UCL CfMR1

View our CfMR interactive map

If you are at UCL and interested in working with the CfMR, please email Michael Duchen


Prof Alexander Gourine

Photo

Personal Profile

Name: Alexander Gourine Email: a.gourine@ucl.ac.uk
Title: Prof Tel: 020 7679 6480
Department: Neuro, Physiology & Pharmacology Fax:
Position: Professor of Physiology Address: Neuroscience, Physiology and Pharmacology, Gower Street, London, WC1E 6BT
Research Domain: Experimental Medicine, Neuroscience, Personalised Medicine Web Page: Personal Web Page

Profile

Research Description


Research Activities

How the brain controls food intake: the emerging role of the brain GLP-1 system in energy balance and autonomic control

Education Description

UCL Collaborators

Dr James Richards; Dr Stefan Trapp

External Collaborators

Dr Frank Reimann; Professor Fiona Gribble; Professor Bill Wisden; Professor Guy Rutter

Publications

    2014

    • Gourine A, Gourine AV (2014). Neural mechanisms of cardioprotection.. Physiology (Bethesda), 29(2), 133 - 140. doi:10.1152/physiol.00037.2013
    • Tang F, Lane S, Korsak A, Paton JF, Gourine AV, Kasparov S, Teschemacher AG (2014). Lactate-mediated glia-neuronal signalling in the mammalian brain.. Nat Commun, 5, 3284 - . doi:10.1038/ncomms4284

    2013

    • Holmström KM, Marina N, Baev AY, Wood NW, Gourine AV, Abramov AY (2013). Signalling properties of inorganic polyphosphate in the mammalian brain.. Nat Commun, 4, 1362 - . doi:10.1038/ncomms2364
    • Kasymov V, Larina O, Castaldo C, Marina N, Patrushev M, Kasparov S, Gourine AV (2013). Differential sensitivity of brainstem versus cortical astrocytes to changes in pH reveals functional regional specialization of astroglia.. J Neurosci, 33(2), 435 - 441. doi:10.1523/JNEUROSCI.2813-12.2013
    • Marina N, Tang F, Figueiredo M, Mastitskaya S, Kasimov V, Mohamed-Ali V, Roloff E, Teschemacher AG, Gourine AV, Kasparov S (2013). Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats.. Basic Res Cardiol, 108(1), 317 - . doi:10.1007/s00395-012-0317-x
    • Ackland GL, Kazymov V, Marina N, Singer M, Gourine AV (2013). Peripheral neural detection of danger-associated and pathogen-associated molecular patterns.. Crit Care Med, 41(6), e85 - e92. doi:10.1097/CCM.0b013e31827c0b05
    • Marina N, Tang F, Figueiredo M, Mastitskaya S, Kasimov V, Mohamed-Ali V, Gourine A, Kasparov S (2013). Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure in rats. JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S237 - S237.
    • Paton JFRY, Sobotka PA, Fudim M, Engelman ZJ, Hart ECJ, McBryde FD, Abdala AP, Marina N, Gourine AV, Lobo M, Patel N, Burchell A, Ratcliffe L, Nightingale A (2013). Response to Role of the Carotid Body in Obesity-Related Sympathoactivation. HYPERTENSION, 61(6), E58 - E58. doi:10.1161/HYPERTENSIONAHA.113.01301
    • Christie IN, Wells JA, Southern P, Marina N, Kasparov S, Gourine AV, Lythgoe MF (2013). fMRI response to blue light delivery in the naïve brain: Implications for combined optogenetic fMRI studies.. Neuroimage, 66, 634 - 641. doi:10.1016/j.neuroimage.2012.10.074
    • Paton JF, Sobotka PA, Fudim M, Engelman ZJ, Hart EC, McBryde FD, Abdala AP, Marina N, Gourine AV, Lobo M, Patel N, Burchell A, Ratcliffe L, Nightingale A (2013). The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases.. Hypertension, 61(1), 5 - 13. doi:10.1161/HYPERTENSIONAHA.111.00064

