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Dr Andrey Abramov

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Personal Profile

Name: Andrey Abramov Email: a.abramov@ucl.ac.uk
Title: Dr Tel: 020778373611
Department: Molecular Neuroscience Fax:
Position: Professorial Research Address: UCL Institute of Neurology, Queen Square, London, WC1N 3BG
Research Domain: Neuroscience Web Page:  

Profile

Research Description


Research Activities

A systematic investigation into the pathogenesis and course of Parkinson's syndrome

Cellular mechanisms of neurodegeneration

Education Description

UCL Collaborators

Prof Tarek Yousry; Prof John Hardy; Dr Jose Tomas Bras; Dr Laura Silveira Moriyama; Dr Mark Cooper; Prof Andrew Lees; Dr Helen Ling; Dr Jan-Willem Taanman; Dr Derralynn Hughes; Prof Michael Duchen; Prof Kailash Bhatia; Prof Tony Schapira; Dr Rita Louro Guerreiro; Prof Nicholas Wood; Prof Tamas Revesz

External Collaborators

Dr Dario Alessi; Dr James Martin Staddon; Dr Alexander James Whitworth; Dr Atul Mehta

Publications

    2014

    • Angelova PR, Agrawalla BK, Elustondo PA, Gordon J, Shiba T, Abramov AY, Chang YT, Pavlov EV (2014). In-situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8.. ACS Chem Biol, , - . doi:10.1021/cb5000696
    • Deas E, Piipari K, Machhada A, Li A, Gutierrez-del-Arroyo A, Withers DJ, Wood NW, Abramov AY (2014). PINK1 deficiency in b-cells increases basal insulin secretion and improves glucose tolerance in mice.. Open Biol, 4(5), 140051 - .
    • Deas E, Piipari K, Machhada A, Li A, Gutierrez-Del-Arroyo A, Withers DJ, Wood NW, Abramov AY (2014). PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice.. Open Biol, 4(5), 140051 - . doi:10.1098/rsob.140051
    • Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM (2014). Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.. Nat Cell Biol, , - . doi:10.1038/ncb2901
    • Duberley KE, Heales SJ, Abramov AY, Chalasani A, Land JM, Rahman S, Hargreaves IP (2014). Effect of Coenzyme Q10 supplementation on mitochondrial electron transport chain activity and mitochondrial oxidative stress in coenzyme Q10 deficient human neuronal cells.. Int J Biochem Cell Biol, , - . doi:10.1016/j.biocel.2014.02.003
    • McNeill A, Magalhaes J, Shen C, Chau KY, Hughes D, Mehta A, Foltynie T, Cooper JM, Abramov AY, Gegg M, Schapira AH (2014). Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells.. Brain, , - . doi:10.1093/brain/awu020
    • Neary MT, Ng KE, Ludtmann MH, Hall AR, Piotrowska I, Ong SB, Hausenloy DJ, Mohun TJ, Abramov AY, Breckenridge RA (2014). Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function.. J Mol Cell Cardiol, , - . doi:10.1016/j.yjmcc.2014.06.013
    • Narayan P, Holmström KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY, Klenerman D (2014). Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage.. Biochemistry, , - . doi:10.1021/bi401606f

