Institute of Nuclear Medicine
The Institute of Nuclear Medicine is part of the Division of Medicine

Medicine News

A Smartphone Tool to Reduce Alcohol Use and Admissions in Alcoholic Liver Disease

Published: Apr 13, 2015 12:07:47 PM

Poem - Festschrift Gordon Stewart

Published: Mar 31, 2015 1:47:00 PM

Graduate Open Day 16th March 2015

Published: Jan 8, 2015 3:38:17 PM

Radiochemistry

Erik Ă…rstad

The UCL radiochemistry group was established in 2008 as part of a collaboration between UCL Department of Chemistry, UCL Division of Medicine and UCLH. Generous funding from HEFCE and CBRC allowed construction of a state-of-the-art radiochemistry facility at the UCL Campus, which was completed in 2010. The group aims to bridge expertise across chemistry, biological sciences and medicine to develop methods for labelling and bioconjugation, support preclinical imaging and translational studies, and to develop tracers for diagnostic imaging. We are also exploring the use of imaging and radiochemical techniques to accelerate drug discovery.

Radiochemistry group

The group recently developed a novel three-component labelling reaction for formation of trisubstituted iodotriazoles directly from aqueous radioiodide, and the parent azide and alkynes. The method is technically straightforward, high yielding and robust, allows rapid access to highly functionalized tracers. We have used this to prepare dual optical and nuclear labelling reagents, and demonstrated imaging of antibody distribution from the cellular level to the whole body (multiscale imaging). The group has also made progress on new 18F chemistry, which is currently implemented for development of metabolic tracers for imaging of drug efflux pumps. In addition, we are working on tracers for imaging of voltage-gated sodium channels, development of novel analgesics, and multimodal (SPECT/MR) imaging agents for inflammation.

Click the links below for further information about radiochemistry research at the INM: