Staff Profile

Prof Jeremy Brown

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Personal Profile

Name: Jeremy Brown Email: jeremy.brown@ucl.ac.uk
Title: Prof Tel: 2076796008
Department: Internal Medicine Fax: 2076796973
Position: Professor of Respiratory Infection Address: Rayne Institute 5 University Street London, , London, WC1E 6JJ
Research Domain: Infection Immunology & Inflammation Web Page: Personal Web Page

Profile

Research Description

The main aim of my research is to understand the molecular pathogenesis of lung infection, specifically pneumonia due to Streptococcus pneumoniae. This will lead to the introduction of improved methods of treating or preventing these common and often serious infections.

Research Activities

Pathogenesis of respiratory infections

Education Description

Lead teacher for respiratory medicine undergraduate teaching at UCLH site. Lead for the respiratory module of the translational medicine MSc, and educational supervisor / programme lead for respiratory clinical and academic Spr programmes.

UCL Collaborators

External Collaborators

Publications

    2013

    • Brown JS, Hill AT (2013). Macrolides and pneumonia.. Thorax, 68(5), 404 - 405. doi:10.1136/thoraxjnl-2012-202425
    • Gil E, Noursadeghi M, Brown JS (2013). The clinical and ecological impact of childhood pneumococcal vaccination.. Br J Hosp Med (Lond), 74(4), 212 - 216.
    • Basavanna S, Chimalapati S, Maqbool A, Rubbo B, Yuste J, Wilson RJ, Hosie A, Ogunniyi AD, Paton JC, Thomas G, Brown JS (2013). The Effects of Methionine Acquisition and Synthesis on Streptococcus Pneumoniae Growth and Virulence. PLOS ONE, 8(1), - . doi:10.1371/journal.pone.0049638
    • Hyams C, Trzcinski K, Camberlein E, Weinberger DM, Chimalapati S, Noursadeghi M, Lipsitch M, Brown JS (2013). Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.. Infect Immun, 81(1), 354 - 363. doi:10.1128/IAI.00862-12
    • Cohen JM, Wilson R, Shah P, Baxendale HE, Brown JS (2013). Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgG.. Vaccine, 31(19), 2328 - 2332. doi:10.1016/j.vaccine.2013.03.013
    • Quint JK, Brown JS (2013). Weighing up risk factors for pneumonia: the role of mental illness and benzodiazepine use. THORAX, 68(2), 121 - 122. doi:10.1136/thoraxjnl-2012-202818

    2012

    • Brown JS, Lipman MC, Zar HJ (2012). What's new in respiratory infections and tuberculosis 2008-2010.. Thorax, 67(4), 350 - 354. doi:10.1136/thoraxjnl-2011-200227
    • Brown JS (2012). Community-acquired pneumonia.. Clin Med, 12(6), 538 - 543.
    • Cohen JM, Chimalapati S, de Vogel C, van Belkum A, Baxendale HE, Brown JS (2012). Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation.. Vaccine, 30(30), 4453 - 4459. doi:10.1016/j.vaccine.2012.04.080
    • Marks DJ, Fisk MD, Koo CY, Pavlou M, Peck L, Lee SF, Lawrence D, Macrae MB, Wilson AP, Brown JS, Miller RF, Zumla AI (2012). Thoracic empyema: a 12-year study from a UK tertiary cardiothoracic referral centre.. PLoS One, 7(1), e30074 - . doi:10.1371/journal.pone.0030074
    • Brown JS (2012). Pneumococcal capsular serotypes and lung infection.. Thorax, 67(6), 473 - 474. doi:10.1136/thoraxjnl-2012-201739
    • Fifer HM, Chiodini PL, Lucas SB, Brown JS (2012). Invasive aspergillosis associated with pulmonary hydatid disease.. Travel Med Infect Dis, 10(5-6), 272 - 274. doi:10.1016/j.tmaid.2012.07.001
    • Chimalapati S, Cohen JM, Camberlein E, Macdonald N, Durmort C, Vernet T, Hermans PW, Mitchell T, Brown JS (2012). Effects of Deletion of the Streptococcus pneumoniae Lipoprotein Diacylglyceryl Transferase Gene lgt on ABC Transporter Function and on Growth In Vivo. PLoS.One., 7(7), e41393 - . doi:10.1371/journal.pone.0041393
    • Wilkosz S, Edwards LA, Bielsa S, Hyams C, Taylor A, Davies RJ, Laurent GJ, Chambers RC, Brown JS, Lee YC (2012). Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae.. Am J Respir Cell Mol Biol, 46(2), 180 - 187. doi:10.1165/rcmb.2011-0182OC

