Centre for Neuroendocrinology
Neuroendocrinology is part of the Division of Medicine

Medicine News

Major Grants from 1st August 2013

Published: Jul 31, 2014 12:23:05 PM

UCL Stroke Case Collection (UStroc)

Published: Jun 30, 2014 4:17:48 PM

Rajiv Jalan

Published: Jun 30, 2014 11:28:01 AM

Publications

  1. Bouloux PM, Legros JJ, Elbers JM, Geurts TB, Kaspers MJ, Meehan AG, Meuleman EJ; Study 43203 Investigators. Effects of oral testosterone undecanoate therapy on bone mineral density and body composition in 322 aging men with symptomatic testosterone deficiency: a 1-year, randomized, placebo-controlled, dose-ranging study. Aging Male. 2013 Jun;16(2):38-47. doi: 10.3109/13685538.2013.773420. 
  2. Hu Y, Pooplasundram S, Graham A, Bouloux PM. GnRH neuronal migration and olfactory bulb neurite outgrowth are dependent on FGF receptor 1 signaling, specifically via the PI3K p110α isoform in chick embryo. Endocrinology, 2013;154(1):388-99.
  3. Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP. SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46. doi: 10.1172/JCI64311.
  4. Lane JD, Keenan NG, Bouloux P, Rogers D. A heart without hormones. Lancet. 2012 May 19;379(9829):1922. doi: 10.1016/S0140-6736(12)60314-6.
  5. Guaraldi G, Beggi M, Zona S, Luzi K, Orlando G, Carli F, Ligabue G, Rochira V, Rossi R, Modena MG, Bouloux P. Erectile dysfunction is not a mirror of endothelial dysfunction in HIV-infected patients. J Sex Med. 2012 Apr;9(4):1114-21. doi: 10.1111/j.1743-6109.2011.02243.x. 
  6. Barry JA, Bouloux P, Hardiman PJ. The impact of eating behavior on psychological symptoms typical of reactive hypoglycemia. A pilot study comparing women with polycystic ovary syndrome to controls. Appetite. 2011 Aug;57(1):73-6. doi: 10.1016/j.appet.2011.03.003. Hu Y and Bouloux PM. X-linked GnRH deficiency: KAL-1 mutations in GnRH deficiency. Molecular and Cellular Endocrinology. 2011;346(1-2):13-20 Hu Y, Bouloux PM. Novel insights in FGFR1 regulation: lessons from Kallmann syndrome. Trends Endocrinol Metab. 2010;21(6):385-93.
  7. Wild D, Theodoraki A, Kurzawinski TR, Bomanji J, Reubi JC, Khan R, Bouloux P, Khoo B. 'Running on empty'. Eur J Nucl Med Mol Imaging. 2010 Jul;37(7):1439-40. doi: 10.1007/s00259-010-1455-8.
  8. Boateng J, Kay R, Lancashire L, Brown P, Velloso C, Bouloux P, Teale P, Roberts J, Rees R, Ball G, Harridge S, Goldspink G, Creaser C. A proteomic approach combining MS and bioinformatic analysis for the detection and identification of biomarkers of administration of exogenous human growth hormone in humans. Proteomics Clin Appl. 2009 Aug;3(8):912-22. doi: 10.1002/prca.200800190. Hu Y, Guimond SE, Travers P, Cadman S, Hohenester E, Turnbull JE, Kim SH, Bouloux PM. Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1. J Biol Chem. 2009;284(43):29905-20.
  9. Aperghis M, Velloso CP, Hameed M, Brothwood T, Bradley L, Bouloux PM, Harridge SD, Goldspink G. Serum IGF-I levels and IGF-I gene splicing in muscle of healthy young males receiving rhGH. Growth Horm IGF Res. 2009 Feb;19(1):61-7. doi: 10.1016/j.ghir.2008.07.002. 
