Ernest B Cady FInstP

Present Position

Consultant Clinical Scientist,
Section Head MR Physics UCLH NHS Trust,
Honorary Senior Lecturer UCL,
Dept Medical Physics & Bioengineering,
UCLH NHS Foundation Trust,

Ground Floor, Rosenheim Building,

25 Grafton Way, London WC1E 6DB.

Tel: 44-0845-1555000 x 2321
FAX: 44-207-380-6985
email: e.cady@medphys.ucl.ac.uk

Education

Diploma in Advanced Science Studies (Radio Astronomy), Victoria University of Manchester, 1976; BSc Hons (Upper Second) Astronomy, University College London, 1974

Professional Experience

  • Director Bloomsbury Centre for Magnetic Resonance Spectroscopy (1990-2008).
  • University College London Honorary Lecturer (1992-2009); Honorary Senior Lecturer (2009-)
  • Examinerships: PhD, University of Hull (1996); MSc/Diploma Biological NMR, University of Dundee, (1996-2002); PhD, Institute of Cancer Research, University of London (1997); PhD, Imperial College, University of London (2004).
  • External Consultancies: Roche Pharmaceuticals (1999-2000); Inspector of Private MRI Clinics Kensington & Westminster and Chelsea Health Authority (2000-2002); Skanska Construction UK Ltd (The London Hospital redevelopment; 2008-2010).
  • Health Professions Council Partner: Registration Assessor (2004-); Fitness-to-Practice Panel Member (2009-); Visitor for Approval Process for Association of Clinical Scientists' Certificate of Attainment (2009-).
  • MRI Safety Advisor: London Upright MRI Centre (2007-); Royal Veterinary College (2008-); University College Hospital (2008-); Nuada Medical (2010-); National Hospital for Neurology and Neurosurgery (2010-).
  • Subgroup Leader: European Commission Biomed 2 Research and Technological Development Shared Cost Project: “Evaluation of brain disease by quantitative magnetic resonance metabolic, perfusion, and diffusion imaging” ref:PL950861.
  • Grant reviewer: Swiss National Science Foundation (2003); Action Medical Research (2004, 2005, 2009); Medical Research Council (2005); Scottish Government Health Directorate (2009, 2010); Wellcome Trust-Dept of Biotechnology India Alliance (2010).
  • Peer reviewer: NMR in Biomedicine, Journal of Physiology, Brain, Pediatric Research, Journal of Magnetic Resonance, Physics in Medicine and Biology, Magnetic Resonance in Medicine, Brain Research, NeuroImage, and American Journal of Obstetrics and Gynecology, Institute of Physics and Engineering in Medicine, Springer, International Society for Magnetic Resonance in Medicine Annual Meeting, European Society for Magnetic Resonance in Medicine and Biology Annual Meeting.
  • Editorial board member: The Open Magnetic Resonance Journal (Bentham Science Publishers Ltd; 2008-).

Professional Memberships

Founder member European Society for Magnetic Resonance in Neuropediatrics 1989-2004; International Society for Magnetic Resonance in Medicine 1990-1998; European Society of Magnetic Resonance in Medicine and Biology 2000-; Institute of Physics 2005-; Health Professions Council (UK) Registered Clinical Scientist (2002-).

Honours

European Society for Magnetic Resonance in Neuropediatrics President 1994-1995; Vice President 1996-1997; Treasurer 1998-2001.
Elected Fellow of the Institute of Physics 2005.

Research Interests

In-vivo magnetic resonance spectroscopy (MRS) of muscle and brain: localisation and quantitation techniques, radio-frequency engineering (MRS probe design), computerised spectroscopic data analysis, MRI and MRS quality assurance, neonatal patient handling and MRI safety.

Recent Grants

Air Products PLC. Neuroprotective effect of Xenon and Hypothermia in a neonatal model of transient hypoxia-ischaemia: an MRI and histology study. Applicants: Robertson NJ, Cady E, 2 years (2006-2008), £293,000.

Wellbeing of Women/Royal College of Obstetricians and Gynaecology (research grant). Does melatonin enhance hypothermic neuroprotection following perinatal asphyxia? Applicants: Robertson N, Raivich G, Cady E.

2 years (2007-2009), £124,964.

Medical Research Council. Neuroprotective effect of hypothermia combined with inhaled xenon following perinatal asphyxia. Applicants: Azzopardi D, Cady EB, Edwards AD, Franks N, Hajnal J, Maze M, Robertson NJ. 3 years (2009-2011), £1,198,854.

UCLH/UCL Comprehensive Biomedical Research Centre. A multimodal, multi-disciplinary clinical imaging resource for translational medical research. Taylor SA, Hawkes D, Robertson N, Cady E. Ref. CBRC 43. 4 years (4/6/2009-3/6/2013), £699,111.