    2012

    • Mastitskaya S, Marina N, Gourine A, Gilbey MP, Spyer KM, Teschemacher AG, Kasparov S, Trapp S, Ackland GL, Gourine AV (2012). Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones.. Cardiovasc Res, 95(4), 487 - 494. doi:10.1093/cvr/cvs212
    • Plun-Favreau H, Burchell VS, Holmström KM, Yao Z, Deas E, Cain K, Fedele V, Moisoi N, Campanella M, Miguel Martins L, Wood NW, Gourine AV, Abramov AY (2012). HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion.. Cell Death Dis, 3, e335 - . doi:10.1038/cddis.2012.77
    • Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sjöquist PO, Ackland GL, Gourine AV, Gourine A (2012). Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms.. Exp Physiol, 97(8), 908 - 917. doi:10.1113/expphysiol.2012.064923
    • Abdala AP, McBryde FD, Marina N, Hendy EB, Engelman ZJ, Fudim M, Sobotka PA, Gourine AV, Paton JF (2012). Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat.. J Physiol, 590(Pt 17), 4269 - 4277. doi:10.1113/jphysiol.2012.237800

    2011

    • Marina N, Abdala AP, Korsak A, Simms AE, Allen AM, Paton JF, Gourine AV (2011). Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata.. Cardiovasc Res, 91(4), 703 - 710. doi:10.1093/cvr/cvr128
    • Gourine AV, Kasparov S (2011). Astrocytes as brain interoceptors.. Exp Physiol, 96(4), 411 - 416. doi:10.1113/expphysiol.2010.053165
    • Trapp S, Tucker SJ, Gourine AV (2011). Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16).. Exp Physiol, 96(4), 451 - 459. doi:10.1113/expphysiol.2010.055848
    • Figueiredo M, Lane S, Tang F, Liu BH, Hewinson J, Marina N, Kasymov V, Souslova EA, Chudakov DM, Gourine AV, Teschemacher AG, Kasparov S (2011). Optogenetic experimentation on astrocytes.. Exp Physiol, 96(1), 40 - 50. doi:10.1113/expphysiol.2010.052597

    2010

    • Gourine AV, Kasymov V, Marina N, Tang F, Figueiredo MF, Lane S, Teschemacher AG, Spyer KM, Deisseroth K, Kasparov S (2010). Astrocytes control breathing through pH-dependent release of ATP.. Science, 329(5991), 571 - 575. doi:10.1126/science.1190721
    • Vaarmann A, Gandhi S, Gourine AV, Abramov AY (2010). Novel pathway for an old neurotransmitter: dopamine-induced neuronal calcium signalling via receptor-independent mechanisms.. Cell Calcium, 48(2-3), 176 - 182. doi:10.1016/j.ceca.2010.08.008
    • Erlichman JS, Leiter JC, Gourine AV (2010). ATP, glia and central respiratory control. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 173(3), 305 - 311. doi:10.1016/j.resp.2010.06.009
    • Ackland GL, Del Arroyo AG, Yao ST, Stephens RC, Dyson A, Klein NJ, Singer M, Gourine AV (2010). Low molecular weight polyethylene glycol improves survival in experimental sepsis.. Critical Care Medicine, 38, 629 - 636.
    • Ackland GL, Yao ST, Rudiger A, Dyson A, Stidwill R, Poputnikov D, Singer M, Gourine AV (2010). Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats.. Crit Care Med, 38(2), 388 - 394. doi:10.1097/CCM.0b013e3181c03dfa
    • Huckstepp RTR, Bihi RI, Eason R, Spyer KM, Dicke N, Willecke K, Marina N, Gourine AV, Dale N (2010). Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity. J PHYSIOL-LONDON, 588(20), 3901 - 3920. doi:10.1113/jphysiol.2010.192088
    • Marina N, Abdala AP, Trapp S, Li A, Nattie EE, Hewinson J, Smith JC, Paton JF, Gourine AV (2010). Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration.. J Neurosci, 30(37), 12466 - 12473. doi:10.1523/JNEUROSCI.3141-10.2010