  10. Legros JJ, Meuleman EJ, Elbers JM, Geurts TB, Kaspers MJ, Bouloux PM; Study 43203 Investigators. Oral testosterone replacement in symptomatic late-onset hypogonadism: effects on rating scales and general safety in a randomized, placebo-controlled study. Eur J Endocrinol. 2009 May;160(5):821-31. doi: 10.1530/EJE-08-0634. Kim S, Hu Y, Cadman S, Bouloux PM. Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome. J Neuroendocrinol. 2008;20(2):141-63. 
  11. Mommers E, Kersemaekers WM, Elliesen J, Kepers M, Apter D, Behre HM, Beynon J, Bouloux PM, Costantino A, Gerbershagen HP, Grønlund L, Heger-Mahn D, Huhtaniemi I, Koldewijn EL, Lange C, Lindenberg S, Meriggiola MC, Meuleman E, Mulders PF, Nieschlag E, Perheentupa A, Solomon A, Väisälä L, Wu FC, Zitzmann M. Male hormonal contraception: a double-blind, placebo-controlled study. J Clin Endocrinol Metab. 2008 Jul;93(7):2572-80. doi: 10.1210/jc.2008-0265. Cadman S, Kim S, Gonzalez-Martinez D, Hu Y and Bouloux PM. Molecular basis of Kallmann’s syndrome. Hormone Research Journal. 2007;67(5):231-42.
  12. Hu Y, Kim S, Cadman S, Bouloux PM. Insights into the Molecular Basis of Kallman Syndrome. Encyclopedia of Life Science. September 2007 Standard Article online publication. http://www.els.net/ [DOI: 10.1002/9780470015902.a0006100].
  13. O'Beirne J, Holmes M, Agarwal B, Bouloux P, Shaw S, Patch D, Burroughs A. Adrenal insufficiency in liver disease - what is the evidence? J Hepatol. 2007 Sep;47(3):418-23.
  14. Pitteloud N, Quinton R, Pearce S, Raivio T, Acierno J, Dwyer A, Plummer L, Hughes V, Seminara S, Cheng YZ, Li WP, Maccoll G, Eliseenkova AV, Olsen SK, Ibrahimi OA, Hayes FJ, Boepple P, Hall JE, Bouloux P, Mohammadi M, Crowley W. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. J Clin Invest. 2007 Feb;117(2):457-63. 
  15. Svensson J, Finer N, Bouloux P, Bevan J, Jonsson B, Mattsson AF, Lundberg M, Harris PE, Koltowska-Häggström M, Monson JP; Growth hormone (GH) replacement therapy in GH deficient adults: predictors of one-year metabolic and clinical response. KIMS International Board. Growth Horm IGF Res. 2007 Feb;17(1):67-76.
  16. Cerrato F, Shagoury J, Kralickova M, Dwyer A, Falardeau J, Ozata M, Van Vliet G, Bouloux P, Hall JE, Hayes FJ, Pitteloud N, Martin KA, Welt C, Seminara SB. Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism. Eur J Endocrinol. 2006 Nov;155 Suppl 1:S3-S10.
  17. Pitteloud N, Meysing A, Quinton R, Acierno JS Jr, Dwyer AA, Plummer L, Fliers E, Boepple P, Hayes F, Seminara S, Hughes VA, Ma J, Bouloux P, Mohammadi M, Crowley WF Jr. Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes. Mol Cell Endocrinol. 2006 Jul 25;254-255:60-9.
  18. Solomon A, Bouloux P. Endocrine therapies for sarcopenia in older men. Br J Hosp Med (Lond). 2006 Sep;67(9):477-81.
  19. Sutcliffe A, Spoudeas HA, Nair D, Bouloux P, Oliver T, Sambrook P, Bannister W, Lambalk CB, Spector T. Comparison of serum FSH and Inhibin B levels between adult male dizygotic and monozygotic twins. Hum Reprod. 2006 Feb;21(2):447-50.
  20. Bouloux P. Testim 1% testosterone gel for the treatment of male hypogonadism.
