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Research Groups

Lower Gastrointestinal Imaging

MRI survey shot

Contact  Dr Andrew Plumb, Prof Steve Halligan

Small Bowel

Small Bowel Motility Map (colour)

The small bowel is a complex organ and can be afflicted by a range of structural and functional diseases. It is relatively inaccessible to even modern endoscopic techniques, and imaging is pivotal to diagnosis and assessment. Lead by Professor Stuart Taylor, the small bowel imaging group in the Centre for Medical imaging has an active research program using advanced imaging techniques, notably MRI to investigate the small bowel. Crohn’s disease is a major research interest with a full translational pipeline from development of new imaging biomarkers of biological activity through to a multicentre study comparing MRI and ultrasound in the diagnosis and staging of Crohn’s disease funded by the NIHR HTA. Working in collaboration with CMIC, we have developed a validated novel software which can quantitate global and segmental enteric motility which has applications not just in structural small bowel disorders, but in disease affecting global enteric function such as Parkinson’s disease, pseudo-obstruction and refractory constipation.

Key research activities

Quantification of enteric motility using MRI

Aberrant intestinal motility is seen in a very wide range of disease including structural disorders such a Crohn’s disease and systematic diseases such as autonomic failure and Parkinson’s disease. We have developed novel software to quantify enteric motility in health and disease. Collaborators include Nottingham University. [Magn Reson Med, Radiology]
Contacts: Alex Menys, Dr David Atkinson, and Prof Stuart Taylor

Development of MRI biomarkers of hypoxia and inflammation in Crohns disease.

Part funded by Crohns and Colitis UK, Industrial partners and the EU FP7 framework, in collaboration with Dr Manuel Rodriquez-Justo. Hypoxia and inflammation are fundamental to the pathophysiology of Crohns disease. Contact Dr Jessica Makanyanga, Prof Stuart Taylor

Diagnostic accuracy of MRI for detection and staging of Crohns disease

There are many imaging and endoscopic techniques available to investigate patients which suspected or known Crohn’s disease, many of which exposure patients to ionising radiation. MRI and Ultrasound may be safer alternatives but their utility in clinical practice is not yet elucidated. We are conducting a NIHR HTA funded multicentre study comparing the diagnostic accuracy of MRI and USS for Crohns disease. Contact Dr Gauraang Bhatnagar, Prof Stuart Taylor

Oncology

Whole Body MRI
Key research activities

Multi-parametric Whole Body MRI in Multiple Myeloma, Lymphoma and Prostate Cancer

Development, optimization and implementation of multi-parametric whole body magnetic resonance imaging protocol (mpWB-MRI) in cancer imaging. Initially, investigating the diagnostic accuracy of mpWB-MRI in multiple myeloma, lymphoma and prostate cancer. Analysis of quantitative derived parameters from functional imaging to investigate novel imaging biomarkers in these three type of cancers. Contact Dr Arash Latifoltojar, Dr Shonit Punwani

Multi-parametric MRI in Head & Neck Cancer

MRI Detection and Characterisation of Lung Nodules


MR Image Acquisition, Reconstruction and Analysis

Targeted FOV Kidney DTI
Key research activities

Diffusion weighted MRI for body applications

We are researching methods to reduce the effects of eddy currents, fat artefacts, motion and field non-uniformities to improve Diffusion MRI outside of the head. The image on the left shows a high resolution kidney image and with our collaborators at KCL, we have recently imaged the cardiac fibre orientations in a patient with a systemic right ventricle [European Heart Journal Flashlight ]. Contact: Rachel Chan, David Atkinson.

Robust Image Registration

Incorporating methods from low rank and sparse data decomposition, we have developed a Robust Data Driven Registration (RDDR) that can register time series images in the presence of contrast changes [MIA paper]. Contact: Valentin Hamy, David Atkinson.

Reconstruction of under-sampled MR data

Motility analysis

Please see the section above on Small Bowel.

Equilibrium Imaging

   Contact Dr Steve Bandula

Urology

  Contact Dr Alex Kirkham

Paediatrics

   Contact Dr Paul Humphries

Adolescent Rheumatology

   Contact Prof Margaret Hall-Craggs

Liver 

MRI liver haemodynamics

Imaging offers new opportunities to study vascular pathophysiology underpinning many of the complex clinical sequelae of chronic liver disease. 

Key research activities

Liver Haemodynamic and Quantitative Imaging

CMI boasts a fully translational MR imaging pipeline beginning with development in the preclinical setting on a 9.4T system through collaboration with CABI, extending to larger scale clinical studies. Current studies focussing on portal hypertension using phase contrast, dynamic contrast enchanced and dynamic hepatocyte-specific contrast enhanced MRI (funded by the Wellcome Trust) are underway. Contact Manil Chouhan, Stuart Taylor

Page last modified on 20 dec 13 22:47