Staff Profile

Dr Erik Arstad

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Personal Profile

Name: Erik Arstad Email: e.arstad@ucl.ac.uk
Title: Dr Tel: 0207 6792344
Department: Metabolism & Experimental Therapeutics Fax: 0207 6792344
Position: Senior Lecturer Address: 235 Euston Road, , London, NW1 2BU
Research Domain: Biomedical Imaging (Frontier Disciplines), Cancer, Neuroscience Web Page:  

Profile

Research Description

Radiochemistry is a newly established discipline at UCL. The main focus of the group will be development of new Molecular tracers (PET, SPECT and optical) for preclinical and clinical imaging, with the aim to further mechanistic understanding of disease and develop tracer to aid medical treatment.

Research Activities

Development and evaluation of tracers for imaging of NMDA receptors function and distribution

Development of 2-[18F]fluoroethylazide as a labelling agent

Development of caspase 3/7 selective Isatins for imaging of Apoptosis

Effect of Tumour Biology on Therapeutic Response

Quantitative emission tomography

Radiochemistry

Education Description

UCL Collaborators

Prof Barbara Pedley; Prof Daniel Hochhauser; Prof Hans Stauss; Prof Quentin Pankhurst; Prof Brian Hutton; Prof Ivan Gout; Prof Sebastien Ourselin; Dr Martin Pule; Prof Simon Arridge; Prof Paul Beard; Prof Mark Lythgoe; Prof Chris Boshoff

External Collaborators

Publications

    2013

    • Francisco Garcia-Arguello S, Fortt R, Steel CJ, Brickute D, Glaser M, Turton DR, Robins EG, Arstad E, Luthra SK (2013). Radiosynthesis of the D2/3 agonist [3-11C]-(+)-PHNO using [11C]iodomethane.. Appl Radiat Isot, 73, 79 - 83. doi:10.1016/j.apradiso.2012.11.009
    • Yan R, Sander K, Galante E, Rajkumar V, Badar A, Robson M, El-Emir E, Lythgoe MF, Pedley RB, Årstad E (2013). A one-pot three-component radiochemical reaction for rapid assembly of 125I-labeled molecular probes.. J Am Chem Soc, 135(2), 703 - 709. doi:10.1021/ja307926g
    • Nguyen Q, Challapalli A, Smith G, Fortt R, Glaser M, Arstad E, Gudi MA, Carroll LS, Perumal M, Witney TH, Graham MA, Aboagye EO (2013). Imaging apoptosis with positron emission tomography: bench-to-bedside development of the caspase-3/7-specific radiotracer [F-18] ICMT-11.
    • O'Shea D, Ahmad R, Arstad E, Avory M, Chau W-F, Durrant C, Hirani E, Jones PA, Khan I, Luthra SK, Mantzilas D, Morisson-Iveson V, Passmore J, Robins EG, Shan B, Wadsworth H, Walton S, Zhao Y, Trigg W (2013). Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands - Potential novel positron emitting tomography imaging agents. Bioorganic and Medicinal Chemistry Letters, 23(8), 2368 - 2372.
    • Yan R, Sander K, Galante E, Rajkumar V, Badar A, Robson M, El-Emir E, Lythgoe MF, Pedley RB, Arstad E (2013). A one-pot three-component radiochemical reaction for rapid assembly of I-125-labelled molecular probes. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 56(2), 62 - 63.
    • Arstad E, Galante E, Sander K, Koepp M (2013). Labelling strategies for development of F-18 PET tracers. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 56(2), 51 - 52.

    2012

    • Pérez-Medina C, Patel N, Robson M, Badar A, Lythgoe MF, Årstad E (2012). Evaluation of a 125I-labelled benzazepinone derived voltage-gated sodium channel blocker for imaging with SPECT.. Org Biomol Chem, 10(47), 9474 - 9480. doi:10.1039/c2ob26695d