  21. Clin Ther. 2005 Mar;27(3):286-98. Hu Y, Sun Z, Eaton JT, Bouloux PM, Perkins SJ. Extended and Flexible Domain Solution Structure of the Extracellular Matrix Protein Anosmin-1 by X-ray Scattering, Analytical Ultracentrifugation and Constrained Modelling. J Mol Biol. 2005;350(3):553-70.  Tanriverdi F, Gonzalez-Martinez D, Hu Y, Kelestimur F, Bouloux PM. GnRH-I and GnRH-II have differential modulatory effects on human peripheral blood mononuclear cell proliferation and interleukin-2 receptor gamma-chain mRNA expression in healthy males. Clin Exp Immunol. 2005;142(1):103-10.
  22. Turton JP, Mehta A, Raza J, Woods KS, Tiulpakov A, Cassar J, Chong K, Thomas PQ, Eunice M, Ammini AC, Bouloux PM, Starzyk J, Hindmarsh PC, Dattani MT. Mutations within the transcription factor PROP1 are rare in a cohort of patients with sporadic combined pituitary hormone deficiency (CPHD). Clin Endocrinol (Oxf). 2005 Jul;63(1):10-8.
  23. Gonzalez-Martinez D, Hu Y, Bouloux PMG. Ontogeny of GnRH and Olfactory Neuronal Systems in Man:  Novel Insights from the Investigation of Inherited forms of Kallmann's Syndrome. Frontiers in Neuroendocrinology. 2004; 25(2):108-130.
  24. Gonzalez-Martinez D, Kim SH, Hu Y, Guimond S, Schofield J, Winyard P, Vannelli GB, Turnbull J, Bouloux PM. Anosmin-1 Modulates Fibroblast Growth Factor Receptor 1 Signaling in Human Gonadotropin-Releasing Hormone Olfactory Neuroblasts through a Heparan Sulfate-Dependent Mechanism. J Neurosci. 2004; 24(46): 10384-10392. 
  25. Hu, Youli, Gonzalez-Martinez D., Kim Soo-Hyun., Bouloux PMG . (2004) Cross-talk of anosmin-1, the protein implicated in X-linked Kallmann's syndrome, with heparan sulphate and urokinase-type plasminogen activator. Biochem J : 384:1-11.
  26. Tanriverdi F, Gonzalez-Martinez D, Silveira LF, Hu Y, Maccoll GS, Travers P, Bouloux PM.  Expression of gonadotropin-releasing hormone type-I (GnRH-I) and type-II (GnRH-II) in human peripheral blood mononuclear cells (PMBCs) and regulation of B-lymphoblastoid cell proliferation by GnRH-I and GnRH-II. Exp Clin Endocrinol Diabetes. 2004;112(10):587-94.Hu Y, Tanriverdi F, MacColl GS, Bouloux PM.  Kallmann’s syndrome: Molecular Pathogenesis. Int J Biochem Cell Biol. 2003; 35:1157-62. Bouloux PM, Hu Y, MacColl G. Recent advances in the pathogenesis of Kallmann's syndrome. Prog Brain Res. 2002; 141:79-83.
  27. MacColl, G., Bouloux , P ., Quinton, R. (2002) Kallmann Syndrome: adhesion, afferents and anosmia. Neuron : 34: 675-678.
  28. MacColl G, Quinton R, Bouloux PM. GnRH neuronal development: insights into hypogonadotrophic hypogonadism. Trends Endocrinol Metab. 2002 Apr;13(3):112-8.
  29. Randeva HS, Davison R, Chamoun V, Bouloux PM. Isolated neurosarcoidosis--a diagnostic enigma: case report and discussion. Endocrine. 2002 Apr;17(3):241-7.
  30. Silveira LF, Bouloux PM, MacColl GS, Camacho-Hubner C, Miraki-Moud F. Growth hormone therapy for non-islet cell tumor hypoglycemia. Am J Med. 2002 Aug 15;113(3):255-7.
  31. Robertson, A., MacColl, GS., Nash, JA., Boehm, MK., Perkins, SJ., Bouloux , PM . (2001) Molecular modelling and experimental studies of mutation and cell-adhesion sites in the fibronectin type III and whey acidic protein domains of human anosmin-1. Biochem J : 1:357(Pt 3):647-59.