Centre for Neuroendocrinology
There are two groups within the centre. One, headed by Dr Bouloux, is
investigating the role of the X-linked Kallmann protein anosmin 1 in
CNS development. It is using recombinant technology to express the
intact fully glycosylated protein in eukaryotic cells, with a view to
investigating its activities as a neurotrophic/neurotropic factor in
the CNS. An interactional trap (Gal4 two hybrid system) is also being
used to to identify potential ligands for anosmin 1.
The second group, working in collaboration with UCL Neuroscience, Physiology & Pharmacology is investigating the prospects for somatic gene transfer of the GH gene into muscle, using muscle specific promoters and enhancers.