Staff Profile

Dr Anton Emmanuel

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Personal Profile

Name: Anton Emmanuel Email: a.emmanuel@ucl.ac.uk
Title: Dr Tel: 020 7380 9311
Department: Internal Medicine Fax: 020 7380 9239
Position: Senior Clinical Lecturer and Honorary Consultant Address: Department of Gastroenterology and Nutrition, University Col, 235 Euston Road, London, NW1 2BU
Research Domain: Neuroscience Web Page: Personal Web Page

Profile

Research Description

Neural and reflex control of gut function in health, MS and spinal injury; manipulation of gut function through altering reflexes; sacral neuromodulation; electrical stimulation of gastric function and interaction with gut hormones in satiety; visceral nerve and muscle interactions in IBS (visceral hypersensitivity); stress response and gut autonomic tone; hypnotherapy in functional GI disorders; gut function in systemic sclerosis.

Research Activities

Gut function in neurological illness

Education Description

UCL Collaborators

External Collaborators

Publications

    2012

    • Emmanuel AV, Kamm MA, Roy AJ, Kerstens R, Vandeplassche L (2012). Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction - a double-blind, placebo-controlled, cross-over, multiple n=1 study. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 35(1), 48 - 55. doi:10.1111/j.1365-2036.2011.04907.x
    • Chatoor D, Emmanuel A (2012). Development and assessment of the constipation-related disability scale.. Aliment Pharmacol Ther, 35(4), 487 - 488. doi:10.1111/j.1365-2036.2011.04959.x
    • Thoua NM, Abdel-Halim M, Forbes A, Denton CP, Emmanuel AV (2012). Fecal incontinence in systemic sclerosis is secondary to neuropathy.. Am J Gastroenterol, 107(4), 597 - 603. doi:10.1038/ajg.2011.399

    2011

    • Parkes GC, Chatoor D, Emmanuel A (2011). THE PROBIOTIC VSL#3 INCREASES SCBM AND REDUCES SYMPTOM SEVERITY SCORES IN PATIENTS WITH FUNCTIONAL CONSTIPATION. doi:10.1136/gut.2011.239301.345
    • Schizas AM, Emmanuel AV, Williams AB (2011). Anal canal vector volume manometry.. Dis Colon Rectum, 54(6), 759 - 768. doi:10.1007/DCR.0b013e3182113be7
    • Schizas AM, Emmanuel AV, Williams AB (2011). Vector volume manometry--methods and normal values.. Neurogastroenterol Motil, 23(9), 886 - e393. doi:10.1111/j.1365-2982.2011.01745.x
    • Preziosi G, Raptis DA, Storrie J, Raeburn A, Fowler CJ, Emmanuel A (2011). Bowel biofeedback treatment in patients with multiple sclerosis and bowel symptoms.. Dis Colon Rectum, 54(9), 1114 - 1121. doi:10.1097/DCR.0b013e318223fd7b
    • Abdel-Halim MR, Crosbie J, Engledow A, Windsor A, Cohen CR, Emmanuel AV (2011). Temporary sacral nerve stimulation alters rectal sensory function: a physiological study.. Dis Colon Rectum, 54(9), 1134 - 1140. doi:10.1097/DCR.0b013e318220c0ba
    • Emmanuel A, Inns S (2011). Lecture Notes in Gastroenterology and Hepatology.

    2010

    • Emmanuel A (2010). Textbook of Female Urology and Urogynecology. In Cardozo L (Ed.), Textbook of Female Urology and Urogynecology (pp. - ). : .
    • Emmanuel A (2010). Pelvic Floor Disorders. In Santoro GA (Ed.), Pelvic Floor Disorders (pp. - ). : Springer Verlag.
    • (2010). Pelvic Organ Dysfunction in Neurological Disease.
    • Bajwa A, Thiruppathy K, Trivedi P, Boulos P, Emmanuel A (2010). Effect of rectal distension on voluntary external anal sphincter function in healthy subjects. Colorectal Dis, epub ahead of publication, - .
    • Thoua N, Bunce C, Brough G, Forbes A, Emmanuel A, Denton C (2010). Assessment of gastrointestinal symptoms in patients with systemic slcerosis in a UK tertiary referral centre.. Rheumatol (Oxford), 49, 1770 - 1775.
    • Emmanuel A (2010). Managing neurogenic bowel dysfunction. Clin Rehabil, 24, 483 - 488.
    • Emmanuel A (2010). Review of the efficacy and safety of trans-anal irrigation for neurogenic bowel dysfunction. Spinal cord, 48, 664 - 673.

    2009

    • Chatoor D, Soligo M, Emmanuel A (2009). Organising a clinical service for patients with pelvic floor disorders.. Best Pract Res Clin Gastroenterol, 23, 611 - 620.
    • Emmanuel A, Tack J, Quigley E, Talley N (2009). Pharmacological management of constipation. Neurogastroenterol Motility, 21(Suppl 2), 41 - 54.
    • Trivedi PM, Thoua N, Boulos PB, Craggs MC, Emmanuel AV (2009). LOWER MOTOR NEURONE SPINAL CORD INJURY REDUCES RECTAL COMPLIANCE WHILST PRESERVING SIGMOID COMPLIANCE.
    • Trivedi PM, Bajwa A, Boulos PB, Craggs MC, Emmanuel AV (2009). INCREASED SIGMOID COMPLIANCE MAY EXPLAIN GUT SYMPTOMS AND RESPONSE TO TREATMENT IN SUPRACONAL SPINAL CORD INJURY.
    • Bajwa A, Emmanuel A (2009). The physiology of continence and evacuation.. Best Practice and Research Clinical Gastroenterology, 23(4), 477 - 485.
    • Chatoor D, De Vita E, Cady E, Bainbridge A, Osborne J, Elneil S, Bartram C, Halligan S, Emmanuel A, Taylor S (2009). Tissue characterisation and strength of the puborectalis muscle in women with faecal incontinence..
    • Emmanuel A, Chatoor D (2009). Common proctology scenarios.. Best Practice and Research Clinical Gastroenterology, 23(4), 461 - 461.
    • Chatoor D, De Vita E, Cady E, Bainbridge A, Osborne J, Elneil S, Bartram C, Halligan S, Emmanuel A, Taylor S (2009). Tissue characterisation and strength of the puborectalis muscle in women with faecal incontinence..
    • Thoua NM, Murray CD, Winchester WJ, Roy AJ, Pitcher MC, Kamm MA, Emmanuel AV (2009). Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome.. Alimentary Pharmacology and Therapeutics, 29(5), 552 - 560.
    • Emmanuel AV, Chung EA, Kamm MA, Middleton F (2009). Relationship between gut-specific autonomic testing and bowel dysfunction in spinal cord injury patients.. Spinal Cord, 47(8), 623 - 627.
    • Preziosi G, Emmanuel A (2009). Neurogenic bowel dysfunction: pathophysiology, clinical manifestations and treatment.. Expert Review of Gastroenterology and Hepatology, 3(4), 417 - 423.
    • Chatoor D, De Vita E, Cady E, Bainbridge A, Osborne J, Elneil S, Bartram C, Halligan S, Emmanuel A, Taylor S (2009). Tissue characterisation and strength of the puborectalis muscle in women with faecal incontinence..
    • Emmanuel A (2009). Colorectal Surgery. In Phillips RKS (Ed.), Colorectal Surgery (pp. - ). : Saunders Ltd.
    • Emmanuel A, Chatoor D (2009). Common proctology scenarios. Preface.. Best Pract Res Clin Gastroenterol, 23(4), 461 - . doi:10.1016/j.bpg.2009.06.003

