MRI Methodologies Available at AMRIG

A range of different MRI scanning techniques are available, from standard Siemens clinical protocols to novel methods developed and optimised in-house. Below are some examples of the type of thing we can do - for more info please contact us.

3D Brain

Structural Brain Imaging

Standard clinical sequences such as dual echo PD-T2 and MPRAGE are used to get high resolution structural images:

Dual Echo PD-T2
MPRAGE brain

At 3T, T1-weighted imaging can be improved by using a modification of the MPRAGE sequence known as MDEFT. This is our 'standard' for anatomical whole brain imaging:

MDEFT brain

Using FLAIR and double IR (DIR) sequences, tissues can be selectively nulled. For example, DIR can be used to minimise signal from CSF and white matter, allowing visualisation of only the grey matter:

DIR brain

Advanced Imaging Methods

Diffusion-weighted imaging (DWI) can be used to identify the white matter fibre tracts in the brain, thus providing information on the connections between different regions of the brain. Colour-coded images are used to represent the principal direction of the fibre bundles (red = left/right; green = anterior/posterior ; blue= superior/inferior):

DTI Colour Maps

Arterial spin labelling (ASL) is a method for mapping cerebral blood flow (CBF) non-invasively. It provides quantitative CBF measurements in units of ml/100g/minute:


Magnetic Resonance Spectroscopy

Using the high SNR provided by a 3T scanner and optimised head array receiver coils, it is possible to acquire good quality MR spectra in clinically feasible scan times (~10 minutes), allowing measurement of metabolites such as NAA, creatine, choline and glutamate:

Cingulate MRS