Ewa Paluch Research Group

2005, PhD in Biophysics, University Paris 7/Institut Curie, Paris
2001, DEA (Master), University Paris 7/Ecole Normale Superieure de Lyon
Ewa Paluch
Tel: +44 20 7679 4337
Awards: 
2008, HFSP Young Investigator Grant
2009, Deutsche Forschungsgemeinschaft
2013, HFSP Young Investigator Grant (Renewal)
2013, European Research Council starting grant
Previous Posts: 
2006-2012, Group Leader at the Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Germany; joint appointment with the International Institute of Molecular and Cell Biology, Warsaw, Poland

Actin cortex mechanics and animal cell morphogenesis

The cell cortex is a network of actin, myosin and associated proteins that lies under the plasma membrane and determines the shape of most animal cells. The cortex enables the cell to resist externally applied stresses and to exert mechanical work. As such, it plays a role in normal physiology during events involving cell deformation such as mitosis, cytokinesis, and cell locomotion, and in the pathophysiology of diseases such as cancer where cortical contractility is upregulated. Despite its importance, little is known about how the cortex is assembled and regulated.

As the cortex is an intrinsically mechanical structure - its biological activity results from its ability to contract and to exert forces - its physiological properties cannot be understood in isolation from its mechanics. The main focus of the group is to understand how these mechanical properties are determined by the molecular components of the cortex and how these properties are regulated, locally and globally, to allow the cell to undergo deformations, particularly during cytokinesis and migration. We combine cell biology, quantitative imaging and physical modelling to investigate:

  • The regulation of the architecture of the cortical network and of the resulting cellular mechanical properties;

  • The role of cortex mechanics during cell shape changes, particularly during cytokinesis and migration;

  • The formation and function of different protrusion types (blebs and lamellipodia) during migration in vivo and in 3-dimensionnal environments.

Lab Members: 
Marc de Gennes
Serres Murielle
Matthew Smith
Ortrud Wartlick
Publications
Jump to: 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 17.

2014

Berthoumieux, H; Maitre, J-L; Heisenberg, C-P; Paluch, EK; Juelicher, F; Salbreux, G; (2014) Active elastic thin shell theory for cellular deformations. NEW JOURNAL OF PHYSICS , 16 , Article ARTN 065005. 10.1088/1367-2630/16/6/065005. Gold open access

Bovellan, M; Romeo, Y; Biro, M; Boden, A; Chugh, P; Yonis, A; ... Charras, G; + view all (2014) Cellular control of cortical actin nucleation. Curr Biol , 24 (14) 1628 - 1635. 10.1016/j.cub.2014.05.069. Green open access
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Clark, AG; Wartlick, O; Salbreux, G; Paluch, EK; (2014) Stresses at the cell surface during animal cell morphogenesis. Curr Biol , 24 (10) R484 - R494. 10.1016/j.cub.2014.03.059.

2013

Biro, M; Romeo, Y; Kroschwald, S; Bovellan, M; Boden, A; Tcherkezian, J; ... Paluch, EK; + view all (2013) Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging. Cytoskeleton (Hoboken) , 70 (11) 741 - 754. 10.1002/cm.21142.

Clark, AG; Dierkes, K; Paluch, EK; (2013) Monitoring actin cortex thickness in live cells. Biophys J , 105 (3) 570 - 580. 10.1016/j.bpj.2013.05.057.

Paluch, EK; Raz, E; (2013) The role and regulation of blebs in cell migration. Curr Opin Cell Biol , 25 (5) pp. 582-590. 10.1016/j.ceb.2013.05.005. Green open access
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2012

Bergert, M; Chandradoss, SD; Desai, RA; Paluch, E; (2012) Cell mechanics control rapid transitions between blebs and lamellipodia during migration. Proc Natl Acad Sci U S A , 109 (36) 14434 - 14439. 10.1073/pnas.1207968109.

Goudarzi, M; Banisch, TU; Mobin, MB; Maghelli, N; Tarbashevich, K; Strate, I; ... Raz, E; + view all (2012) Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility. Developmental Cell , 23 (1) 210 - 218. 10.1016/j.devcel.2012.05.007.

Green, RA; Paluch, E; Oegema, K; (2012) Cytokinesis in Animal Cells. Annual Review of Cell and Developmental Biology , 28 (1) 29 - 58. 10.1146/annurev-cellbio-101011-155718.

Ma�tre, JL; Berthoumieux, H; Krens, SF; Salbreux, G; J�licher, F; Paluch, E; Heisenberg, CP; (2012) Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells. Science , 338 253 - 256. 10.1126/science.1225399.

Salbreux, G; Charras, G; Paluch, E; (2012) Actin cortex mechanics and cellular morphogenesis. Trends Cell Biol , 22 (10) 536 - 545. 10.1016/j.tcb.2012.07.001.

2011

Clark, AG; Paluch, EK; (2011) Mechanics and regulation of cell shape during the cell cycle. In: Kubiak, JZ, (ed.) Cell Cycle in Development. (? - ?). Springer

Sedzinski, J; Biro, M; Oswald, A; Tinevez, J-Y; Salbreux, G; Paluch, E; (2011) Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature , 476 (7361) 462 - 466. 10.1038/nature10286.

2010

Diz-Muñoz, A; Krieg, M; Bergert, M; Ibarlucea-Benitez, I; Muller, DJ; Paluch, E; Heisenberg, CP; (2010) Control of directed cell migration in vivo by membrane-to-cortex attachment. PLoS Biol , 8 (11) , Article e1000544 . 10.1371/journal.pbio.1000544. Green open access
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2009

Paluch, E; Heisenberg, C-P; (2009) Biology and Physics of Cell Shape Changes in Development. Current Biology , 19 (17) R790 - R799. 10.1016/j.cub.2009.07.029.

Tinevez, JY; Schulze, U; Salbreux, G; Roensch, J; Joanny, JF; Paluch, E; (2009) Role of cortical tension in bleb growth. Proc Natl Acad Sci U S A , 106 (44) 18581 - 18586. 10.1073/pnas.0903353106.

2008

Charras, G; Paluch, E; (2008) Blebs lead the way: how to migrate without lamellipodia. NAT REV MOL CELL BIO , 9 (9) 730 - 736. 10.1038/nrm2453.

This list was generated on Mon Mar 2 13:37:07 2015 GMT.