Medicine News

Major Grants from 1st August 2013

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  • £2,436,839 (Total award to UCL £8,875,955) MRC Medical Bio-Informatics, Prof David Lomas, “Data-driven discovery for personalised medicine”
  • £1,273,218 Wellcome Trust/Department of Health, Health Innovation Challenge Fund, Dr Alastair O’Brien, “ATTIRE: Albumin to prevent infection in chronic liver failure”
  • £1,127,761 Wellcome Trust Simon Walker-Samuel, Senior Research Fellowship 
  • £933,494 EPSRC Dr Tammy Kalber, Early Career Fellowship, “Generation of multi-model imaging mesenchymal stem cells”
  • £888,203 MRC. Anthony    Segal    Research Grant: “Identification and characterisation of casula molecules for Crohn's disease and ulcerative colitis”
  • £628,696 (£20,191 to DoM but UCL is lead) - FP7 – William Rosenberg – ‘FLUTCORE: Development of a universal vaccine based on tandem core technology’.
  • £577,127  BBSRC. Huiliang Li. Research Grant: Transgenic approaches to understanding astrocyte hetergeneity
  • £475,224.31 MRC. Richard Day. Research Grant: Improved Delivery and Function of Myoblasts via Soluble TIPS Microcarriers
  • £451,939 (total award to UCL £921,359) Cancer Research UK (via King’s College London).  Prof Mark Lythgoe, Prof Ashley Groves, Dr Shonit Punwani and Dr Erik Arstad, “Comprehensive Cancer Imaging Centre (CCIC 2)”
  • £417,119 NIHR.  Mrs Jackie McRae, Clinical Doctoral Research Fellowship, entitled “The development of a screening instrument for dysphagia following acute cervical spinal cord injury”
  • £368,549  E.U.   Claudia Mauri   FP7: ATHERO-B-CELL
  • £360,000  Rosetrees Trust.  Rachel Batterham,   Research Grant: “Link between obesity gene FTO and gut hormones”
  • £350,000 Replekfarm LLC.  Dr Slavica Tudzarova-Trajkovka, Senior Research Fellowship, entitled “Exploring the potential for collaborative research related to CDC7 kinase-targeting anti-cancer therapy”
  • £287,812 Wellcome Trust. Dr Laura Succony, Research Training Fellowship, entitled “Defining the role of Lrig1-dependent EGFR signalling pathway inhibition in airway homeostasis and lung cancer development”
  • £287,017 Janssen. Claudia Mauri. Collaborative Research Agreement
  • £286,308  BRC    Shonit    Punwani.  BRC Cancer Programme Funding
  • £286,000  Arthritis Research UK 4 yr Clinical Research Fellowship. Corinne Fisher (Centre for Rheumatology)
  • £285,845 Prostate Cancer UK.   Shonit Punwani    Project Grant: Localising Occult prostate Cancer metastases with Advanced imaging Techniques (LOCATE)
  • £282,678 (total award to UCL £872,299) European Commision FP7 award,Dr Erik Arstad, entitled “EPITARGET”
  • £250,000 National Institute of Academic Anaesthesia (via BJA), Dr Gareth Ackland, entitled “Parasympathetic modulation of perioperative myocardial injury”

CABI at Royal Society Summer Science Exhibition 2014

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RSSE-2014

The DoM Centre for Advanced Biomedical Imaging (CABI) were centre stage at the   Royal Society Summer Science Exhibition (1-6 July 2014). 15,000 attended the showcase, with adults and children chatting to CABI scientists about jellyfish and transparent brains as well as the wonders of modern imaging at UCL.

UCL Stroke Case Collection (UStroc)

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UCL Stroke Case Collection

Dr Reecha Sofat, Clinical Senior Lecturer and Dr Martina Colicchia, Research Fellow in the Division of Medicine, shown above with Elizabeth Tollady. 

Rajiv Jalan

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Congratulations to Rajiv Jalan who has been elected the Editor-in-Chief of the Journal of Hepatology

2014 Medicine Code of Practice

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 The 2014 Medicine Code of Practice is now available on the Intranet Safety page

Early Career Research Conference

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 10th-11th September 2014

University of Leeds

Early Career Research Conference Flyer

UCL Applied Renal Physiology 2014 - course

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This is a modular course and includes the following sections: a primer in renal physiology, a 2-day course on fluids, electrolytes and acid-base and, finally, a 1-day cutting-edge science symposium. 

