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Seminars

  • Speaker: Professor Yiannis Ventikos

  • Title: “Multiscale computational modelling in healthcare provision: the case for cerebral aneurysms”

  • Date: Monday, 17 March 2014

  • Time: 1-2 pm

  • Venue: Roberts Room G08, Roberts Building, UCL, Torrington Place, London WC1E 7JE

ABSTRACT:

Cerebral aneurysms, possibly due to their focal nature and particularly adverse outcomes when rupture occurs, have been at the focus of intense study for a variety of scientific communities, beyond medicine: from biology to applied mathematics and from biomechanics to computer science. In this presentation, we shall offer an overview of computational techniques spanning the entire spectrum of aneurysms healthcare management, including device deployment, thrombosis models, inflammation models and rupture risk evaluation.
Three broad themes will be discussed:
1) Computation of hemodynamics. By solving the relevant equations of mass and momentum transport, indicators that are directly correlated to inception, growth or rupture are extracted. Usually, statistically meaningful numbers of cases are examined in such studies. In effect such approaches strive to bypass the biological complexity of vascular wall biomechanics and link directly hemodynamics with system-level responses and clinical outcomes.
2) Hemodynamics and arterial wall biology modelling. An almost first principles coupling of mechanical stimuli (flow-induced Wall Shear Stress for example) with outcomes (inception, growth or rupture) by accounting explicitly for the vascular inflammation, growth & remodelling processes at play.
3) Computational assessment of interventional devices. In this case the desired outcome is to evaluate whether a particular device will introduce adequate blood flow stagnation and thus lead to stable thrombus formation. Beyond assessing existing devices and evaluating device-deployment scenarios, this modality allows for the invention and virtual testing of new devices too.

BRIEF BIOGRAPHY:

Yiannis Ventikos is the Kennedy Professor of Mechanical Engineering and the Head of Department of Mechanical Engineering at University College London. Before that, he has worked or studied in Greece, the USA and Switzerland and he joined UCL from Oxford in July 2013. His research focuses on transport phenomena and fluid mechanics, as they are applied to biomedical engineering problems, energy, innovative industrial processes and biocomplexity. Areas of research include arterial haemodynamics and tissue remodelling (with an emphasis on vascular malformations, like aneurysms), cerebrospinal fluid dynamics, shock-induced bubble collapse, droplet generation and deposition, targeted drug delivery, swirling flows, chaos, mixing and dynamical systems, organogenesis, micro- and nano-technologies. Yiannis established the Fluidics and Biocomplexity Group that currently comprises about twenty researchers, mostly at the doctoral and postdoctoral level. He has published about 100 papers in peer-reviewed scientific journals, has contributed chapters in 5 books, has presented more than 200 papers in international conferences and workshops and has filed six international patents to date. He is the senior academic founder of a spin-out company and consults internationally on topics of his expertise.

About the Medical Physics Lunchtime Seminar:

The Medical Physics Lunchtime Seminar is normally held on the last Monday of every month (except Bank holidays) between 1 and 2 pm. The seminar series is open to all and features
principal investigators in and collaborators with the Department of Medical Physics and Bioengineering at UCL and UCLH. Staff and students within the department are strongly encouraged to attend to find out more about the various exciting activities going on in the department. The seminar series aims to introduce the career path of the speakers, cultivate a stronger identity within the department, share current research fields with the wider UCL community, and to inspire the next generation of scientists and students.

Enquiries: Dr Ilias Tachtsidis (<span class="underline">i.tachtsidis@ucl.ac.uk</span><span class="underline"> </span>)

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