A Smartphone Tool to Reduce Alcohol Use and Admissions in Alcoholic Liver Disease
Publication date: 13 April 2015
Gautam Mehta, Kevin Moore and Rajiv Jalan, in collaboration with Cyberliver Ltd. have obtained a grant (£75K) from the Health Foundation to test a smartphone based app, to deliver brief interventions and prevent re-admission in patients with alcohol liver disease. This exciting approach will have a national press launch from the Health Foundation on the 20th April. Cyberliver Ltd. Is a startup founded by Jalan and colleagues with the aim of building a platform for the remote management of patients with liver disease.
Poem - Festschrift Gordon Stewart
Publication date: 31 March 2015
by Professor John Martin
Gordon was a well-loved doc
He sashayed round the ward
Graduate Open Day 16th March 2015
Publication date: 8 January 2015
Seminar Room 210, Second Floor, Rayne Building, 5 University Street, London, WC1E 6JF
2nd DoM Career Development Workshop 13th January 2015
Publication date: 23 December 2014
Thinking about applying for a research/teaching fellowship
13th January 2015 at 2 p.m.
Lilly Scientific Achievement Award 2014 to Rachel Batterham
Publication date: 20 November 2014
Dr Rachel Batterham, Head of the Centre for Obesity Research, Division of Medicine, UCL and clinical lead of the bariatrics service at UCLH, has been awarded the 2014 Lilly Scientific Achievement Award by The Obesity Society.
Sheila Sherlock Updates 4-6 December 2014
Publication date: 17 November 2014
A new series of international meetings with the Sheila Sherlock brand aimed at renovating the tradition of the periodic updates introduced by Dame Sheila Sherlock at the Royal Free Hospital. In this first meeting of the new series, Hepatology and Liver Transplant will be associated with a broader gastrointestinal agenda including topics like IBD, pancreatic cancer, neuroendocrine tumours and other aspects mastered by the specialists operating at the Royal Free and at UCLH. In addition, a special relevance will be given to frontier basic and translational research in Liver and Digestive Diseases.
The good, the bad and the ugly: Bugs in the gut
Publication date: 17 November 2014
In mammals trillions of bacteria colonize the skin and mucosal surfaces. The largest community is found in the gut, collectively known as the gut-microbiota. So far variations in microbiota have been linked predominately to the development of gut pathology. However, a new study published in Nature Medicine by Professor Claudia Mauri's group (UCL Division of Medicine) in collaboration with microbiologists from the Institute of Child Health directly links the gut-microbiota to arthritis development and a population of B cells known as regulatory B cells (Bregs), cells originally identified by Professor Mauri’s group as immunosuppressive.
The study, funded by arthritis research UK (ARUK), identifies that treatment with broad-spectrum antibiotics, ablating the microbiota, reduces both arthritis severity and, paradoxically, the number of Bregs. Furthermore, the group demonstrates that Bregs expand in number in response to “danger signals” induced in response to the cooperation between gut-microbiota and arthritic stimuli, to limit severe joint swelling and damage, which in their absence would otherwise develop.
Graduate Careers and Research Day 1st December 2014
Publication date: 31 October 2014
Myelin vital for learning new practical skills
Publication date: 20 October 2014
New evidence of myelin’s essential role in learning and retaining new practical skills, such as playing a musical instrument, has been uncovered by UCL research
The Challenge of Chronic Pain 11-13 March 2015
Publication date: 1 October 2014
The Challenge of Chronic Pain
11-13 March 2015
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
BSc/MSci Applied Medical Sciences Open Day 30th October 2014
Publication date: 1 October 2014
The next open day for the BSc/ MSci Applied Medical Sciences programme for 2015 entry is scheduled for Thursday 30th October 2014 from 11am - 3pm at the UCL Royal Free Campus in Hampstead, London NW3.
