Key Publications

Key Publications

  1. C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC), Wensley, F., Gao, P., Burgess, S., Kaptoge, S., Di Angelantonio, E., Shah, T., Engert, J.C., Clarke, R., Davey-Smith, G., Nordestgaard, B.G., Saleheen, D., Samani, N.J., Sandhu, M., Anand, S., Pepys, M.B., Smeeth, L., Whittaker, J., Casas, J.P., Thompson, S.G., Hingorani, A.D. and Danesh, J. (2011) Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. B.M.J., 342: d548.
  2. Kolstoe, S.E., Mangione, P.P., Bellotti, V., Taylor, G.W., Tennent, G.A., Deroo, S., Morrison, A.J., Cobb, A.J.A., Coyne, A., McCammon, M.G., Warner, T.D., Mitchell, J., Gill, R., Smith, M.D., Ley, S.V., Robinson, C.V., Wood, S.P. and Pepys, M.B. (2010) Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc. Natl. Acad. Sci. USA, 107: 20483-20488.
  3. Bodin, K., Ellmerich, S., Kahan, M.C., Tennent, G.A., Loesch, A., Gilbertson, J.A., Hutchinson, W.L., Mangione, P.P., Gallimore, J.R., Millar, D.J., Minogue, S., Dhillon, A.P., Taylor, G.W., Bradwell, A.R., Petrie, A., Gillmore, J.D., Bellotti, V., Botto, M., Hawkins, P.N. and Pepys, M.B. (2010) Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature, 468: 760-767.
  4. Gillmore, J.D., Tennent, G.A., Hutchinson, W.L., Gallimore, J.R., Lachmann, H.J., Goodman, H.J.B., Offer, M., Millar, D.J., Petrie, A., Hawkins, P.N. and Pepys, M.B. (2010) Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis. Br. J. Haematol., 148: 760-767.
  5. Emerging Risk Factors Collaboration, Kaptoge, S., Di Angelantonio, E., Lowe, G., Pepys, M.B., Thompson, S.G., Collins, R., Danesh, J., et al. (2010) C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet, 375: 132-140.
  6. Kolstoe, S.E., Ridha, B.H., Bellotti, V., Wang, N., Robinson, C.V., Crutch, S.J., Keir, G., Kukkastenvehmas, R., Gallimore, J.R., Hutchinson, W.L., Hawkins, P.N., Wood, S.P., Rossor, M.N. and Pepys, M.B. (2009) Molecular dissection of Alzheimer's disease neuropathy by depletion of serum amyloid P component. Proc. Natl. Acad. Sci. USA, 106: 7619-7623.
  7. Lachmann, H.J., Kone-Paut, I., Kuemmerle-Deschner, J.B., Leslie, K.S., Hachulla, E., Quartier, P., Gitton, X., Widmer, A., Patel, N. and Hawkins, P.N.; Canakinumab in CAPS Study Group (2009) Use of canakinumab in the cryopyrin-associated periodic syndrome. N. Engl. J. Med., 360: 2416-2425.
  8. Lachmann, H.J., Goodman, H.J.B., Gilbertson, J.A., Gallimore, J.R., Sabin, C.A., Gillmore, J.D. and Hawkins, P.N. (2007) Natural history and outcome in systemic AA amyloidosis. N. Engl. J. Med., 356: 2361-2371.
  9. Dember, L.M., Hawkins, P.N., Hazenberg, B.P., Gorevic, P.D., Merlini, G., Butrimiene, I., Livneh, A., Lesnyak, O., Puechal, X., Lachmann, H.J., Obici, L., Balshaw, R., Garceau, D., Hauck, W. and Skinner, M. (2007) Eprodisate for the treatment of renal disease in AA amyloidosis. N. Engl. J. Med., 356: 2349-2360.
  10. Pepys, M.B., Hirschfield, G.M., Tennent, G.A., Gallimore, J.R., Kahan, M.C., Bellotti, V., Hawkins, P.N., Myers, R.M., Smith, M.D., Polara, A., Cobb, A.J.A., Ley, S.V., Aquilina, J.A., Robinson, C.V., Sharif, I., Gray, G.A., Sabin, C.A., Jenvey, M.C., Kolstoe, S.E., Thompson, D. and Wood, S.P. (2006) Targeting C-reactive protein for treatment of cardiovascular disease. Nature, 440: 1217-1221.
  11. Pepys, M.B. (2006) Amyloidosis. Annu. Rev. Med., 57: 223-241.
  12. Stangou, A.J., Heaton, N.D. and Hawkins, P.N. (2005) Transmission of systemic transthyretin amyloidosis by means of domino liver transplantation. N. Engl. J. Med., 352: 2356.
  13. Pepys, M.B. (2005) CRP or not CRP? That is the question. Arterioscler. Thromb. Vasc. Biol., 25: 1091-1094.
  14. Danesh, J., Wheeler, J.G., Hirschfield, G.M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G.D.O., Pepys, M.B. and Gudnason, V. (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med., 350: 1387-1397.
  15. Pepys, M.B. and Hirschfield, G.M. (2003) C-reactive protein: a critical update. J. Clin. Invest., 111: 1805-1812.
  16. Hawkins, P.N., Lachmann, H.J. and McDermott, M.F. (2003) Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N. Engl. J. Med., 348: 2583-2584.
  17. Lachmann, H.J., Booth, D.R., Booth, S.E., Bybee, A., Gilbertson, J.A., Gillmore, J.D., Pepys, M.B. and Hawkins, P.N. (2002) Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. N. Engl. J. Med., 346: 1786-1791.
  18. Pepys, M.B., Herbert, J., Hutchinson, W.L., Tennent, G.A., Lachmann, H.J., Gallimore, J.R., Lovat, L.B., Bartfai, T., Alanine, A., Hertel, C., Hoffmann, T., Jakob-Roetne, R., Norcross, R.D., Kemp, J.A., Yamamura, K., Suzuki, M., Taylor, G.W., Murray, S., Thompson, D., Purvis, A., Kolstoe, S., Wood, S.P. and Hawkins, P.N. (2002) Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature, 417: 254-259.