    2011

    • Lucie B, Chimalapati S, Schoehn G, Brown JS, Vernet T, Durmort C (2011). Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence. Molecular Microbiology, , - .
    • Wilson RJ, Cohen JM, Hyams C, van Wamel WJ, de Vogel C, van Belkum A, Gordon SB, Brown JS (2011). ANTI-PROTEIN SEROLOGICAL RESPONSES TO STREPTOCOCCUS PNEUMONIAE, IN DIVERSE POPULATIONS. doi:10.1136/thoraxjnl-2011-201054b.127
    • Batchelor H, Brill S, Brown JS, Hurst JR (2011). ASSOCIATIONS OF DEPRESSION, FATIGUE AND QUALITY OF LIFE IN ADULT NON-CF BRONCHIECTASIS. doi:10.1136/thoraxjnl-2011-201054c.248
    • Hyams C, Trzcinski K, Weinberger DM, Lipsitch M, Brown JS (2011). HIGHLY INVASIVE CAPSULAR SEROTYPES OF STREPTOCOCCUS PNEUMONIAE BIND HIGH LEVELS OF FACTOR H AND ARE RESISTANT TO COMPLEMENT AND PHAGOCYTOSIS. doi:10.1136/thoraxjnl-2011-201054b.128
    • Loisel E, Chimalapati S, Bougault C, Imberty A, Gallet B, Di Guilmi AM, Brown JS, Vernet T, Durmort C (2011). Biochemical characterization of the histidine triad protein PhtD as a cell surface zinc-binding protein of pneumococcus.. Biochemistry, 50(17), 3551 - 3558.
    • Tomlinson GS, Elkington PTG, Bell L, Walker NF, Tsang J, Brown JS, Breen R, Lipman M, Katz D, Miller RF, Chain BM, Noursadeghi M (2011). Macrophage HIV-1 infection dysregulates host responses to Mycobacterium tuberculosis by inhibition of interleukin 10.. AIDS, , - .
    • Cohen J, Chimalapati S, Camberlein E, Hyams C, Baxendale H, Brown JS (2011). Protective Contributions against Invasive Streptococcus pneumoniae Pneumonia of Antibody and Th17-Cell Responses to Nasopharyngeal Colonisation. PLoS One, , - .
    • Brill SE, Lim WS, Brown JS (2011). Respiratory tract infections: uncommon pathogens and misleading presentations. CLINICAL MEDICINE, 11(6), 567 - 570.
    • Brown JS, Baxendale H, Floto A (2011). Primary and secondary immunodeficiencies and the development of bronchiectasis. In (Ed.), Bronchiectasis (pp. - ). : .
    • Hyams C, Opel S, Hanage W, Yuste J, Bax K, Henriques-Normark B, Spratt BG, Brown JS (2011). Effects of Streptococcus pneumoniae Strain Background on Complement Resistance. PLoS One, , - .
    • Sanchez C, Hinojosa CA, Shivshankar P, Hyams C, Camberlein E, Brown JS, Orihuela CJ (2011). Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence. PLoS One, 6(10), - . doi:10.1371/journal.pone.0026587
    • Brown JS, Quint JK (2011). Cyanosis. British Journal of Hospital Medicine, 72(9), M130 - M133.
    • Chimalapati S, Cohen J, Camberlein E, Durmort C, Baxendale H, de Vogel C, van Belkum A, Brown JS (2011). Infection with conditionally virulent Streptococcus pneumoniae Δpab strains induces antibody to conserved protein antigens but does not protect against systemic infection with heterologous strains.. Infect Immun, 79(12), 4965 - 4976. doi:10.1128/IAI.05923-11

    2010

    • Hyams C, Camberlein E, Cohen JM, Bax K, Brown JS (2010). The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms. INFECT IMMUN, 78(2), 704 - 715. doi:10.1128/IAI.00881-09
    • Yuste J, Sen A, Truedsson L, Jonsson G, Hyams C, Cohen JM, Camberlein E, Sriskandan S, Brown JS (2010). Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency. Microbes and Infection, 12(8-9), 626 - 634.
    • Stables MJ, Newson J, Ayoub S, Brown JS, Hyams C, Gilroy D (2010). Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic susceptible and resistant bacteria. Blood, , - .
    • Hyams C, Tam JC, Brown JS, Gordon S (2010). C3b/iC3b deposition on Streptococcus pneumoniae is not affected by HIV infection. PLoS One, 5(1), - . doi:10.1371/journal.pone.0008902
    • Hyams C, Yuste J, Bax K, Camberlein E, Weiser JN, Brown JS (2010). Streptococcus pneumoniae Resistance to Complement-Mediated Immunity Is Dependent on the Capsular Serotype. INFECT IMMUN, 78(2), 716 - 725. doi:10.1128/IAI.01056-09
    • Yuste J, Khandavilli S, Ansari N, Muttardi K, Ismail L, Hyams C, Weiser J, Mitchell T, Brown JS (2010). Inhibition of complement-mediated immunity to Streptococcus pneumoniae by PspC is dependent on strain background. Infection and Immunity, 1, 283 - 292.

