Staff Profile

Prof Pierre-Marc Bouloux

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Personal Profile

Name: Pierre-Marc Bouloux Email: p.bouloux@ucl.ac.uk
Title: Prof Tel: 0207 830 2414
Department: Metabolism & Experimental Therapeutics Fax: 0207 431 6435
Position: Professor of Endocrinology Address: Royal Free Campus, Centre for Neuroendocrinology, Royal Free Hospital School of Medicine, Hampstead, London, NW3 2QG
Research Domain: Basic Life Sciences, Neuroscience Web Page: Personal Web Page

Profile

Research Description


Research Activities

Hypogonadism in the male

Male hormonal c

Neuroendocrinology of gonadal function

Phaeochromocytoma

Regeneration and repair of soft tissue inc. mucosa and skeletal muscle

Education Description

UCL Collaborators

Prof Mark Lewis; Dr Stefano Fedele; Dr Vivek Mudera

External Collaborators

Publications

    2012

    • Fede G, Spadaro L, Tomaselli T, Privitera G, Germani G, Tsochatzis E, Thomas M, Bouloux PM, Burroughs AK, Purrello F (2012). Adrenocortical dysfunction in liver disease: a systematic review.. Hepatology, 55(4), 1282 - 1291. doi:10.1002/hep.25573
    • Guaraldi G, Beggi M, Zona S, Luzi K, Orlando G, Carli F, Ligabue G, Rochira V, Rossi R, Modena MG, Bouloux P (2012). Erectile dysfunction is not a mirror of endothelial dysfunction in HIV-infected patients.. J Sex Med, 9(4), 1114 - 1121. doi:10.1111/j.1743-6109.2011.02243.x
    • Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP (2012). SOX2 regulates the hypothalamic-pituitary axis at multiple levels.. J Clin Invest, 122(10), 3635 - 3646. doi:10.1172/JCI64311

    2011

    • Hu Y, Bouloux PM (2011). X-linked GnRH deficiency: role of KAL-1 mutations in GnRH deficiency.. Mol Cell Endocrinol, 346(1-2), 13 - 20. doi:10.1016/j.mce.2011.04.001
    • Kroll H, Bolsover S, Hsu J, Kim SH, Bouloux PM (2011). Kisspeptin-evoked calcium signals in isolated primary rat gonadotropin- releasing hormone neurones.. Neuroendocrinology, 93(2), 114 - 120. doi:10.1159/000321678

    2009

    • Hu Y, Guimond SE, Travers P, Cadman S, Hohenester E, Turnbull JE, Kim SH, Bouloux PM (2009). Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1.. Journal of Biological Chemistry, Aug 20., - .

    2008

    • Mommers E, Kersemaekers WM, Elliesen J, Kepers M, Apter D, Behre HM, Beynon J, Bouloux PM, Costantino A, Gerbershagen HP, Grønlund L, Heger-Mahn D, Huhtaniemi I, Koldewijn EL, Lange C, Lindenberg S, Meriggiola MC, Meuleman E, Mulders PF, Nieschlag E, Perheentupa A, Solomon A, Väisälä L, Wu FC, Zitzmann M (2008). Male hormonal contraception: a double-blind, placebo-controlled study.. J Clin Endocrinol Metab, 93(7), 2572 - 2580. doi:10.1210/jc.2008-0265
    • Kim SH, Hu Y, Cadman S, Bouloux P (2008). Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome.. J Neuroendocrinol, 20(2), 141 - 163.

    2007

    • Solomon A, Sinanan ACM, Bouloux PMG, Lewis MP (2007). Effects of androgens on differentiation of human muscle-derived cells in vitro are related to changes in local IGF-1 expression.
    • Pitteloud N, Quinton R, Pearce S, Raivio T, Acierno J, Dwyer A, Plummer L, Hughes V, Seminara S, Cheng YZ, Li WP, Maccoll G, Eliseenkova AV, Olsen SK, Ibrahimi OA, Hayes FJ, Boepple P, Hall JE, Bouloux PG, Mohammadi M, Crowley W (2007). Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism.. Journal of Clinical Investigation, 117(2), 457 - 463. doi:10.1172/JCI29884