Away Day 24th April 2015
Publication date: 29 September 2014
The Away Day will take place on Friday 24th April 2015. To register please e-mail Anita Waterman
Major Grants from 1st August 2013
Publication date: 31 July 2014
- £5.3 million grant from the MRC for Image-directed Health Care. Shonit Punwani (Institute of Nuclear Medicine) and Prof Mark Lythgoe (Centre for Advanced Biomedical Imaging) (co-investigators with Mark Emberton, Division of Surgery)
- £3.2 million from the MRC to investigate “Enhancing immunity and vaccination responses in older humans by targeting the p38 MAP kinase signalling pathway and vitamin D supplementation” Professor Derek Gilroy (Clinical Pharmacology and Experimental Therapeutics) (co-investigator with Professor Arne Akbar, Division of Infection and Immunity)
- £2,282,063 MRC. Professor Sam Janes (PI): DPFS/DSC MSC trial in lung cancer
- £1.35m of a £5.9m European Union Horizon 20:20 grant on a new therapeutic for the treatment of liver cirrhosis and non-alcoholic fatty liver disease. Professor Rajiv Jalan (Institute for Liver and Digestive Health, PI)
- £1,273,218 Wellcome Trust/Department of Health, Health Innovation Challenge Fund, Dr Alastair O’Brien, “ATTIRE: Albumin to prevent infection in chronic liver failure”
- £1,127,761 Wellcome Trust Simon Walker-Samuel, Senior Research Fellowship
- £933,494 EPSRC Dr Tammy Kalber, Early Career Fellowship, “Generation of multi-model imaging mesenchymal stem cells”
- £888,203 MRC. Anthony Segal Research Grant: “Identification and characterisation of casula molecules for Crohn's disease and ulcerative colitis”
- £628,696 (£20,191 to DoM but UCL is lead) - FP7 – William Rosenberg – ‘FLUTCORE: Development of a universal vaccine based on tandem core technology’.
- £630,000 Project Grant from the Linbury Trust to study Skin problems in the elderly. Professor Chris Bunker:.
- £625.000 (€800,000) EU Horizon 20:20 programme. Prof John Wood (Wolfson Institute for Biomedical Research) to investigate bone pain.
- £577,127 BBSRC. Huiliang Li. Research Grant: Transgenic approaches to understanding astrocyte hetergeneity
- £567,350 MRC. Professor Alan Salama (Centre for Nephrology; co-investigator): “Targeting glycans in ischaemia reperfusion”.
- £500,000 BRC - Dr Reecha Sofat: Project Grant to develop an Integrated strategy for Investigation of Stroke
- £475,224.31 MRC. Richard Day. Research Grant: Improved Delivery and Function of Myoblasts via Soluble TIPS Microcarriers
- £460,000 from the MRC. Derek Gilroy (Clinical Pharmacology and Experimental Therapeutics) & Alastair O’Brien (Institute for Liver & Digestive Diseases): for “Reversal of immune suppression in cirrhosis patients by inhibiting prostaglandin E2”.
- £451,939 (total award to UCL £921,359) Cancer Research UK (via King’s College London). Prof Mark Lythgoe, Prof Ashley Groves, Dr Shonit Punwani and Dr Erik Arstad, “Comprehensive Cancer Imaging Centre (CCIC 2)”
- £428,165 European Union Grant for IMI Combacte-Magnet Consortium. Professor Mervyn Singer (Centre for Intensive Care Medicine, PI).
- £417,119 NIHR. Mrs Jackie McRae, Clinical Doctoral Research Fellowship, entitled “The development of a screening instrument for dysphagia following acute cervical spinal cord injury”
- £383,532 GSK. Dr Jo Porter. Clinical Fellowship for Theresia Mikolasch.
- £368,549 E.U. Claudia Mauri FP7: ATHERO-B-CELL
- £360,000 Rosetrees Trust. Rachel Batterham, Research Grant: “Link between obesity gene FTO and gut hormones”
- £350,000 Replekfarm LLC. Dr Slavica Tudzarova-Trajkovka, Senior Research Fellowship, entitled “Exploring the potential for collaborative research related to CDC7 kinase-targeting anti-cancer therapy”
- £350,160 Biomedical Research Centre grant for radiopharmaceutical GMP laboratory. Dr Erik Arstad (Institute of Nuclear Medicine).
- £347,901 Arthritis Research UK Career Development Fellowship. Dr Blandine Poulet (Centre for Rheumatology and Connective Tissue Diseases): for a 5 year Arthritis Research UK Career Development Fellowship.