    2008

    • Thoua N, Khoo D, Kalantzis C, Emmanuel A (2008). Acid-related oesophageal sensitivity, not dysmotility, differentiates subgroups of patients with non-erosive reflux disease. Aliment Pharmacol Ther, 27, 396 - 403.
    • Murray CD, Le Roux CW, Emmanuel AV, Halket JM, Przyborowska AM, Kamm MA, Murray-Lyon IM (2008). The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion. Appetite, 51(3), 747 - 750.
    • Emmanuel A (2008). Imaging Pelvic Floor Disorders. In Stoker J, Baert ALFRW, Taylor S, DeLancey JOL (Ed.), Imaging Pelvic Floor Disorders (pp. - ). : Springer Verlag.
    • Taylor SA, Thiruppathy K, Chatoor D, Halligan S, Emmanuel A (2008). Static and dynamic pelvic floor mRI: correlation with symptoms and function.
    • De Vita E, Chatoor DR, Cady EB, Bainbridge A, Osborne JL, Elneil S, Emmanuel AV, Bartram CI, Halligan S, Taylor SA (2008). Proton magnetic resonance spectroscopy characterisation of puborectalis muscle..
    • Thiruppathy K, Cohen R, Emmanuel A, Halligan S, Taylor SA (2008). Role of endoanal Us in the management of women with clinical diagnosis of 3rd/4th degree obstetric-related perineal tears.
    • Hart AL, Plamondon S, Emmanuel AV, Kamm MA (2008). Prospective evaluation of the relationship between stress and relapse in ulcerative colitis.. Journal of Clinical Gastroenterology, 42(8), 963 - 964.

    2007

    • Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton L, Hungin P, Jones R, Kumar D, Rubin G, Trudgill N, Whorwell P (2007). Guidelines on the irritable bowel syndrome: mechanisms and practical management. GUT, 56(12), 1770 - 1798. doi:10.1136/gut.2007.119446
    • Taylor SA, Chatoor D, Emmanuel A, Cohen RC, Windsor A, Elneil S, Osbourne J, Hare C, Halligan S (2007). Validation of supine MR proctography in the assessment of rectal dysfunction against fluoroscopic barium proctography and clinical outcome..
    • Thiruppathy K, Cohen R, Taylor SA, Emmanuel AV (2007). MRI findings of the pelvic floor correlates with function..
    • Chatoor DR, Thoua NM, Emmanuel AV (2007). Functional symptoms and their psychological correlates in patients with a rectocoele and evacuation difficulties.
    • Emmanuel A (2007). Urogenital Pain in Clinical Practice. In Baranowski AP, Abrams P, Fall M (Ed.), Urogenital Pain in Clinical Practice (pp. - ). : Informa HealthCare.
    • Kamm MA, Jordan CC, Leaker BR, Nicholson FB, Murray CD, Taylor S, Marshall M, Gibbs A, Carter EG, Emmanuel AV (2007). Pharmacological modulation of gut mucosal and large vessel blood flow. Aliment.Pharmacol.Ther., 25(6), 693 - 702.
    • Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton , L , Hungin , P , Jones , R , Kumar , D , Rubin , G , Trudgill , N , Whorwell , P (2007). Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut, 56(12), 1770 - 1798.
    • Thoua NM, Kalantzis C, Roy AJ, Emmanuel AV (2007). Functional heartburn patients with somatisation trait demonstrate generalised visceral hypersensitivity.
    • Chatoor DR, Taylor SJ, Cohen CR, Emmanuel AV (2007). Faecal incontinence. Br.J.Surg., 94(2), 134 - 144.
    • Chatoor DR, Emmanuel AV, Elneil S, Cohen R, Windsor AC, Osborne J, Halligan S, Taylor SA (2007). What does MR proctography add in comparison to fluoroscopic proctography in patients with evacuation difficulty?.
    • Thiruppathy K, Cohen R, Taylor SA, Bajwa AA, Emmanuel AV (2007). Short-term faecal incontinence after 3rd/4th degree tear is uncommon..
    • Thoua N, Taylor SA, Emmanuel A (2007). Evidence of external anal sphincter atrophy and disturbed autonomic activity in systemic sclerosis..
    • Chaliha C, Sultan AH, Emmanuel AV (2007). Normal ranges for anorectal manometry and sensation in women of reproductive age.. Colorectal Disease, 9(9), 839 - 844.