    2013

    • Kovac S, Abramov AY, Walker MC (2013). Energy depletion in seizures: anaplerosis as a strategy for future therapies.. Neuropharmacology, 69, 96 - 104. doi:10.1016/j.neuropharm.2012.05.012
    • Bartolome F, Wu HC, Burchell VS, Preza E, Wray S, Mahoney CJ, Fox NC, Calvo A, Canosa A, Moglia C, Mandrioli J, Chiò A, Orrell RW, Houlden H, Hardy J, Abramov AY, Plun-Favreau H (2013). Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels.. Neuron, 78(1), 57 - 64. doi:10.1016/j.neuron.2013.02.028
    • Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, Plun-Favreau H (2013). The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.. Nat Neurosci, , - . doi:10.1038/nn.3489
    • Bobkova NV, Medvinskaya NI, Kamynina AN, Aleksandrova IY, Nesterova IV, Samokhin AV, Koroev DO, Filatova MP, Nekrasov PV, Abramov AY, Leonov SV, Volpina OM (2013). Immunization with either prion protein fragment 95-123 or the fragment-specific antibodies rescue memory loss and neurodegenerative phenotype of neurons in olfactory bulbectomized mice.. Neurobiol Learn Mem, , - . doi:10.1016/j.nlm.2013.10.019
    • Duberley KE, Abramov AY, Chalasani A, Heales SJ, Rahman S, Hargreaves IP (2013). Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.. J Inherit Metab Dis, 36(1), 63 - 73. doi:10.1007/s10545-012-9511-0
    • Wood-Kaczmar A, Deas E, Wood NW, Abramov AY (2013). The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.. Adv Exp Med Biol, 961, 241 - 249. doi:10.1007/978-1-4614-4756-6_20
    • Vaarmann A, Kovac S, Holmström KM, Gandhi S, Abramov AY (2013). Dopamine protects neurons against glutamate-induced excitotoxicity.. Cell Death Dis, 4, e455 - . doi:10.1038/cddis.2012.194
    • Holmström KM, Marina N, Baev AY, Wood NW, Gourine AV, Abramov AY (2013). Signalling properties of inorganic polyphosphate in the mammalian brain.. Nat Commun, 4, 1362 - . doi:10.1038/ncomms2364
    • Suwanjang W, Holmström KM, Chetsawang B, Abramov AY (2013). Glucocorticoids reduce intracellular calcium concentration and protects neurons against glutamate toxicity.. Cell Calcium, 53(4), 256 - 263. doi:10.1016/j.ceca.2012.12.006
    • Kamynina AV, Holmström KM, Koroev DO, Volpina OM, Abramov AY (2013). Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity.. Int J Biochem Cell Biol, 45(4), 899 - 907. doi:10.1016/j.biocel.2013.01.011
    • Baev AY, Holmstrom KM, Levitskaya YV, Abramov AY (2013). Role of Polyphosphate in Mitochondria: From Modification of Energy Metabolism to Induction of the Cell Death.
    • Kamynina AV, Filatova MP, Koroev DO, Abramov AY, Volpina OM (2013). Antibodies to synthetic fragment 95-123 of the prion protein protect neurons and astrocytes from beta-amyloid toxicity. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 39(2), 113 - 120. doi:10.1134/S1068162013020076
    • Smithen M, Elustondo PA, Winkfein R, Zakharian E, Abramov AY, Pavlov E (2013). Role of polyhydroxybutyrate in mitochondrial calcium uptake.. Cell Calcium, , - . doi:10.1016/j.ceca.2013.04.006
    • Suwanjang W, Abramov AY, Govitrapong P, Chetsawang B (2013). Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells.. J Steroid Biochem Mol Biol, , - . doi:10.1016/j.jsbmb.2013.04.008
    • Abramov AY (2013). ROLE OF ASTROCYTE SIGNALLING IN THE NEUROTOXICITY OF beta-AMYOID: ROLES OF ASTROCYTES IN NEURONAL DEATH IN ALZHEIMER'S DISEASE?.
    • Holmström KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY (2013). Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.. Biol Open, 2(8), 761 - 770. doi:10.1242/bio.20134853
    • Fitzgerald JC, Ugun-Klusek A, Allen G, De Girolamo LA, Hargreaves I, Ufer C, Abramov AY, Billett EE (2013). Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins.. FASEB J, , - . doi:10.1096/fj.13-235481
    • Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, Towers N, Bennett M, Kienesberger PC, Smolenski RT, Siddall HK, Offer JL, Mocanu MM, Yelon DM, Dyck JR, Griffin JL, Abramov AY, Gould AP, Mohun TJ (2013). Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism.. PLoS Biol, 11(9), e1001666 - . doi:10.1371/journal.pbio.1001666
    • Elustondo PA, Angelova PR, Kawalec M, Michalak M, Kurcok P, Abramov AY, Pavlov EV (2013). Polyhydroxybutyrate Targets Mammalian Mitochondria and Increases Permeability of Plasmalemmal and Mitochondrial Membranes.. PLoS One, 8(9), e75812 - . doi:10.1371/journal.pone.0075812
    • Tucci A, Liu YT, Preza E, Pitceathly RD, Chalasani A, Plagnol V, Land JM, Trabzuni D, Ryten M, on behalf of UKBEC , Jaunmuktane Z, Reilly MM, Brandner S, Hargreaves I, Hardy J, Singleton AB, Abramov AY, Houlden H (2013). Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy.. J Neurol Neurosurg Psychiatry, , - . doi:10.1136/jnnp-2013-306387
    • Domijan AM, Kovac S, Abramov AY (2013). Lipid peroxidation is essential for phospholipase C activity and IP3 related calcium signal.. J Cell Sci, , - . doi:10.1242/jcs.138370
    • Ludtmann MH, Angelova PR, Zhang Y, Abramov AY, Dinkova-Kostova AT (2013). Nrf2 impacts the efficiency of mitochondrial fatty acid oxidation.. Biochem J, , - . doi:10.1042/BJ20130863
    • Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, Towers N, Bennett M, Kienesberger PC, Smolenski RT, Siddall HK, Offer JL, Mocanu MM, Yelon DM, Dyck JR, Griffin JL, Abramov AY, Gould AP, Mohun TJ (2013). Correction: Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism.. PLoS Biol, 11(12), - . doi:10.1371/annotation/a9a7f37a-3fa7-4f7f-8310-1339bf5a666e