Action Medical Research. Does the α2 adrenoceptor, dexmedetomidine, an adult intensive care sedative, enhance neuroprotection when combined with therapeutic hypothermia in a model of perinatal asphyxia? Applicants: Robertson NJ, Maze M, Sanders R, Gressens P, Golay X, Cady E, Raivich G. Ref. S/P/4553; 2 years (1/1/2011 - 31/12/2012), £198,827.

Wellcome Trust (Intermediate Level Research Fellowship). The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates. Tachtsidis I (collaborators M Smith, E Cady, NJ Robertson, T Yousry). 5 years (2009-2013), £458,784.

Selected Publications

  • Cady EB. In-vivo cerebral 31P magnetic resonance spectroscopy. In: "Advances in Neurobiology", "Neural Metabolism In Vivo"; Lajtha A, Gruetter R, Choi I-Y eds, Springer, New York. 2011. In press.
  • Cady EB, Penrice J, Robertson NJ. Improved reproducibility of magnetic-resonance-spectroscopy regional brain thermometry by "amplitude-weighted-combination". NMR in Biomed. 2011. In press.
  • Thayyil S, Chandrasekaran M, Taylor AM, Bainbridge A, Cady EB,Chong WK, Murad S, Omar RZ, Robertson NJ. In-vivo cerebral magnetic resonance biomarkers for predicting long-term neurodevelopmental outcome following neonatal encephalopathy:A meta-analysis. Pediatrics, 2010 125:e382-e395.
  • Hagmann CF, De Vita E, Bainbridge A, Gunny R, Kapetanakis A, Chong W, Cady EB, Gadian D, Robertson NJ.MRI T2 is an objective measure of cerebral white matter signal abnormality in preterm infants at term equivalent age. Radiology, 2009 252:209-217.
  • Iwata O, Iwata S, Bainbridge A, De Vita E, Matsuishi T, Cady EB, Robertson NJ.Supra- and sub-baseline phosphocreatine recovery in developing brain after transient hypoxia-ischaemia: relation to baseline energetics, insult severity and outcome. Brain, 2008 131:2220-2226.
  • Robertson NJ, De Vita E, Cady EB. Principles of magnetic resonance imaging and spectroscopy. In:Neonatal Cerebral Investigation. Rennie JM, Hagmann CF, Robertson NJ (eds). Cambridge University Press, Cambridge, UK, 2008 pp 22-44.
  • Cady EB, Iwata O, Bainbridge A, Wyatt JS, Robertson NJ. Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet. J Neurochem, 2008 107:1027-1035.
  • Cheong JLY, Cady EB, Penrice J, Wyatt JS, Cox IJ, Robertson NJ. Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: Metabolite peak-area ratios, relaxation times, and absolute concentrations. Am J Neuroradiol, 2006 27:1546-1554.
  • Shanmugalingam S, Thornton JS, Iwata O, Bainbridge A, O'Brien FE, Priest AN, Ordidge RJ, Cady EB, Wyatt JS, Robertson NJ. Comparative prognostic utilities of early quantitative magnetic resonance imaging spin-spin relaxometry and proton magnetic resonance spectroscopy in neonatal encephalopathy. Pediatrics, 2006 118:1467-1477.
  • De Vita E, Bainbridge A, Cheong JLY, Hagmann C, Lombard R, Chong WK, Wyatt JS, Cady EB, Ordidge RJ, Robertson NJ. Magnetic resonance imaging of neonatal encephalopathy at 4.7 Tesla: initial experiences. Pediatrics, 2006 118:e1812-e1821.
  • Iwata O, Thornton JS, Sellwood MW, Iwata S, Sakata Y, Noone MA, O’Brien FE, Bainbridge A, De Vita E, Raivich G, Peebles D, Scaravilli F, Cady E, Ordidge R, Wyatt JS, Robertson N. Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia. Ann Neurol, 2005 58:75-87.
  • De Vita E, Bainbridge A, Cheong J, Kinchesh P, Huertas-Ceballos A, Ordidge RJ, Robertson NJ, Cady EB. Localised 4.7 Tesla proton magnetic resonance spectroscopy in neonatal encephalopathy: implementation, safety, and preliminary interpretation of results. Imaging Decisions, 2005 9:31-41.
  • Priest A, Cady EB. Nuclear magnetic resonance spectroscopy: Surface coil. In: "Encyclopedia of Analytical Science 2nd Ed, Vol 6", Townshend A, Macrae R, Haswell SJ, Lederer M, Wilson ID, Worsfold P eds, Elsevier, Oxford, 2004 366-373.
  • Brainbridge A, Cady EB. Nuclear magnetic resonance spectroscopy: In vivo spectroscopy using localization techniques. In: "Encyclopedia of Analytical Science 2nd Ed Vol 6", Townshend A, Macrae R, Haswell SJ, Lederer M, Wilson ID, and Worsfold P eds, Elsevier, Oxford, 2004 374-381.