    2009

    • Gourine AV, Wood JD, Burnstock G (2009). Purinergic signalling in autonomic control.. Trends Neurosci, 32(5), 241 - 248. doi:10.1016/j.tins.2009.03.002
    • Gourine AV, Spyer KM (2009). Autonomic Nervous System: Central Respiratory Control. In (Ed.), New Encyclopedia of Neuroscience (pp. 883 - 890). : .
    • Spyer KM, Gourine AV (2009). Chemosensory pathways in the brainstem controlling cardiorespiratory activity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 364(1529), 2603 - 2610. doi:10.1098/rstb.2009.0082
    • Paschalis A, Churchill L, Marina N, Kasymov V, Gourine A, Ackland G (2009). beta1-Adrenoceptor distribution in the rat brain: an immunohistochemical study.. Neurosci Lett, 458(2), 84 - 88. doi:10.1016/j.neulet.2009.04.023
    • Tian F, Gourine AV, Huckstepp RT, Dale N (2009). A microelectrode biosensor for real time monitoring of L-glutamate release. Anal.Chim.Acta, 645(1-2), 86 - 91.

    2008

    • Trapp S, Aller MI, Wisden W, Gourine AV (2008). A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing. J.Neurosci., 28(35), 8844 - 8850.
    • Gourine AV, Spyer KM, Gourine A (2008). Beta-blockers: acting in the brain but healing the heart. Expert.Rev.Cardiovasc.Ther., 6(7), 913 - 915.
    • Gourine AV, Dale N, Korsak A, Llaudet E, Tian F, Huckstepp R, Spyer KM (2008). Release of ATP and glutamate in the nucleus tractus solitarii mediate pulmonary stretch receptor (Breuer-Hering) reflex pathway. J PHYSIOL-LONDON, 586(16), 3963 - 3978. doi:10.1113/jphysiol.2008.154567
    • Gourine A, Bondar SI, Spyer KM, Gourine AV (2008). Beneficial effect of the central nervous system beta-adrenoceptor blockade on the failing heart.. Circulation Research, 102(6), 633 - 636. doi:10.1161/CIRCRESAHA.107.165183

    2007

    • Gourine AV, Dale N, Llaudet E, Poputnikov DM, Spyer KM, Gourine VN (2007). Release of ATP in the central nervous system during systemic inflammation: real-time measurement in the hypothalamus of conscious rabbits.. The Journal of Physiology, 585(1), 305 - 316. doi:10.1113/jphysiol.2007.143933
    • Gourine VN, Krotov VP, Gourine AV, Korol'kov VI, Gordeev I (2007). [Effects of antiorthostatic hypokinesia on blood levels of interleukine-1beta and interleukine-6 in primates]. Space & Ecological Medicine (in Russian), 41(6), 56 - 58.
    • Ackland GL, Kasymov V, Gourine AV (2007). Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing.. Biochem Soc Trans, 35(Pt 5), 1264 - 1268. doi:10.1042/BST0351264

    2006

    • Lapikov SI, Gourine VN, Gourine AV (2006). [Response of the afferent vagal fibers to lipopolysaccharides of gram-negative bacteria administered intrapulmonarily: an experimental model]. Human Physiology (in Russian), 32(1), 108 - 114.
    • Spyer KM, Ackland GL, Gourine AV (2006). Neurophysiology: Overview.. In (Ed.), Encyclopedia of respiratory medicine (pp. 131 - 138). : .

