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Lungs for Living Research Centre

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Respiratory research

We have a comprehensive respiratory research program with a strong theme of understanding the processes causing and controlling lung cancer, and of developing new methods of early detection, staging, and treatment. The main themes are summarised below, along with examples of current projects.

   

Lung cancer biology

Diagnosis and staging 

  • Stem cell biology
  • Lung cell homeostasis
  • Mechanisms of carcinogenesis
  • Field cancerisation
  • Understanding progression: why some pre-invasive lung lesions become invasive carcinomas, yet others regress 
  • Interventional bronchoscopy and Endobronchial Ultrasound (EBUS)
  • Leadership of the LungSEARCH trial
  • Leadership of the Lung-BOOST trial
  • Leadership of the STREAMLINE trial alongside our MRI colleagues

Developing new treatments

Airway regeneration

  • Developing novel lung cancer treatments, including cellular therapies
  • Photodynamic therapy and the PEARL trial
  • Replacing diseased airway and REGENVOX2 trial

Airway Regeneration and Carcinogenesis Group 

Prof Sam Janes

Airway section with a preinvasive squamous lesion (green) and adenocarcinoma (red)

Lung cancer biology

We are interested in understanding how the stem cells of the airway maintain our epithelial layer, and importantly what happens when things go wrong. In particular we study the mechanisms controlling cell fate decisions, and define whether it is failure in the control of these cells that causes early lung cancer lesions. This work fits our clinical interest in monitoring a large cohort of patients with pre-invasive lung cancer lesions. 

We also investigate the potential of using bone marrow stem cells to deliver anti-cancer therapies. A successful pre-clinical project was funded by the Wellcome Trust, which led to an ongoing clinical trial funded by the MRC.

Mesothelioma

Mesothelioma is a cancer of the lung's lining for which current treatment options are limited. We collaborated with Ultan McDermott’s lab in the Wellcome Trust Sanger Institute to determine if mutations commonly seen in mesothelioma affected how the cancer would respond to different drugs. We found that mesothelioma cells with a mutant BAP1 gene are sensitive to the anticancer drug TRAIL. Since BAP1 is the most common mutation in mesothelioma, these findings may lead the way to a new treatment approach. 

Airway regeneration

Finally we have a group working on airway regeneration, again understanding the key mechanisms of airway epithelial proliferation and differentiation with and endpoint of supplying the epithelial lining of clinical tracheal and laryngeal grafts. 

Some of our latest research papers:

Clinical Trials Group 

Dr Neal Navani

Neal Navani is a Clinician and Clinical Trialist at UCLH and is based academically at the Lungs for Living centre. We have run several successful trials through UCLH, and Neal also has an honorary contract with the MRC clinical trials unit. 

Neal aims to make UCLH the key centre for lung cancer trials, including interventional and diagnostic trials, non-chemotherapy treatment trials, and other non-treatment trials.