    2012

    • Gandhi S, Abramov AY (2012). Mechanism of oxidative stress in neurodegeneration.. Oxid Med Cell Longev, 2012, 428010 - . doi:10.1155/2012/428010
    • Cremades N, Cohen SI, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TP, Dobson CM, Klenerman D (2012). Direct observation of the interconversion of normal and toxic forms of α-synuclein.. Cell, 149(5), 1048 - 1059. doi:10.1016/j.cell.2012.03.037
    • Charlesworth G, Plagnol V, Holmström KM, Bras J, Sheerin UM, Preza E, Rubio-Agusti I, Ryten M, Schneider SA, Stamelou M, Trabzuni D, Abramov AY, Bhatia KP, Wood NW (2012). Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis.. Am J Hum Genet, 91(6), 1041 - 1050. doi:10.1016/j.ajhg.2012.10.024
    • Domijan AM, Kovac S, Abramov AY (2012). Impact of fumonisin B1 on glutamate toxicity and low magnesium-induced seizure activity in neuronal primary culture.. Neuroscience, 202, 10 - 16. doi:10.1016/j.neuroscience.2011.12.005
    • Kovac S, Domijan AM, Walker MC, Abramov AY (2012). Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death.. J Cell Sci, 125(Pt 7), 1796 - 1806. doi:10.1242/jcs.099176
    • Holmstrom KM, Baird L, Dinkova-Kostova AT, Abramov AY (2012). Nrf2 Controls Mitochondrial Bioenergetics. BIOPHYSICAL JOURNAL, 102(3), 573A - 573A.
    • Ding S, Riddoch-Contreras J, Abramov AY, Qi Z, Duchen MR (2012). Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca2+ transients and nitric oxide.. J Muscle Res Cell Motil, 33(5), 327 - 337. doi:10.1007/s10974-012-9318-5
    • Ding S, Riddoch-Contreras J, Abramov AY, Qi Z, Duchen MR (2012). Erratum to: Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca(2+) transients and nitric oxide.. J Muscle Res Cell Motil, 33(5), 339 - . doi:10.1007/s10974-012-9327-4
    • Kamynina AV, Holmstrom KM, Koroev DO, Volpina OM, Abramov AY (2012). Anti-peptide antibodies to synthetic fragments of alpha7-subunit acetylcholine receptor or prion protein protect cells against beta-amyloid toxicity. JOURNAL OF PEPTIDE SCIENCE, 18, S136 - S136.
    • Plun-Favreau H, Burchell VS, Holmström KM, Yao Z, Deas E, Cain K, Fedele V, Moisoi N, Campanella M, Miguel Martins L, Wood NW, Gourine AV, Abramov AY (2012). HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion.. Cell Death Dis, 3, e335 - . doi:10.1038/cddis.2012.77
    • Gandhi S, Vaarmann A, Yao Z, Duchen MR, Wood NW, Abramov AY (2012). Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.. PLoS One, 7(5), e37564 - . doi:10.1371/journal.pone.0037564

