Research into Down Syndrome with Children


Group members

Professor Annette Karmiloff-Smith - Principal Investigator

Dr Hana D'Souza - Postdoctoral Research Fellow

Dr Dan Brady - Postdoctoral Research Fellow

Kate Hughes – PhD student



Neurocognitive phenotypes of infants with Down syndrome: potential to predict protective/risk markers for Alzheimer’s disease.

Although many individuals with DS do not go on to develop the dementia associated with Alzheimer’s disease (AD), virtually all individuals with DS will present brain tissue features common in AD by the age of 30.

One proposed explanation is that the APP gene on chromosome 21 plays a role, as it is over-expressed from infancy onwards.

However, other genes are also involved and it is still not fully understood why some individuals with DS develop AD dementia whilst others do not. 

We argue that to understand any observable characteristic, it is crucial to trace its features back to its origins in early development.


The aims of the current project are to understand individual differences during infancy that may be associated with specific neurocognitive characteristics of AD.

A specific focus will be on individual performances that are meaningfully above or below the group average.

These individual differences may elucidate the protective and risk markers for AD.


The project received a great deal of publicity when it was first announced in 2012 (take a look at our article in The Observer).

We have continued to share our research ideas with the scientific community since then (see our poster presented at the Cognition in Down Syndrome Workshop, Washington DC, USA, April 2013).

What we will be doing

One-hundred-fifty infants between the ages of 6 and 48 months will be recruited from Down syndrome organisations and parental support groups.

A sub-group of these individuals will be followed longitudinally to allow us to track specific neurocognitive phenotypes over this developmentally-intense period.

We will use non-verbal tasks including high-density electroencephalography (EEG see Fig. 1), to compute Event Related Brain Potentials (ERPs), and use eye-tracking techniques (see Fig. 2). 

Figure 1


Infants wearing the EEG cap, a lightweight sensor cap that measures the electrophysiological activity coming out of the child’s brain (like how a thermometer would measure temperature); nothing goes into the brain.


An average brain Event Related Potential collected from a group of infants’ responses to repeated standard sounds versus unexpected deviant sounds (infants show memory discrimination for auditory stimuli).

Figure 2


Results from an eye-tracking experiment. The eye tracker is able to measure exactly where the child is looking on the screen as the child scans a display.

Left: Eye tracking data from an infant with Down syndrome;

Right: infant with William syndrome.

We will also measure sleep patterns across the sleep/wake cycle using actigraphy, as we know that sleep plays a critical role in memory and neurocognitive development and that changes in sleep patterns precede Alzheimer Disease symptoms in typically developing adults (see Fig 3).

Figure 3


Actigraphy watches worn by infants (at their ankle). They record movement and are used to monitor infants’ sleep/wake cycles.

These measures will be correlated with questionnaires to investigate cognitive and socio-economic profiles with respect to brain changes during infancy.

This model aims to be of great benefit to individuals with DS, by the targeting of very early intervention strategies.

To learn more about the infant stream please see our information sheet, or if you have a baby with Down syndrome aged 6 to 60 months and would like to get involved in the study, please email:

Page last modified on 05 jul 16 18:05