Science Direct paper for the Pichaud Group

A review On the transcriptional regulation of tissue organisation and cell morphogenesis: The fly retina as a case study

Abstract

Understanding
how a functional organ can be produced from a small group of cells
remains an outstanding question in cell and developmental biology. The
developing compound eye of Drosophila has long been a model of
choice for addressing this question by dissecting the cellular, genetic
and molecular pathways that govern cell specification, differentiation,
and multicellular patterning during organogenesis. In this review, the
author focussed on cell and tissue morphogenesis during fly retinal
development, including the regulated changes in cell shape and cell
packing that ultimately determine the shape and architecture of the
compound eye. In particular, the author reviewed recent studies that
highlight the prominent roles of transcriptional and hormonal controls
that orchestrate the cell shape changes, cell–cell junction remodeling
and polarized membrane growth that underlie photoreceptor morphogenesis
and retinal patterning.