    2011

    • Abramov AY, Ionov M, Pavlov E, Duchen MR (2011). Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease.. Aging Cell, 10(4), 595 - 603. doi:10.1111/j.1474-9726.2011.00685.x
    • Abramov AY, Duchen MR (2011). Measurements of threshold of mitochondrial permeability transition pore opening in intact and permeabilized cells by flash photolysis of caged calcium.. Methods Mol Biol, 793, 299 - 309. doi:10.1007/978-1-61779-328-8_19
    • Kovac S, Domijan AM, Walker MC, Abramov AY (2011). ROLE OF MITOCHONDRIAL FUNCTION IN SEIZURE-INDUCED NEURONAL CELL DEATH.
    • Kovac S, Domijan A, Walker MC, Abramov AY (2011). PROLONGED SEIZURE ACTIVITY IMPAIRS MITOCHONDRIAL BIOENERGETICS AND INDUCES CELL DEATH.
    • Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW (2011). PINK1 cleavage at position A103 by the mitochondrial protease PARL.. Hum Mol Genet, 20(5), 867 - 879. doi:10.1093/hmg/ddq526
    • Abramov AY, Gegg M, Grunewald A, Wood NW, Klein C, Schapira AH (2011). Bioenergetic consequences of PINK1 mutations in Parkinson disease.. PLoS One, 6(10), e25622 - . doi:10.1371/journal.pone.0025622
    • Yao Z, Gandhi S, Burchell VS, Plun-Favreau H, Wood NW, Abramov AY (2011). Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease.. J Cell Sci, 124(Pt 24), 4194 - 4202. doi:10.1242/jcs.088260
    • Domijan AM, Abramov AY (2011). Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis--implication to mechanism of cell toxicity.. Int J Biochem Cell Biol, 43(6), 897 - 904. doi:10.1016/j.biocel.2011.03.003
    • Abeti R, Abramov AY, Duchen MR (2011). Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death.. Brain, 134(Pt 6), 1658 - 1672. doi:10.1093/brain/awr104
    • Ionov M, Burchell V, Klajnert B, Bryszewska M, Abramov AY (2011). Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity.. Neuroscience, 180, 229 - 237. doi:10.1016/j.neuroscience.2011.02.045

    2010

    • Yao Z, Gandhi S, Plun-Favreau H, Wood NW, Abramov AY (2010). PINK1 Deficiency and Mitochondrial Dysfunction in Neurons and Skeletal Myocytes. BIOPHYSICAL JOURNAL, 98(3), 381A - 381A.
    • Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW (2010). The large-conductance Ca2+-activated K+ channel is essential for innate immunity (Retraction of vol 427, pg 853, 2004). NATURE, 468(7320), 122 - 122. doi:10.1038/nature09562
    • Abramov AY, Smulders-Srinivasan TK, Kirby DM, Acin-Perez R, Enriquez JA, Lightowlers RN, Duchen MR, Turnbull DM (2010). Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.. Brain, 133(Pt 3), 797 - 807. doi:10.1093/brain/awq015
    • Pavlov E, Aschar-Sobbi R, Campanella M, Turner RJ, Gómez-García MR, Abramov AY (2010). Inorganic polyphosphate and energy metabolism in mammalian cells.. J Biol Chem, 285(13), 9420 - 9428. doi:10.1074/jbc.M109.013011
    • Abramov AY, Duchen MR (2010). Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons.. Biochimica et Biophysica Acta (BBA) - General Subjects, , - . doi:10.1016/j.bbagen.2009.08.002
    • Igosheva N, Abramov AY, Poston L, Eckert JJ, Fleming TP, Duchen MR, McConnell J (2010). Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes.. PLoS One, 5(4), e10074 - . doi:10.1371/journal.pone.0010074
    • Vaarmann A, Gandhi S, Gourine AV, Abramov AY (2010). Novel pathway for an old neurotransmitter: dopamine-induced neuronal calcium signalling via receptor-independent mechanisms.. Cell Calcium, 48(2-3), 176 - 182. doi:10.1016/j.ceca.2010.08.008
    • Vaarmann A, Gandhi S, Abramov AY (2010). Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase.. J Biol Chem, 285(32), 25018 - 25023. doi:10.1074/jbc.M110.111450
    • Burchell VS, Gandhi S, Deas E, Wood NW, Abramov AY, Plun-Favreau H (2010). Targeting mitochondrial dysfunction in neurodegenerative disease: Part II.. Expert Opin Ther Targets, 14(5), 497 - 511. doi:10.1517/14728221003730434
    • Burchell VS, Gandhi S, Deas E, Wood NW, Abramov AY, Plun-Favreau H (2010). Targeting mitochondrial dysfunction in neurodegenerative disease: Part I.. Expert Opin Ther Targets, 14(4), 369 - 385. doi:10.1517/14728221003652489