  • Cady EB, Reynolds EOR. Brain MRS of infants and children. In "Methods in Biomedical Magnetic Resonance Imaging and Spectroscopy, Vol. 2", Young IR ed, Wiley, Chichester, 2002 pp 1086-1100.
  • Cady EB. Phosphorus and proton magnetic resonance spectroscopy of the brains of newborn human infants. In: Advances in Neurochemistry Volume 8 (Magnetic Resonance Spectroscopy and Imaging in Neurochemistry), Bachelard H ed, Plenum Press, New York, 1997 pp 289-327.
  • Cady EB, Amess P, Penrice J, Wylezinska M, Sams V, Wyatt JS. Early cerebral-metabolite quantification in perinatal hypoxic-ischaemic encephalopathy by proton and phosphorus magnetic resonance spectroscopy. Magn Reson Imaging, 1997 15:605-11.
  • Penrice J, Cady EB, Lorek A, Wylezinska M, Amess PN, Aldridge RF, Stewart A, Wyatt JS, Reynolds EO. Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia. Pediatr Res, 1996 40:6-14.
  • Cady EB, Wylezinska M, Penrice J, Lorek A, Amess P. Quantitation of phosphorus metabolites in newborn human brain using internal water as reference standard. Magn Reson Imaging, 1996 14:293-304.
  • Cady EB. Metabolite concentrations and relaxation in perinatal cerebral hypoxic-ischemic injury. Neurochem Res, 1996 21:1043-52.
  • Cady EB, Penrice J, Amess PN, Lorek A, Wylezinska M, Aldridge RF, Franconi F, Wyatt JS, Reynolds EO. Lactate, N-acetylaspartate, choline and creatine concentrations, and spin-spin relaxation in thalamic and occipito-parietal regions of developing human brain. Magn Reson Med, 1996 36:878-86.
  • Cady EB. Quantitative combined phosphorus and proton PRESS of the brains of newborn human infants. Magn Reson Med, 1995 33:557-63.
  • Cady EB, D'Souza PC, Penrice J, Lorek A. The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy. Magn Reson Med, 1995 33:862-7.
  • Cady EB, Reynolds EOR. Pediatric brain spectroscopy: Clinical utility. In "Encyclopedia of NMR", Grant DM, Harris RK eds, Wiley, Chichester, 1995 pp 3498-3512.
  • Cady EB, Lorek A, Penrice J, Reynolds EO, Iles RA, Burns SP, Coutts GA, Cowan FM. Detection of propan-1,2-diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. Magn Reson Med, 1994 32:764-7.
  • Cady EB, Boesch C, Martin E, Magnetic resonance spectroscopy. In "Perinatal Asphyxia" Haddad J, Saliba E eds. Springer, Heidelberg, 1993 pp 166-194.
  • Cady EB. MRS of the newborn human infant. In "Magnetic Resonance Spectroscopy in Biology and Medicine" eds JD de Certaines JD, Bovee WMMJ, and Podo F. Pergamon Press, Oxford, 1992 pp 437-477.
  • Cady EB. Determination of absolute concentrations of metabolites from NMR spectra. In "NMR - Basic Principles and Progress Vol 26 - In Vivo Magnetic Resonance Spectroscopy I" Diehl P, Fluck E, Gunther H, Kosfeld R, Seelig J, Rudin M eds, Springer Verlag, Heidelberg, West Germany, 1992 pp 249-281.
  • Cady EB, Hennig J, Martin E. Magnetic Resonance Spectroscopy. In "Techniques for imaging the central nervous system of the neonates" Willard D, Messer J, Haddad J eds, Springer Verlag, Heidelberg, West Germany, 1991 pp 117-146.
  • Cady EB. Clinical Magnetic Resonance Spectroscopy. 1990 PLENUM Press. New York, USA.
  • Azzopardi D, Wyatt JS, Cady EB, Delpy DT, Baudin J, Stewart AL, Hope PL, Hamilton PA, Reynolds EO. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res 1989. 25:445-51.
  • Hamilton PA, Hope PL, Cady EB, Delpy DT, Wyatt JS, Reynolds EO. Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities. Lancet 1986. 1:1242-6.
  • Hope PL, Costello AM de L, Cady EB, Delpy DT, Tofts PS, Chu A, Hamilton PA, Reynolds EO, Wilkie DR. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet 1984 2:366-70.
  • Cady EB, Costello AM de L, Dawson MJ, Delpy DT, Hope PL, Reynolds EO, Tofts PS, Wilkie DR. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet 1983 1:1059-62.
  • Griffiths JR, Cady EB, Edwards RHT, McCready VR, Wilkie DR, Wiltshaw E. 31P NMR studies of a human tumour in situ. Lancet 1983 1:1435.
  • Cady EB, Ritchings RT. Pulsar interpulses and other off-pulse emission. Nature 1977 269:126-127.