, Cavanna J, Brown SDM (). Microdissection of mammalian chromosomes..
    • Fisher EMC, Greenfield A, Cavanna J, Brown SDM (). Microdissection of mammalian chromosomes..
    • Fisher EMC, Greenfield A, Cavanna J, Brown SDM (). Microdissection of the mouse X chromosome..
    • Fisher EMC, Cavanna J, Brown SDM (). Microdissection of the mouse X chromosome..
    • Fisher EMC, Cavanna J, Brown SDM (). Microdissection of the mouse X chromosome..
    • Fisher EMC, Cavanna J, Brown SDM (). Microdissection of the mouse X chromosome..
    • Fisher EMC, Greenfield A, Cavanna J, Brown SDM (). Microdissection of the mouse X chromosome..
    • Fisher EMC, Cavanna J, Brown SDM (). Microdissection of the mouse X chromosome..
    • Fisher EMC, Cavanna J, Brown SDM (). Microdissection of the mouse X chromosome..
    • Hernandez D, Tybulewicz V, Fisher EMC (). Modelling aspects of Down syndrome in mice..
    • Hernandez D, Tybulewicz V, Fisher EMC (). Modelling down syndrome in mice..
    • Cleary JO, Norris FC, Wiseman FK, Price AN, Choy MK, Tybulewicz VLJ, Ordidge RJ, Fisher EMC, Lythgoe MF (). Optimised µMRI for Phenotyping the Tc1 Model of Down Syndrome.
    • Cleary JO, Norris FC, Wiseman FK, Price AN, Choy MK, Tybulewicz VLJ, Ordidge RJ, Fisher EMC, Lythgoe MF (). Optimised μMRI for Phenotyping the Tc1 Model of Down Syndrome.
    • Brun A, The-FReJA-Consortium (). Pathology of FTD3..
    • Bowen S, Bird MM, Deinhardt K, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, Hoyle A, El-Tawil T, Hazarika R, Nickols C, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, Franklin R, Revesz T, King RHM, Fisher EMC, Schiavo G, Martin JE (). Phagocytosis of cell and non-cell debris by neurons in vitro and in vivo..
    • Farrer MH, Prasher VP, Fisher EMC, Kessling AM (). Phenotype/genotype mapping Alzheimer-type dementia in Down syndrome..
    • Sadri R, Fisher EMC, Martin JE (). Phenotypes analysis of potential mouse models of motor neuron disease: a protocol..
    • Nickols CK, Peters J, Fisher EMC, Rogers D, Martin JE (). Phenotypic analysis of the mouse mutant gammy (gam) and the effects of laterality on scoring in the SHIRPA protocol..
    • Ward CL, Fisher EMC, Peters J, Martin JE (). Phenotypic and genetic characterisation of feeble..
    • Ward C, Mileham P, Peters J, Fisher EMC (). Phenotypic and genetic characterization of feeble..
    • Ghazi-Noori S, Stanczak-Mrozek K, Smidak M, Powell C, O'Malley C, Linehan JM, Fisher EMC, Brandner S, Collinge J, Asante EA, Isaacs AM (). Phenotypic characterisation of Chmp2b knock out mice..
    • Ghazi-Noori S, Houghton R, Fisher EMC, Collinge J, Asante EA, Isaacs AM (). Phenotypic characterization of CHMP2B knockout mice..
    • Hafezparast M, Ahmad-Annuar A, Shah P, Witherden AS, Bowen S, Ball S, Peters J, Martin JE, Fisher EMC (). Physical and genetic mapping of Loa: a gene involved in motor neuron degeneration..
    • Bermingham N, Peters J, Martin JE, Fisher EMC (). Positional cloning of legs at odd angles (Loa)..
    • Bermingham N, Peters J, Rogers D, Martin J, Fisher EMC (). Positional cloning of the neurological mutant: Legs at odd angles (Loa)..
    • Gade A, Skibinski G, Gydesen S, FReJA-Consortium (). Preclinical signs of impairment in persons at high risk of frontotemporal dementia related to chromosome 3 (FTD3): preliminary findings in neuropsychological tests..
    • Baker CS, Price KM, Bowen S, Hafezparast M, Ahmad-Annuar A, Peters J, Fisher EMC, Martin JE (). Protein studies of the Loa mutant..
    • Lloyd SE, Beck JA, Fisher EMC, Collinge J (). Quantative trait locus analysis of prion disease incubation time..
    • Lloyd SE, Thompson S, Mott R, Collinge J, Fisher EMC (). Quantitative trait locus analysis of prion disease incubation time in mice..