    2009

    • Cantley J, Selman C, Shukla D, Abramov AY, Forstreuter F, Esteban MA, Claret M, Lingard SJ, Clements M, Harten SK, Asare-Anane H, Batterham RL, Herrera PL, Persaud SJ, Duchen MR, Maxwell PH, Withers DJ (2009). Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.. Journal of Clinical Investigation, 119(1), 125 - 135. doi:10.1172/JCI26934
    • Galkin A, Abramov AY, Frakich N, Duchen MR, Moncada S (2009). Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury?. J Biol Chem, 284(52), 36055 - 36061. doi:10.1074/jbc.M109.054346
    • Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman D, Tabrizi SJ, Wood NW (2009). PINK1 is necessary for long term survival and mitochondrial function in primary human dopaminergic neurons.
    • Gandhi S, Wood-Kaczmar A, Yao Z, Plun-Favreau H, Deas E, Klupsch K, Downward J, Latchman DS, Tabrizi SJ, Wood NW, Duchen MR, Abramov AY (2009). PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Molecular Cell, 33(5), 627 - 638. doi:10.1016/j.molcel.2009.02.013
    • Gandhi S, Wood-Kaczmar A, Wood NW, Duchen MR, Abramov AY (2009). PINK1 associated Parkinson's disease is caused by neuronal vulnerability to calcium induced cell death.

    2008

    • Abramov AY, Kasymov VA, Zinchenko VP (2008). Beta amyloid activates synthesis of nitric oxide in hyppocampal astrocytes and causes death of neurons. BIOL MEMBRANY, 25(1), 11 - 17.
    • Wood-Kaczmar A, Gandhi S, Yao Z, Abramov ASY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, Downward J, Mansfield L, Jat P, Taylor J, Heales S, Duchen MR, Latchman DL, Tabrizi SJ, Wood NW (2008). PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE, 3(6), e2455 - . doi:10.1371/journal.pone.0002455
    • Campanella M, Casswell E, Chong S, Farah Z, Wieckowski MR, Abramov AY, Tinker A, Duchen MR (2008). Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.. Cell Metabolism, 8(1), 13 - 25. doi:10.1016/j.cmet.2008.06.001
    • Aschar-Sobbi R, Abramov AY, Diao C, Kargacin ME, Kargacin GJ, French RJ, Pavlov E (2008). High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach.. J Fluoresc, 18(5), 859 - 866. doi:10.1007/s10895-008-0315-4
    • Abramov AY, Duchen MR (2008). Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777(7-8), 953 - 964. doi:10.1016/j.bbabio.2008.04.017

    2007

    • Abramov AY, Scorziello A, Duchen MR (2007). Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. Journal of Neuroscience, 27, 1129 - 1138. doi:10.1523/JNEUROSCI.4468-06.2007
    • Abramov AY, Fraley C, Diao CT, Winkfein R, Colicos MA, Duchen MR, French RJ, Pavlov E (2007). Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death.. Proceedings of the National Academy of Sciences of the United States of America, 104(46), 18091 - 18096.