    2005

    • Gourine AV, Llaudet E, Dale N, Spyer KM (2005). ATP is a mediator of chemosensory transduction in the central nervous system.. Nature, 436(7047), 108 - 111. doi:10.1038/nature03690
    • Gourine AV, Poputnikov DM, Zhernosek N, Melenchuk EV, Gerstberger R, Spyer KM, Gourine VN (2005). P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats. BRIT J PHARMACOL, 146(1), 139 - 145. doi:10.1038/sj.bjp.0706287
    • Gourine AV, Llaudet E, Dale N, Spyer KM (2005). Release of ATP in the ventral medulla during hypoxia in rats: Role in hypoxic ventilatory response. J NEUROSCI, 25(5), 1211 - 1218. doi:10.1523/JNEUROSCI.3763-04.2005
    • Gourine AV (2005). Wellcome Prize Lecture. On the peripheral and central chemoreception and control of breathing: an emerging role of ATP. The Journal of Physiology, 568(3), 715 - 724. doi:10.1113/jphysiol.2005.095968

    2004

    • Spyer KM, Dale N, Gourine AV (2004). ATP is a key mediator of central and peripheral chemosensory transduction.. Experimental Physiology, 89(1), 53 - 59.
    • Gourine AV, Dale N, Spyer KM (2004). Chemosensory control of the respiratory function. Working towards understanding the role of ATP-mediated purinergic signalling.. Advances in Experimental Medicine and Biology, 551, 31 - 38.
    • Gourine AV, Dale N, Gourine VN, Spyer KM (2004). Fever in systemic inflammation: roles of purines.. Frontiers in Bioscience, 9, 1011 - 1022.

    2003

    • Rong W, Gourine AV, Cockayne DA, Xiang Z, Ford APDW, Spyer KM, Burnstock G (2003). Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. Journal of Neuroscience, 23(36), 11315 - 11321.
    • Yao ST, Gourine AV, Spyer KM, Barden JA, Lawrence AJ (2003). Localisation of P2X2 receptor subunit immunoreactivity on nitric oxide synthase expressing neurones in the brain stem and hypothalamus of the rat: a fluorescence immunohistochemical study.. Neuroscience, 121(2), 411 - 419.
    • Gourine AV, Atkinson L, Deuchars J, Spyer KM (2003). Purinergic signalling in the medullary mechanisms of respiratory control in the rat: respiratory neurones express the P2X2 receptor subunit.. The Journal of Physiology, 552(1), 197 - 211. doi:10.1113/jphysiol.2003.045294
    • Gourine AV, Spyer KM (2003). Chemosensitivity of medullary respiratory neurones. A role for ionotropic P2X and GABA(A) receptors.. Advances in Experimental Medicine and Biology, 536, 375 - 387.

    2002

    • Gourine AV, Gourine VN, Tesfaigzi Y, Caluwaerts N, Van Leuven F, Kluger MJ (2002). Role of alpha(2)-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice.. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 283(1), R218 - R226.
    • Gourine AV, Llaudet E, Thomas T, Dale N, Spyer KM (2002). Adenosine release in nucleus tractus solitarii does not appear to mediate hypoxia-induced respiratory depression in rats. The Journal of Physiology, 544(1), 161 - 170.
    • Gourine VN, Gourine AV, Melenchuk EV, Spyer KM (2002). Effect of activation and blockade of central P2X receptors on body temperature. Russian Journal of Physiology, 88(6), 731 - 740.
    • Dale N, Gourine AV, Llaudet E, Bulmer D, Thomas T, Spyer KM (2002). Rapid adenosine release in the nucleus tractus solitarii during defence response in rats: real-time measurement in vivo. The Journal of Physiology, 544.1, 149 - 160.
    • Gourine AV, Melenchuk EV, Poputnikov DM, Gourine VN, Spyer KM (2002). Involvement of purinergic signalling in central mechanisms of body temperature regulation in rats. British Journal of Pharmacology, 135(8), 2047 - 2055.

    2001

    • Gourine AV, Spyer KM (2001). Chemosensitivity of medullary inspiratory neurones: A role for GABA(A) receptors?. NEUROREPORT, 12(15), 3395 - 3400.
    • Gourine AV, Rudolph K, Korsak AS, Kubatko J, Tesfaigzi J, Kozak W, Kluger MJ (2001). Role of capsaicin-sensitive afferents in fever and cytokine responses during systemic and local inflammation in rats.. Neuroimmunomodulation, 9(1), 13 - 22.

