Centre for Cardiovascular Biology and Medicine



Centre for Cardiovascular Biology and Medicine

Professor Ian Zachary’s research, supported by major funding by the British Heart Foundation and the European Union (FP7), investigates how the essential angiogenic factor, Vascular Endothelial Growth Factor (VEGF), signals endothelial cells to form new blood vessels, with major interests in. signalling involved in endothelial cell migration, and the role of Neuropilin-1.

These questions are addressed using diverse techniques in cell and molecular biology and in vivo zebrafish and genetically altered mutant mice models.

A major part of our translational research, led by Professor John Martin, is the use of stem cells for treating heart disease.

The Centre received the first grant awarded by the UK Stem Cell Foundation to perform a clinical trial of autologous stem cells and repair of the heart immediately after a heart attack. If successful, this trial may have a considerable impact on NHS practice in the treatment of heart attack patients.

Dr Paul Frankel’s group combines molecular analysis of cell signalling required for cancer cell motility with state-of-the-art imaging technologies - particularly optical projection tomography and fluorescence-based biosensors – using novel zebrafish models of cancer. 

Fluorescent 3-D imaging technique tracks disease models without surgery

Dr Richard Day leads the Applied Biomedical Engineering Group, focussing on interdisciplinary research and regenerative medicine for debilitating conditions including incontinence, visual impairment, muscular dystrophy and cardiovascular disease as part of the UCL Grand Challenge of Human Wellbeing.