Lungs for Living Research Centre

Medicine News

Major Grants from 1st August 2013

Published: Jul 31, 2014 12:23:05 PM

UCL Stroke Case Collection (UStroc)

Published: Jun 30, 2014 4:17:48 PM

Rajiv Jalan

Published: Jun 30, 2014 11:28:01 AM

Publications

  1. Teixeira VH,Parthiban N,Graham TA, Pipinikas CP, Brown JM, Falzon M, Nye Emma N, Poulsom R, Lawrence D, Wright NA, McDonald S, Giangreco A. Simons BD, Janes SM. Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors. ELIFE. 2013 Oct.
  2. Lu L, Teixeira VH, Yuan Z, Graham TA, Endesfelder D, Kolluri K, Al-Juffali N,Hamilton N, Nicholson AG, Falzon M, Kschischo M, Swanton C, Wright NA, Carroll B, Watt FM, George JP, Jensen KB, Giangreco A, Janes SM. LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development. J Pathol. 2013 Mar;229(4):608-20.
  3. Hynds RE, Giangreco A. Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine. Stem Cells. 2013 Mar;31(3):417-22.
  4. Rosewell IR, Giangreco A. Murine aggregation chimeras and wholemount imaging in airway stem cell biology. Methods Mol Biol. 2012;916:263-74.
  5. Butler C, Birchall M, Giangreco A. Interventional and intrinsic airway homeostasis and repair. Physiology (Bethesda). 2012 Jun;27(3):140-7.
  6. Giangreco A, Hoste E, Takai Y, Rosewell I, Watt FM. Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity. J Immunol. 2012 Feb 1;188(3):1514-22.
  7. Giangreco A, Lu L, Vickers C, Teixeira VH, Groot KR, Butler CR, Ilieva EV, George PJ, Nicholson AG, Sage EK, Watt FM, Janes SM. β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol. 2012 Mar;226(4):575-87.
  8. Giangreco A, Lu L, Mazzatti DJ, Spencer-Dene B, Nye E, Teixeira VH, Janes SM. Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance. J Pathol. 2011 Jun;224(2):190-202.
  9. Giangreco A, Jensen KB, Takai Y, Miyoshi J, Watt FM. Necl2 regulates epidermal adhesion and wound repair. Development. 2009 Oct;136(20):3505-14.
  10. Giangreco A, Arwert EN, Rosewell IR, Snyder J, Watt FM, Stripp BR. Stem cells are dispensable for lung homeostasis but restore airways after injury. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9286-91.
  11. Loebinger MR, Giangreco A, Groot KR, Prichard L, Allen K, Simpson C, Bazley L, Navani N, Tibrewal S, Davies D, Janes SM. Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade. Br J Cancer. 2008 Jan 29;98(2):380-7.
  12. Giangreco A, Groot KR, Janes SM. Lung cancer and lung stem cells: strange bedfellows? Am J Respir Crit Care Med. 2007 Mar 15;175(6):547-53.
  13. Kalber TL, Campbell-Washburn AE, Siow BM, Sage E, Price AN, Ordidge KL, Walker-Samuel S, Janes SM, Lythgoe MF. Primed infusion with delayed equilibrium of Gd.DTPA for enhanced imaging of small pulmonary metastases. PLoS One. 2013;8(1):e54903.
  14. Navani N, Lawrence DR, Kolvekar S, Hayward M, McAsey D, Kocjan G, Falzon M, Capitanio A, Shaw P, Morris S, Omar RZ, Janes SM; REMEDY Trial Investigators. Endobronchial ultrasound-guided transbronchial needle aspiration prevents mediastinoscopies in the diagnosis of isolated mediastinal lymphadenopathy: a prospective trial. Am J Respir Crit Care Med. 2012 Aug 1;186(3):255-60.
  15. Navani N, Brown JM, Nankivell M, Woolhouse I, Harrison RN, Jeebun V, Munavvar M, Ng BJ, Rassl DM, Falzon M, Kocjan G, Rintoul RC, Nicholson AG, Janes SM. Suitability of endobronchial ultrasound-guided transbronchial needle aspiration specimens for subtyping and genotyping of non-small cell lung cancer: a multicenter study of 774 patients. Am J Respir Crit Care Med. 2012 Jun 15;185(12):1316-22.
  16. Navani N, Molyneaux PL, Breen RA, Connell DW, Jepson A, Nankivell M, Brown JM, Morris-Jones S, Ng B, Wickremasinghe M, Lalvani A, Rintoul RC, Santis G, Kon
  17. OM, Janes SM. Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Thorax. 2011 Oct;66(10):889-93.
  18. Navani N, Nankivell M, Woolhouse I, Harrison RN, Munavvar M, Oltmanns U, Falzon M, Kocjan G, Rintoul RC, Janes SM. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study. J Thorac Oncol. 2011 Sep;6(9):1505-9.
  19. McCaughan F, Pipinikas CP, Janes SM, George PJ, Rabbitts PH, Dear PH. Genomic evidence of pre-invasive clonal expansion, dispersal and progression in bronchial dysplasia. J Pathol. 2011 Jun;224(2):153-9.
  20. Loebinger MR, Sage EK, Davies D, Janes SM. TRAIL-expressing mesenchymal stem cells kill the putative cancer stem cell population. Br J Cancer. 2010 Nov 23;103(11):1692-7.
  21. Loebinger MR, Janes SM. Stem cells as vectors for antitumour therapy. Thorax. 2010 Apr;65(4):362-9.
  22. Aguilar S, Scotton CJ, McNulty K, Nye E, Stamp G, Laurent G, Bonnet D, Janes SM. Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS One. 2009 Nov 24;4(11):e8013.
  23. Loebinger MR, Kyrtatos PG, Turmaine M, Price AN, Pankhurst Q, Lythgoe MF, Janes SM. Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles. Cancer Res. 2009 Dec 1;69(23):8862-7.
  24. Loebinger MR, Eddaoudi A, Davies D, Janes SM. Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer. Cancer Res. 2009 May 15;69(10):4134-42.
  25. Navani N, Spiro SG, Janes SM. Mediastinal staging of NSCLC with endoscopic and endobronchial ultrasound. Nat Rev Clin Oncol. 2009 May;6(5):278-86.