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We have developed a computational model of the neonatal piglet brain. It is an adaption and extention of the model of circulation and metabolism in the adult brain which is described here (link to Physiological Modelling section in NIRS). Both NIRS and MRS (magnetic resonance spectroscopy) measurements can be predicted. This will allow us to use the model to help analyse results from the ongoing experiments involving hypoxia ischaemia. To aid in testing and developing the model, we have applied it to experiments involving brief anoxia in piglets. More about this work, and a full description of the model can be found here.
For further information you can have a look at T. Moroz ISCBFM Brain 2011, ISOTT 2011 and ICSB 2011 poster [Poster Link]. For enquires you contact directly Tracy Moroz [email].
Multimodal Brain Spectroscopy (Ilias Tachtsidis, Tingting Zhu, Luke Dunne)
Optical and magnetic resonance (MR) spectroscopy are two non-invasive techniques that have been used individually as in-vivo monitoring techniques of brain anatomy, physiology and pathology. Both use non-ionising radiation and can provide information on oxygenation and energy metabolism; however MR can only be used intermittently while optical techniques have the capability to provide continuous measurements at the bedside. We have recently developed instrumentation and methodologies which allow combination of these technologies with the specific aim of delivering multimodal measurements of cerebral oxygenation, haemodynamics and metabolism for the clinical management of brain injury in adult and neonatal patients.
Currently we study neonatal hypoxic-ischaemia as part of a collaboration with the Perinatal Brain Magnetic Resonance Group at UCL.
For further information you can have a look at I. Tachtsidis UCL Neuroscience Symposium poster [Poster Link] and ISCBFM Brain 2011 abstract [Abstract Link], A. Bainbridge ISMRM 2011 poster [poster link]
Tachtsidis I., Bainbridge A., Faulkner S., Mahoney S., Price D., Thomas D., Cady E., Robertson N., Golay X. "Fusion of near-infrared and magnetic resonance spectroscopy delivers novel multimodal investigation of neonatal hypoxic-ischaemic brain injury.” Brain 2011, Barcelona, Spain, May 2011
Bainbridge A., Tachtsidis I., Faulkner S., Mahoney S., Price D., Thomas D., Cady E., Robertson N., Golay X. “Combined 1H MRS and Near-Infrared Spectroscopy Measurements of Cerebral Blood Volume, Oxygenation, Cytochrome Oxidase, and Intracellular Metabolites During Perinatal Hypoxia-Ischaemia” ISMRM 2011, Montreal, Canada, May 2011
Functional Activation (Tingting Zhu, Jabed F. Ahmed, Ilias Tachtsidis)
Measuring brain haemodynamics, oxygenation and metabolism during brain functional activation can offer information for brain neuronal activation and provide further insights into neurovascular coupling. We have adopted a multimodal approach that allow us to simultaneously measure: (1) the changes in brain tissue oxy- and deoxy-haemoglobin ([HbO2] [HHb]) and the redox changes in cytochrome-c-oxidase ([ox-redCCO] or [CtOx]), which is a marker of mitochondrial metabolism and (2) the changes in systemic physiology including blood pressure, heart rate and scalp blood flow. We have implemented a plethora of methodologies (SPM, ICA, Wavelets) to explore the crosstalk between systemic changes and NIRS signal changes during frontal lobe activation and have been recently reporting at the presence of false positives in NIRS frontal lobe functional activation studies.
E. Kirilina, A. Jelzow, R. Bruehl, A. Heine, M. Niessing, A. M. Jacobs, B. Ittermann, H. Wabnitz, R. Macdonald, and I. Tachtsidis "Physiological origin of systemic artifacts in functional near infrared spectroscopy as revealed by fMRI." ISMRM 2011, Montreal, Canada, May 2011
Jelzow A,Tachtsidis I,Kirilina E,Niessing M,Bruhl R,Wabnitz H,Heine A,Ittermann B,Macdonald R, “Simultaneous measurement of time-domain fNIRS and physiological signals during a cognitive task.” SPIE-INT SOC OPTICAL ENGINEERING, DIFFUSE OPTICAL IMAGING III, Volume 8088 (2011).