Staff Profile

Dr Shane Minogue

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Personal Profile

Name: Shane Minogue Email: s.minogue@ucl.ac.uk
Title: Dr Tel: 020 7433 2785
Department: lnstitute of Liver and Digestive Health Fax: 020 7433 2817
Position: Lecturer Address: Centre for Molecular Cell Biology, Division of Medicine, Royal Free Campus, Hampstead, NW3 2PF
Research Domain: Basic Life Sciences, Biomedical Imaging (Frontier Disciplines), Cancer, Neuroscience Web Page:  

Profile

Research Description


Research Activities

Phosphoinositides in membrane trafficking and signalling

Education Description


MBBS (Cancer Biology)

Cancer MSc


Molecular Medicine iBSc


Clinical Sciences iBSc

UCL Collaborators

External Collaborators

Publications

    2013

    • Clayton EL, Minogue S, Waugh MG (2013). Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.. Mol Neurobiol, 47(1), 361 - 372. doi:10.1007/s12035-012-8358-6
    • Clayton EL, Minogue S, Waugh MG (2013). Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks.. Prog Lipid Res, 52(3), 294 - 304. doi:10.1016/j.plipres.2013.04.002

    2012

    • Mohamed F, Minogue S, Winstanley A, Luong T, Habtesion A, Davies N, Jalan R (2012). Chloroquine: A novel strategy for the prevention of Hepatocellular carcinoma.
    • Minogue S, Waugh MG (2012). Lipid rafts, microdomain heterogeneity and inter-organelle contacts: impacts on membrane preparation for proteomic studies.. Biol Cell, 104(10), 618 - 627. doi:10.1111/boc.201200020
    • Mohamed F, Minogue S, Shah N, Davies N, Habtesion A, Luong T, Winstanley A, Dhillon AP, Mookerjee R, Jalan R (2012). TLR 9 INHIBITION: A NOVEL TARGET OF THERAPY FOR PRIMARY LIVER CANCER. GUT, 61, A110 - A110. doi:10.1136/gutjnl-2012-302514b.91
    • Mohamed FEZ, Minogue S, Dhar D, Shah N, Davies N, Habtesion A, Luong TV, Winstanley A, Dhillon AP, Mookerjee RP, Jalan R (2012). TLR 9 INHIBITION: A NOVEL TARGET OF THERAPY FOR PRIMARY LIVER CANCER.
    • Minogue S, Waugh MG (2012). The Phosphatidylinositol 4-Kinases: Don't Call it a Comeback.. Subcell Biochem, 58, 1 - 24. doi:10.1007/978-94-007-3012-0_1

    2011

    • Waugh MG, Minogue S, Clayton EL, Hsuan JJ (2011). CDP-diacylglycerol phospholipid synthesis in detergent-soluble, non-raft, membrane microdomains of the endoplasmic reticulum.. J Lipid Res, 52(12), 2148 - 2158. doi:10.1194/jlr.M017814
    • Waugh MG, Chu KME, Clayton E, Minogue S, Hsuan JJ (2011). Detergent-Free Isolation and characterization of cholesterol-rich membrane domains from trans-Golgi network vesicles. Journal of Lipid Research, 52(3), 582 - 589.
    • Yuan Y, Zhao L, Chen Y, Moorhead JF, Varghese Z, Powis SH, Minogue S, Sun Z, Ruan XZ (2011). Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro.. Am J Physiol Renal Physiol, 301(1), F236 - F243. doi:10.1152/ajprenal.00646.2010

    2010

    • Chu KM, Minogue S, Hsuan JJ, Waugh MG (2010). Differential effects of the phosphatidylinositol 4-kinases, PI4KII[alpha] and PI4KIII[beta], on Akt activation and apoptosis.. Cell Death and Disease., 1(12), e106 - . doi:10.1038/cddis.2010.84
    • Simons P, Al-Shawi R, Ellmerich S, Slamova I, Bodin K, Minogue S, Pepys MB, Hawkins PN (2010). Controllable expression of SAA in transgenic mice: a refined model of systemic amyloidosis.
    • Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dillon AP, Taylor GW, Bradwell AR, Petrie A, Gilmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MB (2010). Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature, 468(7320), 93 - 97. doi:10.1038/nature09494
    • Tennent GA, Loesch A, Kahan M, Bodin K, Ellmerich S, Minogue S, Pepys MB (2010). Macrophage dependent elimination of amyloid following treatment with anti-SAP antibody.
    • Banerji S, Ngo M, Lane CF, Robinson CA, Minogue S, Ridgway ND (2010). Oxysterol Binding Protein (OSBP)-Dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires PtdIns 4-Kinase IIa. Molecular Biology of the Cell, 21(23), 4141 - 4150.
    • Minogue S, Chu KME, Westover EJ, Covey DF, Hsuan JJ, Waugh MG (2010). Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organisation and lateral diffusion of PI4KIIα at the trans-Golgi Network. Journal of Lipid Research, 51(8), 2314 - 2324. doi:10.1194/jlr.M005751
    • Vigor KL, Kyrtatos PG, Minogue S, Al-Jamal KT, Kogelberg H, Tolner B, Kostarelos K, Begent RH, Pankhurst QA, Lythgoe MF, Chester KA (2010). Nanoparticles functionalized with recombinant single chain Fv antibody fragments (scFv) for the magnetic resonance imaging of cancer cells.. Biomaterials, 31(6), 1307 - 1315. doi:10.1016/j.biomaterials.2009.10.036