    2005

    • Abramov AY, Duchen MR (2005). The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides.. Philosophical Transactions of the Royal Society B: Biological Sciences, 360(1464), 2309 - 2314.
    • Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR (2005). Expression and modulation of an NADPH oxidase in mammalian astrocytes. Journal of Neuroscience, 25(40), 9176 - 9184. doi:10.1523/JNEUROSCI.1632-05.2005
    • Abramov AY, Duchen MR (2005). Mechanisms underlying the loss of mitochondrial potential calcium homeostasis in neurons during glutamate excitotoxicity.
    • Abramov AY, Canevari L, Duchen MR (2005). Expression, function and modulation of an NADPH oxidase in mammalian astrocytes.

    2004

    • Abramov AY, Canevari L, Duchen MR (2004). Amyloid beta peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase..
    • Abramov AY, Canevari L, Duchen MR (2004). Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. Journal of Neuroscience, 24(2), 565 - 575. doi:10.1523/JNEUROSCI.4042-03.2004
    • Ahluwalia J, Tinker A, Clapp LH, Duchen MR, Abramov AY, Pope S, Nobles M, Segal AW (2004). The large-conductance Ca2+-activated K channel is essential for innate immunity.. Nature, 427(6977), 853 - 858. doi:10.1038/nature02356
    • Canevari L, Abramov AY, Duchen MR (2004). Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress.. Neurochemical Research, 29(3), 637 - 650.
    • Abramov AY, Canevari L, Duchen MR (2004). Calcium signals induced by amylold beta peptide and their consequences in neurons and astrocytes in culture. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1742(1-3), 81 - 87.

    2003

    • Abramov AY, Canevari L, Duchen MR (2003). Amyloid beta peptide causes [Ca2+](c) fluctuations and decreases [GSH] in rat astrocytes..
    • Abramov AY, Canevari L, Duchen MR (2003). Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. Journal of Neuroscience, 23(12), 5088 - 5095.
    • Abramov AY, Duchen MR (2003). Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells.. Cell Calcium, 33(2), 101 - 112.

    2001

    • Sukocheva OA, Abramov AY, Levitskaya JO, Gagelgans AI, Carpenter DO (2001). Modulation of intracellular Ca(2+) concentration by vitamin B12 in rat thymocytes.. Blood Cells Mol Dis, 27(5), 812 - 824. doi:10.1006/bcmd.2001.0450
    • Abramov AY, Zamaraeva MV, Hagelgans AI, Azimov RR, Krasilnikov OV (2001). Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers.. Biochim Biophys Acta, 1512(1), 98 - 110.

    1999

    • Zamaraeva MV, Hagelgans AI, Lubnina LV, Abramov AY, Ahmedhodjaeva HS, Saidhodjaev AI, Glazyrina NG, Salakhutdinov BA (1999). Hormonal activity and membrane action of plants terpenoids. CELL MOL BIOL LETT, 4(2), 189 - 201.

    1998

    • Sagdullaev BT, Abramov AY, Gagelgans AI, Dzhakhangirov FN, Usmanov PB (1998). Effect of a diterpene alkaloid series on calcium homeostases of rat cardiomyocites - Structure-activity bond. KHIM PRIR SOEDIN+, (4), 523 - 526.

    1997

    • Zamaraeva MV, Hagelgans AI, Abramov AY, Ternovsky VI, Merzlyak PG, Tashmukhamedov BA, Saidkhodzjaev AI (1997). Ionophoretic properties of ferutinin.. Cell Calcium, 22(4), 235 - 241.

    • Abramov AY (). Human neuronal coenzyme Q(10) deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment.. , , - .
    • Abramov AY (). Mild stress of caffeine increased mtDNA content in skeletal muscle cells: the interplay between Ca(2+) transients and nitric oxide.. , , - .