    2009

    • Basavanna S, Khandavilli S, Yuste J, Cohen JM, Hosie AHF, Webb AJ, Thomas GH, Brown JS (2009). Screening of Streptococcus pneumoniae ABC Transporter Mutants Demonstrates that LivJHMGF, a Branched-Chain Amino Acid ABC Transporter, Is Necessary for Disease Pathogenesis. INFECT IMMUN, 77(8), 3412 - 3423. doi:10.1128/IAI.01543-08
    • Khandavilli S, Wilson P, Cookson B, Cepeda J, Bellingan G, Brown J (2009). Utility of spa typing for investigating the local epidemiology of MRSA on a UK intensive care ward.. Journal of Hospital Infection, 71(1), 29 - 35.
    • Brown JS (2009). Geography and the aetiology of community-acquired pneumonia. RESPIROLOGY, 14(8), 1068 - 1071. doi:10.1111/j.1440-1843.2009.01641.x

    2008

    • Brown JS (2008). Pneumonia in the non-HIV immunocompromised host. In (Ed.), Clinical Respiratory Medicine (pp. 365 - 378). : Mosby Elsevier.
    • Khandavilli S, Homer KA, Yuste J, Basavanna S, Mitchell T, Brown JS (2008). Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence. Molecular Microbiology, in press, - .
    • Yuste J, Sen A, Truedsson L, Jonsson G, Tay LS, Hyams C, Baxendale HE, Goldblatt F, Botto M, Brown JS (2008). Impaired opsonisation with C3b and phagocytosis of Streptococcus pneumoniae in serum from subjects with defects in the classical complement pathway. Infection and Immunity, 76(8), 3761 - 3770.
    • Baxendale H, Johnson M, Stephens RCM, Yuste J, Klein N, Brown JS, Goldblatt D (2008). Natural human antibodies to pneumococcus have distinctive molecular characteristics and protect against pneumococcal disease. Clinical and Experimental Immunology, 151(1), 51 - 60.

    2007

    • Yuste J, Botto M, Bottoms S, Brown J (2007). Serum Amyloid P Aids Complement Mediated Immunity to Streptococcus pneumoniae. PLoS Pathogens, 3(9), 1208 - 1219. doi:10.1371/journal.ppat.0030120
    • Brown JS (2007). Oral biofilms, periodontitis and pulmonary infections - Commentary. ORAL DIS, 13(6), 513 - 514. doi:10.1111/j.1601-0825.2007.1410b.x
    • Brown JS (2007). Oral biofilms, periodontitis and pulmonary infections. Oral Diseases, 13(6), 513 - 514.

    2006

    • Yuste J, Ali S, Sriskandan S, Hyams C, Botto M, Brown JS (2006). Roles of the alternative complement pathway and C1q during innate immunity to Streptococcus pyogenes.. The Journal of Immunology, 176(10), 6112 - 6120.
    • Jomaa M, Terry S, Hale C, Jones C, Dougan G, Brown J (2006). Immunization with the iron uptake ABC transporter proteins PiaA and PiuA prevents respiratory infection with Streptococcus pneumoniae.. Vaccine, 24(24), 5133 - 5139.

    2005

    • Brown J (2005). Glucose, bronchial secretions and MRSA. Thorax, 60, 711 - 712.
    • Jomaa M, Yuste J, Paton J, Dougan G, Brown J (2005). Immune responses to immunisation with two iron uptake ABC transporter lipoproteins, PiaA and PiuA. Infection and Immunity, 73, 6852 - 6859.
    • Jomaa M, Yuste J, Paton JC, Jones C, Dougan G, Brown JS (2005). Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae. INFECT IMMUN, 73(10), 6852 - 6859. doi:10.1128/IAI.73.10.6852-6859.2005
    • Yuste J, Botto M, Paton JC, Holden DW, Brown JS (2005). Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia.. The Journal of Immunology, 175(3), 1813 - 1819.
    • Doffman S, Agrawal S, Brown J (2005). Treatment of invasive aspergillosis. Expert Review of Anti-Infective Therapy, 3, 613 - 628.