    • Lloyd SE, Thompson S, Mott R, Fisher EMC, Collinge J (). Quantitative trait locus analysis of prion disease incubation time in mice..
    • Curtin JA, Tsipouri V, Latham I, Nolan P, Hardisty R, Vizor L, Sims MA, Parsons C, Martin J, Rooke LJ, Rastan S, Hunter AJ, Brown S, Fisher EMC (). Rapid genome scan reveals linkage to mouse chromosome 15 for the ENU induced circling mouse mutant spin cycle, a potential model for DFNA17..
    • Fisher EMC, Alford K, Dunlevy L, Lana-Elola E, Haas M, Line S, Reynolds L, Ruparelia A, Sheppard O, Watson S, Wiseman F, Zynuk L, Bennerman D, Guillemot F, Hodivala-Dilke K, Jones M, Mohun T, Tybulewicz VLJ (). Recent data on the phenotype of the Tc1 mouse model of Down syndrome..
    • Kuta A, Banks G, Parkinson N, Quwailid MM, Fisher EMC (). Screening for dynein complex mutations in an ENU mouse library..
    • Acevedo-Arozena A, Rowe C, Fisher EMC (). Searching for SOD1 ALS modifiers in the mouse..
    • Acevedo-Arozena A, Corrochano S, Ricketts T, Carter S, Ribinsztein DC, Fisher EMC, Brown SDM (). Sensitised ENU screens for Huntingtons Disease and Amyotrophic Lateral Sclerosis..
    • Martin JE, Rogers D, Hunter AJ, Peters J, Brown SDM, Fisher EMC (). SHIRPA - A standardised protocol for phenotypic assessment..
    • Richtsmeier J, Hill C, Wilmore K, Fisher EMC, Tybulewicz VLJ, Sharpe P, Reeves R (). Skull shape in Down syndrome mouse models..
    • Nickols CD, Fisher EMC, Martin JE (). Study of the development of the hindlimb in the gammy (gam) mouse..
    • Price KM, Hussain I, Mustafa A, Nickols CD, Bird MM, Ateh D, Baker CS, Greensmith L, Schiavo G, Hafezparast M, Fisher EMC, Martin JE (). Subcellular functional specificyt of dynein-dynactin complex subunits - disturbances in neurodegenerative disease..
    • Mensah A, Mulligan C, Linehan J, Ruf S, O'Doherty A, Hernandez D, Grygalewicz B, Shipley J, Groet J, Tybulewicz VLJ, Fisher EMC, Brandner S, Nizetic D (). Suppression of neural fate of pluripotent mouse embryonic stem cells in vivo by trisomy 21, using a novel experimental system of transchromosomic teratomas..
    • Nolan P, Peters J, Vizor L, Washbourne R, Thornton C, Glenister P, Greenaway S, Hewitt M, Selley R, Strivens M, Martin J, Fisher EMC, Rogers D, Hagan J, Spurr N, Rastan S, Browne M, Hunter J, Brown S (). Systematic approaches to identifying novel behavioural mutations using ENU mutagenesis..
    • Ricketts T, Fisher EMC, Acevedo-Arozena A (). Tdp43: searching for new mouse models of ALS..
    • Sinclair B, Cleary JO, Modat M, Norris VC, Wiseman F, Tybulewicz V, Fisher EMC, Lythgoe MF, Ourselin S (). Tensor-based morphometry of the Tc1 mouse model of Down syndrome highlights previously undetected phenotypes.
    • Sinclair B, Cleary JO, Modat M, Norris VC, Wiseman F, Tybulewicz V, Fisher EMC, Lythgoe MF, Ourselin S (). Tensor-based morphometry of the Tc1 mouse model of Down syndrome highlights previously undetected phenotypes.
    • Sinclair B, Cleary JO, Modat M, Norris VC, Wiseman F, Tybulewicz V, FISHER E, Lythgoe MF, Ourselin S (). Tensor-based morphometry of the Tc1 mouse model of Down syndrome highlights previously undetected phenotypes..
    • Bros V, Golding M, Chia R, Schiavo G, Flenniken A, Adamson SL, Rossant J, Fisher EMC, Greensmith L, Hafezparast M (). The Arl mouse - a new mouse strain with a mutation in the cytoplasmic dynein heavy chain..
    • Bros V, Golding M, Schiavo G, Chia R, Philpott A, Flenniken A, Adamson SL, Rossant J, Greensmith L, Fisher EMC, Hafezparast M (). The Arl mouse - a new mouse strain with a mutation in the cytoplasmic dynein heavy chain..
