Centre for Clinical Pharmacology and Therapeutics

Key Publications

1 Grosso A, Douglas I, Hingorani A, MacAllister R, Smeeth L. Oral bisphosphonates and risk of atrial fibrillation and flutter in women: a self-controlled case-series safety analysis. PLoS One. 2009;4:e4720. 2009
2
 Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D,Wilkins MR, MacAllister RJ, Hobbs AJ. Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial
hypertension. Am J Respir Crit Care Med. 2008 ;178:861-9
3
 Loukogeorgakis SP, Williams R, Panagiotidou AT, Kolvekar SK, Donald A, Cole TJ, Yellon DM, Deanfield JE, MacAllister RJ. Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism. Circulation. 2007;116:1386-95. 2007
4
Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G, Gilroy DW. Effects of low-dose aspirin on acute inflammatory responses in man. J. Immunology. 183(3):2089-96. 2009
5
 Rajakariar R, Newson J, Jackson E, Sawmynaden P, Smith A, Rahman F, Yaqoob M, Gilroy DW. Non-resolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease has lower adenosine and cAMP. J. Immunology. 182(5):3262-9, 2009
6
 Harmer SC, Wilson AJ, Aldridge R, Tinker A. (2010) Mechanisms of disease pathogenesis in long QT syndrome type 5. American Journal of Physiology (Cell Physiology) in press (PMID: 19907016)
7
 Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Ehler E, Birks EJ, Barton PJR, Tinker A, Mohun TJ (2009). Overexpression of the transcription factor Hand1 causes a predisposition towards arrhythmia in mice. Journal of Molecular and Cellular Cardiology. 47, 133-41.
8
 Orie NN, Thomas AM, Perrino BA, Tinker A, Clapp LH. Ca2+/calcineurin regulation of cloned vascular KATP channels: crosstalk with the protein kinase A pathway. Br J Pharmacol 157:554-64, 2009
9

Jabr RI, Wilson AJ, Riddervold MH, Jenkins AH, Perrino BA, Clapp LH. Nuclear translocation of calcineurin Aß but not Aa by platelet-derived growth factor in rat aortic smooth muscle. Am J Physiol (Cell), 292:C2213-2225, 2007
10

Madani R, Karastergiou K, Ogston NC, Miheisi N, Bhome R, Haloob N, Tan GD, Karpe F, Malone-Lee J, Hashemi M, Jahangiri M, Mohamed-Ali V. RANTES release by human adipose tissue in vivo and evidence for depot-specific differences. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1262-8
11
 Ogston NC, Karastergiou K, Hosseinzadeh-Attar MJ, Bhome R, Madani R, Stables M, Gilroy D, Flachs P, Hensler M, Kopecky J, Mohamed-Ali V. Low-dose acetylsalicylic acid inhibits the secretion of interleukin-6 from white adipose tissue. Int J Obes (Lond). 2008 Dec;32(12):1807-15
12
 Loebinger MR*, Kyrtatos PG*, Turmaine M, Price AP, Pankhurst Q, Lythgoe MF# and Janes SM# # Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles. *Joint First Authors #Joint Senior Authors. Cancer Res. 2009 Dec 1;69(23):8862-7
13
 Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM. Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 374 (2009) 467–475
14 Pourcet B., Pineda-Torra I., Derudas B., Staels B. and Glineur C. Sumoylation of the human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCOR. J Biol. Chem 2009 Dec 2.
15 Pineda Torra I., Ismaili N., Feig JE., Cavasotto C., Chongfeng X., Pancratov R., Bowers M., Rogatsky I., Neubert T., Fisher EA., Garabedian MJ. Phosphorylation of LXRa selectively regulates target gene expression in macrophages. Mol Cell Biol. (2008) 28, 2626-2636
16 Breckenridge RA, Kelly P, Nandi M, Vallance PJ, Mohun TJ, Leiper J. A role for Dimethylarginine Dimethylaminohydrolase 1 (DDAH1) in mammalian development.  Int J Dev Biol. 2010;54(1):215-20