    2011

    • Yan R, El-Emir E, Rajkumar V, Robson M, Jathoul AP, Pedley RB, Årstad E (2011). One-pot synthesis of an 125I-labeled trifunctional reagent for multiscale imaging with optical and nuclear techniques.. Angew Chem Int Ed Engl, 50(30), 6793 - 6795. doi:10.1002/anie.201102072
    • Perez-Medina C, Patel N, Badar A, Arstad E (2011). Voltage-Gated Sodium Channel Tracers II. Radioiodinated Benzazepinone Derivative. J LABELLED COMPD RAD, 54, S288 - S288.
    • Perez-Medina C, Patel N, Badar A, Arstad E (2011). Voltage-Gated Sodium Channel Tracers I. Radioiodinated WIN17317-3 Analogue. J LABELLED COMPD RAD, 54, S287 - S287.
    • ROBINS E, ARSTAD E (2011). Imaging 18F or 11C-labelled alkylthio-substituted phenyl guanidines.
    • STOREY A, Davis JD, ARSTAD E, GUILBERT B, GAETA A (2011). IN VIVO IMAGING AGENTS.
    • Glaser M, Arstad E, Gaeta A, Woodcraft J, Nairne J, Trigg W, Robins E (2011). Cu/H+ mediated Reduction of 2-[F-18]Fluoroethylazide to 2-[F-18]Fluoroethylamine. J LABELLED COMPD RAD, 54, S464 - S464.
    • Smith G, Zhao Y, Leyton J, Shan B, Nguyen QD, Perumal M, Turton D, Årstad E, Luthra SK, Robins EG, Aboagye EO (2011). Radiosynthesis and pre-clinical evaluation of [(18)F]fluoro-[1,2-(2)H(4)]choline.. Nucl Med Biol, 38(1), 39 - 51. doi:10.1016/j.nucmedbio.2010.06.012

    2010

    • ARSTAD E, JESUS O, KOVACS E, GLASER M, SYUD F (2010). SELECTIVE RADIOLABELING OF BIOMOLECULES.
    • ROBINS E, ARSTAD E (2010). RADIOLABELLING METHODS.
    • ABOAGYE E, Smith GS, NGUYEN Q, ARSTAD E, GLASER M (2010). ISATIN DERIVATIVES FOR USE AS IN VIVO IMAGING AGENTS.
    • Robins EG, Zhao YJ, Khan I, Wilson A, Luthra SK, Arstad E (2010). Synthesis and in vitro evaluation of F-18-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET. BIOORG MED CHEM LETT, 20(5), 1749 - 1751. doi:10.1016/j.bmcl.2010.01.052
    • ARSTAD E, Turton D (2010). RADIOLABELLING METHODS.
    • ARSTAD E (2010). CHEMICAL METHODS AND APPARATUS.
    • ARSTAD E (2010). MEASUREMENT OF NEURAL ACTIVITY.
    • Schoultz BW, Hjornevik T, Willoch F, Marton J, Noda A, Murakami Y, Miyoshi S, Nishimura S, Arstad E, Drzezga A, Matsunari I, Henriksen G (2010). Evaluation of the kappa-opioid receptor-selective tracer [(11)C]GR103545 in awake rhesus macaques.. Eur J Nucl Med Mol Imaging, 37(6), 1174 - 1180. doi:10.1007/s00259-010-1384-6
    • Garcia-Arguello SF, Arstad E, Brickute D, Luthra SK, Turton DR, Glaser M, Fortt R, Robins EG (2010). Automated synthesis of [11C]-(+)-PHNO from [11C]methyl iodide. doi:10.1016/j.neuroimage.2010.04.177
    • GLASER M, ARSTAD E (2010). RADIOFLUORINATION.
    • GLASER M, ARSTAD E (2010). RADIOLABELLING METHODS.

