As obligate intracellular parasites viruses intimately rely on host cell factors for all stages of their replication.  Our group is interested in deciphering the complex interactions that occur between poxviruses and their host cells during all stages of the infection cycle.

 

We investigate how viruses initiate their internalization by endocytosis, and how they utilize transport within cellular endocytic systems to their advantage.  We are also analyzing how the viral genome and accessory proteins escape into the cytosol, and how replication proceeds.

 

For these we combine cellular, molecular, and virological techniques with state-of-the-art technologies such as automated small compound and image-based siRNA screening, advanced proteomics, super-resolution, live cell microscopy, and electron microscopy. Our particular interests lie in uncovering novel mechanisms by which viruses subjugate host cell functions to facilitate their entry, replication, and spread.