    2006

    • Emmanuel A (2006). Diseases of the colon. In Wexner SD, Stollman N (Ed.), Diseases of the colon (pp. - ). : Informa HealthCare.
    • Chung EA, Emmanuel AV (2006). Gastrointestinal symptoms related to autonomic dysfunction following spinal cord injury.. Progress in Brain Research, 152, 317 - 333.
    • Murray CDR, le Roux CW, Gouveia C, Bassett P, Ghatei MA, Bloom SR, Emmanuel AV, Gabe SM (2006). The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients.. Clinical Nutrition, 25(4), 626 - 633.
    • Soligo M, Salvatore S, Emmanuel AV, De Ponti E, Zoccatelli M, Cortese M, Milani R (2006). Patterns of constipation in urogynecology: clinical importance and pathophysiologic insights.. American Journal of Obstetrics and Gynecology, 195(1), 50 - 55.
    • Craggs MD, Balasubramaniam AV, Chung EAL, Emmanuel AV (2006). Aberrant reflexes and function of the pelvic organs following spinal injury in man.. Autonomic Neuroscience, 126-127, 355 - 370.
    • Murray CDR, Booth CE, Bulmer DCE, Kamm MA, Emmanuel AV, Winchester WJ (2006). Ghrelin augments afferent response to distension in rat isolated jejunum.. Neurogastroenterology and Motility, 18(12), 1112 - 1120.
    • Thoua N, Emmanuel AV (2006). Managing functional GI symptoms. Postgraduate Medical Journal, 6(5), 449 - 452.

    2005

    • Emmanuel A (2005). Frontiers in colorectal surgery. In Phillips RKS, Clark S (Ed.), Frontiers in colorectal surgery (pp. - ). : Tfm Pub Ltd.
    • Murray CD, Martin NM, Patterson M, Taylor SA, Ghatei MA, Kamm MA, Johnston C, Bloom SR, Emmanuel AV (2005). Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut, 54(12), 1693 - 1698.
    • Hart AL, Al-Hassi HO, Rigby RJ, Bell SJ, Emmanuel AV, Knight SC, Kamm MA, Stagg AJ (2005). Characteristics of intestinal dendritic cells in inflammatory bowel diseases. Gastroenterology, 129(1), 150 - 165.
    • Murray C, Emmanuel A (2005). Diabetes. In Shaw K, Cummings MH (Ed.), Diabetes (pp. - ). : Wiley.
    • Chung A, Emmanuel A (2005). Autonomic dysfunction after spinal cord injury. In Weaver LC, Polosa C (Ed.), Autonomic dysfunction after spinal cord injury (pp. - ). : Elsevier Science.

    2004

    • Emmanuel AV, Stern J, Traesure J, Forbes A, Kamm MA (2004). Anorexia nervosa in gastrointestinal practice. European Journal of Gastroenterology and Hepatology, 16(11), 1135 - 1142.
    • Murray CD, Flynn J, Ratcliffe L, Jacyna MR, Kamm MA, Emmanuel AV (2004). Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome.. Gastroenterology, 127, 1695 - 1703. doi:10.1053/j.gastro.2004.08.057
    • Rayner CK, Hart AL, Hayward CM, Emmanuel AV, Kamm MA (2004). Azathioprine dose escalation in inflammatory bowel disease.. Alimentary Pharmacology and Therapeutics, 20(1), 65 - 71.
    • Murray CD, Emmanuel A (2004). Ghrelin and Helicobacter pylori. , 53(2), 315 - 315.
    • Emmanuel AV, Shand A, Kamm MA (2004). Erythromycin for the treatment of chronic intestinal pseudo-obstruction: description of six cases with positive response.. Alimentary Pharmacology and Therapeutics, 19(6), 687 - 694.
    • Jarrett ME, Emmanuel AV, Vaizey CJ, Kamm MA (2004). Behavioural therapy (biofeedback) for solitary rectal ulcer syndrome improves symptoms and mucosal blood flow.. Gut, 53, 368 - 370.
    • Emmanuel A, Murray C (2004). Pathophysiology of the enteric nervous system. In Spiller RC, Grundy D (Ed.), Pathophysiology of the enteric nervous system (pp. - ). : Wiley-Blackwell.