Rosetrees Trust Studentships - September 2014

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Applications are invited for three separate 3-year PhD studentships to start in September 2014 jointly funded by the Rosetrees Trust & Royal Free Charity.

Professor Andrew Burroughs

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We are greatly saddened to announce the death of Prof Andrew Burroughs, who passed away on Saturday 15th March, at the age of 60.  Prof Burroughs was an eminent and world renowned Professor of Hepatology and Consultant Physician/Hepatologist.  He joined the UCL Institute of Liver and Digestive Health last year, having previously worked in the Sheila Sherlock Liver Centre at the Royal Free Hospital for the majority of his career. 

Professor Massimo Pinzani, Sheila Sherlock Chair of Hepatology and Director of the UCL Institute for Liver and Digestive Health, commented:

"Andy was one of the greatest hepatologists in history and the true representative of Dame Sheila Sherlock's legacy.  For more than thirty years, Andy led world class clinical research at the Royal Free providing major advances in clinical practice.  He was a world leader and an amazing mentor for generations of hepatologists trained at the Royal Free. Our thoughts go to his family and to the memories of him working with us."

UEG Rising Star Award 2014

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Tsochatzis Manolis

Congratulations to Emmanuel (Manolis) Tsochatzis on receiving the 2014 Rising Star Award by the United European Gastroenterology Society (UEG). This is awarded to 8 emerging young clinical scientists from Europe based on a track record of international quality research and developing scientific independence. The recipients of the award give state-of-the-art lectures and chair scientific sessions at the UEG week.

in2scienceUK Summer Internship

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giangreco

Rebecca McKelvey (Neuroscience) and Adam Giangreco (Medicine) have secured funding from Development and Alumni Relations and UCL Outreach to support the UCL-led In2ScienceUK laboratory placement scheme.  The aim of this scheme is to inspire and motivate AS level science students from low income backgrounds and support them in their application to competitive research universities.  

Now in its 5th year, the goal of this year’s programme is to place over 100 students in labs at UCL, Imperial and Kings.  The scheme is very successful, with 80% of former students gaining places at UK universities (compared with around 17% in this demographic nationwide) – but a key to this success is finding labs that are happy to act as hosts.  This occurs for 2 weeks in July-August, is a great experience for a senior PhD student or postdoc, and involves no additional administrative duties.  Students can shadow group members, talk to PIs/postdocs/students in other labs, watch demonstrations, analyse data, or get involved in any other task which is appropriate.  In2scienceUK will organize the placement, interview and select the students, and complete any necessary paperwork.  

If you or someone in your lab would like to make a real difference to the prospects of these young people please contact Rebecca McKelvey

New insights into how the kidney works

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Bockenhauser Kleta and Klootwijk

 Professor Robert Kleta and team have discovered a new disease mechanism shedding light onto how the kidney works (Klootwijk et al., NEJM, 2014, 370, 129-138). As a trained paediatrician and geneticist he and Dr Detlef Bockenhauer from the Institute of Child Health together lead a competitive team based at Royal Free Hospital comprised out of renal doctors, geneticists, bioinformaticians, computer scientists, cell and molecular biologists and physiologists focused on the study of rare renal disease. They investigated a clinical problem called autosomal dominant renal Fanconi syndrome in paediatric and adult patients and thereby discovered a completely novel disease mechanism: they showed that aberrant trafficking of an enzyme can cause disease not by its absence in the organelle it was intended to be, but by disturbing function of the organelle it is wrongly routed to. They discovered that a mutation in a peroxisomal protein caused misrouting to the mitochondria and interfered with mitochondrial metabolism.

Prof. Leon Fine, Professor and Chair, Dept of Biomedical Sciences, Vice-Dean, Research and Graduate Research Education, Cedars-Sinai Medical Center, Los Angeles, USA, formely UCL, commented “The paper is a tour de force of clinical observation, interdisciplinary science, multi-institutional collaboration, genomics and cellular physiology, which has led to the determination of the cause of an inherited disease. A truly outstanding achievement.”