    • Ruparelia A, Pearn M, Wu C, Schiavo G, Fisher EMC, Tybulewicz V, Mobley W (). The effect of trisomic Hsa21 genes on axonal transport and neuronal morphology in a mouse model of Down syndrome.
    • Bros-Facer V, Baisland L, Hafezparast M, Fisher EMC, Duchen M, Schiavo G, Greensmith L (). The effects of a dynein mutation on mitochondria in SOD1 motoneurons.
    • Nolan PM, Peters J, Vizor L, Strivens M, Washbourne R, Hough T, Wells C, Glenister P, Thornton C, Martin J, Fisher EMC, Rogers D, Hagan J, Reavill C, Gray I, Wood J, Spurr N, Browne M, Rastan S, Hunter J, Brown SDM (). The generation of a new mutant map of the mouse..
    • Fisher EMC (). The genetics of motor neurone disorders..
    • Skibinski G, Chakrabarti L, Fisher EMC, Collinge JC, FReJA-Consortium (). The molecular characterisation of Frontotemporal dementia linked to Human Chromosome 3 (FTD-3)..
    • Skibinski G, Chakrabarti L, The-FReJA-Consortium (). The molecular characterisation of Frontotemporal dementia linked to Human Chromosome 3 (FTD-3)..
    • Brown S, Peters J, Vizor L, Thornton C, Glenister P, Greenaway S, Hewitt M, Selley R, Strivens M, Nolan P, Martin J, Fisher EMC, Rogers D, Hagan J, Spurr N, Rastan S, Browne M, Hunter J (). The mutant map of the mouse..
    • Bermingham N, Peters J, Rogers D, Martin J, Fisher EMC (). The neurological mutant: legs at odd angles (Loa)..
    • Chia R, Achilli F, Festing MFW, Fisher EMC (). The origins and uses of mouse outbred stocks..
    • Wiseman F, Sheppard O, Barkus C, Pettingill P, Ruparelia A, Slender A, Taylor A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy of human chromosome 21 in the development of Alzheimer disease.
    • Wiseman F, Sheppard O, Barkus C, Pettingill P, Ruparelia A, Slender A, Taylor A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy of human chromosome 21 in the development of Alzheimer disease.
    • Wiseman F, Sheppard O, Barkus C, Ruparelia A, Bannerman D, Tybulewicz V, FISHER E (). The role of trisomy of human chromosome 21 in the development of Alzheimer disease..
    • Wiseman F, Sheppard O, Barkus C, Ruparelia A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy of human chromosome 21 in the development of Alzheimer disease. Models of dementia: the good the bad and the future.
    • Wiseman F, Sheppard O, Barkus C, Pettingill P, Ruparelia A, Slender A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy of human chromosome 21 in the development of Alzheimer’s disease.
    • Wiseman F, Sheppard O, Barkus C, Pettingill P, Ruparelia A, Slender A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy of human chromosome 21 in the development of Alzheimer’s disease.
    • Wiseman F, Sheppard O, Line S, Ruparelia A, Deacon R, Bannerman D, Tybulewicz VLJ, Fisher EMC (). The role of trisomy of human chromosome 21 in the development of Alzheimer's disease..
    • Wiseman F, Sheppard O, Barkus C, Pettingill P, Ruparelia A, Slender A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy y of human chromosome 21 in the development of Alzheimer’s disease.
    • Wiseman F, Sheppard O, Barkus C, Pettigill P, Ruparelia A, Slender A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy y of human chromosome 21 in the development of Alzheimer’s disease.
    • Wiseman F, Sheppard O, Barkus C, Pettigill P, Ruparelia A, Slender A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy y of human chromosome 21 in the development of Alzheimer’s disease.
    • Wiseman F, Sheppard O, Barkus C, Pettingill P, Ruparelia A, Slender A, Bannerman D, Tybulewicz V, Fisher EMC (). The role of trisomy y of human chromosome 21 in the development of Alzheimer’s disease.
    • O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe P, Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Tybulewicz VLJ, Fisher EMC (). The Tc1 mouse an aneuploid mouse with a human chromosome that modesl aspects of Down syndrome..
    • Tybulewicz VLJ, Morice E, Dunlevy L, Alford K, Lana-Elola E, Watson S, Wiseman F, Fiegler H, Rajan D, Vanes L, Tadrzak A, Broughton T, Carter N, Mohun T, Bliss TVP (). The Tc1 mouse model of Down syndrome..