    2003

    • Rayner CK, McCormack G, Emmanuel AV, Kamm MA (2003). Long-term results of low-dose intravenous ciclosporin for acute severe ulcerative colitis.. Alimentary Pharmacology and Therapeutics, 18(3), 303 - 308.
    • Murray C, Kamm M, Bloom S, Emmanuel A (2003). Ghrelin for the gastroenterologist: history and potential. Gastroenterology, 125, 1492 - 1502.
    • Rutter M, Saunders B, Emmanuel A, Price A (2003). Endoscopic snare polypectomy for bleeding postinflammatory polyps.. Endoscopy, 35(9), 788 - 790.
    • Kenefick NJ, Emmanuel A, Nicholls RJ, Kamm MA (2003). Effect of sacral nerve stimulation on autonomic nerve function.. British Journal of Surgery, 90(10), 1256 - 1260.
    • Murray CD, Kamm MA, Bloom SR, Emmanuel AV (2003). Ghrelin for the gastroenterologist: history and potential. Gastroenterology, 125(5), 1492 - 1502.

    2002

    • Emmanuel A (2002). Bowel Care in Older People. In (Ed.), Bowel Care in Older People (pp. 77 - 88). : Royal College of Physicians.
    • Emmanuel A (2002). Practical gastroenterology. In Bloom S (Ed.), Practical gastroenterology (pp. 383 - 392). : Informa HealthCare.
    • Mimura T, Emmanuel AV, Kamm MA (2002). Pathophysiology of diverticular disease. Best Practice and Research Clinical Gastroenterology, 16(4), 563 - 576.
    • Emmanuel AV, Roy AJ, Nicholls TJ, Kamm MA (2002). Prucalopride, a systemic enterokinetic, for the treatment of constipation.. Alimentary Pharmacology and Therapeutics, 16(7), 1347 - 1356.
    • Murray CD, Emmanuel AV (2002). Medical management of diverticular disease. Best Practice and Research Clinical Gastroenterology, 16(4), 611 - 620.
    • Van Den Bogaerde J, Cahill J, Emmanuel AV, Vaizey CJ, Talbot IC, Knight SC, Kamm MA (2002). Gut mucosal response to food antigens in Crohn’s disease. Alimentary Pharmacology and Therapeutics, 16(11), 1903 - 1915.

    2001

    • Emmanuel AV, Kamm MA (2001). Response to a behavioural treatment, biofeedback, in constipated patients is associated with improved gut transit and autonomic innervation.. Gut, 49, 209 - 213. doi:10.1136/gut.49.2.209
    • Emmanuel AV, Mason HJ, Kamm MA (2001). Relationship between psychological state and level of activity of extrinsic gut innervation in patients with a functional gut disorder.. Gut, 49, 214 - 219. doi:10.1136/gut.49.2.214

    2000

    • Emmanuel A, Kamm MA (2000). Laser Doppler flowmetry as a measure of extrinsic colonic innervation in functional bowel disease. Gut, 46(2), 212 - 217.
    • Roy AJ, Emmanuel AV, Storrie JB, Bowers J, Kamm MA (2000). Behavioural treatment (biofeedback) for constipation following hysterectomy. British Journal of Surgery, 87(1), 100 - 105.
    • Emmanuel AV, Kamm MA, Beard RW (2000). A reproducible assessment of vaginal and rectal mucosal and skin blood flow: Laser Doppler fluximetry of pelvic microcirculation. Clinical Science (London), 98(2), 201 - 207.

    1999

    • Emmanuel AV, Kamm MA (1999). Doppler measurement of rectal mucosal blood flow. Gut, 46(2), 212 - 217.

    1998

    • Vaizey CJ, van den Bogaerde JB, Emmanuel AV, Talbot IC, Nicholls RJ, Kamm MA (1998). Solitary Rectal Ulcer Syndrome. British Journal of Surgery, 85(12), 1617 - 1623.
    • Emmanuel AV, Kamm MA, Roy AJ, Antonelli K (1998). Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.. Gut, 42(4), 511 - 516.
    • Emmanuel A, Kamm M, Roy A, Antonelli K (1998). Effect of a novel prokinetic drug, R093877, on gastrointestinal transit in healthy volunteers.. Gut, 42, 511 - 516.
    • Vaizey C, Bogaerde JVD, Emmanuel A, Talbot I, Nicholls J, Kamm M (1998). Solitary rectal ulcer syndrome. British J Surgery, 85, 1617 - 1623.