## Maps

- Frequency of 13907*G
- Frequency of 13910*T
- Frequency of 13915*G
- Frequency of 14009*G
- Frequency of 14010*C
- Phenotype frequencies
- Phenotype frequencies based on LP-associated allele frequencies
- Phenotype frequencies based on -13,910 C>T allele frequency data only.
- Phenotype frequencies based on -14,010 G>C, -13,915 T>G, and -13,907 C>G allele frequency data
- Genotype-phenotype correlation
- Genotype-phenotype correlation p-values

Dots represent collection locations. Colours and colour key show the frequencies of the LP phenotype estimated by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Dots represent collection locations. Colours and colour key show the frequencies of the LP phenotype estimated by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Dots represent collection locations. Colours and colour key show the frequencies of the LP phenotype estimated by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Dots represent collection locations. Colours and colour key show the frequencies of the LP phenotype estimated by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Dots represent collection locations. Colours and colour key show the frequencies of the LP phenotype estimated by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Dots represent collection locations. Colours and colour key show the
frequencies of the LP phenotype estimated by surface interpolation. Taken from Itan et al 2010

##### -14,010 G>C, -13,915 T>G, -13,907 C>G, and -13,910 C>T

LP frequency prediction assumes
Hardy-Weinberg equilibrium and dominance. Crosses represent collection
locations where all 4 currently known LP-associated alleles were genotyped,
and diamonds represent collection locations where the only data on the
-13,910 C>T allele is available. Colour key shows the predicted LP
phenotype frequencies estimated by surface interpolation. Taken from Itan et al 2010

LP frequency prediction
assumes Hardy-Weinberg equilibrium and dominance. Stars represent collection
locations. Colour key shows the predicted LP phenotype frequencies estimated
by surface interpolation. Taken from Itan et al 2010

**Predicted
Old World LP phenotype frequencies based on frequency data for the currently
known LP associated allelic variants, excluding the -13,910 C>T allele**.
LP frequency prediction assumes Hardy-Weinberg equilibrium and dominance.
Crosses represent collection locations. Colour key shows the predicted
LP phenotype frequencies estimated by surface interpolation. Taken from Itan et al 2010

Old
World LP genotype-phenotype correlation, obtained by calculating the
quantitative difference between observed LP phenotype frequency and
that predicted using frequency data on all 4 LP-associated alleles.
Positive and negative values represent cases of LP-correlated genotype
under- and over-predicting the LP phenotype, respectively. Dots represent
LP phenotype collection locations, crosses represent data collection
locations for all currently known 4 LP-correlated alleles, and diamonds
represent -13,910 C>T only data collection locations. Colour key
shows the values of the predicted LP phenotype frequencies (Figure 2)
subtracted from the observed LP phenotype frequencies (Figure 1). Taken from Itan et al 2010

Old
World LP genotype-phenotype correlation, obtained by the GenoPheno Monte
Carlo test. Dots represent LP phenotype data collection locations,
crosses represent data collection locations for all currently known
4 LP-correlated alleles, and diamonds represent collection locations
for data on -13,910 C>T only. Colour key shows the p value obtained
by the GenoPheno test. Red colour represents values of p<0.01, indicating
a highly significant lack of correlation, yellow colour represents values
of 0.01≤p<0.05, indicating a significant lack of correlation,
and blue colour represents values of p≥0.05, indicating no significant
lack of correlation. Taken from Itan et al 2010