British Bangladeshi Power & Inspiration List 2014

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Anisur Rahman

Very well done to Anisur Rahman for his place in the British Bangladeshi Power & Inspiration List 2014 and to Jayne Kavanagh who received the Provost's Award for Public Engagement. Jayne was nominated for this award for her leading role in creating and running the Beacon-funded 2013/14 project ‘Stories from the soul: doctors’ choices, women’s lives’.  'Stories from the soul’ includes three evenings of storytelling, music and discussion that bring together healthcare providers with members of the public to explore how doctors’ decisions affect women’s lives.

ILTS Distinguished Service Award

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Andrew Burroughs

 Professor Andrew K. Burroughs, a faculty of the UCL Institute for Liver and Digestive Health and consultant hepatologist at the Royal Free London, has recently been awarded the 2014 Distinguished Service Award of the International Liver Transplantation Society (ILTS) for his outstanding contribution to this field. Indeed, Professor Burroughs is one of the pioneers of transplant Hepatology and his research has greatly contributed to establishing the current management of liver transplantation. This represents a great honour for UK and European Hepatology.
During 2013, Professor Burroughs received two other major career awards: the Distinguished Career Award of the European Association for the Study of the Liver (EASL) and the highest honour from the British Society of Gastroenterology (BSG):  the Sir Arthur Hurst Lecture.
In addition to his value as clinician and researcher, these awards were motivated by Professor Burroughs’ exceptional ability to mentor emerging talent in his field; indeed he has provided mentorship for an incredible number of UK and international hepatologists, in keeping with a tradition established at the Royal Free by his mentor Professor Dame Sheila Sherlock.

Women in Science Fellowship 2014

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Applications for the 2014 L’Oréal-UNESCO UK & Ireland
For Women in Science Fellowships now open


L’Oréal UK & Ireland, the UK National Commission for UNESCO and the Irish National Commission for UNESCO, with the support of the Royal Society have partnered together to provide a dedicated UK & Ireland For Women in Science fellowship programme for women scientists at post-doctoral level to enable and/or facilitate promising scientific research in the life and physical sciences.
Four Fellowships will be awarded in 2014 to outstanding female postdoctoral scientists to assist them with their research. The Fellowships, each worth £15,000 (equivalent Euros for candidates in Ireland), are tenable at any UK or Irish university or research institute to support a 12-month period of research.
The Fellowship money can be spent in any number of innovative ways to enable women scientists to further their careers and facilitate world class research - such as buying equipment, paying for childcare or funding travel costs to an overseas conference.

Key Dates:

Applications open: Saturday 1st February
Application close: Friday 14th March
Shortlist published: Tuesday 3rd June
Awards ceremony: Thursday 19th June

New Divisional Lead for Safety

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roberta-perelli-4

Welcome to Roberta Perelli – the new Divisional Lead for Safety

Health Innovation Challenge Fund

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 Dr Alastair O’Brien has received £1.6 million from the Health Innovation Challenge Fund (joint Wellcome Trust & Department of Health) for ATTIRE (Albumin To prevenT Infection in chronic liveR failure). This is to fund a multi-centre clinical phase II and phase III trial at >15 sites that will examine whether administration of albumin to patients with liver failure in order to increase plasma levels to near normal will prevent hospital acquired infection. The clinical research network (LCRN) will fund the research nurse costs (>£1million). Over 100,000 patients are admitted to hospital every year with advanced liver cirrhosis and infection is their most common problem. Dr O’Brien and his team have shown that in these patients leukocyte function is markedly impaired by an up regulation of the hormone Prostaglandin E2 and infusion of albumin can reverse this process by binding and neutralising its effects. Albumin is widely considered to be beneficial in infection by hepatologists but until now there was no putative mechanism and therefore no consensus as to how to prescribe it. They wish to repurpose it as an immune restorative drug to improve leukocyte function in patients with advanced cirrhosis and therefore improve their ability to fight off infection.  It is hoped to demonstrate that its use will lead to reduced nosocomial infection rates, mortality and length of stay and thereby reduce health care costs.

Nuffield Foundation Research Placement Programme

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We are pleased to announce that Piumi Nikawala, a student of the Applied Biomedical Engineering Group, received the Gold CREST (CREactivity in Science and Technology) Award for her project on TIPS microspheres within the Nuffield Foundation Research Placement Programme.  This is a nationally recognized scheme to reward Science & Technology project work. 