    2000

    • Tzschentke B, Basta D, Gourine AV, Gourine VN (2000). Influence of bombesin on neuronal hypothalamic thermosensitivity during the early postnatal period in the Muscovy duck (Cairina moschata).. Regulatory Peptides, 88(1), 33 - 39. doi:10.1016/S0167-0115(99)00114-7
    • Gourine AV, Leon LR, Rudolph K, Tesfaigzi J, Kluger MJ (2000). Cytokine cascade induced by endotoxin in TNF double receptor knockout mice: Evidence supporting a role for IL-10 in mediating antipyretic action of TNF. Journal of Thermal Biology, 25(1-2), 21 - 27. doi:10.1016/S0306-4565(99)00051-0
    • Gourine AV, Rudolph K, Leon LR, Kluger MJ (2000). Effect of interleukin-11 on body temperature in afebrile and febrile rats.. Neuroimmunomodulation, 8(1), 8 - 12.

    1999

    • Gourine VN, Sandakov DB, Gourine AV (1999). [Role of proteinase inhibitors in the process that provide coupling between body's functional systems]. Vestn.Ross.Akad.Med.Nauk (in Russian), (6), 25 - 29.
    • Gourine VN, Sandakov DB, Gourine AV (1999). [Brain proteinase activity and the mobilization of endogenous proteolytic inhibitors as factors in the development of the functional state of the body]. Human Physiology (in Russian), 25(1), 71 - 77.

    1998

    • Gourine AV, Leon LR, Rudolph K, Korsak AS, Kluger MJ (1998). Anterior hypothalamic interleukin-1 receptors are involved in mediation of fever during bacterial sepsis in rats.. Annals of the New York Academy of Sciences, 856, 266 - 269.
    • Semenenia IN, Gourine AV (1998). [Changes in the prolactin content of the cerebrospinal fluid and blood serum in rabbits in dynamic hyperthermia induced by Freund's complete adjuvant]. Zh.Evol.Biokhim.Fiziol. (in Russian), 34(2), 270 - 272.
    • Gourine AV, Rudolph K, Tesfaigzi J, Kluger MJ (1998). Role of hypothalamic interleukin-1beta in fever induced by cecal ligation and puncture in rats.. American Journal of Physiology, 275(3), R754 - R761.
    • Rudolph K, Gourine AV, Korsak AS, Kluger MJ (1998). Interleukin-6 and tumor necrosis factor-alpha during fever induced by bacterial infection.. Annals of the New York Academy of Sciences, 856, 300 - 303.

    1997

    • Gourine AV (1997). [The functional role of nitric oxide in the central nervous system]. Adv Physiol Sci (in Russian), 28(1), 53 - 60.
    • Gourine VN, Gourine AV (1997). [Role of the processes of disinhibition of pacemakers in reflex activity of neural centers]. Human Physiology (in Russian), 23(2), 147 - 149.

    1995

    • Gourine AV (1995). Pharmacological evidence that nitric oxide can act as an endogenous antipyretic factor in endotoxin-induced fever in rabbits.. General Pharmacology, 26(4), 835 - 841. doi:10.1016/0306-3623(94)00240-N
    • Semenenia IN, Gourine AV (1995). [The neurotropic effects developing on the administration of Freund's complete adjuvant (FCA) to rats]. Zh.Vyssh.Nerv.Deiat.Im I.P.Pavlova (in Russian), 45(4), 817 - 818.

    1994

    • Koulchitsky SV, Azev OA, Gourine AV, Kulchitsky VA (1994). Capsaicin-sensitive area in the ventral surface of the rat medulla.. Neuroscience Letters, 182(2), 129 - 132. doi:10.1016/0304-3940(94)90780-3