    2009

    • Glaser M, Arstad E, Luthra SK, Robins EG (2009). Two-step radiosynthesis of [F-18]N-succinimidyl-4-fluorobenzoate ([F-18]SFB). J LABELLED COMPD RAD, 52(7-8), 327 - 330. doi:10.1002/jlcr.1601
    • Torres Martin de Rosales R, Arstad E, Blower PJ (2009). Nuclear imaging of molecular processes in cancer.. Target Oncol, 4(3), 183 - 197. doi:10.1007/s11523-009-0120-2
    • ARSTAD E, Wilson IW, Luthra SKL, Brady FB, Langstrom BL, KARIMI F, ROBINS E, Shan BS (2009). TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR).
    • Leyton J, Smith G, Zhao Y, Perumal M, Nguyen QD, Robins E, Arstad E, Aboagye EO (2009). [18F]fluoromethyl-[1,2-2H4]-choline: a novel radiotracer for imaging choline metabolism in tumors by positron emission tomography.. Cancer Res, 69(19), 7721 - 7728. doi:10.1158/0008-5472.CAN-09-1419
    • Glaser M, Solbakken M, Turton DR, Pettitt R, Barnett J, Arukwe J, Karlsen H, Cuthbertson A, Luthra SK, Arstad E (2009). Methods for 18F-labeling of RGD peptides: comparison of aminooxy [18F]fluorobenzaldehyde condensation with 'click labeling' using 2-[18F]fluoroethylazide, and S-alkylation with [18F]fluoropropanethiol.. Amino Acids, 37(4), 717 - 724. doi:10.1007/s00726-008-0200-0
    • Robins EG, Glaser M, Idris J, Shan B, Arstad E, Luthra SK (2009). TWO STEP ORGANIC PHASE SYNTHESES OF [18F]N-SUCCINIMIDYL-4-FLUOROBENZOATE AND 4-[18F] FLUOROBENZYL BROMIDE. J LABELLED COMPD RAD, 52, S157 - S157.
    • Smith G, Nguyen Q, Glaser M, Perumal M, Arstad E, Aboagye E (2009). DEVELOPMENT OF AN ISATIN-5-SULFONAMIDE BASED PET PROBE FOR IMAGING APOPTOSIS IN VIVO. J LABELLED COMPD RAD, 52, S36 - S36.
    • Nguyen QD, Smith G, Glaser M, Perumal M, Arstad E, Aboagye EO (2009). Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide.. Proc Natl Acad Sci U S A, 106(38), 16375 - 16380. doi:10.1073/pnas.0901310106
    • ARSTAD E, Henriksen GH (2009). IN VIVO IMAGING COMPOUNDS.
    • ARSTAD E (2009). METHOD FOR THE PREPARATION OF [18F]FLUOROALKYLHALIDES.
    • ARSTAD E, GLASER M (2009). Radiofluorinated Compounds and their Preparation.
    • ARSTAD E, ROBINS E, ZHAO Y (2009). TRICYCLIC OXAZEPINES AS IN VIVO IMAGING COMPOUNDS.
    • ARSTAD E (2009). FLUORIDE DRYING METHOD.
    • ARSTAD E (2009). METHOD FOR THE PURIFICATION OF RADIOLABELLED COMPOUNDS.
    • ARSTAD E, Steel CS (2009). Chemical methods and apparatus.

    2008

    • Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS (2008). Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study.. Psychopharmacology, 197(3), 401 - 408.
    • ARSTAD E, ROBINS E (2008). Pet Radiotracers.
    • Smith G, Glaser M, Perumal M, Nguyen QD, Shan B, Arstad E, Aboagye EO (2008). Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.. J Med Chem, 51(24), 8057 - 8067. doi:10.1021/jm801107u
    • Schoultz BW, Arstad E, Marton J, Willoch F, Drzezga A, Wester HJ, Henriksen G (2008). A New Method for Radiosynthesis of C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [C]GR103545.. Open Med Chem J, 2, 72 - 74. doi:10.2174/1874104500802010072
    • JESUS O, KOVACS E, GLASER M, ARSTAD E, SYUD F (2008). SELECTIVE RADIOLABELING OF BIOMOLECULES.

    2007

    • Teare H, Robins EG, Årstad E, Luthra SK, Gouverneur V (2007). Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide. Chemical Communications, (23), 2330 - 2332.
    • Stone JM, Pilowsky LS, Bressan R, Erlandsson K, Ell RJ, Arstad E, Squassante L, Teneggi V (2007). Ketamine reduces NMDA receptor SPET ligand [123I]CNS1 261 VT in humans - Relationship to psychotic symptons.
    • Arstad E (2007). ‘Click Labeling’ with [18F]fluoroethylazide for Positron Emission tomography (PET). Bioconjugate Chemistry, 18(3), 989 - .
    • Teare H, Robins EG, Arstad E, Luthra SK, Gouverneur V (2007). Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide.. Chem Commun (Camb), (23), 2330 - 2332.
    • GLASER M, ARSTAD E (2007). RADIOLABELLED CONJUGATES OF RGD-CONTAINING PEPTIDES AND METHODS FOR THEIR PREPARATION VIA CLICK-CHEMISTRY..
    • Luthra SKL, Brady FB, JEFFERY N, ARSTAD E, GIBSON A, WYNN D, CUTHBERTSON A, SOLBAKKEN M (2007). Purification methods.
    • Brady FB, JEFFERY N, Luthra SKL, ARSTAD E (2007). Method for Coating the Internal Surface of a Reaction Vessel.

