software

## Software

The downloadable files located on this page contain software developed in the
Molecular and Cultural Evolution lab or at The Centre for Genetic Anthropology.
Most zip files contain a Word doc help file. Programs were developed on a PC or
Mac but in many cases can be implemented on other platforms as well. In general,
the software has been developed for Python, Matlab/Octave or R/S-Plus environments.

Currently, the
software packages available are:

## YTIME

This is a set of Matlab/Octave functions to estimate Time to Most Recent Common Ancestor in a clade for which linked microsatellite data are available. The methods assume that the haplotype of the root ancestor is known. This software was first described in Behar et al. (2003), AJHG 73: 768-79

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## TEST_h_DIFF

This is a set of functions to test for a significant difference in genetic diversity h between two populations, based on samples of haplotypes at a single locus. Both frequentist and Bayesian solutions are presented, and the relative merits discussed. The functions are implemented both in Matlab/Octave and in R/S-Plus. This software was first described in Thomas et al. (2002), AJHG 70: 1411-1420

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## FLIP

FLIP stands for “Flexible Likelihood Inference on Populations”. It is made up of a series of Matlab/Octave functions that implement the “Monte Carlo Likelihood” method outlined in the paper "Y chromosome evidence for Anglo-Saxon mass migration" by M.E. Weale, D.A. Weiss, R.F. Jager, N. Bradman and M.G. Thomas, Molecular Biology and Evolution 19: 1008-1021.

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## GenoPheno

This is an R program to run a Monte Carlo method to test departure from expected phenotype levels under the null hypothesis that this is caused by complete association with a fully penetrant binary locus, together with phenotyping error. This method was first described in Mulcare et al. (2004), AJHG 74:1102-1110.

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## PopA

This is a set of Matlab/Octave functions to analyse haplotype frequency data from several populations, calculate statistics that measure the degree of diversity within populations and the genetic distance between populations, and perform bootstrap tests to look for significant differences in these statistics among different populations.

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## MantelPartialCorr

This is an R routine to perform Mantel-type permutation testing of the partial correlation of matrix A on B given C. User defines the form of A, B and C. This software was first described in Nadkarni et al. (2005), J Biol Rhythms 20:490-9.

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## TagIT

This is a set of Matlab routines for selecting and evaluating tagging SNPs. The most recent version includes automated routines for selecting tagging SNPs for large candidate gene lists using HapMap data. The methods implemented in TagIT are described in Weale et al. (2003), AJHG 73: 551-565, in Goldstein et al. (2003), Trends in Genetics 19: 615-622 and in Ahmadi et al (2005), Nature Genetics 37: 84-89.

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## Assocint

This is a set WinBUGS routines for Bayesian estimation of the boundaries of an associated interval around a SNP that has been nominated as having an association with a phenotype of interest. The associated interval is defined as the region within which other SNPs are in high enough LD with the nominated SNP to be also considered as putative functionals. The methods implemented in AssocInt are described in Supplementary Material of Soranzo et al. (2004), Genome Research 14: 1333-44.

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## WinMTSEQreader

This is a WinZip file that contains PC-only stand alone software that takes aligned HVS-1 sequence data in .GDE flat format and produces a list of Variable Sites Only (VSO) for each sample and tentatively groups them into mtDNA haplogroups which can be used to type specific coding region markers as described by Holmquist et al 2006 (in preparation). This software also joins together samples that have been sequenced multiple times. For full description and instructions see readme file within Zip file. It must be extracted using a recent version of WinZip.

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## WinVSOreader

This is a WinZip file that contains PC-only stand alone software that takes Variable Sites Only (VSO) lists from HVS-1 sequence data and tentatively groups samples into mtDNA haplogroups which can be used to type specific coding region markers as described by Holmquist et al 2006 (in preparation). For full description and instructions see readme file within Zip file. It must be extracted using a recent version of WinZip.

#### DOWNLOAD

## MTCOD-RES-EXCEL

This Excel spreadsheet with embedded formulae acts as a template for inserting data generated using either WinMTSEQreader or WinVSOreader software in order to type appropriate mtDNA coding region markers according to the scheme of Holmquist et al 2006 (in preparation)