    2004

    • Brown JS, Gilliland SM, Basavanna S, Holden DW (2004). phgABC, a three-gene operon required for growth of Streptococcus pneumoniae in hyperosmotic medium and in vivo.. Infection and Immunity, 72(8), 4579 - 4588.
    • Brown JS, Gilliland SM, Spratt BG, Holden DW (2004). A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice.. Infection and Immunity, 72(3), 1587 - 1593.

    2002

    • Brown JS, Holden DW (2002). Iron acquisition by Gram positive bacteria. Microbes and Infection, 4(11), 1149 - 1156.
    • Brown J, Gilliland S, Ruiz-Albert J, Holden D (2002). Characterisation of Pit, a Streptococcus pneumioniae iron uptake ABC transporter. Infection and Immunity, 70, 4389 - 4398.
    • Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, Walport MJ, Botto M (2002). The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proceedings of the National Academy of Sciences of the United States of America, 99(26), 16969 - 16974. doi:10.1073/pnas.012669199

    2001

    • Brown JS, Gilliland SM, Holden DW (2001). A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence.. Molecular Microbiology, May; 40(3), 572 - 585.

    2000

    • Brown JS, Smith J, Aufauvre-Brown A, Brown J, Holden DW (2000). Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity. Molecular Microbiology, 36, 1371 - 1380.

    1999

    • Brown JS, Spiro SG (1999). Update on lung cancer and mesothelioma. Journal of the Royal College of Physicians of London, 33, 506 - 512.

    1998

    • Brown JS, Meecham-Jones J, Wedzicha JA (1998). Using nasal intermittent positive pressure ventilation on a general respiratory ward. Journal of the Royal College of Physicians of London, 32, 219 - 224.
    • Brown JS, Aufauvre-Brown A, Holden DW (1998). Insertional mutagenesis of Aspergillus fumigatus.. Molecular and General Genetics, 259, 327 - 335.
    • Brown JS, Holden DW (1998). Insertional mutagenesis of pathogenic fungi. Current Opinion in Microbiology, 1, 390 - 394.
    • Aufauvre-Brown A, Brown JS, Holden DW (1998). Comparison of virulence between clinical and environmental isolates of Aspergillus fumigatus. European Journal of Clinical Microbiology and Infectious Diseases, 17, 778 - 780.

    1996

    • Brown JS, Davison A, Eraut D (1996). Age and treatment of lung cancer. Thorax, 51, 564 - 568.
    • Fox RA, De L Stanbridge R, Brown JS, Riordan JF, Rudd RM (1996). Expandable metal stents for non-malignant bronchial obstruction. Thorax, 51, 963 - 964.

    1995

    • Jenks P, Brown JS, Barnes NC (1995). Candida glabarta epididymo-orchitis. Journal of Infection, 31, 711 - 72.
    • Brown JS, Wells F, Duckworth G, Paul EA, Barnes NC (1995). Improving notification rates for tuberculosis. BMJ (Clinical Research Ed.), 310, 974 - 974.
    • Brown JS, Rudd RM (1995). New staging investigations for lung cancer: 'What will they have to offer to be clinically useful. European Journal of Nuclear Medicine, 22, 497 - 498.
    • Brown JS, Cohen J (1995). Bacterial and viral infections in the immunocompromised host (excluding AIDS). Current Opinion in Critical Care, 1, 358 - 363.

    1994

    • Brown JS, Hughes DTD (1994). 'Shrinking lung syndrome and systemic lupus erythematosus. Respiratory Disease in Practice, 11, 22 - 23.

    1990

    • Coleman RJ, Brown JS, Butler P, Swash M (1990). 'Cerebellar syndrome with hydrocephalus due to Mycoplasma pneumoniae infection. Postgraduate Medical Journal, 666, 554 - 556.

    • Brown J, Brown JS (). The immunocompromised host: patients with haematolgocal disorders. In (Ed.), Lung Infections (pp. - ). : Oxford University Press.
    • Hyams C, Trzcinski K, Weinberger DM, Lipsitch M, Brown JS (). Highly invasive Streptococcus pneumoniae capsular serotypes bind high levels of Factor H and are resistant to complement and phagocytosis. Journal of Infectious Diseases, , - .
    • Brown JS (). Pneumonia in the Non-HIV Immunocompromised Host. In Albert S, Jett (Ed.), Clinical Respiratory Medicine, 4th Edition (pp. - ). : .
    • Albert , Navani , Brown , Spiro (). Clinical Cases in Respiratory Medicine.
    • Brown JS, Chimalapati S (). Signal peptidase II. In Rawlings ND, Salvesen G (Ed.), Handbook of Proteolytic Enzymes 3rd Edition (pp. - ). : .
    • Potton E, Brown JS (). Infections with agents causing granulomatous inflammation. In (Ed.), Sarcoidosis (pp. - ). : Hodder.