Seminars & Events

Seminars and events
Unravelling the twists and turns of the serpinopathies
David Lomas
Mon, 28/04/2014 - 16:00
Molecular mechanims of Wnt signalling
Mariann Bienz
Mon, 19/05/2014 - 16:00
Biodiversity and environment: methodological approaches in a theory-poor and data-rich area of applied research
Georgina Mace
Mon, 09/06/2014 - 16:00
Past Seminars and Events
Preclinical intravital microscopy of cancer invasion, metastasis and therapy response
Peter Friedl
Mon, 14/04/2014 - 16:00
Preclinical intravital microscopy of cancer invasion, metastasis and therapy response
Biomechanical regulation of tissue morphogenesis
Thomas Lecuit
Mon, 07/04/2014 - 16:00
Syntax in C. elegans locomotion: A systems approach to behaviour
Andre Brown
Mon, 31/03/2014 - 16:00
Ciliary and flagellar motility: From single molecules to collective motion
Jonathon Howard
Thu, 27/03/2014 - 16:00
Claude Desplan
Mon, 24/03/2014 - 16:00
Stochastic or deterministic patterning in the Drosophila visual system
Claude Desplan
Mon, 24/03/2014 - 16:00
A dissection of mesenchymal directional cell migration: new approaches, new ideas James Bear
James Bear
Thu, 20/03/2014 - 17:00
Host cell Invasion by Toxoplasma: Insights on how parasite overcome the host cell cortical constraints?
Isabelle Tardieux
Wed, 19/03/2014 - 16:00
Reciprocal signalling drives dendritic cell migration and lymph node expansion via CLEC-2/Podoplanin interactions
Sophie Acton
Thu, 13/03/2014 - 16:00
uMentor: An introduction to UCL's new mentoring scheme
Penny Bridges
Mon, 10/03/2014 - 16:00
The role of CORVET and HOPS complex components in organizing the endo-lysosomal system
Judith Klumperman
Mon, 03/03/2014 - 16:00
Stochastic signal encoding strategies in single cells
James Locke
Mon, 24/02/2014 - 16:00
Locke, J.C.W Sainsbury Laboratory, Cambridge University, Cambridge, UK, Gene expression can be surprisingly dynamic and heterogeneous. This variability in gene expression, even in a clonal population of cells grown under the same condition, has been observed in diverse organisms, from mammalian stem cells to bacteria. It remains unclear how this variability is generated and what function it can serve. We are using the B. subtilis general stress response regulator sigB as a model system to understand how heterogeneous cell states can be generated. By carrying out time-lapse microscopy of cells expressing a reporter of sigB activity, we discovered that sigB expression occurs in discrete pulses. The regulation of these pulses is input dependent. Energy stress causes sigB to be activated in continuous stochastic pulses. Environmental stress, however, results in a single pulse of sigB activation. By using a combination of mathematical modelling and synthetic biology techniques we were able to understand the mechanism of these two different dynamical regulation schemes. We are now testing whether pulsing is a common regulatory strategy for the cell.
Nanoscale characterisation of living systems by atomic force microscopy
Bart Hoogenboom
Mon, 17/02/2014 - 16:00
Atomic force microscopy (AFM) is a unique tool to resolve molecular and submolecular structure of living systems without the need for crystallisation, freezing or drying. Its resolving power can be illustrated by our visualisation of the DNA double helix in aqueous solution. Its main advantages, however, lie in its ability to probe (bio)physical characteristics such as kinetics (by real-time imaging) and nanomechanics of functional molecules and molecular complexes. I will illustrate the former case with our experimental results on membrane perforation by peptides/proteins, and the latter by our biophysical characterisation of the transport barrier in intact nuclear pore complexes.
Myelin plasticity and motor skills learning
Bill Richardson
Mon, 10/02/2014 - 16:00
From a connectome to functional neural maps: brain-wide calcium-imaging in C. elegans
Manuel Zimmer
Mon, 03/02/2014 - 16:00
Sorting out protein traffic: Ubiquitin-mediated endocytosis and ESCRT-mediated endosomal sorting
Dr. Scott Emr
Thu, 30/01/2014 - 16:00
Viva talk "Cellular analysis of HIV transmission from primary macrophages"
Sebastian Giese
Fri, 24/01/2014 - 12:00
Time, space and transcription during development
David Ish-Horowicz
Mon, 20/01/2014 - 16:00
RNA localization for cell size regulation
Mike Fainzilber
Mon, 09/12/2013 - 16:00