Well done, Piumi!”

Grand Challenge PD student wins Dean's Prize

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Lauren Bourke


Lauren Bourke, a Grand Challenge PhD student in UCL’s Division of Medicine, has been awarded the Dean’s prize for her research into cardiac injury in systemic lupus erythematosus (SLE).

SLE is a systemic autoimmune condition which can affect multiple organs, although cardiovascular disease accounts for 25% of mortality.  Lauren’s research has focused on ischaemic reperfusion (I/R) injury after myocardial infarction.  This is a cause of up to half of cell death after MI, and occurs when hypoxic cells are reoxygenated. More specifically, she has found that hydroxychloroquine (a drug frequently used in the treatment of SLE) is protective against this kind of damage to cardiac muscle cells in vitro.

In2scienceUK and the Division of Medicine

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giangreco

A recent BBC news item highlighted that Gifted A-level science students from poorer socio-economic backgrounds face major obstacles in securing places at top UK research universities.  While 96% of students from independent schools progress to higher education only 16% of students eligible for free school meals programmes accomplish the same.

£6 Million Award for Medical Imaging PhDs

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Seb Ourselin, Mark Lythgoe and Geraint Rees (CDT Directors) alongside others, have been awarded £6M for a UCL Centre for Doctoral Training in Medical Imaging by the EPSRC. This will train 70 students over the next 5 years. The Centre will address the shortage of UK trained imaging scientists and prepare medical imaging leaders of the future to tackle the most critically important healthcare challenges with innovative engineering solutions. The 4-year PhD programme in Medical Imaging will provide a strong focus on new imaging technologies, novel analysis methods and integration with computational modelling.

NIHR clinical doctoral research fellowship

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Jackie McRae, Speech and Language Therapist at RNOHT has been awarded an NIHR clinical doctoral research fellowship supervised by Dr Anton Emmanuel and Dr Christina Smith at UCL.  Her research will focus on the management of swallowing problems in ITU in patients following cervical spinal cord injury.

Top Administrator Award 2012-13

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We are pleased to announce that Carolyn Cohen has won the UCL Medical School Top Administrator Award 2012-13 for the 4th consecutive year.  Congratulations Carolyn!

MPhil/PhD Upgrade Prizes for 2012/13

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Congratulations to the following on winning prizes for best talks in this year’s DoM/ICS Seminar. 

Clinical MPhil/PhD upgrade category:
Dr Saima Saeed  from Intensive Care Medicine for her talk on "The role of mitochondrial biogenesis in recovery of skeletal muscle function following critical illness"

Basic Science MPhil/PhD upgrade category:
Freya Boardman-Pretty (Institute of Cardiovascular Science) "Investigating genetic architecture of carotid thickness to find functional variation involved in atherosclerosis"

Athena Swan Silver Award

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Athena Swan Silver Award




The Division of Medicine received a departmental Athena SWAN Silver Award following our April 2013 application. We feel extremely honored to have received such a meaningful and far-reaching recognition of the efforts made to create a supportive environment that ultimately benefits us all, men and women. The Division’s Athena SWAN team (Ines Pineda-Torra, Prof Raymond MacAllister, Blathnaid Mahony, Prof Ian Zachary, Prof Margaret Ashcroft, Markella Ponticos, Reecha Sofat, Petra Disterer, Slavica Tudzarova, Aisha Carroll, John Hurst, Prof Rachel Chambers and Robin McNaulty) worked very hard for this. We also counted with Prof Jean McEwan and Harriet Jones aid as well as with the strong commitment of the Director of the Division, Prof Raymond MacAllister. We truly believe we have come a long way since this process started. During the past year we dedicated a career workshop and started a mentoring scheme to facilitate the transition of female postdoctoral staff towards scientific independence. The Division now takes a much more proactive attitude towards senior promotions, identifying suitable women that are encouraged and mentored through this process. The Division also appointed Prof Claudia Mauri as the new Champion for Women and allocated funds to support students and staff during their maternity leave. Finally, there has been a dramatic increase in female representation at Divisional events, with a gender-balanced composition of chairpersons and a marked increase in the number of female speakers. Many other issues regarding gender-equality will need to be assessed in the future. However, the first steps have been taken towards a more balanced representation of both genders across the Division.

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