Laboratory for Protein Crystallography

  1. Pal, M., Erskine, P.T., Gill, R.S., Wood, S.P. and Cooper, J.B. (2010) Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei. Acta Cryst., F66: 990-993.
  2. Kolstoe, S.E. and Wood, S.P. (2010) Drug targets for amyloidosis. Biochem. Soc. Trans., 38: 466-470.
  3. Montgomery, M.G., Coker, A.R., Taylor, I.A. and Wood, S.P. (2010) Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase. J. Mol. Biol., 396: 1379-1391.
  4. Bowyer, A., Mikolajek, H., Stuart, J.W., Wood, S.P., Jamil, F., Rashid, N., Akhtar, M. and Cooper, J.B. (2009) Structure and function of the L-threonine dehydrogenase (TkTDH) from the hyperthermphilic archaeon Thermococcus kodakaraensis. J. Struct. Biol., 168: 294-304.
  5. Gill, R., Kolstoe, S.E., Mohammed, F., Al D-Bass, A., Mosely, J.E. Sarwar, M., Cooper, J.B., Wood, S.P. and Shoolingin-Jordan, P.M. (2009) Structure of human porphobilinogen deaminase at 2.8 Å: the molecular basis of acute intermittent porphyria. Biochem. J., 420: 17-25.
  6. Erskine, P.T., Knight, M.J., Ruaux, A., Mikolajek, H., Wong Fat Sang, N., Withers, J., Gill, R., Wood, S.P., Wood, M., Fox, G.C. and Cooper, J.B. (2006) High resolution structure of BipD: an invasion protein associated with the type III secretion system of Burkholderia pseudomallei. J. Mol. Biol., 363: 125-136.
  7. Coates, L., Erskine, P.T., Mall, S., Gill, R., Wood, S.P., Myles, D.A.A. and Cooper, J.B. (2006) X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases. Eur. Biophys. J., 35: 559-566.
  8. Erskine, P.T., Beaven, G.D.E., Hagan, R., Findlow, I.S., Werner, J.M., Wood, S.P., Vernon, J., Giese, K.P., Fox, G. and Cooper, J.B. (2006) Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory. J. Mol. Biol., 357: 1536-1547.
  9. Williams, P., Coates, L., Mohammed, F., Gill, R., Erskine, P., Bourgeois, D., Wood, S.P., Anthony, C. and Cooper, J.B. (2006) The 1.6 Å X-ray structure of the unusual c-type cytochrome, cytochrome cL, from the methylotrophic bacterium Methylobacterium extorquens. J. Mol. Biol., 357: 151-162.
  10. Gill, R., Mohammed, F., Badyal, R., Coates, L., Erskine, P., Thompson, D., Cooper, J., Gore, M. and Wood, S. (2005) High resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy. Acta Cryst., D61: 545-555.
  11. Dunn, G., Montgomery, M.G., Mohammed, F., Coker, A., Cooper, J.B., Robertson, T., Garcia, J.-L., T.D.H. Bugg and Wood, S.P. (2005) The structure of the C-C bond hydrolase MhpC provides insights into its catalytic mechanism. J. Molec. Biol., 346: 253-265.