    • Tsipouri VD, Curtin JA, Nolan PM, Rooke LJ, Vizor L, Martin JE, Peters J, Hunter AJ, Rogers D, Rastan S, Brown SDM, Fisher EMC, Spurr NG, Gray IC (). Three novel pigmentation mutants generated by mouse ENU mutagenesis..
    • Cleary J, Price A, Thayyil S, Schambler P, Tybulewicz VLJ, Fisher EMC, Taylor A, Ordidge R, Lythgoe M (). Towards 3D virtual histology using high-field magnetic resonance imaging..
    • Hough T, Gray IC, Nolan PM, Peters J, Fisher EMC, Martin J, Browne M, Vizor L, Bouzyk M, Kelsell D, Hunter AJ, Brown SDM, Rastan S (). Towards a mutant map of the mouse - new mutant models for bone, renal failure and blood lipids..
    • Shah PR, Ahmad-Annuar A, Ahmadi KR, Soranzo N, Russ C, Sapp PC, Kasperaviciute D, Horvitz HR, Brown RH, Goldstien DB, Fisher EMC (). Towards a systematic screen of cytoplasmic dynein-dynactin genes and other candidates for association with motor neuron degeneration disorders by tagging SNP analysis..
    • Hernandez D, Mee P, Martin J, Tybulewicz V, Fisher EMC (). Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21..
    • Hernandez D, Tybulewicz VLJ, Fisher EMC (). Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21..
    • Hernandez D, Mee P, Martin J, Tybulewicz V, Fisher EMC (). Transchromosomal mouse embyronic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21..
    • Fisher EMC, Grimmett W, Johnstone K, McKie J, O'Donnell H, Pollock P, Yulug IG, Scambler PJ (). Transferring subchromosomal fragments into mouse embryonic carcinoma and stem cells..
    • Hernandez D, Tybulewicz V, Fisher EMC (). Transgenic mouse model for Down syndrome..
    • Fisher EMC (). Treating hybrid cell lines with retinoic acid..
    • Mulligan C, Mensah A, Burtscher I, Groet J, Schnappauf F, Ruf S, O'Doherty A, Hernandez D, Shipley J, Denyer G, Epstein CJ, Tybulewicz VLJ, Fisher EMC, Nizetic D (). Trisomy 21-caused deregulation of non-HSA21 genes persists from undifferentiated ES cell to adulthood, in mouse models of Down syndrome..
    • Reynolds L, Baker M, Fisher EMC, Tybulewicz VLJ, Hodivala-Dilke K (). Trisomy of chromosome 21 inhibits angiogenesis..
    • Sheppard O, Plattner F, Rubin A, Tybulewicz V, Fisher EMC, Wiseman F (). Trisomy of DYRK1A and phosphorylation of tau in a mouse model of Down syndrome.
    • Sheppard O, Plattner F, Rubin A, Tybulewicz VLJ, Fisher EMC, Wiseman FK (). Trisomy of DYRK1A and phosporylation of Tau in a mouse model of Down syndrome..
    • Wiseman F, Sheppard O, Barkus C, Pettingill P, Ruparelia A, Slender A, Taylor A, Bannerman D, Tybulewicz V, Fisher EMC (). Trisomy of human chromosome 21 and the development of Alzheimer’s disease : a mouse model.
    • Holm IE, Englund E, The-FReJA-Consortium (). Ubiquitin positive inclusions in Frontotemporal Dementia linked to chromosome 3 (FTD-3).
    • Holm IE, Englund E, The-FReJA-Consortium (). Ubiquitin positive inclusions in Frontotemporal Dementia linked to chromosome 3 (FTD-3)..
    • Martin JE, Peters J, Mileham P, Brown SDM, Hunter AJ, Fisher EMC (). Use of a standardised screening protocol for the assessment of phenotype in mouse models of motor neuron disease..
    • Watson-Scales S, Lana-Elola E, Fisher EMC, Tybulewicz V (). Using chromosome engineering to identify phenotype to genotype relationships in Down syndrome.
    • Acevedo-Arozena A, Ricketts T, Kalmar B, Kent R, Greensmith L, Fisher EMC (). Using ENU mutagenesis to search for modifiers of SOD1 ALS in the mouse..
    • Hafezparast M, Ahmad-Annuar A, Witherden A, Martin JEM, Fisher EMC (). What have we learnt from Legs at odd angles - a mouse model of motor neuron degeneration?.
    • Banks G, Kuta A, Bros-Facer V, Schiavo G, Koltzenburg M, Greensmith L, Fisher EMC (). Working with mouse mutants to uncover the roles of transport proteins..