MRes Clinical Drug Development

Course Tutor: Dr Ross Breckenridge

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This MRes offers specialised training in state-of-the-art biomedical science (including exposure to leading research scientists, biotechnologists and pharmaceutical companies), research methodology, including the translation of basic science research into novel therapies for human disease, and the philosophy, governance and social implications of health research.

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How does the MRes differ from the MSc?

The Master of Research (MRes) programme, while containing some taught elements, focuses more on research skills. It will provide an excellent introduction to research methods and will provide a good preparation for postdoctoral study. Although both the MSc and MRes programmes share the same modules, the emphasis is different for the MRes degree as more than half of the course content consists of research project work (105 credits) compared to the MSc, which has a 60 credit research project.


Programme Structure

Full Time

Students on the full-time programme must take modules to the value of 180 credits. The MRes programme consists of 3 core research modules (45 credits), a choice of one optional module (30 credits) and a Research Project (105 credits):

Core Modules
Credit Value
Term Day
MEDCG001 Statistical Methods in Research
15
Term 1
Tues
MEDCG005 Ethics and Regulation of Research
15
Term 1 
Thurs
MEDCG002 Advanced Statistical Methods
15
Term 2
Thurs
MEDCGR99 Research Project
 105 Term 3
 n/a
MEDCG003 Drug Discovery I  30 Term 1
Tues

Part-time

Students on the part-time programme must take the above modules, totalling 180 credits, over two years. We recommend that the research project is taking over two years. Below is a suggested schedule for attendance on one day per week:


Year One (30 taught credits)

Core Modules
Credit Value
Term Day
MEDCG001 Statistical Methods of Research 15
Term 1
Tues
MEDCG003 Drug Discovery I  30 Term 1
Tues


Year Two (45 taught credits)

Core Modules
Credit Value
Term Day
MEDCGR99 Research Project
105 Term 3
 n/a
MEDCG002 Advanced Statistical Methods 15
Term 2 
Thurs
MEDCG005 Ethics and Regulation of Research
15
Term 1
Thurs

Research Projects

This is an example of projects taken by our current students:

 Topic Title
 Supervisor
Does Secretory Leukocyte Protease Inhibitor (SLPI) cause its anti-inflammatory effect via up regulation of COX induced prostaglandin E2? Dr Alastair O'Brien
Validation of a novel preoperative POSSUM score in elective orthopaedic surgery. Dr Ramani Moonesinghe
Small molecule inhibitors of the HIF pathway in cancer drug development Dr Margaret Ashcroft
Lymphocyte mediated endogenous opioid analgesia in the postoperative period. Dr Gareth Ackland
In vitro optimization of chemical modifications of spliceswitching
oligonucleotides for the treatment of familial
hypercholesterolemia
Dr Bernard Khoo
Pharmacokinetic modelling of alternative dosing regimens of anti-infectives for paediatric patients in resource-limited areas. Dr Oscar della Pasqua (GSK)
Surrogate decision-making in learning disability Dr Sarah Edwards
Generalisability (external validity) of RCTs for antiretroviral therapy strategies for the treatment of naïve and experienced HIV-positive patients Dr Alejandro Arenas-Pinto
Delineating a role for endothelium-derived C-type natriuretic peptide in the pathogenesis of septic shock Professor Adrian Hobbs
Physicochemical properties and metabolic fate of tetrathiomolybdate (TTM), a copper chelator and sulphide donor. Dr Alex Dyson
Clinical Research Activity in the EU Dr Ross Breckenridge
What is the best way to Investigate a Brain Hemorrhage? Dr David Werring
How does the production of superoxide change in neuroinflammatory disease? Professor Kenneth Smith
 Which factors influence a patient's decision whether or not to participate in a clinical trial? A qualitative and quantitative study comparing the acute and non-acute setting.  Dr Sarah Edwards
 Factors that control neutrophil chemokine receptor expression  Dr Andrew Williams
 Cardiac MRI  Dr James Moon
 A Retrospective analysis into the discriminatory power of exhaled breath temperature monitoring in a population of mild to moderate chronic obstructive pulmonary disease subjects from healthy ex and current cigarette smokers. 
 Dr John Hurst
 The design, synthesis and evaluation of new inhibitors of the kinesin Eg5 as lead drug candidates for the treatment of multiple myeloma. Professor Frank Kozielski
 The evaluation of clinical evidence and Cost effectiveness analysis based on NICE guidance: Drug treatment for breast cancer.  Professor Nicholas Freemantle
 Pharmacokinetics and Pharmacodynamics of Tetrathiomolybdate  Professor Mervyn Singer
 Development of a novel caspase 3-specific radiotracer for                        the detection of apoptosis in response to chemotherapy  Professor Barbara Pedley
 Development of a Cardiac Patch Using the Novel Nanocomposite Polymer POSS-PCU Professor Alexander Seifalian
 Persisting blood propofol levels in the critically ill and levels of sedation following the termination of a long term (>72 hours) infusion  Professor Mervyn Singer
 Klotho gene variants that can protect from adverse outcomes in CKD  Dr Ben Caplin
 A Genetic Approach to Identify Biological Pathways Relevant to Stroke and its Subtypes.  Dr Reecha Sofat
 Feasibility of using “bench-top” MRI for assessment of experimental stroke  Dr Daniel Stuckey

Research Departments

Research Department of Clinical Physiology
Research Department of Inflammation
Research Department of Internal Medicine
Research Department of Metabolism and Experimental Therapeutics
Wolfson Institute for Biomedical Research
UCL Institute for Liver and Digestive Health

Careers

All current students are supported by the extensive services offered by the UCL Careers Service, as well as the department's own specialist Careers Day, which forms part of our annual calender of events.

This MSc provides an ideal foundation for graduates who wish subsequently to undertake a PhD in biomedical science within UCL or elsewhere. In addition the course provides key transferable skills for those wishing to pursue careers in drug discovery.

Destinations of recent graduates of the department include:

  • Imperial College London: Research Associate
  • GlaxoSmithKline: Senior Scientist
  • St George's Hospital: Consultant Physician
  • Garvan Institute: Researcher
  • UCL: Laboratory Manager and Research Assistant

For more information about applying for a PhD after the MRes, please visit our Postgraduate Research Degrees page.

Page last modified on 25 mar 14 16:02