Mecheng News Publication
- Lecturer Dr Vanessa Diaz: Appointed Chair of the Science, Engineering & Technology panel
- Bright Club - Are bio-fuels funny?
- Mark Miodownik: Stuff Matters review
- 2013 UCL Bright Ideas Awards
- Royal Academy of Engineering Rooke Medal
- In vivo preclinical stage started for the Triskele UCL Transcatheter Aortic Valve
- Formula Student 2013
- Macromolecular Rapid Communications
- Osborne Reynolds Research Student award
- Mr Santiago Suárez De La Fuente wins IMarEST Stanley Gray Fellowship 24 July 2013
- Senior Promotions for 2013
- Cell Electrospinning featured on BBC World News
- An encapsulated drug delivery system for recalcitrant urinary tract infection
- James Cook wins the first Parmigiani Spirit Award
- Prof Edirisinghe scoops third Royal Society award
- Event: "Lost in Translation" Tuesday November 19, 13:00
- Coastal storm talk online
- What's in a SNAME?
- What do you get an engineer for Christmas?
- Meet Helen Czerski, Bubble Scientist
- On the road again: UCL Racing 2014 seeks drivers
- Mark Miodownik: Bye bye brolly
- "Super-hydrophobic?" Meet Dr Manish K Tiwari
- "and the winner is..." researchers Sherwood and Nithyanandan pick up prizes
- In pictures: SET for Britain 2014
- New device for four-layered macromolecular particles invented
- Limitless: An interview with Professor Yiannis Ventikos
- Major changes to global shipping needed to reduce emissions
- UCL’s Media Communicator of the Year (Broadcast) is…
- MechEng undergraduates storm the UK top ten
- The passing of John Inns
- Six days, seven nights: my week as a Royal Navy submariner by Lucy Collins
- Usher shines amongst Chinese stars
- UCL team look to the future with new eco marathon entry
- Watching stressful movies triggers changes to your heartbeat
- Helen Czerski: Low carbon flight on the horizon?
- MechEng researcher/alumni scoop prestigious international naval awards
- James Cook awarded for his Bright Idea
- "Computational Biomedicine" a Q&A with Dr Vanessa Diaz
- The future of mitral valve surgery?
- Israfil's nano-delight
- Event: 'Animals and Engineers: learning from nature.'
- Academic promotions 2014
- Event: Micro and Nano Flows Conference 2014
- UCL MechEng to research ultra efficient engines in £6m EPSRC projects
- Jaguar Land Rover invests £1m in engine combustion research project
- Mark Miodownik’s excellent week
- MUSE team wins Marie Curie ‘blue skies’ research funding
- Biomaterials EPSRC hat-trick to help launch academic careers
- Stuff really matters: Mark Miodownik wins Royal Society Winton Prize for Science Books
- REF 2014: The impact behind the power
- Prized naval architect Jeom Kee Paik joins UCL MechEng team
- Cover story: "Creating optically tunable protein bubbles..."
- Royal Navy honours Dan Hall with YARD Prize
- The new Pindelski-Barrack Bursary: Alumni fund places for MechEng undergraduates
- Dr Paul Hellier: Fuelling the Future
- Dr Sunthar Mahalingam wins international young researcher award
- Leverhulme Fellowship allows Vanessa Diaz to "imagine the impossible"
- Professor Paik claims William Froude Medal for Naval Architecture
- Review paper on engineering micro-organisms for designer fuels production
- UCL MechEng students head to Rotterdam with a Euro vision
- MechEng undergrads to mentor local schools in global STEM initiative
- Cover story: “Coupling Infusion and Gyration for the Nanoscale Assembly of Functional Polymer Nanofibers..."
New device for four-layered macromolecular particles invented
27 March 2014
New process could allow for treatment of four diseases simultaneously.
A new device that allows the mass production of four-layered macromolecular particles and fibres has been invented by a team at UCL Mechanical Engineering. This electrohydrodynamic (EHD) device, which contains four coaxial nozzles that simultaneously deliver four polymer solutions under an applied voltage, can revolutionize the concept of polypharmacy and biomedical engineering applications.
The paper on this new research, developed by the Biomaterials Processing Laboratory lead by Professor Mohan Edirisinghe, has been published as the front cover feature in the March issue of the journal Macromolecular Rapid Communications, released Wednesday.
Professor Edirisinghe said: “We are able to make four-layered polymer particles with each layer having a different polymer. This allows us to load a different drug in each layer, attached to a polymer so you have the ability to simultaneously treat four diseases. We can also use this device to make four-layered fibres. This has never been attempted in the fibre area and we have a working engineering device to do that, and this will enable the inclusion of multi-composition fibre strands in tissue scaffolds.”
Potential applications for the patented device include the production of ‘polypills’ where multiple active pharmaceutical ingredients can be combined to treat numerous diseases.
The Biomaterials lab is now collaborating on projects with Dr Mine Orlu Gul from UCL’s School of Pharmacy to further research potential polypill applications of the EHD device.
“The next phase of work is to start to load the layers with selected drugs for testing in vitro and in vivo” said Edirisinghe, who was keen to acknowledge his co-authors Labbaf, Ghanbar and Stride, as well as the crucial grant funding received from the EPSRC, which enabled this work.
- Read the journal article: Preparation of Multilayered Polymeric Structures Using a Novel Four-Needle Coaxial Electrohydrodynamic Device - Sheyda Labbaf , Hanif Ghanbar , Eleanor Stride, Mohan Edirisinghe*
- Prof Edirisinghe’s research profile
Page last modified on 27 mar 14 11:55