    2006

    • Stone JM, Arstad E, Erlandsson K, Waterhouse RN, Ell PJ, Pilowsky LS (2006). [I-123]TPCNE - A novel SPET tracer for the sigma-1 receptor: First human studies and in vivo haloperidol challenge. SYNAPSE, 60(2), 109 - 117. doi:10.1002/syn20281
    • Stone JM, Arstad E, Erlandsson K, Waterhouse RN, Ell PJ, Pilowsky LS (2006). [(123)I]TPCNE-A novel SPET tracer for the sigma-1 receptor: First human studies and in vivo haloperidol challenge.. Synapse, 60(2), 109 - 117.
    • Stone JM, Erlandsson K, Arstad E, Bressan RA, Squassante L, Teneggi V, Ell PJPL (2006). Ketamine displacement of [123I]CNS-1261 – a novel NMDA receptor SPET probe.. Nuclear Medicine and Biology, 33(2), 239 - 243.
    • Zhao YJ, Robins E, Turton D, Brady F, Luthra SK, Arstad E (2006). Synthesis and characterization of N-(2-chloro-5-methylthiophenyl)-N '-(3-methylthiophenyl)-N '- [C-11]methylguanidine [C-11]CNS 5161, a candidate PET tracer for functional imaging of NMDA receptors. J LABELLED COMPD RAD, 49(2), 163 - 170. doi:10.1002/jlcr.1033
    • Stone JM, Erlandsson K, Arstad E, Bressan RA, Squassante L, Teneggi V, Ell PJ, Pilowsky LS (2006). Ketamine displaces the novel NMDA receptor SPET probe [(123)I]CNS-1261 in humans in vivo.. Nucl Med Biol, 33(2), 239 - 243. doi:10.1016/j.nucmedbio.2005.12.001
    • Arstad E, Gitto R, Chimirri A, Caruso R, Constanti A, Turton D, Hume SP, Ahmad R, Pilowsky LS, Luthra SK (2006). Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer.. Bioorg Med Chem, 14(14), 4712 - 4717. doi:10.1016/j.bmc.2006.03.034
    • Arstad E, Platzer S, Berthele A, Pilowsky LS, Luthra SK, Wester HJ, Henriksen G (2006). Towards NR2B receptor selective imaging agents for PET-synthesis and evaluation of N-[11C]-(2-methoxy)benzyl (E)-styrene-, 2-naphthyl- and 4-trifluoromethoxyphenylamidine.. Bioorg Med Chem, 14(18), 6307 - 6313. doi:10.1016/j.bmc.2006.05.046

    2005

    • Teneggi V, Stone JM, Erlandsson K, Squassante L, Arstad E, Bressan RA, Ell PJ, Bye A, Pilowsky LS (2005). Ketamine NMDA receptor inhibition and psychotic symptoms. A SPET study in humans with a novel NMDA receptor ligand.
    • Stone J, Erlandsson K, Arstad E, Bressan RA, Teneggi V, Ell PJ, Pilowsky LS (2005). Ketamine displacement of the NMDA ion channel spet ligand [123I]CNS-1261 in vivo.

    2004

    • Arstad E, Stone JS, Erlandsson K, Waterhouse RN, Norbury R, Ell PJ, Pilowsky LS (2004). [1231]TPCNE - A novel SPET tracer for the sigma-1 receptor: First human studies.
    • Arstad E, Erlandsson K, Waterhouse RN, Norbury R, Ell PJ, Pilowsky LS (2004). First human study of the sigma-1 receptor radiotracer [123I]TPCNE.

    2003

    • Arstad E, Barrett AGM, Tedeschi L (2003). ROMPgel-supported tris(triphenylphosphine)rhodium(I) chloride: a selective hydrogenation catalyst for parallel synthesis. TETRAHEDRON LETT, 44(13), 2703 - 2707. doi:10.1016/S0040-4039(03)00351-4
    • Arstad E, Hoff P, Skattebøl L, Skretting A, Breistøl K (2003). Studies on the synthesis and biological properties of non-carrier-added [(125)I and (131)I]-labeled arylalkylidenebisphosphonates: potent bone-seekers for diagnosis and therapy of malignant osseous lesions.. J Med Chem, 46(14), 3021 - 3032. doi:10.1021/jm021107v

    2002

    • Arstad E, Barrett AG, Hopkins BT, Köbberling J (2002). ROMPgel-supported triphenylphosphine with potential application in parallel synthesis.. Org Lett, 4(11), 1975 - 1977.
    • Arstad E, Skattebol L (2002). Reactions of diethyl mesyl- or tosyloxyphosphonates with diethyl phosphite and base: a method claimed to yield bisphosphonates. TETRAHEDRON LETT, 43(48), 8711 - 8712.
    • ARSTAD E, SKATTEBOL L (2002). Bis-phosphonate compounds.