    2004

    • Hu Y, González-Martínez D, Kim S, Bouloux PM (2004). Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator. Biochemical Journal, 384(3), 495 - 505. doi:10.1042/BJ20041078
    • Gonzalez-Martinez D, Kim SH, Hu Y, Guimond S, Schofield J, Winyard P, Vannelli GB, Turnbull J, Bouloux PM (2004). Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism. Journal of Neuroscience, 24(46), 10384 - 10392. doi:10.1523/JNEUROSCI.3400-04.2004
    • Tanriverdi F, Gonzalez-Martinez D, Silveira LF, Hu Y, Maccoll GS, Travers P, Bouloux PM (2004). Expression of gonadotropin-releasing hormone type-I (GnRH-I) and type-II (GnRH-II) in human peripheral blood mononuclear cells (PMBCs) and regulation of B-lymphoblastoid cell proliferation by GnRH-I and GnRH-II.. Experimental and Clinical Endocrinology and Diabetes, 112(10), 587 - 594.
    • Gonzalez-Martinez D, Hu Y, Bouloux PG (2004). Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome.. Frontiers in Neuroendocrinology, 25(2), 108 - 130. doi:10.1016/j.yfrne.2004.06.001
    • Korbonits M, Slawik M, Cullen D, Ross RJ, Stalla G, Schneider H, Reincke M, Bouloux PM, Grossman AB (2004). A comparison of a novel testosterone bioadhesive buccal system, striant, with a testosterone adhesive patch in hypogonadal males.. Journal of Clinical Endocrinology and Metabolism, 89(5), 2039 - 2043.

    2003

    • Tanriverdi F, Silveira LF, MacColl GS, Bouloux PM (2003). The hypothalamic-pituitary-gonadal axis: immune function and autoimmunity. Journal of Endocrinology, 176(3), 293 - 304.
    • Beaumont NJ, Skinner VO, Tan TMM, Ramesh BS, Byrne DJ, MacColl GS, Keen JN, Bouloux PM, Mikhailidis DP, Bruckdorfer KR, Vanderpump MP, Srai KS (2003). Ghrelin can bind to a species of high density lipoprotein associated with paraoxonase. Journal of Biological Chemistry, 278(11), 8877 - 8880. doi:10.1074/jbc.C200575200
    • Hu Y, Tanriverdi F, MacColl GS, Bouloux P (2003). Kallmann?s syndrome: molecular pathogenesis. The International Journal of Biochemistry and Cell Biology, 35(8), 1157 - 1162.
    • Bouloux PM, Nieschlag E, Burger HG, Skakkebaek NE, Wu FC, Handelsman DJ, Baker GH, Ochsenkuehn R, Syska A, McLachlan RI, Giwercman A, Conway AJ, Turner L, van Kuijk JH, Voortman G (2003). Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alone. Journal of Andrology, 24(4), 604 - 611.
    • Hameed A, Brothwood T, Bouloux P (2003). Delivery of testosterone replacement therapy. Current Opinion in Investigational Drugs, 4(10), 1213 - 1219.
    • Garland J, Buscombe JR, Bouvier C, Bouloux P, Chapman MH, Chow AC, Reynolds N, Caplin ME (2003). Sandostatin LAR (long-acting octreotide acetate) for malignant carcinoid syndrome: a 3-year experience. Alimentary Pharmacology and Therapeutics, 17(3), 437 - 444.