- £334,000 grant from the Charles Wolfson Foundation on Crohn’s Disease. Professor Tony Segal (Centre for Molecular Medicine, PI):
- £289,722 Pancreatic Cancer UK. Dr Steve Pereira: over three years for 'Creating a rapid diagnostic pathway for patients with pancreatic cancer'.
- £287,812 Wellcome Trust. Dr Laura Succony, Research Training Fellowship, entitled “Defining the role of Lrig1-dependent EGFR signalling pathway inhibition in airway homeostasis and lung cancer development”
- £287,017 Janssen. Claudia Mauri. Collaborative Research Agreement
- £286,308 BRC Shonit Punwani. BRC Cancer Programme Funding
- £286,000 Arthritis Research UK 4 yr Clinical Research Fellowship. Corinne Fisher (Centre for Rheumatology)
- £285,845 Prostate Cancer UK. Shonit Punwani Project Grant: Localising Occult prostate Cancer metastases with Advanced imaging Techniques (LOCATE)
- £282,678 (total award to UCL £872,299) European Commision FP7 award,Dr Erik Arstad, entitled “EPITARGET”
- £250,000 National Institute of Academic Anaesthesia (via BJA), Dr Gareth Ackland, entitled “Parasympathetic modulation of perioperative myocardial injury”
- £246,279, UCL Wellcome Trust. Professor Sam Janes: PhD Programme for Clinicans for Neelam Kumar
- £245,588 Wellcome Trust. Professor Derek Gilroy: Research Training Fellowship for Julia Flint
- £223,355 ESPRC grant for networking. Dr Kris Thielemans (Institute of Nuclear Medicine, PI)
- £206,806 Clinical Research Fellowship from Action Medical Research. Dr John Ioannou (Centre for Rheumatology, PI). "Investigating the link between puberty, the immune system and juvenile systemic lupus erythematosus".
- £200,758.00 GlaxoSmithKline (UCL-GSK Fibrosis Hub). Prof Justin Hsuan (Institute for Liver and Digestive Health)
- £148,300 from Arthritis Research UK on “Manipulation of gut microiota”. Professor Claudia Mauri (Centre for Rheumatology and Bloomsbury Rheumatology Unit, PI).
UCL Stroke Case Collection (UStroc)
Publication date: 30 June 2014
Publication date: 30 June 2014
Congratulations to Rajiv Jalan who has been elected the Editor-in-Chief of the Journal of Hepatology
2014 Medicine Code of Practice
Publication date: 26 June 2014
The 2014 Medicine Code of Practice is now available on the Intranet Safety page.
Early Career Research Conference
Publication date: 29 April 2014
10th-11th September 2014
University of Leeds
UCL Applied Renal Physiology 2014 - course
Publication date: 3 April 2014
This is a modular course and includes the following sections: a primer in renal physiology, a 2-day course on fluids, electrolytes and acid-base and, finally, a 1-day cutting-edge science symposium.
Rosetrees Trust Studentships - September 2014
Publication date: 24 March 2014
Professor Andrew Burroughs
Publication date: 19 March 2014
We are greatly saddened to announce the death of Prof Andrew Burroughs, who passed away on Saturday 15th March, at the age of 60. Prof Burroughs was an eminent and world renowned Professor of Hepatology and Consultant Physician/Hepatologist. He joined the UCL Institute of Liver and Digestive Health last year, having previously worked in the Sheila Sherlock Liver Centre at the Royal Free Hospital for the majority of his career.
Professor Massimo Pinzani, Sheila Sherlock Chair of Hepatology and Director of the UCL Institute for Liver and Digestive Health, commented:
"Andy was one of the greatest hepatologists in history and the true representative of Dame Sheila Sherlock's legacy. For more than thirty years, Andy led world class clinical research at the Royal Free providing major advances in clinical practice. He was a world leader and an amazing mentor for generations of hepatologists trained at the Royal Free. Our thoughts go to his family and to the memories of him working with us."
