During the immune response, the lymph node functions as communication and activation centre for immune cells. Dendritic cells (DCs) that encounter a virus or bacterium migrate to the lymph node to activate T cells which will fight the infection. Within the lymph node, specialized fibroblasts – fibroblastic reticular cells (FRCs) – form a cellular network facilitating migration and interaction of DCs and T cells. DC migration along FRCs depends on interaction of C-type lectin-like receptor 2 (CLEC-2) on DCs with podoplanin (PDPN) on FRCs. Simultaneously, this interaction results in elongation of FRCs allowing lymph node expansion. This is essential for T cell infiltration and proliferation in the lymph node. My research focuses on the molecular mechanisms and downstream signalling underlying PDPN activation. Furthermore, I will explore how the interaction between DCs and FRCs orchestrates the adaptive immune response. This project will significantly broaden our understanding of the immunoregulatory role of FRCs upon infection.