    2009

    • Simons JP, Al-Shawi R, Minogue S, Waugh MG, Wiedemann C, Evangelou S, Loesch S, Sihra TS, King R, Warner TT, Hsuan JJ (2009). Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons. Proceedings of the National Academy of Sciences of the United States of America, 106(28), 11535 - 11539. doi:10.1073/pnas.0903011106
    • Waugh MG, Minogue S, Hsuan JJ (2009). Quantification of Multiple Phosphatidylinositol 4-Kinase Isozyme Activities in Cell Extracts..
    • Waugh MG, Minogue S, Hsuan J (2009). Quantification of Multiple Phosphatidylinositol 4-Kinase Isozyme Activities in Cell Extracts. Methods in Molecular Biology, 462(1), 1 - 11. doi:10.1007/978-1-60327-115-8_19

    2008

    • Hsuan JJ, Waugh MG, Minogue S (2008). Phosphatidylinositol 4-kinase type II-alpha. UCSD-Nature Molecule Pages, , - . doi:10.1038/mp.a002426.01
    • Kogelberg H, Tolner B, Thomas GJ, Di Cara D, Minogue S, Ramesh B, Sodha S, Marsh D, Lowdell MW, Meyer T, Begent RHJ, Hart I, Marshall JF, Chester K (2008). Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus. J MOL BIOL, 382(2), 385 - 401. doi:10.1016/j.jmb.2008.07.013
    • Minogue S, Hsuan JJ (2008). Phosphatidylinositol 4-kinase type II beta. doi:10.1038/mp.a003141.01

    2006

    • Minogue S, Waugh MG, De Matteis MA, Stephens DJ, Berditchevski F, Hsuan JJ (2006). Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor. Journal of Cell Science, 119(3), 571 - 581. doi:10.1242/jcs.02752
    • Waugh MG, Minogue S, Chotai D, Berditchevski F, Hsuan JJ (2006). Lipid and peptide control of P14KIIalpha activity on Golgi-endosomal rafts. Journal of Biological Chemistry, 281(7), 3757 - 3763. doi:10.1074/jbc.M506527200
    • Minogue S, Waugh MG, de Matteis MA, Stephens DJ, Berditchevski F, Hsuan JJ (2006). Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor. Journal of Cell Science, 119(3), 571 - 581. doi:10.1242/jcs.02752

    2005

    • Waugh MG, Minogue S, Chotai D, Berditchevski F, Hsuan JJ (2005). Lipid and peptide control of P14KIIalpha activity on Golgi-endosomal rafts. Journal of Biological Chemistry, , - . doi:10.1074/jbc.M506527200

    2003

    • Waugh MG, Minogue S, Blumenkrantz D, Anderson JS, Hsuan JJ (2003). Identification and characterization of differentially active pools of type IIalpha phosphatidylinositol 4-kinase activity in unstimulated A431 cells. Biochemical Journal, 376(Pt 2), 497 - 503. doi:10.1042/BJ20031212
    • Waugh MG, Minogue S, Anderson JS, Balinger A, Blumenkrantz D, Calnan DP, Cramer RK, Hsuan JJ (2003). Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/VCP-rich fraction of the endoplasmic reticulum. Biochemical Journal, 373(1), 57 - 63.
    • Waugh MG, Minogue S, Anderson JS, Balinger A, Blumenkrantz D, Calnan DP, Cramer R, Hsuan JJ (2003). Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum. Biochemical Journal, 373(Pt 1), 57 - 63.

    2001

    • Minogue S, Anderson S, Waugh MG, dos Santos M, Corless S, Cramer R, Hsuan JJ (2001). Cloning of a Human Type II Phosphatidylinositol 4-Kinase Reveals a Novel Lipid Kinase Family. Journal of Biological Chemistry, 276(20), 16635 - 16640. doi:10.1074/jbc.M100982200
    • Waugh MG, Minogue S, Anderson JS, dos SM, Hsuan JJ (2001). Signalling and non-caveolar rafts. Biochemical Society Transactions, 29(Pt 4), 509 - 511.

    1998

    • Hsuan JJ, Minogue S, dos Santos M (1998). Phosphoinositide 4- and 5-kinases and the celluar roles of phosphatidylinositol 4,5-bisphosphate. Advances in Cancer Research, 74, 167 - 216.

    1997

    • dos Santos M, Minogue S, Hsuan JJ (1997). Phosphatidylinositol-4-phosphate 5-kinase disrupts the actin cytoskeleton. FASEB J, 11(9), A1298 - A1298.

    1996

    • Carvajal JJ, Pook MA, dos Santos M, Doudney K, Hillermann R, Minogue S, Williamson R, Hsuan JJ, Chamberlain S (1996). The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase. Nature Genetics, 14(2), 157 - 162.