UEG Rising Star Award 2014
Publication date: 19 March 2014
Congratulations to Emmanuel (Manolis) Tsochatzis on receiving the 2014 Rising Star Award by the United European Gastroenterology Society (UEG). This is awarded to 8 emerging young clinical scientists from Europe based on a track record of international quality research and developing scientific independence. The recipients of the award give state-of-the-art lectures and chair scientific sessions at the UEG week.
in2scienceUK Summer Internship
Publication date: 17 March 2014
Rebecca McKelvey (Neuroscience) and Adam Giangreco (Medicine) have secured funding from Development and Alumni Relations and UCL Outreach to support the UCL-led In2ScienceUK laboratory placement scheme. The aim of this scheme is to inspire and motivate AS level science students from low income backgrounds and support them in their application to competitive research universities.
Now in its 5th year, the goal of this year’s programme is to place over 100 students in labs at UCL, Imperial and Kings. The scheme is very successful, with 80% of former students gaining places at UK universities (compared with around 17% in this demographic nationwide) – but a key to this success is finding labs that are happy to act as hosts. This occurs for 2 weeks in July-August, is a great experience for a senior PhD student or postdoc, and involves no additional administrative duties. Students can shadow group members, talk to PIs/postdocs/students in other labs, watch demonstrations, analyse data, or get involved in any other task which is appropriate. In2scienceUK will organize the placement, interview and select the students, and complete any necessary paperwork.
If you or someone in your lab would like to make a real difference to the prospects of these young people please contact Rebecca McKelvey
New insights into how the kidney works
Publication date: 21 February 2014
Professor Robert Kleta and team have discovered a new disease mechanism shedding light onto how the kidney works (Klootwijk et al., NEJM, 2014, 370, 129-138). As a trained paediatrician and geneticist he and Dr Detlef Bockenhauer from the Institute of Child Health together lead a competitive team based at Royal Free Hospital comprised out of renal doctors, geneticists, bioinformaticians, computer scientists, cell and molecular biologists and physiologists focused on the study of rare renal disease. They investigated a clinical problem called autosomal dominant renal Fanconi syndrome in paediatric and adult patients and thereby discovered a completely novel disease mechanism: they showed that aberrant trafficking of an enzyme can cause disease not by its absence in the organelle it was intended to be, but by disturbing function of the organelle it is wrongly routed to. They discovered that a mutation in a peroxisomal protein caused misrouting to the mitochondria and interfered with mitochondrial metabolism.
Prof. Leon Fine, Professor and Chair, Dept of Biomedical Sciences, Vice-Dean, Research and Graduate Research Education, Cedars-Sinai Medical Center, Los Angeles, USA, formely UCL, commented “The paper is a tour de force of clinical observation, interdisciplinary science, multi-institutional collaboration, genomics and cellular physiology, which has led to the determination of the cause of an inherited disease. A truly outstanding achievement.”
British Bangladeshi Power & Inspiration List 2014
Publication date: 20 February 2014
Very well done to Anisur Rahman for his place in the British Bangladeshi Power & Inspiration List 2014 and to Jayne Kavanagh who received the Provost's Award for Public Engagement. Jayne was nominated for this award for her leading role in creating and running the Beacon-funded 2013/14 project ‘Stories from the soul: doctors’ choices, women’s lives’. 'Stories from the soul’ includes three evenings of storytelling, music and discussion that bring together healthcare providers with members of the public to explore how doctors’ decisions affect women’s lives.
ILTS Distinguished Service Award
Publication date: 18 February 2014
Professor Andrew K. Burroughs, a faculty of the UCL Institute for Liver and Digestive Health and consultant hepatologist at the Royal Free London, has recently been awarded the 2014 Distinguished Service Award of the International Liver Transplantation Society (ILTS) for his outstanding contribution to this field. Indeed, Professor Burroughs is one of the pioneers of transplant Hepatology and his research has greatly contributed to establishing the current management of liver transplantation. This represents a great honour for UK and European Hepatology.
During 2013, Professor Burroughs received two other major career awards: the Distinguished Career Award of the European Association for the Study of the Liver (EASL) and the highest honour from the British Society of Gastroenterology (BSG): the Sir Arthur Hurst Lecture.
In addition to his value as clinician and researcher, these awards were motivated by Professor Burroughs’ exceptional ability to mentor emerging talent in his field; indeed he has provided mentorship for an incredible number of UK and international hepatologists, in keeping with a tradition established at the Royal Free by his mentor Professor Dame Sheila Sherlock.