    2002

    • Bevan JS, Atkin SL, Atkinson AB, Bouloux PM, Hanna F, Harris PE, James RA, McConnell M, Roberts GA, Scanlon MF, Stewart PM, Teasdale E, Turner HE, Wass JA, Wardlaw JM (2002). Primary medical therapy for acromegaly: an open, prospective, multicenter study of the effects of subcutaneous and intramuscular slow-release octreotide on growth hormone, insulin-like growth factor-I, and tumor size. Journal of Clinical Endocrinology and Metabolism, 87(10), 4554 - 4563.
    • Silveira LF, Stewart PM, Thomas M, Clark DA, Bouloux PM, MacColl GS (2002). Novel homozygous splice acceptor site GnRH receptor (GnRHR) mutation: human GnRHR "knockout". Journal of Clinical Endocrinology and Metabolism, 87(6), 2973 - 2977.
    • MacColl G, Quinton R, Bouloux PM (2002). GnRH neuronal development: insights into hypogonadotrophic hypogonadism. Trends in Endocrinology and Metabolism, 13(3), 112 - 118.
    • Bouloux PM, Hu Y, MacColl G (2002). Recent advances in the pathogenesis of Kallmann's syndrome. Progress in Brain Research, 141, 79 - 83.
    • Bouloux P, Warne DW, Loumaye E (2002). Efficacy and safety of recombinant human follicle-stimulating hormone in men with isolated hypogonadotropic hypogonadism. Fertility and Sterility, 77(2), 270 - 273.
    • Bouloux PMG, Harris PE (2002). Editorial. CME Bulletin Endocrinology and Diabetes, 4(1), 3 - .
    • MacColl G, Bouloux P, Quinton R (2002). Kallmann syndrome: adhesion, afferents, and anosmia. Neuron, 34(5), 675 - 678.
    • Silveira LFG, MacColl GS, Bouloux PMG (2002). Hypogonadotropic hypogonadism. Seminars in Reproductive Medicine, 20(4), 327 - 338.
    • Stephens JW, Katz JR, McDermott N, MacLean AB, Bouloux PM (2002). An unusual steroid-producing ovarian tumour: case report. Human Reproduction, 17(6), 1468 - 1471.
    • Silveira LF, Bouloux PM, MacColl GS, Camacho-Hubner C, Miraki-Moud F (2002). Growth hormone therapy for non-islet cell tumor hypoglycemia. The American Journal of Medicine, 113(3), 255 - 257.
    • Randeva HS, Davison R, Chamoun V, Bouloux PM (2002). Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion. Endocrine, 17(3), 241 - 247.

    2001

    • MacColl G, Bunn C, Goldspink G, Bouloux P, Gorecki DC (2001). Intramuscular plasmid DNA injection can accelerate autoimmune responses. Gene Therapy, 8(17), 1354 - 1356.
    • Bouloux PM, Handelsman DJ, Jockenhovel F, Nieschlag E, Rabinovici J, Frasa WL, de Bie JJ, Voortman G, Itskovitz-Eldor J (2001). First human exposure to FSH-CTP in hypogonadotrophic hypogonadal males. Human Reproduction, 16(8), 1592 - 1597.
    • Quinton R, Duke VM, Robertson A, Kirk JM, Matfin G, de Zoysa PA, Azcona C, MacColl GS, Jacobs HS, Conway GS, Besser M, Stanhope RG, Bouloux PM (2001). Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization. Clinical Endocrinology, 55(2), 163 - 174.
    • Quinton R, Beirne P, Bouloux PM, Stanhope RG, Conway GS (2001). Routine neuroimaging in classical isolated gonadotrophin deficiency is of limited clinical value. Clinical Endocrinology, 54(1), 127 - 129.

    2000

    • McGrath S, Bouloux PMG (2000). Adrenogenital syndrome. In Fink G (Ed.), Encyclopedia of Stress (pp. 75 - 80). : Academic Press.
    • Rogers DPS, Bouloux PMG, Vanderpump MPJ (2000). Cytokine-mediated reversible hypopituitarism in POEMS syndrome. Journal of Endocrinology, 164(Suppl), 28 - .
    • Robertson A, MacColl G, Bouloux PMG (2000). Mechanism of anosmin-1 cleavage in vitro. Journal of Endocrinology, 164(Suppl), 175 - .
    • Randeva H, Bouloux PMG (2000). Cushing's Syndrome. Student BMJ, 8, 100 - 104.
    • Randeva H, Bouloux PMG (2000). Thyrotoxicosis. Student BMJ, 8, 62 - 64.
    • Bouloux PM, Harris P (2000). Editorial. CME Bulletin Endocrinology and Diabetes, 3(2), 38 - .
    • Bouloux PM, Harris P (2000). Editorial. CME Bulletin Endocrinology and Diabetes, 3(1), 3 - .

    1995

    • Bouloux PG, Fakeeh M (1995). Investigation of phaeochromocytoma.. Clin Endocrinol (Oxf), 43(6), 657 - 664.