milk

GLAD

Global Lactase persistence Association Database

Lactase persistence (LP) is the ability of adult humans to digest the milk sugar lactose. LP is a dominant Mendelian trait that has been a subject of extensive genetic, medical, and evolutionary research.

This is an online database resource presenting the full LP phenotypic and LP-associated allele frequency data, including worldwide interpolated LP frequencies and genotype-phenotype correlation maps. 

We encourage researchers to send us new LP phenotype / genotype data to Professor Dallas Swallow in an Excel format using headers identical to those in the tables linked below. 

Please make sure that the submitted phenotype data conform to the following criteria:

-Random sampling

-Known ethnicity and sampling location

-Indigenous population

-No hospital patients or individuals self reporting with gut problems

Latest maps

Frequency of 13907*G

V-13907G


Dots represent collection locations. Colours and colour key show the allele frequency distribution represented by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Frequency of 13910*T

V-13910T


Dots represent collection locations. Colours and colour key show the allele frequency distribution represented by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Frequency of 13915*G

V-13915G


Dots represent collection locations. Colours and colour key show the allele frequency distribution represented by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Frequency of 14009*G

V-14009G


Dots represent collection locations. Colours and colour key show the allele frequency distribution represented by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Frequency of 14010*C

V-14010C


Dots represent collection locations. Colours and colour key show the allele frequency distribution represented by surface interpolation. Taken from supplementary Figure 2 of Liebert et al 2017

Previous maps

Data

Database Version Reference
LP Genotypes 2017 - DOWNLOAD
Liebert et al 2017
  2012 - DOWNLOAD Itan et al 2010
LP Phenotypes 2012 - DOWNLOAD Itan et al 2010
LP Ancient Genotypes 2013 - DOWNLOAD  To be updated

Credits

Maps

Yuval Itan, Mark Thomas, Nicolas Montalva, Dallas Swallow

Database

Anke Liebert, Yuval Itan, Bryony Leigh Jones, Catherine Ingram, Dallas Swallow, Mark Thomas

Corrections

Thanks to Favia Domizia  Nardi, Laure Segurel, and several others, for supplying corrections 

Last update

28th March 2018 by Adrian Timpson